Predictive control. Adaptive control systems -- Design. Airplanes -- Control systems.
A direct method to design data-based model predictive controllers is presented. The design method uses system identification techniques to identify model predictive controller gains directly from a set of excitation input and disturbance corrupted...
In large and complex networks such as the Internet and road networks, traffic routing is typically decentralized. Users in the network choose their routes independently to minimize their own delay, leading to complicated and nonintuitive outcomes...
Antineoplastic agents -- Mechanism of action. Hemoglobin -- Synthesis -- Regulation. Protein kinases. Cellular signal transduction. Promoters (Genetics) -- Methylation. Azacitidine -- pharmacology. Fetal Hemoglobin -- biosynthesis. p38...
The β-hemoglobinopathies sickle cell disease and β-thalassemia represent some of the most common inherited diseases. It is recognized that increased fetal hemoglobin (HbF) ameliorates symptoms, mortality and morbidity in β-hemoglobinopathy...
Ultra-high molecular weight polyethylene (UHMWPE) remains the most common bearing material for total joint arthroplasty. Advances in radiation cross-linking and other post-consolidation treatments have led to a rapid differentiation of polyethylene...
Casimir effect. Zero-point field. Electric conductivity. Quantum electrodynamics.
The Casimir force arises from an alteration of boundary condition in vacuum and is often regarded as a manifestation of quantum zero point energy. Considerable progress has been made in the last decade with an impressive achievement of experimental...
Brain -- Tomography. Magnetic resonance imaging -- Brain. Near infrared spectroscopy. Image processing -- Digital techniques.
Diffuse optical tomography (DOT) using near infrared (NIR) light has become a promising modality because it has the capability to non-invasively quantify oxygen saturation and hemoglobin content with potentially high temporal resolution and...
Emergency medical response requires timely and efficient assessment and treatment of casualties. Mass casualty situations, in particular, strain the resources of emergency responders, prompting the need for a well-organized, effective, automated...
In the late 1960s, Ihara began work that led to the Ihara zeta function, a zeta function which is defined on a finite graph. This function is an interesting graph invariant which gives information on expansion properties of the graph. It also...
The eukaryotic flagellum is a complex organelle that uses the force generated by dynein motors to cause beating motion of the flagellum. The central apparatus of eukaryotic flagella has been implicated in the regulation of dynein-driven motility....
NIMA-related kinases (Neks) control several aspects of cell division downstream of master mitotic regulators such as Cdk1 and Plk1. Though depletion of Nek6, Nek7, or Nek9 results in cytokinesis failure, to date no molecular mechanism has been...
Arabidopsis thaliana -- Physiology. Zinc -- Physiological transport. Iron -- Physiological transport. Homeostasis. Trace elements in plant nutrition.
Iron and zinc are essential metal micronutrients that most humans acquire from plant-based diets. Unfortunately, plants are not a good source of these micronutrients, so billions of people worldwide suffer from deficiencies of these two elements....
The radio-frequency single-electron transistor (RF-SET) [1-3] has attracted significant interest as one of the fastest charge detectors known today. In this thesis, we show that by designing an on-chip superconducting LC matching network for the...
Two localized spectroscopic imaging methods were investigated to detect and discriminate microscopic pathologies at the surface of excised breast tissues in order to improve resection completeness during breast conserving surgery. A scanning in...
Cosmic acceleration could be an effect of a ""dark energy"" fluid pervading the Universe. It could also be an indication that general relativity is not the correct theory of gravity at cosmological length scales. Unfortunately, observations of the...
Topological graph theory. Aperiodicity. Paths and cycles (Graph theory)
The condition ""every cycle has an entry"" first appeared in the literature in Kumjian, Pask, and Raeburn's paper on Cuntz-Krieger algebras of directed graphs, where it was called Condition (L). It provides a necessary condition for simplicity of...
Near infrared reflectance spectroscopy. Breast -- Cancer -- Tomography. Breast -- Cancer -- Imaging. Breast -- Cancer -- Diagnosis. Image reconstruction. Diagnostic imaging. Image Processing
Pharmacologic induction of fetal hemoglobin (HbF) has proven therapeutic potential for ß-hemoglobinopathy patients. Increased HbF reduces disease severity by decreasing sickling in sickle cell disease and reducing α-chain imbalance in...
