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Synthetic studies on viridin class of furanosteroids.
The furanosteroids are a special class of natural products that feature a furan ring fused to the steroid nucleus at C-4 and C-6. In 1945, viridin, the parent member of this group, was isolated by Grove and coworkers from the fungas Gliocladium...
Dartmouth Dissertations

Diffuse tomography of absorbing and fluorescent optical exogenous contrast guided by simultaneously acquired magnetic resonance images.
Optical tomography. Fluorescence. Imaging systems -- Design and construction. Diagnostic imaging -- Mathematical models. Brain -- Diseases -- Diagnosis. Brain -- Magnetic resonance imaging.
Fluorescent molecules targeted to reveal information on tissue function have been used as research tools in ex vivo and subsurface characterization of diseased tissue for years. Exploiting this specificity for in vivo imaging through centimeters of...
Dartmouth Dissertations

Tray 10
Mexico. 1956.
Mexico. 1956.
Stoiber Slides

Tray 03
El Salvador.
El Salvador.
Stoiber Slides

Tray 01
El Salvador.
El Salvador.
Stoiber Slides

Tray 28
Canary Islands, Costa Rica, Indonesia, Malta, Reunion, U.S.A.
Canary Islands, Costa Rica, Indonesia, Malta, Reunion, U.S.A.
Stoiber Slides

Tray 14
Canada, Europe, Guatemala.
Canada, Europe, Guatemala.
Stoiber Slides

Tray 29
Nicaragua.
Nicaragua.
Stoiber Slides

Effects of mesencephalic reticular formation and mesencephalic auditory pathway lesions on long- and short-term habituation processes in the rat.
Habituation (Neuropsychology) Mesencephalon. Rats as laboratory animals.
Dartmouth Dissertations

Links and regulatory loops between phospholipase C activity and colonization by the O2-responsive regulator Anr in Pseudomonas aeruginosa / by Angelyca A. Jackson.
Pseudomonas aeruginosa is a virulent opportunistic pathogen that is frequently cultured from infectious sites, and is estimated to cause ~12% of nosocomial infections worldwide [1]. P. aeruginosa infections occur in a majority of adults with the...
Dartmouth Dissertations

Quantitative analysis of polycyclic aromatic hydrocarbons in airborne particulates: Semiquantitative determination of organic material in woodsmoke.
Hydrocarbons -- Analysis. Smoke -- Analysis.
Dartmouth Dissertations

Allosteric modulation of GABAa receptors by anabolic-androgenic steroids.
GABA -- Receptors. Allosteric regulation. ; Anabolic steroids -- Physiological effect. ; Androgens -- Physiological effect. ; Receptors
Anabolic-androgenic steroids (AAS) are synthetic derivatives of the gonadal hormone, testosterone. Despite their many untoward side effects, AAS are wildly abused for their ergogenic properties. AAS have numerous effects on many organ systems,...
Dartmouth Dissertations

The differentiation and survival of long-lived plasma cells.
Plasma cells. ; Lymphocyte transformation. ; B cells. Immune response -- Regulation. ; Immunologic Memory -- physiology.
During an immune reaction to an invading pathogen, a population of lymphocytes with receptors that specifically recognize the pathogen are activated and become memory cells. Characteristically, memory lymphocytes persist for long periods of time...
Dartmouth Dissertations

Collisional damping of waves in plasmas.
Plasma waves.
Dartmouth Dissertations

I. Synthesis and cycloaddition reactions of 4H-furo(3,4-b)indoles; II. Novel regioselective fluorobenzyne cycloadditions to furans.
Alkaloids -- Synthesis. ; Carbazole. Furans. ; Condensation.
Dartmouth Dissertations

The functional roles of the rostral pons in the control of respiration in mammals.
Respiration -- Regulation. ; Cats -- Respiration. ; Rats -- Respiration. ; Pons Varolii -- Physiology.
Dartmouth Dissertations

