Mitomycin C -- Genetic aspects. ; DNA damage. ; Drug resistance in cancer cells. ; Cancer -- Chemotherapy -- Genetic aspects.
Our laboratory is concerned whether the distribution of chemically-induced DNA damage is non-random at the level of individual genes. Using changes in gene expression as a marker for DNA damage, we have previously demonstrated that genotoxic...
Metalorganic chemical vapor deposition (MOCVD) is a complex process. In this thesis, we try to understand the formation mechanism of cadmium (Cd) and cadmium sulfide (CdS) thin films by MOCVD. CdS can be formed from the spontaneous reaction of...
Since its discovery in the 1930's, the Cherenkov effect has been paramount in the development of high-energy physics research. It results in light emission from charged particles traveling faster than the local speed of light in a dielectric...
Clinical medicine -- Practice. ; Medicine -- Practice. ; Group medical practice.
Health care micro-systems are small, organized groups of clinicians and staff working together with a shared clinical purpose to provide care for a defined set of patients. The size of individual micro-systems vary--a micro-system must be large...
Chapter one: Synthesis, resolution and application of P-chirogenic phosphines. This chapter serves as a general introduction, and gives a brief overview of the synthesis, resolution and applications of chiral organophosphorus compounds. In...
Plant MADS proteins play critical roles in vegetative and reproductive development. DNA binding and yeast three-hybrid assays suggest that plant MADS proteins function as dimers or multimers. However, little is known about how plant MADS proteins...
The problem of perceived annoyance as a function of number of noise events and maximum noise level was investigated in a series of seven laboratory experiments. Four models were tested: the Equal Energy Model, the Scandinavian Model, the Variance...
Niemann-Pick type C (NPC) disease is a fatal autosomal recessive pediatric neurovisceral disorder characterized clinically by progressive neurodegeneration in the central nervous system (CNS) and hepatosplenomegaly. Biochemically, it is...
Computer generated 3-D images are proving useful in a wide variety of applications including data visualization, computer animation, virtual reality, telepresence and terrain generation. High-end applications in these fields require images to be...
Ovaries -- Cancer -- Photochemotherapy.
Ovaries -- Cancer -- Treatment -- Evaluation.
Ovaries -- Cancer -- Treatment -- Mathematical models.
The translational potential of new therapeutic strategies for cancer is limited, in part, by a lack of biological models that capture important aspects of tumor growth and treatment response. It is also becoming increasingly evident that no single...
(109) (in emulsion: 109. Remarkable cut bank formation. Pitt Point.) 50815 [109 May 1, 1914 Remarkable cut bank formation at Pitt Point; Wilkins No.109; Original Catalog No.50815
Chapter 1: Munchnones and mesoionic heterocycles The reactivity, regioselectivity, and synthetic applications of munchnones (1,3-oxazolium-5-olates) is a common theme which runs through Chapters 2-5. The definition, structure, and reactivity of...
Nanoparticles have made significant advances in recent years in the realm of cancer therapy. These nanoparticles typically range in size from 10-250nm in diameter, allowing for differential systemic-based biodistribution. The enhanced permeability...
Despite the array of targeted therapeutics that currently exist to combat breast cancer, disease progression leading to metastasis, and tumor recurrence still remains a significant clinical challenge. Efforts to identify novel pathways and...
Earlier work has suggested that various neurological or neuropsychiatric disorders may result in characteristic spatial patterns in brain activation, potentially allowing their detection from maps of brain activity under different conditions....
Cytochrome P450 (CYP) 2E1 is considered the sole CYP responsible for APAP bioactivation leading to hepatotoxicity. CYP2E1 is also considered the alcohol-inducible CYP and therefore, the sole CYP responsible for alcohol-mediated increases in APAP...
Breast -- Cancer -- Tomography. ; Breast -- Cancer -- Imaging. ; Microwave imaging in medicine. ; Breast -- Electric properties. ; Breast Neoplasms -- diagnosis. ; Diagnostic Imaging -- methods.