Accurate chromosome segregation in human oocytes requires that meiotic sister chromatid cohesion remain intact for decades and work in model organisms indicates that deterioration of meiotic cohesion over time may be a major determinant of...
The identification and characterization of functional genetic variation is essential for future advances in molecular diagnostics, pharmacogenomics, and personalized medicine. Recent attempts at identifying nucleotide level variation (somatic...
Sexual selection is a driver of biodiversity and creates spectacular forms of variation. However, only recently have we begun to understand how this variation operates on the postcopulatory level and how cryptic mechanisms affect male-male...
The multisubunit eukaryotic Mediator complex integrates diverse positive and negative gene regulatory signals and transmits them to the core transcription machinery. It is also involved in chromatin structure related epigenetic silencing through...
Pseudomonas aeruginosa is the leading cause of morbidity and mortality amongst cystic fibrosis (CF) patients. Following initial colonization of the CF lung by P. aeruginosa , the bacterium establishes chronic, long-term infections. Chronic P....
Apoptosis is important for tissue homeostasis and is the mechanism of cell death induced by many anticancer agents. The apoptotic machinery is present in all cells, such that tight regulation must exist to prevent untimely cell and tissue death. To...
Anabolic-androgenic steroids (AAS) are synthetic derivatives of the gonadal hormone, testosterone. Despite their many untoward side effects, AAS are wildly abused for their ergogenic properties. AAS have numerous effects on many organ systems,...
I investigate the kinematics and space densities of the local cataclysmic variable (CV) population. CVs are close binary star systems composed of a white dwarf that accretes matter from a less compact companion star in Roche lobe overflow....
CD4+ T cells are critical for the control of virus infections, memory cell formation and immune surveillance. Epstein-Barr virus and Kaposi’s sarcoma-associated herpesvirus are two γ-herpesviruses identified in humans and are strongly associated...
Immune response -- Regulation. Tretinoin. T cells. B cells. Plasma cells. Immunity.
Adaptive immunity licenses higher organisms to generate potent immune responses against foreign antigens. Two hallmarks of adaptive immunity are A) the ability of T and B cells to distinguish self from non-self and B) the ability to mount a...
Whistler-mode chorus waves have recently drawn tremendous attention as an important mechanism for controlling the energetic electron flux in Earth’s radiation belt. This dissertation aims to answer questions about whistler-mode chorus waves, such...
Cellulase -- Biotechnology. ; Hydrolysis. ; Paper industry -- Technological innovations. ; Biomass energy -- Economic aspects. ; Saccharomyces cerevisiae -- Genetics. ; Enzymes -- Industrial applications.
Paper sludge is the largest solid waste stream produced by pulp and paper industry, and is also an attractive feedstock for emergent technologies based on processing of cellulosic biomass featuring enzymatic hydrolysis. This study focuses on...
Safety in transportation systems is a global concern with millions of road accidents happening worldwide every year. Despite sophisticated advancement in automotive design and accident serverity reduction technologies, traffic fatalities continue...
The main research objective of this thesis is to address distributed target tracking for mobile sensor networks. Based on real-life limitations, we are particularly interested in mobile sensors with Limited Sensing Range (LSR). There are three...
Proper regulation of chromosome segregation during cell division is essential to prevent aneuploidy. During mitosis as well as meiosis, the cohesin complex physically holds sister chromatids together and is necessary for proper segregation of...
This thesis characterized the solubilities of sugar monomers and xylooligomers in water and explored the potential role of solubility for pretreatment of cellulosic Biomass by hemicellulose hydrolysis in only water. A novel apparatus was developed...
Bronchi -- Cancer -- Chemoprevention. ; Cyclins. ; Retinoids -- Therapeutic use. ; Cellular control mechanisms. ; G1 Phase.
Retinoids, natural and synthetic derivatives of vitamin A, are active in cancer treatment and chemoprevention. There is a need for an in-depth understanding of the mechanisms that account for retinoid response or resistance in lung cancer...
