Dartmouth Digital Library Program

Thumbnail

Title

Subject

Description

Collection

Thermodynamic and spectroscopic studies of metal binding properties of histidine-rich peptides and proteins.
Histidine. ; Peptides -- Analysis. ; Proteins -- Analysis. ; Metal ions. ; Binding sites (Biochemistry) -- Thermodynamics. ; Macromolecules -- Spectra. ; Thermometric titration. ; Calorimetry. ; Electron paramagnetic resonance spectroscopy.
Dartmouth Dissertations

Observation of changing information sources.
Information resources management -- Mathematical models. ; Database management -- Methodology. ; Change. ; World Wide Web.
Many modern information management tasks consist of an observer that must maintain current knowledge of a collection of changing information. The goal of this observer is to maintain acceptably accurate state estimates given limited observation...
Dartmouth Dissertations

Echocardiographic tissue characterization of normal, ischemic and infarcted myocardium.
Echocardiography. ; Heart -- Diseases -- Diagnosis.
Dartmouth Dissertations

Synthetic studies directed toward investigation of cholesterol regulation.
Cholesterol -- Synthesis -- Regulation. ; Anticholesteremic agents -- Synthesis. ; Squalene.
Chapter II of this thesis describes the synthesis of a number of sulfobetaines and bissulfobetaines to be evaluated as inhibitors of squalene synthase (SS) on the basis of the idea proposed by Shechter that their zwitterionic structure would be...
Dartmouth Dissertations

Examinations of structured dispersive features of auroral HF waves observed with sounding rockets.
Ionospheric radio wave propagation -- Observations. Auroras -- Alaska -- Observations. Electromagnetic waves -- Observations. Sounding rockets -- Observations.
Earth's high latitude ionosphere, highly disturbed by particle and energy inputs and associated aurora, is the stage for plasma wave activity across a wide range of frequencies. These waves often exhibit strikingly distinct time-frequency structure...
Dartmouth Dissertations

A study of irradiance scintillation effects of an optical wave propogating through a turbulent atmosphere.
Plasma (Ionized gases). ; Wave-motion, Theory of.
Dartmouth Dissertations

NPC1-mediated trafficking of intracellular cholesterol.
Cholesterol -- Physiological transport. Cholesterol -- Genetic aspects. Cholesterol -- Metabolism. Genetic disorders -- Molecular aspects.
Niemann-Pick type C (NPC) is a neurovisceral disease that causes intracellular accumulation of cholesterol and other lipids. The exact mechanism how the defects in cholesterol trafficking pathways result in the progressive neurological damage is...
Dartmouth Dissertations

Solution chemistry of a New Hampshire subalpine ecosystem.
Forest ecology -- New Hampshire. Solution (Chemistry).
Dartmouth Dissertations

Applications of the exterior algebra to graphs and linear codes.
Hypergraphs.
Dartmouth Dissertations

Intramembranous particle clusters and cytoplasmic vesicles in mice with nephrogenic defects of urinary concentration.
Diabetes -- Research. ; Mice as laboratory animals.
Dartmouth Dissertations

Three dimensional stress engineered microstructures.
Microelectronics -- Design and construction. ; Micromachining. ; Strains and stresses. ; Silicon compounds.
This dissertation presents the use and extension of capabilities of surface machining technology, utilizing stress engineering between polysilicon and silicon nitride layers to build three-dimensional microstructures. A new theory and experimental...
Dartmouth Dissertations

Geology of the Lake Atitlan area, Guatemala : a study of subduction zone volcanism and caldera formation.
Geology -- Guatemala -- Lake Atitlan area; Volcanism -- Guatemala -- Lake Atitlan area; Calderas -- Guatemala -- Lake Atitlan area.
Geological mapping, petrological and geophysical studies in the lake Atitlan area, Guatemala, have revealed four distinct periods of stratovolcano growth, each followed by major silicic eruptions and caldera collapse. The first period (12 - 11 my...
Dartmouth Dissertations

