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A role for TP63 in breast cancer initiation.
Despite the availability of targeted therapies, breast cancer metastasis and recurrence remain clinically challenging problems. Understanding the function of stem cells in this disease may lead to identification of genetic pathways underlying...
Dartmouth Dissertations

The causes and consequences of regulation of [Delta]NP63[alpha] in mammary and breast cancer stem cells / by Andrew Joseph DeCastro.
Despite the array of targeted therapeutics that currently exist to combat breast cancer, disease progression leading to metastasis, and tumor recurrence still remains a significant clinical challenge. Efforts to identify novel pathways and...
Dartmouth Dissertations

Induced optical effects in germanium-doped silica glass.
Silica, Vitreous -- Optical properties.
Dartmouth Dissertations

The expression and activity of TP63 in the mammary epithelial regenerative hierarchy.
Tumor proteins. ; p53 antioncogene. ; Epithelial cells. ; Mammary glands -- Cytology. ; Stem cells. ; Regeneration (Biology). ; Genetic transcription -- Regulation. ; Cellular signal transduction.
Dartmouth Dissertations

Electron transfer reaction in solution: initial charge separation distance distribution and its impact on free ion formation.
Free radicals (Chemistry). ; Electron donor-acceptor complexes. ; Ions.
In this study, the initial charge separation distance and its impact on free radical ion (FRI) formation are investigated in detail. Transient photocurrent techniques together with other spectroscopic methods were used with a series of donors and...
Dartmouth Dissertations

On the leukemogenic mechanisms of core binding factor translocation products.
Transcription factors -- Pathophysiology. Myeloid leukemia -- Genetic aspects. Genetic transcription -- Regulation.
Core binding factor translocations and inversions are among the most frequently identified mutations in acute myeloid leukemia. We present work that characterizes the functional contributions of domains within the fusion proteins resulting from the...
Dartmouth Dissertations

New technologies for constructing C-C, C-N, and C-S bonds
I. Intermolecular C-S Bond Forming Reactions The relatively small number of efficient C-S bond forming reactions in the literature prompted an investigation into the synthesis of allylic thioethers. The technology that we developed allowed us, in...
Dartmouth Dissertations

Some partition theorems and ultrafilters on w [i.e. omega].
Partitions (Mathematics) Ultrafilters (Mathematics).
Dartmouth Dissertations

Laser-based oxygen isotopic studies of Acadian metamorphism in eastern Vermont.
Metamorphism (Geology) -- Vermont. Garnet -- Vermont. Laser spectroscopy.
This study presents δ18O analyses of garnets microsampled by laser fluorination from two localities in the deep seated, Barrovian metamorphic terrane of eastern Vermont. The broad goals of the research were to constrain further the amount,...
Dartmouth Dissertations

Methods for rapid EEG-based mapping of human brain functions.
Electroencephalography. ; Brain mapping -- Methodology. ; Evoked potentials (Electrophysiology).
Brain mapping via EEG activation is a useful tool of basic neuroscience, and has wide clinical applications as well. The mapping is achieved by means of Event Related Potentials (ERPs), task-related changes in EEG time series. The methodology of...
Dartmouth Dissertations

Radial diffusion of radiation belt electrons in three dimensions.
Van Allen radiation belts -- Mathematical models. Electrons -- Diffusion -- Mathematical models. Magnetohydrodynamic waves -- Mathematical models.
It is becoming increasingly important to understand the dynamics of radiation belt energetic particles given their potentially hazardous effects on satellites and our ever-increasing dependence on those satellites. There is a need to determine...
Dartmouth Dissertations

Control of developmental timing in Caenorhabditis elegans by lin-14.
Caenorhabditis elegans -- Genetics. ; Caenorhabditis elegans -- Growth. ; Cellular control mechanisms. ; Heterochrony (Biology). ; Developmental genetics.
The heterochronic gene lin-14 affects certain somatic cell-fate choices during post-embryonic development in C. elegans. In lin-14 mutants, cells express stage-specific developmental programs, such as cell divisions or dauer entry, at inappropriate...
Dartmouth Dissertations

Identifying the biologically active forms of HEDGEHOG proteins.
Hedgehog (HH) proteins play an important and evolutionary conserved patterning role in metazoan development. Aside from this physiological role, pathologically HH proteins are implicated in human developmental disorders and post-developmental...
Dartmouth Dissertations

