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All fields: AGENTS

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- UCN-01: a protein kinase antagonist abrogating cell cycle checkpoint control.
- Protein kinase C -- Antagonists. Cells -- Growth -- Regulation. Antineoplastic agents -- Mechanism of action.
- Dartmouth Dissertations
- Apoptosis as a mechanism of cell death by anticancer agents.
- Apoptosis. Antineoplastic agents.
- Dartmouth Dissertations
- Synthetic approaches to pyridocarbazoles via new indole and pyridine lithiaton methodology.
- Antineoplastic agents. ; Pyridocarbazoles.
- Dartmouth Dissertations
- A comparison of the acute toxicity and teratogenic effects of succinonitrile and tetramethylsuccinonitrile: the role of cyanide.
- Nitriles -- Toxicology. ; Teratogenic agents. ; Cyanides -- Toxicology.
- Dartmouth Dissertations
- The retinoid inducible nuclear receptor coregulator, RIP140: a limiting factor in retinoid and estrogen signaling.
- Antineoplastic agents. Tretinoin. Nuclear receptors (Biochemistry). Genetic regulation.
- Dartmouth Dissertations
- Methods for prevention of oral Toxoplasma gondii infection-induced hyperimmune response in mice.
- Toxoplasma gondii. ; Biological response modifiers. ; Immune response -- Regulation. ; Toxoplasmosis -- Immunotherapy. ; Interleukin-10 -- therapeutic use. ; Cholera Toxin -- therapeutic use. ; Anti-Inflammatory Agents -- therapeutic use.
- Dartmouth Dissertations
- Studies on the purification and binding characteristics of neurotoxin from Leiurus quinquestriatus.
- Neurotoxic agents. ; Scorpions -- Venom. ; Peptides -- Separation.
- Dartmouth Dissertations
- Novel diphosphate surrogates: synthesis of potential inhibitors of cholesterol biosynthesis.
- Cholesterol -- Synthesis -- Inhibitors. ; Anticholesteremic agents -- Synthesis. ; Pyrophosphates.
- Dartmouth Dissertations
- Carbon-fluorine bond activation of iridium (III) compounds induced by acids and reducing agents.
- Organoiridium compounds -- Synthesis. ; Organofluorine compounds -- Synthesis. ; Ligands.
- Dartmouth Dissertations
- Biochemical and electrophysiological analysis of the interaction between sodium channel α and ß subunits.
- Sodium channels -- Genetic aspects. ; Sodium channels -- Chemistry. ; Sodium channels -- Physiology. ; Ion channels -- Genetic aspects. ; Neurotoxic agents -- Physiological effect.
- Dartmouth Dissertations
- Mechanisms for the enhancement of radiation-induced cell killing by carboplatin.
- Antineoplastic agents. ; Radiation chemistry. ; Cancer -- Treatment. ; Cell death.
- Dartmouth Dissertations
- Seuss (Doctor) folder 2 Theodor Seuss Geisel
- Theodor Seuss Geisel
- Dartmouth College Photographic Files
- Specific enolates from alpha-bromoketones.
- Dartmouth Dissertations
- Geochemistry of silica in Lake Powell.
- Silica -- Colorado -- Powell Lake (Utah and Arizona).
- Dartmouth Dissertations
- Press Translations, Japanese
- Tokyo, Japan
- Press Translations, Japan, 1945-1946
- Secure collaboration in an open environment.
- Internet -- Security measures. Public key infrastructure (Computer security). Digital signatures. Peer-to-peer architecture (Computer networks) -- Security measures.
- The Internet has become a virtual place where people not only operate in isolation but also interact with other Internet users. Collaborative systems are becoming more popular. Applications now being introduced could provide better remote education...
- Dartmouth Dissertations
- Mobility and communication in sensor networks.
- Sensor networks. Robots -- Control systems. Detectors. Synchronization. Computer network protocols.
- This thesis considers the two special sensor networks for future sensor network design: mobile sensor networks and hybrid network of sensors and robots. To investigate two types of networks, we abstract two most important aspects that are ingrained...
- Dartmouth Dissertations
- Hepatic T cells and MDSCs in TGF-ß1-deficient mice.
- Chronic active hepatitis -- Pathogenesis. ; Suppressor cells. ; Transforming growth factors-beta. ; CD4-Positive T-Lymphocytes -- immunology. ; Transforming Growth Factor beta1 -- immunology.
- Autoimmune hepatitis (AIH) is an autoimmune liver disease characterized by immune-mediated necroinflammatory liver damage associated with CD4 + T cell infiltration in liver parenchyma. Despite advances in the understanding of AIH, its etiology...
- Dartmouth Dissertations
- 5-AMINOLEVULINIC-INDUCED PROTOPORPHYRIN.