The regulation of AMP-activated protein kinase (AMPK) in an insulinoma cell line, adipocytes and muscle.
Protein kinases. ; Adenylic acid. ; Islands of Langerhans -- Tumors. ; Fat cells. ; Muscle cells. ; Adenoviruses.
Dartmouth Dissertations

Ku-band (13.9 GHz) radar backscatter over sea ice in the Southern Ocean.
Sea ice -- Antarctica -- Weddell Sea -- Remote sensing. ; Backscattering. ; Radar in earth sciences. ; Sea ice -- Computer simulation.
Dartmouth Dissertations

Versatile 2-lithioindoles, syntheses and Diels-Alder reactions of pyrrolo[3,4-b]indoles.
Indole alkaloids -- Synthesis. Diels-Alder reaction.
An efficient synthetic approach to both 2-acyl-1-(substituted)indoles and 2-nitro-1-(substituted)indoles by reaction of 2-lithio-1-(substituted)indoles with appropriate electrophiles is presented. Inverse quenching of 2-lithioindoles 5 and 208 with...
Dartmouth Dissertations

Von Hippel Lindau (VHL) tumor suppressor regulation of MT1-MMP in renal cell carcinoma.
Antioncogenes. Metalloproteinases. Genetic regulation. Kidneys -- Cancer.
Dartmouth Dissertations

The pathophysiology of transforming growth factor-beta in breast cancer.
Transforming growth factors-beta -- Pathophysiology. ; Breast -- Cancer -- Pathophysiology.
Dartmouth Dissertations

Identifying the biologically active forms of HEDGEHOG proteins.
Hedgehog (HH) proteins play an important and evolutionary conserved patterning role in metazoan development. Aside from this physiological role, pathologically HH proteins are implicated in human developmental disorders and post-developmental...
Dartmouth Dissertations

Synthetic approaches to indolo[2,3-a]carbazole alkaloids.
Indole alkaloids -- Synthesis. ; Carbazole.
Dartmouth Dissertations

Structural studies of Vibrio cholerae virulence gene regulators.
Vibrio cholerae -- Molecular genetics. ; Virulence (Microbiology) -- Molecular aspects. ; Genetic regulation. ; Viral proteins.
Cholera is a diarrheal disease caused by the Gram-negative bacterium Vibrio cholerae. The disease is acquired by oral ingestion of contaminated water or food. In order for Vibrio cholerae to cause the disease cholera, it must produce two important...
Dartmouth Dissertations

Effects of mitomycin C and other DNA crosslinking agents on gene expression: modulation of cancer cell multidrug resistance in cell culture and in vivo.
Mitomycin C -- Genetic aspects. ; DNA damage. ; Drug resistance in cancer cells. ; Cancer -- Chemotherapy -- Genetic aspects.
Our laboratory is concerned whether the distribution of chemically-induced DNA damage is non-random at the level of individual genes. Using changes in gene expression as a marker for DNA damage, we have previously demonstrated that genotoxic...
Dartmouth Dissertations

Self-reconfiguring robots: designs, algorithms, and applications.
Robots -- Control systems. ; Robots -- Motion. ; Computer algorithms. ; Electronic data processing -- Distributed processing.
Self-reconfiguring robots are robots composed of many physically connected modules which can change their structural configuration to support multiple functionalities. We claim that self-reconfiguring robots are more versatile, extensible, and...
Dartmouth Dissertations

The role of tocopherol (vitamin E) in rotifer ecology.
Rotifera. ; Vitamin E.
Dartmouth Dissertations

Mechanisms for chromium-induced signaling changes in pulmonary epithelial cells.
Chromium -- Pathophysiology. ; Lungs -- Pathophysiology. ; Epithelial cells. ; Cellular signal transduction. ; Transcription factors -- Pathophysiology. ; Protein kinases -- Pathophysiology. ; src-Family Kinases. ; Mitogen-Activated Protein Kinases.
Both human epidemiological and animal studies have associated inhalation of chromium(VI) (Cr(VI)) with increased incidence of pulmonary disease. This thesis examined the hypotheses that Cr(VI) activates cell signaling through kinase cascades and...
Dartmouth Dissertations

