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Characterization of catalase and its role in life-span determination in Caenorhabditis elegans.

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Call No.	QL391.N4 T38 2001
Author	Taub, James J.
Title	Characterization of catalase and its role in life-span determination in Caenorhabditis elegans.
Date	2001
Abstract	In nematodes an alternative third larval stage, often called the dauer stage, allows the animals to weather periods of low food availability (if free living) or to disperse (if parasitic). Recently, studies of mutations in the nematode Caenorhabditis elegans have indicated that mutations in age-1 and daf-2 , genes that control the entry into and exit from the dauer stage, have a profound effect upon the life span of the animal. Catalase activity is increased in age-1 and daf-2 animals and might be important for life-span extension. We show that C. elegans contains two catalases, CTL-2 is a typical animal peroxisomal catalase. The ctl-1 gene encodes the first cytosolic catalase identified in an animal. The ctl-1 catalase is regulated by age-1 and daf-2 and is responsible for the increase in catalase activity seen in these mutants. We have identified a mutation affecting the expression of ctl-1. The ctl-1 mutation causes the early death of dauer larvae and prevents the life-span extension of the dauer (daf) mutations as well as shortening the life-span of wild type animals carrying the ctl-1 mutation. This putative cytosolic form of catalase may have evolved to allow prolonged periods of dormancy before reproductive maturity.
Description	1 online resource (158 leaves) : illustrations (some color)
Format	application/pdf
Advisor	Ambros, Victor R.
Subject	Caenorhabditis elegans -- Genetics. ; Caenorhabditis elegans -- Larvae. ; Caenorhabditis elegans -- Growth. ; Catalase -- Genetic aspects.
College	Dartmouth College -- Department of Biological Sciences.
Issuing Body	Dartmouth Dissertations are made available through the Dartmouth Digital Library.
Degree	Thesis (Ph.D)--Dartmouth College.
Copyright	In Copyright. This material is protected by copyright and/or related rights. You are free to use this material in any way that is permitted by copyright law that applies to your use. For other uses, you need to obtain permission from the rights-holder(s). http://rightsstatements.org/page/InC/1.0/
DOI	https://doi.org/10.1349/ddlp.3431

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Characterization of catalase and its role in life-span determination in Caenorhabditis elegans.

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