- Brain tumors account for ~2% of all cancers, with gliomas accounting for ~70% of all brain tumors. Evidence suggests that extent of resection provides both a quality of life and survival benefit to patients. Recent work has shown the utility of...
- Dartmouth Dissertations
- New pathways of NAD+ metabolism and longevity.
- NAD (Coenzyme) -- Metabolism. Nicotinamide -- Mechanism of action. Genetic regulation. Nicotinamide-beta-riboside.
- NAD+ is an essential co-enzyme for hydride transfer enzymes and a consumed substrate of multiple signaling enzymes including the sirtuins, a family of protein lysine deacetylases shown to regulate longevity in a wide array of organisms. We have...
- Dartmouth Dissertations
- Synthetic approaches to the azamacrolides [Part] I; Synthetic approaches to carbazoles and 2-acylindoles [Part] II.
- Alkaloids -- Synthesis. ; Allomones. ; Indole. ; Carbazone. ; Diels-Alder reaction.
- A novel synthetic route to the synthesis of 9-propyl-10-azacyclododecan-12-olide (1), a natural allomone isolated from the Mexican bean beetle pupa, is presented. The salient features of this synthetic route are a regioselective Beckmann...
- Dartmouth Dissertations
- A proteomics approach to NIMA-related kinase signaling in mitosis / by Sierra N. Cullati
- NIMA-related kinases (Neks) control several aspects of cell division downstream of master mitotic regulators such as Cdk1 and Plk1. Though depletion of Nek6, Nek7, or Nek9 results in cytokinesis failure, to date no molecular mechanism has been...
- Dartmouth Dissertations
- Activation of aliphatic carbon-fluorine bonds in iridium complexes.
- Organoiridium compounds -- Synthesis. ; Organofluorine compounds -- Synthesis.
- Dartmouth Dissertations
- Molecular characterization of human deoxyribonuclease II[alpha]: structural determinants of activity and therapeutic implications.
- Deoxyribonucleases. ; Deoxyribonucleases -- Therapeutic use. ; Endonucleases -- Genetic aspects. ; Structure-activity relationships (Biochemistry). ; Pichia pastoris -- Cytogenetics. ; Cystic fibrosis -- Chemotherapy.
- Dartmouth Dissertations
- Identification of crucial residues involved in the catalysis of acyl-coenzyme A:cholesterol acyltransferase.
- Acyltransferases. ; Cholesterol -- Metabolism. ; Catalysis. ; Acyl Coenzyme A. ; Cholesterol Acyltransferase.
- Acyl-coenzyme A: cholesterol acyltransferase (ACAT) plays important roles in cellular cholesterol homeostasis and in early stages of atherogenesis. ACAT has been investigated as a pharmaceutical target, yet its active site(s) remain largely...
- Dartmouth Dissertations
- Reward and self-regulation in online digital environments.
- Reward (Psychology). ; Self-control. ; Internet addiction -- Physiological aspects. ; Behavior Addictive -- pathophysiology.
- The motivational and rewarding properties of our immediate environment affect how humans interact with our world in a number of ways. One important aspect in which reward representation shapes behavior is in the development, maintenance and...
- Dartmouth Dissertations
- The role of gut commensals in regulating susceptibility to acute liver damage / by Stela Celaj.
- Liver disease of different etiologies confers significant morbidity and mortality and hence it constitutes a major health concern worldwide. Stemming from a range of causes, such as viral, drug-induced, alcoholic, or autoimmune, the rate of...
- Dartmouth Dissertations
- Computational methods for the discovery and application of protein sequence-structure-function relationships / by Lu He.
- Proteins are ubiquitous in cells and are essential to a wide range of biological processes. Since existing proteins occupy only a small portion of the space of possible amino acid composition, understanding their sequence-structure-function...
- Dartmouth Dissertations
- High-speed MRI-guided near-infrared tomography system to monitor breast hemodynamics in vivo ;
- Near infrared spectroscopy -- Instruments -- Design and construction.;""Magnetic resonance imaging -- Instruments -- Design and construction."";""Breast -- Cancer -- Imaging."";""Breast -- Magnetic resonance imaging."";""Breast -- Cancer --...
- Dartmouth Dissertations
- Searching for a hijacked epoxide: structural, mechanisitic, and functional characterization of Cif, a virulence factor secreted by Pseudomonas aeruginosa
- The opportunistic pathogen Pseudomonas aeruginosa secretes a protein that triggers the accelerated degradation of the cystic fibrosis transmembrane conductance regulator (CFTR) in airway epithelial cells. This protein, known as the CFTR inhibitory...
- Dartmouth Dissertations
- Characterization of the major mitotic apparatus proteins and its subunits.