Investigations of alkene-ozone kinetics using atmospheric-pressure static methods: ethene, 1-pentene, isoprene.
Alkenes. ; Ozone. ; Chemical kinetics. ; Atmospheric pressure -- Measurement.
Dartmouth Dissertations

An investigation of the microstructure, mechanical properties, and tribological performance of ultra high molecular weight polyethylene for applications in total joint arthroplasty.
Polyethylene -- Mechanical properties. ; Polyethylene -- Microstructure. ; Tribology. ; Polyethylene -- Effect of radiation on. ; Polyethylene -- Thermal fatigue. ; Polyethylene -- Testing. ; Artificial joints -- Materials.
Ultra high molecular weight polyethylene (UHMWPE) is the most common bearing material in joint arthroplasty due to its biocompatibility, its wear resistance, and its mechanical toughness. Despite the favorable properties of UHMWPE and its success...
Dartmouth Dissertations

Investigating EMIC waves as a precipitation mechanism for relativistic electrons.
Loss processes greatly impact the dynamics of the Earth's radiation belts. In 1996, a balloon-borne germanium detector flown over Kiruna, Sweden detected the first terrestrial X-rays with energies on the order of 1 MeV. The spectrum for these...
Dartmouth Dissertations

The interplay between GATA4-FOG2 transcriptional regulation and the canonical WNT signaling pathway in mouse organogenesis.
Mice -- Morphogenesis. ; Mice -- Genetics. ; Transcription factors. ; Cellular signal transduction. ; Genetic regulation. ; GATA4 Transcription Factor -- genetics. ; Wnt Proteins -- physiology.
Dartmouth Dissertations

Gain experiments with a grating based free electron laser.
Free electron lasers -- Experiments. Wave guides -- Design and construction. Diffraction gratings -- Experiments. Electron beams. Infrared sources.
The far infrared region of the electromagnetic spectrum, 15-3000 Œºm in wavelength, has a paucity of narrow band laser sources. To address the issue of whether a grating based free electron laser could operate well as such a source, a grating...
Dartmouth Dissertations

Self-relevance, attention and the brain.
Selectivity (Psychology). Self-perception. Self-interest. Brain -- Imaging. Psychophysiology.
The central topic of the self has proven a vexing conundrum for philosophers and psychologists alike for centuries. Prior research suggests that the self is a powerful cognitive structure which biases attentional mechanisms in favor of apprehension...
Dartmouth Dissertations

Investigation of the human monocyte receptors CD163 and CD64.
Cell receptors. Fc receptors. Monocytes. Immune response -- Regulation. Proteins -- Immunology. Receptors
Monocytes and macrophages play a key role in a number of immune functions including inflammation, antigen presentation and the clearance of microorganisms and free hemoglobin. Two surface receptors which are important for these functions are CD163...
Dartmouth Dissertations

Enzymatic hydrolysis of cellulosic biomass solids prepared by leading pretreatments and identification of key features governing performance.
Cellulase -- Absorption and adsorption. Enzymes -- Biotechnology. Cellulose -- Biodegradation. Lignocellulose -- Biotechnology. Biomass conversion. Hydrolysis. Corn stover. Poplar -- Biotechnology.
Prior to biological conversion of lignocellulosic biomass, natural barriers to efficient enzymatic hydrolysis must be overcome, and a few pretreatment technologies effectively accomplish this job with chemicals. Although several factors are...
Dartmouth Dissertations

Functions of prostacyclin in vascular and uterine smooth muscle.
Prostacyclin -- Physiological effect. Vascular smooth muscle. Vascular endothelium -- Physiology. Myometrium -- Physiology. Cardiovascular system -- Diseases. Cellular signal transduction.
Prostacyclin (PGI2) is a major product of COX-2 derived arachidonic acid metabolism in the endothelium and uterine myometrium. Evidence indicates that PGI 2 protects against development and progression of vascular disease. While it has been known...
Dartmouth Dissertations