Random quantum dynamics : from random quantum circuits to quantum chaos.
Quantum computers. ; Quantum chaos. ; Many-body problem. ; Hamiltonian systems.
Dartmouth Dissertations

Molecular and biochemical studies on human ACAT genes and proteins.
Acyltransferases -- Genetic aspects. ; Genetic transcription. ; Enzymatic analysis.
Since acyl Co-A: cholesterol acyltransferase (ACAT) is believed to be involved in important physiological functions such as lipoprotein assembly, cholesterol absorption, steroidogenesis, and pathogenesis of atherosclerosis, ACAT has been studied...
Dartmouth Dissertations

Cyber-based behavioral modeling.
Human behavior -- Mathematical models. ; Web usage mining. ; Internet users.
Whom we e-mail, where we browse, what we purchase, and the things we search for on the World Wide Web all leave identifiable traces of who we are as individuals. In today's technology focused landscape, cyberspace represents the new environment in...
Dartmouth Dissertations

Computations of wall-bounded two-dimensional turbulence.
Turbulence. ; Navier-Stokes equations -- Numerical solutions. ; Galerkin methods. ; Boundary layer -- Mathematical models. ; Viscous flow -- Mathematical models.
Dartmouth Dissertations

Self-consistent steady-state model of the low-lattitude boundary layer.
Magnetopause -- Mathematical models. Solar wind -- Mathematical models. Magnetosphere -- Mathematical models.
Dartmouth Dissertations

Role of GATA-1 in β-globin locus chromatin structure reorganization and eryrhoid [i.e. erythroid] gene expression.
Chromatin -- Structure. Globin genes -- Expression. Transcription factors. Erythropoiesis. Genetic transcription -- Regulation.
Despite being cloned over twenty years ago, many regulatory mechanisms of the β-globin genes have yet to be fully elucidated. The regulation of the β-globin locus in erythroid cells requires chromatin structural changes before the genes can be...
Dartmouth Dissertations

Characterization of transporters involved in uptake of choline and other trimethylamine-containing compounds in the opportunistic pathogen Pseudomonas aeruginosa / by Adel A. Malek.
Tumors -- Treatment -- Methodology.;""Nanoparticles -- Therapeutic use."";""Cell receptors."";""Antigenic determinants."";""Neoplasms -- therapy."";""Nanotechnology -- methods."";""Epitopes.""
Dartmouth Dissertations

Biochemical and structural studies of prion protein misfolding / by Geoffrey P. Noble
The transmissible spongiform encephalopathies (TSEs), also known as the prion diseases, are a unique group of fatal neurodegenerative diseases affecting humans and other mammals that have infectious, inherited and sporadic etiologies. A central...
Dartmouth Dissertations

Experimental studies of fine-particle transport in turbulent flows
Sediment transport.;""Silt."";""Turbulence.""
Dartmouth Dissertations

Vasopressin gene expression by non-neuronal cells: production in the gastrointestinal system and neoplasms of the lung.
Vasopressin. ; Gene expression. ; Gastrointestinal system. ; Lungs -- Cancer. ; Immunocytochemistry.
Dartmouth Dissertations

Restraint and disinhibition in the brain.
Self-control -- Physiological aspects. Nucleus accumbens -- Psychophysiology. Reducing diets -- Psychological aspects. Eating disorders -- Psychological aspects. Promiscuity -- Psychological aspects.
As humans we create goals and strive toward ideals, engaging in a constant endeavor to better ourselves or maintain our success. Whether goals are distant hopes for the future, or small steps of change, success requires some control over...
Dartmouth Dissertations

Synthesis of porphobilinogen and studies on the synthesis of cobyric acid.
Tetrapyrroles -- Synthesis. ; Porphyrins -- Synthesis. ; Vitamin B12 -- Synthesis.
Dartmouth Dissertations

Novel techniques for the investigation of GPCR structure and function / by Joshua A. Weiner.
G protein coupled receptors (GPCRs) make up somewhere between 30-50% of all current drug targets, yet the structural characterization of these receptors has been moderate at best. Until recently, structural data were almost nonexistent and...
Dartmouth Dissertations

