Most solid tumors are aneuploid, and many tumor cells persistently mis-segregate whole chromosomes at an elevated rate in a process called chromosomal instability (CIN). CIN occurs due to loss of chromosome segregation fidelity during mitosis,...
Magnetic nanoparticle-based hyperthermia for cancer treatment is a promising technology, particularly when applied as part of an adjuvant strategy with established cancer therapies (chemotherapy, radiation and surgery). In Europe, early clinical...
The Mixed Lineage Leukemia ( Mll ) gene is essential for embryonic hematopoietic stem cell (HSC) development but its role during adult hematopoiesis is unknown. Using a Mx1-Cre inducible knockout model, we demonstrate that Mll is essential for the...
In this thesis, we characterize and enumerate the permutations which are realized by the orbits of signed shifts, a family of discrete dynamical systems on words. The permutations, which are called patterns of the signed shifts, are given by the...
Little behavioral research, and less neural work, has examined how we process quantities like negative numbers, which are worth less than nothing and yet have value. The goal of this dissertation was to determine whether negative number processing...
Proteins -- Structure -- Mathematical models. Recombinant proteins -- Mathematical models. Mathematical optimization -- Data processing. Dynamic programming. Protein engineering.
Site-directed protein recombination produces improved and novel protein variants by recombining sequence fragments from parent proteins. The resulting hybrids accumulate multiple mutations that have been evolutionarily accepted together. Subsequent...
Human cancer is developed as the consequence of the activation of oncogenes and inactivation of tumor suppression genes. Modern sciences has identified and characterized the functions of such genes to understand the mechanism of cancer development...
Predictive control. Adaptive control systems -- Design. Airplanes -- Control systems.
A direct method to design data-based model predictive controllers is presented. The design method uses system identification techniques to identify model predictive controller gains directly from a set of excitation input and disturbance corrupted...
Cataclysmic variable stars (CVs) are close, interacting binary systems comprised of a white dwarf and a companion star, which is typically a late-type dwarf star. Their progenitor systems are post common envelope binaries (PCEBs) with a white dwarf...
Quantum dots. Heterostructures. Metal oxide semiconductors -- Design and construction. Silicon oxide. Electron gas. Ohmic contacts. Microelectronics -- Technological innovations.
Solid-state approaches to quantum computing include quantum dot qubit implementations based on the Loss-DiVincenzo proposal. Prior work in GaAs two-dimensional electron gas (2DEG) materials serves as a proving ground for device designs that can be...
Graph algorithms. Nuclear magnetic resonance spectroscopy -- Data processing. Proteins -- Structure -- Mathematical models. Proteins -- Crosslinking -- Mathematical models. Protein folding -- Mathematical models.
The study of three-dimensional protein structures produces insights into protein function at the molecular level. Graphs provide a natural representation of protein structures and associated experimental data, and enable the development of graph...
I investigate the kinematics and space densities of the local cataclysmic variable (CV) population. CVs are close binary star systems composed of a white dwarf that accretes matter from a less compact companion star in Roche lobe overflow....
Chapter One. Synthesis and Structure of Chiral Pt(Duphos) Terminal Phosphido Complexes. Treatment of Pt halide precursors with a secondary phosphine in the presence of the base NaOSiMe 3 gave the terminal phosphido complexes Pt(Duphos)(Ph)(PMeIs)....
Cosmic acceleration could be an effect of a ""dark energy"" fluid pervading the Universe. It could also be an indication that general relativity is not the correct theory of gravity at cosmological length scales. Unfortunately, observations of the...
Breast -- Cancer -- Tomography. Near infrared spectroscopy. Breast -- Cancer -- Imaging. Breast -- Cancer -- Diagnosis.
Near-infrared (NIR) light provides potential for a new approach to non-invasive detection, diagnosis and clinical management of breast cancer. Using NIR spectroscopic imaging techniques, the physiological information about breast tissue composition...
Constructibility (Set theory). Trees (Graph theory).
This thesis investigates possible initial segments of the degrees of constructibility. Specifically, we completely characterize the structure of degrees in generic extensions of the constructible universe L via forcing with Souslin trees. Then we...
Casimir effect. Zero-point field. Electric conductivity. Quantum electrodynamics.
The Casimir force arises from an alteration of boundary condition in vacuum and is often regarded as a manifestation of quantum zero point energy. Considerable progress has been made in the last decade with an impressive achievement of experimental...
For many scientific applications, the data set cannot entirely fit in main memory. The data must reside out-of-core, i.e., on parallel disks. For many basic data-movement operations such as permuting, if the programmer does not design efficient...
Microwave spectroscopy. Imaging systems -- Design and construction. Diagnostic imaging -- Digital techniques. Breast -- Cancer -- Diagnosis. Microwave imaging in medicine.
Microwave spectroscopy has been investigated as a possible modality for breast imaging because of the significant contrast in electrical properties between normal and malignant tissue over the microwave spectrum. A liquid-coupled, non-contacting...
This research extends previous findings that the behavior of individuals high as compared to low in Private Self-consciousness, an individual difference in self-awareness, is more influenced by subtle primes. Manipulations of self-awareness were...
Endoplasmic reticulum (ER) homeostasis requires the coordination of anabolic and catabolic activities. A primary function of the ER is the biosynthesis and export of secretory proteins and lipids. Anterograde transport of only properly folded and...
Polynomials. Finite fields (Algebra). Algebraic functions. Number theory.
The ring of univariate polynomials over a finite field shares many foundational arithmetic properties with the ring of rational integers. This similarity makes it possible for many problems in elementary number theory to be translated 'through the...
We describe a set of natural image statistics that are built upon two multi-scale image decompositions, the quadrature mirror filter pyramid decomposition and the local angular harmonic decomposition. These image statistics consist of first- and...
Automatic control -- Sensitivity. Structural control (Engineering). Strains and stresses -- Computer simulation. Structural analysis (Engineering). Engineering models.
Autonomous damage detection in engineering structures is critically important as the demands placed upon those structures are increased. It has been well established that damage detection can be done through monitoring the modal frequencies of the...
We present a number of findings concerning groupoid dynamical systems and groupoid crossed products. The primary result is an identification of the spectrum of the groupoid crossed product when the groupoid has continuously varying abelian...
This thesis contains material relating to two separate subjects. The first section determines when the C*-algebra affiliated to a directed graph has continuous trace. We use groupoid methods and the focus is on producing conditions on a graph that...
The Euler '-function and Carmichael -function are extremely important in modern number theory, and much work has been devoted to studying the distribution and arithmetic properties of the values of each function. One interesting unresolved question...
Nursing services -- United States -- Evaluation. Nursing services -- United States -- Personnel management. Hospitals -- United States -- Administration. Outcome assessment (Medical care). Nursing Service.
This thesis focuses on the emergence of universal dynamical scaling in quantum critical spin systems driven out of equilibrium, with emphasis on quench dynamics which involves isolated standard critical points, multi-critical points, and...