Nucleophilic addition to electron deficient indoles and the synthesis of fused heterocyclic ring systems.
Indole -- Synthesis. ; Heterocyclic compounds -- Synthesis.
The chemistry of indole can be reversed and redirected by the addition of powerful electron-withdrawing groups. Incorporation of a nitro group at C-2 or C-3 renders the adjacent carbon susceptible to nucleophilic attack. Nitro, cyano, and...
Dartmouth Dissertations

Infinitary languages, generalized quantifiers, and generalized products.
Infinitary languages. ; Logic.
Dartmouth Dissertations

Halogenated oxabicyclo[3.2.1]octenes as building blocks for the synthesis of natural products.
Bicyclic compounds -- Reactivity. ; Natural products -- Synthesis. ; Halogens. ; Diels-Alder reaction.
The previously synthesized 3,4-dibromo-8-oxabicyclo[3.2.1]octa-3,6-dien-2-one has been shown to be a very versatile building block for the synthesis of complex natural product structures. This key building block has been made in both...
Dartmouth Dissertations

Geology of the Lake Atitlan area, Guatemala : a study of subduction zone volcanism and caldera formation.
Geology -- Guatemala -- Lake Atitlan area; Volcanism -- Guatemala -- Lake Atitlan area; Calderas -- Guatemala -- Lake Atitlan area.
Geological mapping, petrological and geophysical studies in the lake Atitlan area, Guatemala, have revealed four distinct periods of stratovolcano growth, each followed by major silicic eruptions and caldera collapse. The first period (12 - 11 my...
Dartmouth Dissertations

Synthetic studies toward the furanosteroids.
Furans -- Synthesis. Steroid drugs. Enzyme inhibitors -- Therapeutic use. Cancer cells -- Growth -- Regulation.
The furanosteroids are an important class of natural products that have been found to effectively inhibit various biologically important enzymes. These enzymes include the phosphoinositide-3-kinase (PI3K) family and the polo-like kinase (PLK1)...
Dartmouth Dissertations

Catalytic asymmetric P-C bond formation with Pt-phosphido complexes.
Organoplatinum compounds -- Synthesis. Organoplatinum compounds -- Reactivity. Organophosphorus compounds -- Synthesis. Organophosphorus compounds -- Reactivity. Asymmetric synthesis. Phosphate carbon. Platinum catalysts.
Chapter One. Synthesis and Structure of Chiral Pt(Duphos) Terminal Phosphido Complexes. Treatment of Pt halide precursors with a secondary phosphine in the presence of the base NaOSiMe 3 gave the terminal phosphido complexes Pt(Duphos)(Ph)(PMeIs)....
Dartmouth Dissertations

Substrate and catalyst control in asymmetric synthesis of p-sterogenic bis(phosphines).
Introduction. This chapter provides a brief overview of the thesis. Chapter 1: tert-butyl-diphosphabutarene - Synthesis and reactivity of a novel phosphacycle. Treatment of 1,2-bis(dichlorophosphino)benzene (12) with tert-butylmagesium chloride...
Dartmouth Dissertations

Computational studies of small group IB clusters and their van der Waals complexes.
Transition metal complexes -- Spectra. ; Chemical reaction.
Dartmouth Dissertations

Investigating EMIC waves as a precipitation mechanism for relativistic electrons.
Loss processes greatly impact the dynamics of the Earth's radiation belts. In 1996, a balloon-borne germanium detector flown over Kiruna, Sweden detected the first terrestrial X-rays with energies on the order of 1 MeV. The spectrum for these...
Dartmouth Dissertations

Statistical analysis and empirical modeling of large- and small-scale plasma drifts in Earth''s high-latitude ionosphere.
Electric fields in the high-latitude regions of Earth's ionosphere are an important component of the coupled magnetosphere-ionosphere-thermosphere system. Characterizing the average behavior of these fields (or the corresponding drifts) is useful...
Dartmouth Dissertations

Operating system support for resilience / by Kathleen McGill.
Robots. ; Reinforcement learning. ; Social interaction. ; Cooperation. ; Biomimetics.
Dartmouth Dissertations