Analysis of aberrant cell cycle regulation in pancreatic ductal adenocarcinoma uncovers novel thereapeutic approaches
Aberrant activation of cyclin D-Cdk4/6 is commonly found in pancreatic ductal adenocarcinoma (PDAC). Here, we show that PD-0332991, a highly specific inhibitor for Cdk4 and Cdk6, exerted growth inhibitory effects on human PDAC cell lines....
Dartmouth Dissertations

Photoconductivity of optical fiber preforms.
Optical fibers -- Measurement. ; Photoconductivity -- Measurement. ; Second harmonic generation.
Dartmouth Dissertations

Surface mismatch inverse based methods in brain deformation modeling.
Three-dimensional imaging in medicine -- Mathematical models. Diagnostic imaging -- Digital techniques. Brain -- Magnetic resonance imaging. Inverse problems (Differential equations).
An accurate registration between the preoperative images and the current surgical scene is critical to image-guided neurosurgery. However, during a neuro-surgical intervention, brain tissues shift and degrade the accuracy of the registration....
Dartmouth Dissertations

Post-translational regulation of the Neurospora crassa circadian system.
Post-translational modification. Circadian rhythms. Neurospora crassa -- Genetics. Genetic regulation. Phosphorylation. Medical Term Circadian Rhythm -- genetics.
Circadian rhythms are found ubiquitously throughout life on the planet. These biological clocks stem from common underlying molecular architecture revolving around a time-delayed feedback oscillator driving robust, approximately 24 hour rhythms. In...
Dartmouth Dissertations

Thermodynamic Studies of Metal Interactions with Four Biomolecules Using Isothermal Titration Calorimetry / by Margaret C. Carpenter
Some biomacromolecules require a metal co-factor to stabilize their physiologically active three-dimensional structure. The fundamental thermodynamic values of the binding of metal ions, particularly Zn2+, to a set of biomacromolecules have been...
Dartmouth Dissertations

Cellulosic biomass to ethanol: kinetic modeling, scale up, and reactor design.
Bioreactors -- Design and construction. ; Biochemical engineering -- Computer simulation. ; Mixing. ; Fermentation. ; Alcohol as fuel. ; Biomass energy.
Biological conversion of biomass to fuels and chemicals offers recognized benefits. The absence of systematic methodologies for scaling up such conversion is an important issue related to realizing these benefits. This thesis addresses this scale...
Dartmouth Dissertations

On methods for solving optimal stopping problems.
Optimal stopping (Mathematical statistics).
Dartmouth Dissertations

The interplay between GATA4-FOG2 transcriptional regulation and the canonical WNT signaling pathway in mouse organogenesis.
Mice -- Morphogenesis. ; Mice -- Genetics. ; Transcription factors. ; Cellular signal transduction. ; Genetic regulation. ; GATA4 Transcription Factor -- genetics. ; Wnt Proteins -- physiology.
Dartmouth Dissertations

The Polycomb Group Complex PRC1 collaborates with cohesin to stabilize the synaptonemal complex and promote crossovers during meiosis / by Pei Zhou.
Lightning -- New Mexico -- Observations.;""Photon emission."";""X-rays -- Spectra -- Measurement -- Instruments."";""X-rays -- Spectra -- Mathematical models.""
Dartmouth Dissertations

Regulation of dendritic cell functions by human uterine epithelial cells: Implications for HIV-1 infection of the endometrium.
Dendritic cells. Uterus -- Immunology. Epithelium -- Immunology. Epithelial cells. HIV infections -- Molecular aspects.
The human female reproductive tract (FRT) maintains a state of immune tolerance to spermatozoa and fetal allografts, while retaining the capacity to respond to a number of sexually transmitted infections (STIs) including human immunodeficiecy virus...
Dartmouth Dissertations

Myc post-transcriptionally iduces HIF1 protein and target gene expression in normal and cancer cells
Myc oncogenes.;""Transcription factors."";""Genetic regulation."";""Genesmyc."";""Hypoxia-Inducible Factor 1 alpha Subunit.""
Dartmouth Dissertations

