APETALA3 ( AP3 ) and PISTILLATA ( PI ) are floral organ identity genes that are necessary and sufficient for petal and stamen development. Surprisingly little is known about molecular mechanisms by which AP3 and PI proteins direct floral organ...
The goal of this work was to improve the computational tools for near-infrared light modeling for clinical applications in photodynamic therapy (PDT) analysis and eventual treatment planning. The tools to facilitate this modeling were developed in...
Yeast vacuole fusion involves three transmembrane SNAREs and a unique soluble SNARE, Vam7p. This SNARE cycles between vacuolar membrane-bound and cytosolic state. In its membrane-bound state, it is able to participate in vacuolar fusion by...
This thesis investigates a notion of Turing reducibility introduced by Winkler [8] that is total on all computably enumerable oracles. Groszek and Weber show in [7] that this is a new notion of reducibility and it is not transitive. They give su...
The study of twin primes gives rise to several famously difficult problems in number theory--in fact, we still cannot definitively say whether there are infinitely many twin primes. In this work, we consider a related problem, namely: What is the...
MicroRNAs (miRNAs) are recently discovered family of genes with short non-coding RNA transcripts of 18 to 25 nucleotides in length. lin-4 and let-7 , the founding members of the miRNA gene family, control the timing of developmental programs in the...
Glutamic acid -- Receptors. Ion channels -- Molecular aspects. Ligand binding (Biochemistry). Biological transport -- Regulation. Receptors.
AMPA receptors (AMPA-Rs) are glutamate-gated ion channels that mediate the majority of excitatory synaptic transmission in the brain. AMPA-Rs are generally found in vivo as hetero-tetramers made up of a combination of the GluR1-GluR4 subunits....
Bioinorganic chemistry, a discipline that bridges chemistry and biology, has become increasingly popular as new techniques and analytical methods have emerged to study metals in biological systems. One such technique that has become increasingly...
Accurate segregation of meiotic chromosomes requires that sister-chromatids remain physically associated from the time of their synthesis during S phase until they segregate toward opposite poles at anaphase II. In Drosophila melanogaster meiosis,...
Goldman and Turaev constructed a Lie bialgebra structure on the free Z-module generated by free homotopy classes of loops on an oriented surface. Turaev conjectured that the cobracket of A is zero if and only if A is a power of a simple class. Chas...
Fluorescence molecular imaging will have an important clinical impact in the area of guided oncology surgery, where emerging technologies are poised to provide the surgeon with real-time molecular information to guide resection, using targeted...
In utero exposure to maternal malnutrition is associated with increase offspring susceptibility to cardiometabolic and neuropsychiatric disease. Epigenetic mechanisms mediate, at least in part, fetal adaptations to adverse in utero environments...
In this thesis, we consider several problems relating to cyclic subgroups of the group [mathematical equation]. Each element of [mathematical equation] has a unique representative in one of the two intervals [mathematical equation] and...
Metal ions. Binding sites (Biochemistry) -- Thermodynamics. Metalloenzymes. Cellular control mechanisms. Thermometric titration. Calorimetry.
The chemistry of biology is complex and there is a great deal that is not understood. A fundamental understanding of biochemical reactions is important to aid in the identification of undiscovered reactions and is critical to fully appreciate the...
Infections by pathogenenic microbes are an increasing problem due to a lack of universal vaccines and growing resistance to current antibiotics. The constant battle for researchers in the fight against pathogens is to design new and improved drugs...
Order picking systems -- Automation -- Computer simulation.
This research ventures into areas beyond traditional control frameworks in its focus. It integrates holonic concepts into a hierarchical control framework of a complex automated order fulfillment technology. Simulation of an actual full-scale order...
The mucosal immune system of the female reproductive tract (FRT) balances the dual functions of protection against invading pathogens and adaptation of the endometrial environment for successful fertilization and implantation. Growth factors are...
Prior to biological conversion of lignocellulosic biomass, natural barriers to efficient enzymatic hydrolysis must be overcome, and a few pretreatment technologies effectively accomplish this job with chemicals. Although several factors are...
Riemannian manifolds. Singularities (Mathematics). Laplacian operator. Spectral theory (Mathematics). Riemann surfaces. Curves on surfaces. Geometry
Historically, inverse spectral theory has been concerned with the relationship between the geometry and the spectrum of compact Riemannian manifolds, where spectrum means the eigenvalue spectrum of the Laplace operator as it acts on smooth...
Topological graph theory. Aperiodicity. Paths and cycles (Graph theory)
The condition ""every cycle has an entry"" first appeared in the literature in Kumjian, Pask, and Raeburn's paper on Cuntz-Krieger algebras of directed graphs, where it was called Condition (L). It provides a necessary condition for simplicity of...
The inappropriate expression of Matrix Metalloproteinases (MMPs) contributes to the pathology of many cancers. Among these, melanoma is a particularly insidious disease in that it is almost completely resistant to every known the therapy, and the...
The Border Gateway Protocol (BGP) facilitates communication between parts of the Internet by determining paths by which data can get from one network to any other. Just as IP is used ubiquitously as an addressing scheme, BGP is used ubiquitously...
A polynomial is a product of distinct cyclotomic polynomials if and only if it is a divisor over [Special characters omitted.] [x ] of xn - 1 for some positive integer n. In this thesis, we will examine two natural questions concerning the divisors...
Chronic infection of the human airway by mucoid Pseudomonas aeruginosa is cited as the leading cause of death among Cystic Fibrosis patients. The persistent nature of these infections is linked to P. aeruginosa's ability to form protective biofilm...
As the visual effect and movie industries are striving for realism and high fidelity images, physically based lighting, global illumination, realistic materials, and highly tessellated geometry are gradually accepted and used in movie and game...
Radio relics are extended regions of synchrotron radio emission that have been found in the outskirts of a few dozen galaxy clusters. Relics are often associated with clusters undergoing merger activity. They are not associated optically with a...
Purple sulfur bacteria (PSB) can dominate the nitrogen, carbon, and sulfur cycles in anoxic ecosystems via their anoxygenic photosynthetic metabolisms and are the only producers of the carotenoid, okenone, a biomarker targeted for photic zone...
Studies presented in this dissertation focus on the transcriptional targets and cellular functions of [Delta]Np63[alpha], the predominant TP63 isoform expressed in epithelial stem cell compartments. TP63, a member of the p53 family of...