Chapter 1: The dimethylation of the C2-symmetric Pt-phosphido complex Pt((R,R)-Me-DuPhos)(IsPCH2PIs) (Is = 2,4,6-(iPr)3C6H2) to yield rac- and meso- [Pt((R,R)-Me-DuPhos)(IsMePCH2PMeIs)][OTf]2 represents an interesting case of the Horeau principle...
How the genome is shaped directly influences how it is expressed. In fact, the genome is organized at many different levels, each imparting specific regulation over transcription. Fundamental principles regulating genome organization are poorly...
I. (3 + 2) Cycloaddition Reactions of Oxyallyl Cationic Intermediates with Indoles Cyclopenta- and cyclohexa[b]indolines are ubiquitous molecular skeletons in natural products and pharmaceutical agents. We have developed (3 + 2) cycloaddition...
CD antigens. T cells -- Receptors. Receptor-ligand complexes. Transplantation immunology. Immunological tolerance -- Molecular aspects. Antigens
Voltage-dependent sodium channels (Na v ) are critical determinants of the ability of a neuron to generate and propagate action potentials. While a large family of Na v isoforms has been identified, the impact of specific isoforms on the electrical...
Actin filaments are integral to a large number of cellular structures. Due to the widespread use of actin, cells must rigorously control when and where new filaments assemble. Formin proteins are expressed in all eukaryotes and provide the...