Toxoplasma gondii is an obligate intracellular pathogen that is able to survive in a range of hosts due to its repertoire of secreted effector proteins. Utilizing the type I and type II Δku80 strains we engineered a collection of targeted knockout...
Most current multiprocessor file systems are designed to use multiple disks in parallel, using the high aggregate bandwidth to meet the growing I/O requirements of parallel scientific applications. Most multiprocessor file systems provide...
Bayesian nonparametric methods have become increasingly popular in machine learning for their ability to allow the data to determine model complexity. In particular, Bayesian nonparametric versions of common latent variable models can learn as...
Magnetic resonance. ; Microwaves -- Physiological effect. ; Thermoelasticity. ; Neutron spin echoes. ; Microwave imaging in medicine. ; Imaging systems in medicine -- Design. ; Breast -- Magnetic resonance imaging.
Magnetic Resonance has been shown to detect tissue displacements generated by a mechanical stimulus or an ultrasound (US) field. Magnetic Resonance Microwave Absorption (MRMA) imaging uses MR to image microwave-induced thermoelastic waves as a...
I consider the problem of extending certain invariants of subsets of natural numbers to their equivalents for subsets of larger cardinals. The two specific questions I will address are the extension of the off-branch number [Special characters...
Microwave spectroscopy. Imaging systems -- Design and construction. Diagnostic imaging -- Digital techniques. Breast -- Cancer -- Diagnosis. Microwave imaging in medicine.
Microwave spectroscopy has been investigated as a possible modality for breast imaging because of the significant contrast in electrical properties between normal and malignant tissue over the microwave spectrum. A liquid-coupled, non-contacting...
Predictive control. Adaptive control systems -- Design. Airplanes -- Control systems.
A direct method to design data-based model predictive controllers is presented. The design method uses system identification techniques to identify model predictive controller gains directly from a set of excitation input and disturbance corrupted...
The Maine Coastal Current (MCC) flows south-westward along the New England coast in the Gulf of Maine. Red tides, river-borne pollutants, and biological species are hypothesized to be transported by the MCC. The transport pathways, and their...
Robots -- Control systems. ; Robots -- Motion. ; Computer algorithms. ; Electronic data processing -- Distributed processing.
Self-reconfiguring robots are robots composed of many physically connected modules which can change their structural configuration to support multiple functionalities. We claim that self-reconfiguring robots are more versatile, extensible, and...
Diagnostic imaging -- Mathematics. Expectation-maximization algorithms. Imaging systems in medicine -- Mathematics.
We have developed a general-purpose registration algorithm for medical images and volumes. The transformation between images is modeled as locally affine but globally smooth, and explicitly accounts for local and global variations in image...
Internet -- Security measures. Public key infrastructure (Computer security). Digital signatures. Peer-to-peer architecture (Computer networks) -- Security measures.
The Internet has become a virtual place where people not only operate in isolation but also interact with other Internet users. Collaborative systems are becoming more popular. Applications now being introduced could provide better remote education...
Multimodality imaging is becoming the standard of care for research and clinical studies. Such an approach is able to provide complementary information which can detect and characterize tumors. Advancing instrumentation for diffuse near-infrared...
Introduction. Nosocomial sepsis in extremely low birth weight (ELBW) infants 501-1000 grams is associated with increased mortality risk, prolonged hospitalization, and increased costs of care. Purpose. The purpose of this thesis was to evaluate the...
The human female reproductive tract (FRT) maintains a state of immune tolerance to spermatozoa and fetal allografts, while retaining the capacity to respond to a number of sexually transmitted infections (STIs) including human immunodeficiecy virus...
Retinitis Pigmentosa is an inherited retinal degenerative disorder, initiated by point mutations on the rhodopsin gene. This thesis set forth to understand the mechanism of this pathogenesis, as well as to further improve our understanding of...
Manifolds (Mathematics) Geodesics (Mathematics) Space and time.
We investigate weak and strong refocusing of light rays in a space-time and related concepts. A strongly causal space-time ( X^ n +1 , g ) is emphstrongly refocusing at x ∈ X if there is a point y ≠ x such that all null-geodesics through y pass...
In utero exposure to maternal malnutrition is associated with increase offspring susceptibility to cardiometabolic and neuropsychiatric disease. Epigenetic mechanisms mediate, at least in part, fetal adaptations to adverse in utero environments...
In this thesis we develop a theory of Fourier analysis and fast Fourier transforms (FFTs) for finite inverse semigroups. Our results generalize results in the theory of Fourier analysis for finite groups. There is a general method for generating...
Friction severely limits performance in precise positioning systems. This thesis investigates one possible approach to counter friction related performance losses, friction cancellation. In this method a friction observer is used to estimate...
Robustness to genetic perturbations is a fundamental property of all living things. The genetic code is degenerate, RNA secondary structure is robust to sequence changes, and protein structure is robust to amino acid substitutions. Complex systems...
Novel biotherapeutics have reshaped drug discovery and promise a continued revolution in disease therapy, yet therapeutic proteins present unique design challenges. One distinguishing risk factor is the prospect of eliciting an adaptive immune...
This thesis investigates a notion of Turing reducibility introduced by Winkler [8] that is total on all computably enumerable oracles. Groszek and Weber show in [7] that this is a new notion of reducibility and it is not transitive. They give su...
In this work we investigate the quantum dynamics of three different configurations of nonlinear cavity systems. We begin by carrying out a quantum analysis of a dc superconducting quantum interference device (SQUID) mechanical displacement detector...
Little is known about the emergence of life from nonliving precursors. A key missing- piece is the origin of homochirality: nearly all life is characterized by exclusively dextrorotary sugars and levorotary amino acids. The research presented in...
Bioinorganic chemistry, a discipline that bridges chemistry and biology, has become increasingly popular as new techniques and analytical methods have emerged to study metals in biological systems. One such technique that has become increasingly...
Two alloys, Fe 55 Mn 19 Al 26 and Fe 30 Ni 20 Mn 35 Al 15 , were studied in this research project. The yield stress anomaly (YSA) of Fe 55 Mn 19 Al 26 single crystal was observed with a yield stress peak at 700 K. In situ TEM straining revealed...
RNA binding proteins are fundamental components of crucial biological processes in all domains of life. The development of techniques to study RNA binding protein complexes is, therefore, broadly impactful. I employed multiple genome-wide...
Gene set testing has become a critical tool for interpreting the results of high-throughput genomic experiments. Despite the development of robust statistical methods and extensive gene set collections, however, the results from gene set testing...
The Euler '-function and Carmichael -function are extremely important in modern number theory, and much work has been devoted to studying the distribution and arithmetic properties of the values of each function. One interesting unresolved question...
Optical tomography. ; Near infrared spectroscopy. ; Image analysis -- Mathematical models. ; Imaging systems -- Image quality -- Mathematical models. ; Image reconstruction -- Mathematical models. ; Least squares. Breast -- Tomography.
Diffuse optical tomography (DOT) has the potential to become a non-invasive and non-ionizing diagnostic imaging technique for breast cancer imaging. DOT uses near-infrared (NIR) light to illuminate the breast, generally through the use of fiber...
The accelerated expansion of space in the Universe has been known for two decades. However, finding a plausible theory that describes this expansion is more difficult: Taking general relativity for granted requires us to stipulate the existence of...