In this thesis we review the methods for computation of cosmological correlations in the early universe known as the in-in formalism which are then applied to the problem of magnetogenesis from inflation. For this computation, a power-law single...
Pseudomonas aeruginosa is one of the model organisms used to study the developmental process of biofilm formation in Gram-negative bacteria. Recently, a genetic approach {O'Toole, 1998 #404} was taken to study biofilm formation in P. aeruginosa and...
The C terminal domain (CTD) of Rpb1, a sub-unit of RNA Pol II, in Saccharomyces cerevisiae, contains 26 repeats of a heptapeptide sequence that is highly conserved in all eukaryotes. The CTD affects the implementation and co-ordination of...
Magnetic resonance. ; Microwaves -- Physiological effect. ; Thermoelasticity. ; Neutron spin echoes. ; Microwave imaging in medicine. ; Imaging systems in medicine -- Design. ; Breast -- Magnetic resonance imaging.
Magnetic Resonance has been shown to detect tissue displacements generated by a mechanical stimulus or an ultrasound (US) field. Magnetic Resonance Microwave Absorption (MRMA) imaging uses MR to image microwave-induced thermoelastic waves as a...
Snow -- Permeability. ; Snow surveys -- Antarctica -- East Antarctica. ; Surfaces -- Areas and volumes. ; Gas flow. ; Porosity.
Recent field investigations of a megadunes region of East Antarctica provide evidence that differences in grain size, thermal conductivity, and permeability across a megadune are due to relative accumulation patterns in the absence of significant...
Core binding factor translocations and inversions are among the most frequently identified mutations in acute myeloid leukemia. We present work that characterizes the functional contributions of domains within the fusion proteins resulting from the...
Macrocyclic tetrapyrroles are essential to life. In nature, they play important roles in living organisms, such as oxygen transportation and photosynthesis. Pentynoic acids are versatile precursors for preparing pyrrolines and higher homologues....
Chromatin -- Structure. DNA -- Methylation. Globin genes -- Expression. Adenosine triphosphatase. Proteins -- Chemical modification.
Epigenetic regulation of gene expression is a developing field of study with many potential therapeutic applications. Chromatin remodeling is necessary for proper mammalian development, and misregulation of this process is associated with many...
Metal powders -- Extrusion. Metal powders -- Microstructure. Shear flow.
The manufacture of bulk parts from metastable powder materials requires new approaches to cold consolidation. One potential technique is equal-channel angular extrusion (ECAE), a simple shear process. This thesis describes an investigation into the...
Sodium channels -- Physiology. Proteins -- Physiological transport. Biological transport -- Regulation. Aldosterone -- Physiological effect. Epithelial cells. Protein Transport. Vesicular Transport Proteins.
Nearly one billion individuals worldwide have elevated blood pressure (BP) and 90% of these cases are due to unknown causes. Aldosterone is the primary hormone regulating Na + reabsorption in the kidney and is therefore a major determinant of the...
The Hedgehog (Hh) and Wnt pathways are key biological signaling pathways responsible for embryonic development, cellular proliferation, stem cell maintenance and self-renewal, and adult somatic tissue homeostasis. Because these pathways serve as...
Actin filaments are integral to a large number of cellular structures. Due to the widespread use of actin, cells must rigorously control when and where new filaments assemble. Formin proteins are expressed in all eukaryotes and provide the...
Renewable energy sources are becoming increasingly important as sustainable alternatives to fossil fuels. One of these renewable sources, cellulosic biomass, is a relatively inexpensive and abundant resource that can be converted into liquid fuels...
Faithful chromosome segregation is vital for cell and organism viability, but is lost in many cancer cells with aneuploid karyotypes that display chromosomal instability (CIN). In normal cells, correct chromosome segragation is ensured through two...
Magnetic resonance elastography (MRE) is a recently developed imaging modality that measures and visualizes the mechanical properties of tissue in vivo. One of the essential reconstruction procedures in MRE is motion estimation. For dynamic...
Chapter 1: Munchnones and mesoionic heterocycles The reactivity, regioselectivity, and synthetic applications of munchnones (1,3-oxazolium-5-olates) is a common theme which runs through Chapters 2-5. The definition, structure, and reactivity of...