Abstract (Summary) Chapter One. Platinum-Catalyzed Asymmetric Alkylation of Bis(secondary) Phosphines. Efficient Screening and the Synthesis of an Enantiomerically Pure C 2 -Symmetric Diphosphine . Platinum-catalyzed asymmetric alkylation of...
Monocytes and macrophages play a key role in a number of immune functions including inflammation, antigen presentation and the clearance of microorganisms and free hemoglobin. Two surface receptors which are important for these functions are CD163...
Magnetic resonance elastography (MRE) is a technique to produce images of the mechanical properties of tissue, which are indicative of a variety of diseases. Tissue motions measured using MRI are used to solve an inverse problem to recover...
Fluorine forms the strongest single bond to carbon, however, it is well established that transition metals can lengthen and weaken C-F bonds in fluorinated ligands. Described here are studies on the activation of C-F bonds in iridium compounds...
The fluxes of radiation belt electrons are highly variable, due to a competition between various acceleration, loss, and transport processes. Studies of any of the processes are equally important. My study focuses on electron-EMIC (electromagnetic...
Post-translational modification.
Circadian rhythms.
Neurospora crassa -- Genetics.
Genetic regulation.
Phosphorylation.
Medical Term Circadian Rhythm -- genetics.
Circadian rhythms are found ubiquitously throughout life on the planet. These biological clocks stem from common underlying molecular architecture revolving around a time-delayed feedback oscillator driving robust, approximately 24 hour rhythms. In...
Proteins are ubiquitous in cells and are essential to a wide range of biological processes. Since existing proteins occupy only a small portion of the space of possible amino acid composition, understanding their sequence-structure-function...
The first chapter of this thesis encompasses progress towards the X-ray structure determination and drug design for the dihydrofolate reductase-thymidylate synthase (DHFR-TS) enzyme from the protozoa Toxoplasma gondii, along with another mutant...
We present aligned hierarchies, a novel solution to the dimension reduction problem, representing high-dimensional and noisy sequential data as a low-dimensional object that encodes relevant information. In this thesis, we motivate our presentation...
This thesis characterized the solubilities of sugar monomers and xylooligomers in water and explored the potential role of solubility for pretreatment of cellulosic Biomass by hemicellulose hydrolysis in only water. A novel apparatus was developed...
Eddy currents (Electric) -- Mathematical models. Electric generators -- Windings. Finite element method.
Magnetic components, such as transformers and inductors, are essential parts of most power electronics circuits. They usually are the largest components in the circuit, and also account for a large portion of the power loss. Reducing the volume of...
The thermodynamic properties of pure polymers and polymer mixtures have been investigated using the so-called Born-Green-Yvon (BGY) lattice theory. Previous results applied pure component pressure-volume-temperature ( PVT ) data in order to...
Decompression sickness (DCS, or the "Bends") is a condition that afflicts hundreds of divers each year and is cause for concern for both the Navy, the Air Force, and NASA. Despite the fact that bubble formation is the purported cause of DCS...
Despite all the efforts and progress in cancer research, cancer remains a devastating disease. After more than 120 years of research, immunotherapy provides a realistic hope to cure cancer. Several formats of immunotherapy, such as...
Brain -- Tomography. Magnetic resonance imaging -- Brain. Near infrared spectroscopy. Image processing -- Digital techniques.
Diffuse optical tomography (DOT) using near infrared (NIR) light has become a promising modality because it has the capability to non-invasively quantify oxygen saturation and hemoglobin content with potentially high temporal resolution and...
Casimir effect. Zero-point field. Electric conductivity. Quantum electrodynamics.
The Casimir force arises from an alteration of boundary condition in vacuum and is often regarded as a manifestation of quantum zero point energy. Considerable progress has been made in the last decade with an impressive achievement of experimental...
Goldman and Turaev constructed a Lie bialgebra structure on the free Z-module generated by free homotopy classes of loops on an oriented surface. Turaev conjectured that the cobracket of A is zero if and only if A is a power of a simple class. Chas...
This thesis centers around a generalization of the classical discrete Fourier transform. We first present a general diagrammatic approach to the construction of efficient algorithms for computing the Fourier transform of a function on a finite...
For a long-lived metastable system, the decay of the survival probability is typically exponential. However, deviations are known to exist at short times (the quantum Zeno effect) and at long times (algebraic tails in classical hydrodynamic...
In Chapter 2 we look at the distribution of permutation statistics in the context of pattern-avoiding permutations. The first part of this chapter deals with a recursively defined bijection of Robertson [37] between 123- and 132-avoiding...
The study of twin primes gives rise to several famously difficult problems in number theory--in fact, we still cannot definitively say whether there are infinitely many twin primes. In this work, we consider a related problem, namely: What is the...
Toxoplasma gondii is a highly successful obligate intracellular parasite capable of infecting humans and poses a significant health threat to people with AIDS and who are immunosuppressed. Infection with T. gondii involves a highly complex...
A polynomial is a product of distinct cyclotomic polynomials if and only if it is a divisor over [Special characters omitted.] [x ] of xn - 1 for some positive integer n. In this thesis, we will examine two natural questions concerning the divisors...
Two strains of mice were identified that possess differing cardiopulmonary responses to hypoxia. CF 1 mice acclimated poorly to chronic hypoxia as indicated by right ventricular hypertrophy, decreased PO 2 , increased [Hb], and increased mortality....
Bayesian nonparametric methods have become increasingly popular in machine learning for their ability to allow the data to determine model complexity. In particular, Bayesian nonparametric versions of common latent variable models can learn as...
Accurate chromosome segregation in human oocytes requires that meiotic sister chromatid cohesion remain intact for decades and work in model organisms indicates that deterioration of meiotic cohesion over time may be a major determinant of...
Robustness to genetic perturbations is a fundamental property of all living things. The genetic code is degenerate, RNA secondary structure is robust to sequence changes, and protein structure is robust to amino acid substitutions. Complex systems...