Temporal regulation of microRNA expression during animal development.
RNA. Cells -- Growth -- Regulation. Caenorhabditis elegans -- Genetics. Caenorhabditis elegans -- Development. Drosophila melanogaster -- Genetic aspects. Drosophila melanogaster -- Development. Neurons -- Growth. Animal genetics.
MicroRNAs (miRNAs) are recently discovered family of genes with short non-coding RNA transcripts of 18 to 25 nucleotides in length. lin-4 and let-7 , the founding members of the miRNA gene family, control the timing of developmental programs in the...
Dartmouth Dissertations

Regulation of apoptosis in the Caenorhabditis elegans nervous system.
Caenorhabditis elegans -- Genetics. Neurons. Apoptosis. Genetic transcription -- Regulation.
Most of the cells that die during the development of a C. elegans hermaphrodite do so within 30 min after being generated. In these cells, the pro-caspase proCED-3 is inherited from progenitors and the transcriptional upregulation of the BH3-only...
Dartmouth Dissertations

Numerical methods in electromagnetics : evanescent nanometry for DNA sequencing, and EM induction for UXO detection and discrimination / by Alex Bijamov.
Mice -- Morphogenesis.;""Mice -- Genetics."";""Transcription factors."";""Cellular signal transduction."";""Genetic regulation."";""GATA4 Transcription Factor -- genetics."";""Wnt Proteins -- physiology.""
Dartmouth Dissertations

Mobility and communication in sensor networks.
Sensor networks. Robots -- Control systems. Detectors. Synchronization. Computer network protocols.
This thesis considers the two special sensor networks for future sensor network design: mobile sensor networks and hybrid network of sensors and robots. To investigate two types of networks, we abstract two most important aspects that are ingrained...
Dartmouth Dissertations

Cu(I)-catalyzed P-C bond formation and the synthesis of C₃- and C₁-symmetric p-stereogenic triphosphine ligands / by Matthew F. Cain.
Cell cycle -- Regulation.; Transcription factors.; Luciferases.; Forkhead Transcription Factors -- genetics.
Dartmouth Dissertations

Parallel out-of-core sorting: the third way.
Sorting (Electronic computers). Parallel processing (Electronic computers). Computer algorithms.
Sorting very large datasets is a key subroutine in almost any application that is built on top of a large database. Two ways to sort out-of-core data dominate the literature: merging-based algorithms and partitioning-based algorithms. Within these...
Dartmouth Dissertations

Prediction of the thermodynamic properties of branched polymer solutions and copolymer systems / by Elizabeth Alice Clark.
Throughout this work, a lattice model was used to capture the behavior of polymer systems. First, the phase behavior of solutions which contain polymer solute in an alkane solvent was investigated. The phase diagrams of these solutions are...
Dartmouth Dissertations

Understanding the vulnerabilities of tumors : a network-based approach to drug target discovery / by Nadia M. Penrod.
The demand for novel molecularly targeted drugs will continue to rise as we make progress toward personalizing cancer treatments to the molecular signatures of individual tumors. While the collection and analysis of genomic data has become routine,...
Dartmouth Dissertations

The evolution of mate recognition in Oecanthus tree crickets / by Laurel Symes.
Many organisms recognize and respond to categories: predator, prey, rival, or juvenile. Organisms recognize these ecologically-important categories by assessing diverse sensory stimuli. A primary focus of my research has been understanding how...
Dartmouth Dissertations

Coordination of cell proliferation and cell fate determination by C. elegans CES-1 Snail / by Bo Yan.
Cyclin-dependent kinases (CDKs) and their associated cyclins are key regulators of cell cycle progression. Caenorhabditis elegans has two predicted A- type cyclins, encoded by the genes cya-1 and cya-2. Cyclin A has been shown to be required for...
Dartmouth Dissertations

Tectonics of the Pacific margin of Northern Central America
Geology, Structural.; Geology -- Central America. ; Plate tectonics -- Pacific Coast (Central America)
Dartmouth Dissertations

Noninvasive fluorescence monitoring for functional assessment of murine glioma treatment.
Gliomas -- Immunotherapy -- Evaluation. Fluorescence spectroscopy. Diagnosis.
Molecular optical imaging in vivo has potential for functional assessment of tumor tissue at the cellular and subcellular level. Advances in biological understanding of genomics and proteomics have increased the knowledge of possible cellular...
Dartmouth Dissertations