- Proteins. ; Cell division.
- Dartmouth Dissertations
- Solution chemistry of a New Hampshire subalpine ecosystem.
- Forest ecology -- New Hampshire. Solution (Chemistry).
- Dartmouth Dissertations
- Glucocorticoids affect the action of gamma interferon on human monocytes.
- Glucocorticoids. ; Interferon. ; Monocytes. ; Immunity.
- Dartmouth Dissertations
- The relationship between the apomorphine and the narcotic receptors of the emetic chemoreceptor trigger zone of the cat.
- Emetics. ; Apomorphine. ; Morphine.
- Dartmouth Dissertations
- Role of genetic and endocrinological factors in the regulation of rat serum dopamine-beta-hydroxylase activity.
- Dopamine.
- Dartmouth Dissertations
- Regulation of human cytochrome P4501A2 gene (CYP1A2) expression: isolation and functional analysis of the 5'-flanking region.
- Cytochrome P-450. ; Genetic regulation. ; Genetic transcription.
- Dartmouth Dissertations
- Respiratory regulation and central depressant drugs.
- Drugs -- Physiological effect. ; Respiratory organs.
- Dartmouth Dissertations
- Actions of substances placed in the cat cerebrospinal fluid space.
- Pharmacology, Experimental. ; Cats.
- Dartmouth Dissertations
- Intramembranous particle clusters and cytoplasmic vesicles in mice with nephrogenic defects of urinary concentration.
- Diabetes -- Research. ; Mice as laboratory animals.
- Dartmouth Dissertations
- A framework of computational opinions / by Fei Yu.
- We have a limited understanding of how an opinion is originated, how an opinion and information supporting and explaining it gets conveyed, and how the communicated opinion is perceived and processed by others. One direction of current research...
- Dartmouth Dissertations
- Isolation and characterization of two distinct mutations affecting cholesteryl ester synthesis in mammalian cells.
- Cholesterol. ; Esters. ; Mammals -- Cytology. ; Cell metabolism.
- Dartmouth Dissertations
- Part I: synthetic approaches to the perfluorotropylium ion; Part II: a new, mild and selective dehydrohalogenating reagent.
- Fluorine.
- Dartmouth Dissertations
- Combining near infrared tomography and magnetic resonance imaging to improve breast tissue chromophore and scattering assessment.
- Breast -- Magnetic resonance imaging. Breast -- Tomography. Near infrared spectroscopy. Optical tomography. Imaging systems -- Design and construction. Diagnostic imaging -- Mathematical models.
- Dartmouth Dissertations
- Effects of elevated endogenous kynurenic acid on spatial working memory, contextual conditioning, and conditional learning.
- Kynurenine -- Derivatives. Cognition. Memory. Brain chemistry. Brain -- Pathophysiology -- Animal models.
- Kynurenic acid (KYNA) is produced and released by astrocytes, and acts as an α7-nicotinic acetylcholine receptor antagonist (at lower, physiological concentrations) and an antagonist of the glycine site of the NMDA receptor (at higher,...
- Dartmouth Dissertations
- On the origins of cancer cell identity : epigenetic deregulation of cellular states / by Kevin Johnson
- The identification of molecular alterations present in cancer is critical to better understand carcinogenesis as well as the clinical trajectories of patients with malignant tumors. Early detection and application of appropriate treatment...
- Dartmouth Dissertations
- The heterogeneous role of the medial prefrontal cortex and nicotinic acetylcholine receptor subtypes in negative occasion setting.
- Prefrontal cortex -- Physiology. ; Acetylcholine -- Receptors. ; Nicotine -- Physiological effect. ; Inhibition.
- Dartmouth Dissertations
- A study of neutral amino acid and drug transport.
- Placenta. ; Maternal-fetal exchange.
- Dartmouth Dissertations
- Organometallic chemistry with perfluorinated ligands. Investigation of group 8-10 metal complexes derived from octafluorocyclooctatetraene (OFCOT).
- Organometallic chemistry. ; Ligands.
- Dartmouth Dissertations
- General purpose medical image registration.
- Diagnostic imaging -- Mathematics. Expectation-maximization algorithms. Imaging systems in medicine -- Mathematics.
- We have developed a general-purpose registration algorithm for medical images and volumes. The transformation between images is modeled as locally affine but globally smooth, and explicitly accounts for local and global variations in image...
- Dartmouth Dissertations
- Characterization of the role of Bacillithiol in Staphylococcus aureus / by Ana Catalina Posada.
- As methicillin-resistant Staphylococcus aureus (MRSA) hospitalizations keep increasing, the understanding of the characteristics that make one isolate more successful over another is paramount. Strain variations among Staphylococcus aureus observed...
- Dartmouth Dissertations

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