Mineral variations in the silver veins of Guanajuato, Mexico.
Mineralogy -- Mexico -- Guanajuato (State). ; Silver ores -- Mexico -- Guanajuato (State).
Dartmouth Dissertations

Intraspecific spatial variation in bird abundance: patterns and processes.
Songbirds -- Ecology -- New Hampshire -- Hubbard Brook Experimental Forest. ; Songbirds -- Habitat -- New Hampshire -- Hubbard Brook Experimental Forest. ; Songbirds -- Behavior -- New Hampshire -- Hubbard Brook Experimental Forest. ; Songbirds --...
Within a species, the abundance of individuals varies in time and space. This dissertation research examines processes giving rise to patterns of spatial and temporal variation in the abundance of multiple species of forest-breeding migratory...
Dartmouth Dissertations

History and function of the teleostean periblast.
Osteichthyes. ; Fishes -- Embryology.
Dartmouth Dissertations

Characterization and rescue of a Drosophila model of prion disease; and The role of carcinine in signaling at the Drosophila photoreceptor synapse.
Drosophila melanogaster -- Genetic aspects. Prion diseases. Neurotransmitters. Photoreceptors.
Drosophila melanogaster is a model organism often used when studying the complex processes of neuronal signaling and neurodegeneration. The short life cycle, malleable genetics, amenability to in vivo electrophysiological assays and sensitivity to...
Dartmouth Dissertations

Electrical impedance tomography for breast imaging.
Electrical impedance tomography -- Equipment and supplies -- Design and construction. ; Breast -- Cancer -- Diagnosis. ; Breast -- Imaging.
Dartmouth Dissertations

On the implementation of ALGOL 68.
ALGOL (Computer program language);Computer programming.
Dartmouth Dissertations

Organism interactions and forest structural change in a nonnative disease complex: Beech bark disease in North America.
American beech -- Ecology -- North America -- Mathematical models. Beech bark disease -- Mathematical models. Fungal populations -- Mathematical models. Nonindigenous pests -- Environmental aspects -- Mathematical models.
When a nonnative insect or pathogen becomes established in a forest, outcomes for host trees can range from local or minor effects to regional extirpation. Elevated host mortality is often accompanied by compensatory recruitment by co-occurring...
Dartmouth Dissertations

The SERM, Arzoxifene, and the rexinoid, LG100268, cooperate to prevent estrogen receptor-positive and -negative breast cancer as well as colon cancer.
Estrogen -- Receptors -- Regulation. Selective estrogen receptor modulators. Receptor-ligand complexes. Breast -- Cancer -- Chemoprevention. Colon (Anatomy) -- Cancer -- Chemoprevention.
We have previously shown that the selective estrogen receptor modulator, Arzoxifene (Arz), and the rexinoid, LG100268 (268) synergistically prevent breast cancer in an ER+ breast cancer model. This study was designed to determine the mechanism of...
Dartmouth Dissertations

Characterizing the impact of single nucleotide variation in breast cancer / by Kinjal Desai
Genome sequencing technology has enabled the identification of genetic variants that are linked with cancer phenotypes, whether these are somatically acquired mutations or common inherited single nucleotide polymorphisms (SNPs). Whereas coding...
Dartmouth Dissertations

Formation and interactions of infectious prions
Prions. ; Proteins -- Conformation. ; Nanoparticles. ; Iron oxides. ; PrPSc Proteins.
Dartmouth Dissertations

Find results with:

Searching collections:

Add or remove other collections to your search:

Narrow your search by:

Title

Subject

Date

You've searched:

Thumbnail

Title

Subject

Description

Collection

QuickView

Layout options:

		Thumbnail with title
		Grid with smaller thumbnails and more detail

Find results with:

Searching collections:

Add or remove other collections to your search:

Narrow your search by:

Title

Subject

Date

You've searched:

Thumbnail Title Subject Description Collection

QuickView

Layout options:

Thumbnail

Title

Subject

Description

Collection