Group 6B metal complexes of three and four membered organic rings.
Organometallic compounds. Transition metal compounds.
Dartmouth Dissertations

Examining auroral downward current region processes using ground based data.
Auroras -- Alaska -- Observations. Magnetospheric currents.
This thesis presents data from ground camera observations of the aurora conducted from Alaska during the winters of 2005 through 2007. In conjunction with these camera observations, conjugate radar observations of the auroral ionosphere were...
Dartmouth Dissertations

A prediction of the interaction of a normal shock with a separating, turbulent boundary layer.
Shock waves. Turbulent boundary layer.
Dartmouth Dissertations

Spectroscopic analyses of type Ia supernovae / by Jerod Parrent.
After decades of searching we have yet to find the progenitor systems for type Ia supernovae. In fact most of what we know about this homogeneous class of supernovae is from spectral features associated with the incinerated remains of the C+O white...
Dartmouth Dissertations

Understanding PDZ affinity and selectivity: all residues considered / by Jeanine F. Amacher.
PDZ protein-protein interaction domains recognize short linear motif (SLiM) sequences typically at the extreme C-terminus of a target protein. These domains often act as scaffolds, connecting target proteins to additional interaction and catalytic...
Dartmouth Dissertations

Analytical and computational approaches for quantitative phosphoproteomics / by Jason M. Gilmore.
Protein phosphorylation is an important regulatory mechanism for the control of countless processes in living systems. The delicate management of phosphate attachment to, and removal from, serine, threonine and tyrosine residues in proteins...
Dartmouth Dissertations

Temperature effects on food web interactions : from lakes to landscapes / by Samuel Butler Fey.
Temperature has powerful effects on all scales of biological organization from biochemical reactions to ecosystem processes. Despite the well-appreciated influence and thorough understanding of the physiological and population consequences of...
Dartmouth Dissertations

Leptin DNA methylation and maternal and infant pregnancy outcomes in the Rhode Island child health study / by Corina Lesseur Perez.
In utero exposure to maternal malnutrition is associated with increase offspring susceptibility to cardiometabolic and neuropsychiatric disease. Epigenetic mechanisms mediate, at least in part, fetal adaptations to adverse in utero environments...
Dartmouth Dissertations

The scaling of forced reconnection in two and three dimensions.
Magnetic reconnection -- Mathematical models. Plasma (Ionized gases). Magnetohydrodynamics -- Mathematical models. Scaling laws (Statistical physics). Forcing (Model theory).
This thesis presents two-fluid simulations of forced magnetic reconnection with finite electron inertia in two and three dimensional periodic systems. Reconnection in the system is driven by a spatially localized forcing function, added to the ion...
Dartmouth Dissertations

Links and regulatory loops between phospholipase C activity and colonization by the O2-responsive regulator Anr in Pseudomonas aeruginosa / by Angelyca A. Jackson.
Pseudomonas aeruginosa is a virulent opportunistic pathogen that is frequently cultured from infectious sites, and is estimated to cause ~12% of nosocomial infections worldwide [1]. P. aeruginosa infections occur in a majority of adults with the...
Dartmouth Dissertations

Thermodynamic and spectroscopic studies of metalloprotein stability ligation and reactivity / by George P. Lisi III.
Metal ions confer structural stability and reactivity to a large number of proteins that use the amino acids histidine (His) and cysteine (Cys) to form stable metal-ligand complexes. The stability of metal-His and metal-Cys interactions and their...
Dartmouth Dissertations

Modulation of swarming motility in Pseudomonas aeruginosa / by Dae Gon Ha.
Swarming motility is a flagella-dependent surface motility, and is also a form of bacterial group behavior. Similar to its counterpart biofilm formation, our understanding of swarming motility has been hampered by its complex set of requirements...
Dartmouth Dissertations

The role of mediator in white-opaque switching / by Anda Zhang.
The multisubunit eukaryotic Mediator complex integrates diverse positive and negative gene regulatory signals and transmits them to the core transcription machinery. It is also involved in chromatin structure related epigenetic silencing through...
Dartmouth Dissertations

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