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Fabrication and characterization of thin film molecularly imprinted polymers.

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Call No.	QD382.I43 C36 2009
Author	Campbell, Sara E.
Title	Fabrication and characterization of thin film molecularly imprinted polymers.
Date	2009
Abstract	Molecularly imprinted polymers are artificial networks designed to have many selective binding sites that are suitable for various applications. In order to develop more of these systems, the fabrication and characterization of imprinted polymers has become a significant area of study in recent years. Though there are several ways to fabricate imprinted polymers, the focus of this study was on a modified phase inversion procedure. A polymer and target of interest were dissolved together in a casting solvent, and then the thin film imprinted polymer systems were created via spin coating. Main characterization methods included infrared spectroscopy, atomic force microscopy, and nanoindentation. Before nanoindentation could be used to study the desired imprinted polymer systems, a protocol for testing was determined. Two different series of templates were examined in this study of imprinted polymers. The first series of templates investigated were the carbohydrates fructose, glucose, and maltose. Imprinted polymer films were made using poly (4-vinylphenol) as the polymer host. The surfaces of these carbohydrate imprinted films were examined, and the successful removal of the template was observed. Some advances were made toward reinserting the carbohydrate template molecules, though the system could be optimized further. Quantification of reinsertion was possible through a chemical assay. Additionally, the solvent N,N-dimethylformamide was used for the fabrication of these imprinted polymers and was found to be an extremely good porogen. The second series of templates investigated were aromatic compounds, primarily methyl 4-nitrobenzoate. Imprinted polymer films were made using both Saran® F-310 and poly (4-vinylphenol) as the polymer hosts. Removal of the template was successful, but some difficulties were found in the reinsertion process. Rather than focus on the reinsertion of methyl 4-nitrobenzoate, a study was made of the surface morphologies of the aromatic templates with differing functionalities. Computational studies were also performed with both template systems to study the polymer/template interactions. Hydrogen bonding interactions were found for both template systems.
Description	xiv, 301 leaves : ill. (some col.) ; 28 cm.
Format	application/pdf
Advisor	Joseph J BelBruno Ursula J Gibson, Robert B Grubbs, W Rudolf Seitz
Subject	Imprinted polymers -- Synthesis. Molecular imprinting. Thin films.
College	Dartmouth College -- Department of Chemistry.
Issuing Body	Dartmouth Dissertations are made available through the Dartmouth Digital Library.
Degree	Thesis (Ph.D.)--Dartmouth College.
Copyright	All rights reserved. No part of this book may be reproduced in any form by any electronic or mechanical means without permission in writing from the author.
DOI	http://dx.doi.org/10.1349/ddlp.290

Title	Page 1
Format	application/pdf
Issuing Body	Dartmouth Dissertations are made available through the Dartmouth Digital Library.
Degree	Thesis (Ph.D.)--Dartmouth College.
Full Text	Fabrication and Characterization of Thin Film Molecularly Imprinted Polymers A Thesis Submitted to the Faculty in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Chemistry by Sara E. Campbell DARTMOUTH COLLEGE Hanover, NH August 25, 2009 Examining Committee: ________________________________ Joseph J. BelBruno, Chair ________________________________ Ursula J. Gibson ________________________________ Robert B. Grubbs ________________________________ W. Rudolph Seitz ________________________________ Brian W. Pogue, PhD Dean of Graduate Studies

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