Dartmouth Digital Library Program

Medical School, Class of 1954-thru
Medical School Cases, Class of 1954-thru
Class of 2004 Danielle Adams; James Ames; Kirsten Andrews; Jeffrey Barrett; Laura Berg; Adam Bier; Jennifer Boyle; Trevor Braden; Marc Brazie; Todd Burdette; Chirstopher Cambic; Jose Carrillo; Avery Ching; Bryan Coffing; Corey Couto; Shimae Cross;...
Dartmouth College Photographic Files

Modulation of CYPS: effect on acetaminophen hepatotoxicity.
Hepatotoxicology. ; Cytochrome P-450 -- Pathophysiology. ; Acetaminophen -- Toxicology. ; Alcohol -- Pathophysiology.
Cytochrome P450 (CYP) 2E1 is considered the sole CYP responsible for APAP bioactivation leading to hepatotoxicity. CYP2E1 is also considered the alcohol-inducible CYP and therefore, the sole CYP responsible for alcohol-mediated increases in APAP...
Dartmouth Dissertations

The scaling of forced reconnection in two and three dimensions.
Magnetic reconnection -- Mathematical models. Plasma (Ionized gases). Magnetohydrodynamics -- Mathematical models. Scaling laws (Statistical physics). Forcing (Model theory).
This thesis presents two-fluid simulations of forced magnetic reconnection with finite electron inertia in two and three dimensional periodic systems. Reconnection in the system is driven by a spatially localized forcing function, added to the ion...
Dartmouth Dissertations

Mechanisms by which arsenite decreases CYP3A.
Cytochrome P-450 -- Pathophysiology. ; Cytochrome P-450 -- Genetics. ; Arsenic compounds -- Physiological effect. ; Liver cells.
Arsenic is implicated in numerous human pathologies, including cancer and several forms of liver disease. One contributing mechanism may involve alterations of CYP levels by arsenic. CYP3As are the most abundant CYP proteins in human liver and...
Dartmouth Dissertations

Identifying airway obstructions from photoplethysmography (PPG).
Plethysmography. ; Airway (Medicine) -- Obstructions. ; Respiration -- Mathematical models. ; Respiration -- Data processing. ; Airway Obstruction -- diagnosis.
Emergency medical response requires timely and efficient assessment and treatment of casualties. Mass casualty situations, in particular, strain the resources of emergency responders, prompting the need for a well-organized, effective, automated...
Dartmouth Dissertations

The importance of p53-dependent transcriptional responses in the differentiation and curability of human embryonal carcinoma.
Testis -- Cancer -- Genetic aspects. p53 antioncogene -- Regulation. Embryonal tumors -- Pathophysiology. Germ cells -- Tumors -- Pathophysiology. Cisplatin -- Mechanism of action. Tretinoin. Testicular Neoplasms -- in children. Neoplasms
Dartmouth Dissertations

Dynamic social network analysis.
Social networks -- Mathematical models. Social networks -- Computer simulation. Dynamics. Social sciences -- Network analysis -- Methodology.
Detecting the significance of relationships between people is a complicated and difficult task. This is especially true when these relationships are intermixed with hundreds of different mundane and ordinary interactions that are simply background...
Dartmouth Dissertations

The involvement of anti-apoptotic Bcl-2 family proteins in vinblastine-induced apoptosis.
Therapeutics, Experimental. Leukemia -- Genetics. Leukemia -- Chemotherapy. Apoptosis. bcl2-Associated Death Protein. Vinblastine. Flavopiridol.
The efficacy of many chemotherapeutic agents can be attenuated by expression of the anti-apoptotic proteins Bcl-2, Bcl-X and Mcl-1. When ML-1 leukemia cells are incubated with vinblastine, they rapidly upregulate Mcl-1. Suppression of Mcl-1 with...
Dartmouth Dissertations

Engineering new tools for targeted drug discovery : design and development of soluble, screenable mimics for challenging proteins / by Chirstopher O. Audu.
The design and synthesis of biomimetic receptor systems capable of binding a target molecule with similar affinities and specificities to their natural counterparts, which are often difficult to obtain in large quantities, has long been a goal of...
Dartmouth Dissertations

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