Many alkaloids of biological importance have the 11H-pyrido (4,3,2-mn) acridine ring structure such as cystodytin and amphimedine. It would be desirable to find an effective way to synthesize a wide variety of these compounds using a single...
Eating disorders are a persistent problem for women on college campuses across the country, and peer education programs are one method that colleges have employed to address these concerns. A previous study found that peer education is actually...
One of the most distinctive aspects of humans as a species is our propensity to form complex social networks made up of intense, non-reproductive bonds with non-kin. Navigating these networks presents a considerable cognitive challenge that is...
Tetrapyrroles -- Synthesis. Tetrapyrroles -- Mechanism of action. Transition metal catalysts.
Previous studies have shown that the mucosal immune system is present in the female reproductive tract and under hormonal control. With the recognition that underlying stromal cells regulate epithelial cell function and hormonal responsiveness,...
This thesis describes the synthesis of sulfobetaines having the general structure $\rm RN\sp{+}(CH\sb3)\sb2(CH\sb2)\sb{x}SO\sb{3\sp{-}}$ as novel inhibitors of squalene synthase. Squalene synthase reductively couples two molecules of farnesyl...
Modifiable Factor Relationships with Biopsychosocial Disability in Multiple Sclerosis
Brant J. Oliver
Problem Statement: Multiple sclerosis (MS) is a chronic disease of the central nervous system and is among the most common neurological...
Spatial localization of sound depends on interaural time delay (ITD), level difference, and on the interaction of the source with the head, torso, and pinna. Head-related transfer functions (HRTFs) model the dynamics that are used by listeners to...
During our fieldwork with real-world organizations---including those in Public Key Infrastructure (PKI), network configuration management, and the electrical power grid---we repeatedly noticed that security policies and related security artifacts...
The overarching goal of this thesis was two-fold. First, to determine if the effects of chronic anabolic androgenic steroid (AAS) treatment on anxiety-like behaviors are sex-specific and second to determine how different environmental modulators...
The Greenland Ice Sheet (GrIS) is responding sensitively to climate change and its meltwater has the potential to influence global sea level. Recently, large changes in the GrIS have occurred including increased velocities of outlet glaciers and...
Digital integrated circuits -- Testing. Digital integrated circuits -- Testing -- Mathematical models. Digital integrated circuits -- Design and construction.
Liver -- Cancer -- Etiology. Hepatotoxicology. Aflatoxins -- Toxicology. Taurine. Liver -- Cancer -- Animal models.
A hypothesis that chronic aflatoxin Bi- (AFBi) induced hepatotoxicity and the resulting compensatory cell proliferation are critical for the growth of preneoplastic lesions was investigated. A commonly utilized protocol which consists of 10 doses...
Earlier work has suggested that various neurological or neuropsychiatric disorders may result in characteristic spatial patterns in brain activation, potentially allowing their detection from maps of brain activity under different conditions....
Dendritic cells. Biological response modifiers. Immune response -- Regulation. T cells. CD antigens. Dendritic Cells -- Immunology. Receptors
Dendritic cells (DCs) are professional antigen-presenting cells (APCs) that regulate antigen-specific T cell activation or tolerance. The maturation state of DCs is critical since immature DCs are believed to induce T cell tolerance whereas mature...
The data presented herein demonstrate the requirement for CD154/CD40 in the development of experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis. Blockade of CD154/CD40 interactions causes a decrease in T cell and...
Chromium -- Toxicity testing. ; Glutathione. ; Vitamin C -- Physiological effect. ; Carcinogenesis. ; DNA damage.
Chromium(VI) is a human carcinogen and causes DNA damage following reduction by intracellular reductants. In order to explore the effects of intracellular reductants on the carcinogenicity of Cr(VI), the roles of glutathione and ascorbate in...