Monocytes and macrophages play a key role in a number of immune functions including inflammation, antigen presentation and the clearance of microorganisms and free hemoglobin. Two surface receptors which are important for these functions are CD163...
Magnetic resonance elastography (MRE) is a technique to produce images of the mechanical properties of tissue, which are indicative of a variety of diseases. Tissue motions measured using MRI are used to solve an inverse problem to recover...
Fluorine forms the strongest single bond to carbon, however, it is well established that transition metals can lengthen and weaken C-F bonds in fluorinated ligands. Described here are studies on the activation of C-F bonds in iridium compounds...
Post-translational modification.
Circadian rhythms.
Neurospora crassa -- Genetics.
Genetic regulation.
Phosphorylation.
Medical Term Circadian Rhythm -- genetics.
Circadian rhythms are found ubiquitously throughout life on the planet. These biological clocks stem from common underlying molecular architecture revolving around a time-delayed feedback oscillator driving robust, approximately 24 hour rhythms. In...
Proteins are ubiquitous in cells and are essential to a wide range of biological processes. Since existing proteins occupy only a small portion of the space of possible amino acid composition, understanding their sequence-structure-function...
A double-acceleration stage linear time of flight mass spectrometer (TOF MS) with Nd/YAG laser ablation cluster source was designed and constructed for cluster production, study and deposition. Cumulenic polycarbons SC n S ( n = 2-27) were...
This thesis centers around a generalization of the classical discrete Fourier transform. We first present a general diagrammatic approach to the construction of efficient algorithms for computing the Fourier transform of a function on a finite...
In Chapter 2 we look at the distribution of permutation statistics in the context of pattern-avoiding permutations. The first part of this chapter deals with a recursively defined bijection of Robertson [37] between 123- and 132-avoiding...
Eddy currents (Electric) -- Mathematical models. Electric generators -- Windings. Finite element method.
Magnetic components, such as transformers and inductors, are essential parts of most power electronics circuits. They usually are the largest components in the circuit, and also account for a large portion of the power loss. Reducing the volume of...
Protein complexes play vital roles in cellular processes within living organisms. They are formed by interactions between either different proteins (hetero-oligomers) or identical proteins (homo-oligomers). In order to understand the functions of...
Smartphones we carry everyday represent the first truly context-aware mobile device. By embedding specialized sensors and pushing AI into phones, it is now possible to continuously sense and infer people's physical activities, social interactions,...
RNA binding proteins are fundamental components of crucial biological processes in all domains of life. The development of techniques to study RNA binding protein complexes is, therefore, broadly impactful. I employed multiple genome-wide...
Polynomials. Finite fields (Algebra). Algebraic functions. Number theory.
The ring of univariate polynomials over a finite field shares many foundational arithmetic properties with the ring of rational integers. This similarity makes it possible for many problems in elementary number theory to be translated 'through the...
The first chapter of this thesis encompasses progress towards the X-ray structure determination and drug design for the dihydrofolate reductase-thymidylate synthase (DHFR-TS) enzyme from the protozoa Toxoplasma gondii, along with another mutant...
We present a number of findings concerning groupoid dynamical systems and groupoid crossed products. The primary result is an identification of the spectrum of the groupoid crossed product when the groupoid has continuously varying abelian...
Microwave imaging (MI) is based on recovering dielectric properties (permittivity and conductivity) of materials. Over the last two decades, MI has attracted increasing interests in biomedical applications, in particular, for breast cancer...
Toxoplasma gondii is a highly successful obligate intracellular parasite capable of infecting humans and poses a significant health threat to people with AIDS and who are immunosuppressed. Infection with T. gondii involves a highly complex...
This thesis presents two-fluid simulations of forced magnetic reconnection with finite electron inertia in two and three dimensional periodic systems. Reconnection in the system is driven by a spatially localized forcing function, added to the ion...
We present aligned hierarchies, a novel solution to the dimension reduction problem, representing high-dimensional and noisy sequential data as a low-dimensional object that encodes relevant information. In this thesis, we motivate our presentation...
Chapter 1: The dimethylation of the C2-symmetric Pt-phosphido complex Pt((R,R)-Me-DuPhos)(IsPCH2PIs) (Is = 2,4,6-(iPr)3C6H2) to yield rac- and meso- [Pt((R,R)-Me-DuPhos)(IsMePCH2PMeIs)][OTf]2 represents an interesting case of the Horeau principle...