This thesis explores practical and theoretical aspects of several privacy-providing technologies, including tools for anonymous web-browsing, verifiable electronic voting schemes, and private information retrieval from databases. State-of-art...
APETALA3 ( AP3 ) and PISTILLATA ( PI ) are floral organ identity genes that are necessary and sufficient for petal and stamen development. Surprisingly little is known about molecular mechanisms by which AP3 and PI proteins direct floral organ...
The goal of this work was to improve the computational tools for near-infrared light modeling for clinical applications in photodynamic therapy (PDT) analysis and eventual treatment planning. The tools to facilitate this modeling were developed in...
This thesis investigates a notion of Turing reducibility introduced by Winkler [8] that is total on all computably enumerable oracles. Groszek and Weber show in [7] that this is a new notion of reducibility and it is not transitive. They give su...
MicroRNAs (miRNAs) are recently discovered family of genes with short non-coding RNA transcripts of 18 to 25 nucleotides in length. lin-4 and let-7 , the founding members of the miRNA gene family, control the timing of developmental programs in the...
The LysR-type virulence regulator, AphB, initiates the Vibrio cholerae virulence cascade resulting in expression of the two critical virulence factors, toxin-coregulated pilus and cholera toxin, by activating transcription at the tcpPH promoter....
Riemannian manifolds. Singularities (Mathematics). Laplacian operator. Spectral theory (Mathematics). Riemann surfaces. Curves on surfaces. Geometry
Historically, inverse spectral theory has been concerned with the relationship between the geometry and the spectrum of compact Riemannian manifolds, where spectrum means the eigenvalue spectrum of the Laplace operator as it acts on smooth...
The opportunistic pathogen Pseudomonas aeruginosa secretes a protein that triggers the accelerated degradation of the cystic fibrosis transmembrane conductance regulator (CFTR) in airway epithelial cells. This protein, known as the CFTR inhibitory...
The identification and characterization of functional genetic variation is essential for future advances in molecular diagnostics, pharmacogenomics, and personalized medicine. Recent attempts at identifying nucleotide level variation (somatic...
Fluorescence molecular imaging will have an important clinical impact in the area of guided oncology surgery, where emerging technologies are poised to provide the surgeon with real-time molecular information to guide resection, using targeted...
In utero exposure to maternal malnutrition is associated with increase offspring susceptibility to cardiometabolic and neuropsychiatric disease. Epigenetic mechanisms mediate, at least in part, fetal adaptations to adverse in utero environments...
Polynomials. Finite fields (Algebra). Algebraic functions. Number theory.
The ring of univariate polynomials over a finite field shares many foundational arithmetic properties with the ring of rational integers. This similarity makes it possible for many problems in elementary number theory to be translated 'through the...
Order picking systems -- Automation -- Computer simulation.
This research ventures into areas beyond traditional control frameworks in its focus. It integrates holonic concepts into a hierarchical control framework of a complex automated order fulfillment technology. Simulation of an actual full-scale order...
Prior to biological conversion of lignocellulosic biomass, natural barriers to efficient enzymatic hydrolysis must be overcome, and a few pretreatment technologies effectively accomplish this job with chemicals. Although several factors are...
Topological graph theory. Aperiodicity. Paths and cycles (Graph theory)
The condition ""every cycle has an entry"" first appeared in the literature in Kumjian, Pask, and Raeburn's paper on Cuntz-Krieger algebras of directed graphs, where it was called Condition (L). It provides a necessary condition for simplicity of...
An organism's long-term survival is critically dependent on its ability to protect itself from pathogenic microbial infections. The first line of defense against such infections is the branch of the immune response referred to as the innate immune...
The inappropriate expression of Matrix Metalloproteinases (MMPs) contributes to the pathology of many cancers. Among these, melanoma is a particularly insidious disease in that it is almost completely resistant to every known the therapy, and the...
A polynomial is a product of distinct cyclotomic polynomials if and only if it is a divisor over [Special characters omitted.] [x ] of xn - 1 for some positive integer n. In this thesis, we will examine two natural questions concerning the divisors...
Chronic infection of the human airway by mucoid Pseudomonas aeruginosa is cited as the leading cause of death among Cystic Fibrosis patients. The persistent nature of these infections is linked to P. aeruginosa's ability to form protective biofilm...
The potential of peptide mimics of V. cholerae lipopolysaccharide (LPS) to elicit cross-reactive immune responses against LPS was investigated, as an alternative approach towards the development of a cholera vaccine. Peptide mimics of two...
Radio relics are extended regions of synchrotron radio emission that have been found in the outskirts of a few dozen galaxy clusters. Relics are often associated with clusters undergoing merger activity. They are not associated optically with a...
Many protocols for adoptive T cell therapy (ACT) include preparative conditioning strategies to deplete host lymphocytes prior to T cell infusion. Total body irradiation and high-dose chemotherapy regimens not only relieve immunosuppression, but...
Purple sulfur bacteria (PSB) can dominate the nitrogen, carbon, and sulfur cycles in anoxic ecosystems via their anoxygenic photosynthetic metabolisms and are the only producers of the carotenoid, okenone, a biomarker targeted for photic zone...
The purpose of this thesis is to describe methods for detecting hidden crevasses on glaciers in Polar regions. Crevasses form in ice sheets as a result of forces imposed upon the brittle ice. The crevasses are hidden from view by bridges of soft...
Patients with cystic fibrosis (CF) are susceptible to respiratory tract infections at an early age; with the most frequent initial isolate being the Gram-positive pathogen Staphylococcus aureus. Subsequently, these patients become chronically...