WC-1 and WC-2 are essential for most light responses in Neurospora crassa, but the molecular mechanisms underlying gene induction and the roles of other real and putative photoreceptors remain poorly characterized. Unsupervised hierarchical...
Runx1 is required for the formation of hematopoietic stem cells (HSCs) during embryogenesis. The extent of developmental plasticity inherent to the HSC remains in question. We developed a system whereby the developmental fate of all Runx1...
Primary care (Medicine) -- United States -- Evaluation.
Medicine -- Specialties and specialists.
Physicians -- Supply and demand -- United States.
Background: Strengthening the role of primary care is considered a key element in improving the outcomes and efficiency of health care delivery. Previous studies of the benefits of primary care have primarily examined the association of primary...
Robots -- Control systems -- Design and construction. Mobile robots. Robots -- Dynamics.
This thesis examines the issues of vehicle and information dynamics in the control of a multi-robot system using a radial-basis potential function controller. Distributed control of multi-robot systems requires each robot to communicate state...
In this thesis I present analyses of optical and X-ray data of early-type galaxies in nearby rich clusters as part of the NOAO Fundamental Plane Survey. Spectroscopic parameters, including linestrengths and velocity dispersions are measured for...
For a local field K, we study the affine buildings Ξ n and Δ n naturally associated to SL n ( K ) and Sp n ( K ), respectively. Since Sp n ( K ) is a subgroup of SL 2 n ( K ), we investigate properties of a natural embedding of Δ n in Ξ 2 n ....
The first chapter of this thesis encompasses progress towards the X-ray structure determination and drug design for the dihydrofolate reductase-thymidylate synthase (DHFR-TS) enzyme from the protozoa Toxoplasma gondii, along with another mutant...
The theory community has worked on Secure Multiparty Computation (SMC) for more than two decades, and has produced many protocols for many settings. One common thread in these works is that the protocols cannot use a Trusted Third Party (TTP), even...
The Border Gateway Protocol (BGP) facilitates communication between parts of the Internet by determining paths by which data can get from one network to any other. Just as IP is used ubiquitously as an addressing scheme, BGP is used ubiquitously...
Cosmic acceleration could be an effect of a ""dark energy"" fluid pervading the Universe. It could also be an indication that general relativity is not the correct theory of gravity at cosmological length scales. Unfortunately, observations of the...
HIV infections -- Immunological aspects.
Breast milk -- Physiological effect.
Human breast milk is a highly complex secretion that serves as a source of nutrients and protective immune factors to the growing infant whose immune system is still developing. Epidemiological studies of infants born to Human Immunodeficiency...
This thesis investigates the embedding theory of orders in central simple algebras, placing a particular emphasis on the role that the phenomenon known as selectivity plays in the theory. Although the notion of selectivity is completely algebraic,...
In this thesis we develop a theory of Fourier analysis and fast Fourier transforms (FFTs) for finite inverse semigroups. Our results generalize results in the theory of Fourier analysis for finite groups. There is a general method for generating...
Spatial heterogeneity inherent in ecological systems impacts both diversity and community structure. However, little is known about the influence of habitat heterogeneity on temporal variability in communities. I performed several studies to...
A metric structure on a set gives a concept of distance between any two elements of that set, and it induces a topology. In this thesis, we provide several ways to put a metric structure on the collection of CW complexes. We accomplish this by...
Since alkoxyamines, O-alkylated nitroxide derivatives, are important control agents for nitroxide-mediated polymerization, protocols for their synthesis should be straigh- forward, cost-effective, and versatile. We have utilized a facile method for...
Manifolds (Mathematics) Geodesics (Mathematics) Space and time.
We investigate weak and strong refocusing of light rays in a space-time and related concepts. A strongly causal space-time ( X^ n +1 , g ) is emphstrongly refocusing at x ∈ X if there is a point y ≠ x such that all null-geodesics through y pass...
Stigma (Social psychology). Aging -- Psychological aspects. Cognition -- Age factors. Older people -- Attitudes.
Extensive research on aging has demonstrated that normal aging debilitates executive function, a system that is critical for regulating stereotypes. However, there is a paucity of research on whether age-related declines to executive function...
Oligomers -- Structure -- Mathematical models. Nuclear magnetic resonance spectroscopy.
Medical Term: Nuclear Magnetic Resonance, Biomolecular.
Protein complexes play vital roles in the fundamental processes of life. In particular, homo-oligomers are involved in cell signaling, regulation, and transport. To make detailed studies of these symmetric proteins, they need to be discovered, and...
The Euler '-function and Carmichael -function are extremely important in modern number theory, and much work has been devoted to studying the distribution and arithmetic properties of the values of each function. One interesting unresolved question...
Electric inductors -- Design and construction.;""DC-to-DC converters -- Design and construction."";""Thin film devices -- Design and construction."";""Microfabrication."";""Magnetic films."";""Thin films Multilayered."";""Granular...
Abstract (Summary) Chapter One. Platinum-Catalyzed Asymmetric Alkylation of Bis(secondary) Phosphines. Efficient Screening and the Synthesis of an Enantiomerically Pure C 2 -Symmetric Diphosphine . Platinum-catalyzed asymmetric alkylation of...
We present designs, theory and the results of fabrication and testing for a novel parallel microrobotic assembly scheme using stress-engineered MEMS microrobots. The robots are 240-280 μm × 60 μm × 7-20 μm in size, each robot consist of a...
This thesis contains some results concerning groupoid dynamical systems and crossed products. We introduce the notion of a proper groupoid dynamical system and of its generalized fixed point algebra. We show that our notion of proper groupoid...
This dissertation details the use of a new catalog of Galactic bulge field RR Lyrae variables to advance the understanding of the structure of the Milky Way Galaxy. The catalog contains 3667 RR0 Lyrae stars from the eight-year MACHO Project...
Most solid tumors are aneuploid, and many tumor cells persistently mis-segregate whole chromosomes at an elevated rate in a process called chromosomal instability (CIN). CIN occurs due to loss of chromosome segregation fidelity during mitosis,...
Ovaries -- Cancer -- Immunotherapy. Dendritic cells. Small interfering RNA. Nanoparticles -- Therapeutic use. Medical Term Ovarian Neoplasms -- therapy. RNA Interference.
Current therapies for ovarian carcinoma are based on surgical debulking followed by chemotherapy. After more than three decades implementing treatments that selectively target the tumor cell, the 5-year survival rate for metastatic ovarian cancer...
Endoplasmic reticulum (ER) homeostasis requires the coordination of anabolic and catabolic activities. A primary function of the ER is the biosynthesis and export of secretory proteins and lipids. Anterograde transport of only properly folded and...
Polynomials. Finite fields (Algebra). Algebraic functions. Number theory.
The ring of univariate polynomials over a finite field shares many foundational arithmetic properties with the ring of rational integers. This similarity makes it possible for many problems in elementary number theory to be translated 'through the...
Identifying and understanding sources of individual variation in fecundity is of central importance to life history theory and population ecology. In this study, I first examined how factors on the breeding grounds in eastern Maryland affected the...
Many of today's communication and imaging technologies share the common challenge of signal deterioration due to water's large absorption coefficient. As an example, it is water molecules that contaminate the fused silica of optical fibers and...
Fluorine forms the strongest single bond to carbon, however, it is well established that transition metals can lengthen and weaken C-F bonds in fluorinated ligands. Described here are studies on the activation of C-F bonds in iridium compounds...
This thesis focuses on the emergence of universal dynamical scaling in quantum critical spin systems driven out of equilibrium, with emphasis on quench dynamics which involves isolated standard critical points, multi-critical points, and...