Structural studies of dihydrofolate reductase-thymidylate synthase from Toxoplasma gondii and dynamin 1 from Rattus norvegicus.
Microbial enzymes -- Structure. Antiprotozoal agents -- Design. Toxoplasma gondii. Guanosine triphosphatase -- Structure. G proteins -- Structure. Thymidylate synthase-dihydrofolate reductase -- chemistry. Dynamins -- chemistry.
The first chapter of this thesis encompasses progress towards the X-ray structure determination and drug design for the dihydrofolate reductase-thymidylate synthase (DHFR-TS) enzyme from the protozoa Toxoplasma gondii, along with another mutant...
Dartmouth Dissertations

Shear consolidation of powders.
Metal powders -- Extrusion. Metal powders -- Microstructure. Shear flow.
The manufacture of bulk parts from metastable powder materials requires new approaches to cold consolidation. One potential technique is equal-channel angular extrusion (ECAE), a simple shear process. This thesis describes an investigation into the...
Dartmouth Dissertations

Epithelial sodium channel regulation in the mouse kidney: two novel approaches to a classic question.
Sodium channels -- Physiology. Proteins -- Physiological transport. Biological transport -- Regulation. Aldosterone -- Physiological effect. Epithelial cells. Protein Transport. Vesicular Transport Proteins.
Nearly one billion individuals worldwide have elevated blood pressure (BP) and 90% of these cases are due to unknown causes. Aldosterone is the primary hormone regulating Na + reabsorption in the kidney and is therefore a major determinant of the...
Dartmouth Dissertations

Exploiting the proteome to improve the genome-wide genetic analysis of epistasis in common human diseases.
Epistasis (Genetics) Protein-protein interactions -- Data processing. Proteomics -- Data processing. Diseases -- Risk factors -- Statistical methods. Chromosome polymorphism. Software measurement -- Evaluation. Computational biology -- Methodology.
The completion of the Human Genome Project in 2003 and the HapMap Project in 2005 has broadened the spectrum of genetic research tools that allow researchers to conduct genome-wide association studies (GWAS) for detecting genetic variants that...
Dartmouth Dissertations

New technologies for constructing C-C, C-N, and C-S bonds
I. Intermolecular C-S Bond Forming Reactions The relatively small number of efficient C-S bond forming reactions in the literature prompted an investigation into the synthesis of allylic thioethers. The technology that we developed allowed us, in...
Dartmouth Dissertations

Modifiable factor relationships with biopsychosocial disability in multiple sclerosis
Modifiable Factor Relationships with Biopsychosocial Disability in Multiple Sclerosis Brant J. Oliver Problem Statement: Multiple sclerosis (MS) is a chronic disease of the central nervous system and is among the most common neurological...
Dartmouth Dissertations

Innate immune responses to HIV-1 and Chlamydia trachomatis in the human female reproductive tract / by Lucy Rudo Mukura.
Female reproductive tract (FRT) secretions contain a spectrum of cytokines, chemokines and antimicrobials that inhibit infection of target cells by HIV-1 and other sexually transmitted pathogens. Innate immune protection maintained by the presence...
Dartmouth Dissertations

A Baird's Sandpiper on her nest [July 1915?] 51615...
A Baird's Sandpiper on her nest [July 1915?] 51615 (51615 Baird's Sandpiper and her nest [July 25, 1915?]) (text reversed in emulsion: 293 A Baird's Sandpiper & it's nest July 13, 1915) [293 July 1915 A Bairds Sandpiper and Her nest.] ] 51615 Bird,...
Stefansson Collection of Arctic Photographs - Photographic Prints

Tray 18
Japan, Nicaragua.
Japan, Nicaragua.
Stoiber Slides

Tray 17
South Seas: Fiji, French Polynesia, Reunion, Vanuatu. Also, Canary Islands, Europe.
South Seas: Fiji, French Polynesia, Reunion, Vanuatu. Also, Canary Islands, Europe.
Stoiber Slides

Tray 34.2
Costa Rica, El Salvador, Guatemala.
Costa Rica, El Salvador, Guatemala.
Stoiber Slides

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