One man is wearing a traditional Native American-style sash under his coat and a watch chain. The second has a watch chain made of paper clips. Individuals, male; Clothing, western-style; Paper clip; Pipe; Watch chain.
Constructibility (Set theory). Trees (Graph theory).
This thesis investigates possible initial segments of the degrees of constructibility. Specifically, we completely characterize the structure of degrees in generic extensions of the constructible universe L via forcing with Souslin trees. Then we...
NIMA-related kinases (Neks) control several aspects of cell division downstream of master mitotic regulators such as Cdk1 and Plk1. Though depletion of Nek6, Nek7, or Nek9 results in cytokinesis failure, to date no molecular mechanism has been...
CD antigens. T cells -- Receptors. Receptor-ligand complexes. Transplantation immunology. Immunological tolerance -- Molecular aspects. Antigens
Voltage-dependent sodium channels (Na v ) are critical determinants of the ability of a neuron to generate and propagate action potentials. While a large family of Na v isoforms has been identified, the impact of specific isoforms on the electrical...
Digital integrated circuits -- Testing. Digital integrated circuits -- Testing -- Mathematical models. Digital integrated circuits -- Design and construction.
Public key infrastructure (Computer security). ; Computer networks -- Security measures. ; Operating systems (Computers). ; Microcomputers.
In 1976, Whitfield Diffie and Martin Hellman demonstrated how public key cryptography could enable secure information exchange between parties that do not share secrets. In order for public key cryptography to work in modern distributed...
In this thesis, we study the dynamics of magnetic flows on compact nilmanifolds. Magnetic flows are generalizations of geodesic flows. They model the motion of a particle of unit mass and unit charge in a smooth manifold M in the presence of a...
In this thesis we develop a theory of Fourier analysis and fast Fourier transforms (FFTs) for finite inverse semigroups. Our results generalize results in the theory of Fourier analysis for finite groups. There is a general method for generating...
Phospholipase C -- Mechanism of action. Retinal degeneration -- Pathophysiology. Retinal degeneration -- Genetic aspects. Endocytosis. Rhodopsin. Cellular signal transduction. Light -- Physiological effect. Arrestin. Clathrin. Adaptor Proteins
Mutations in the Drosophila retinal-specific Phospholipase C (NORPA) cause massive retinal degeneration within five days of constant light exposure. We have previously shown that in norpA mutants persistent complexes between the light receptor...
This thesis comprises two separate but related studies, dealing with two strongly interacting nanoscale systems on the border between the quantum and classical domains. In Part 1, we use a Born-Markov approximated master equation approach to study...
This thesis describes the synthesis of sulfobetaines having the general structure $\rm RN\sp{+}(CH\sb3)\sb2(CH\sb2)\sb{x}SO\sb{3\sp{-}}$ as novel inhibitors of squalene synthase. Squalene synthase reductively couples two molecules of farnesyl...
Some biomacromolecules require a metal co-factor to stabilize their physiologically active three-dimensional structure. The fundamental thermodynamic values of the binding of metal ions, particularly Zn2+, to a set of biomacromolecules have been...
Core-binding factors (CBFs) are a small family of transcription factors that play important roles in several developmental processes and in human disease. CBFs consist of CBFα (Runx1, Runx2, or Runx3) and CBFβ. The CBFα subunit binds DNA in a...
Microtubule motors are essential for cell division. Although the functions of some mitotic motor proteins have been elucidated, the precise mechanisms by which they govern spindle assembly and chromosome segregation remain largely unknown. This...
We consider a problem of information overload: the conflict between vast amounts of data available in electronic form and inadequate tools for finding relevant information. To alleviate this problem we look at the information organization:...
Part 1 . A computational study targeting the lowest energy structure, electronic state and physical properties of small carbon clusters containing one or two heteroatoms has been done. The structural properties sought included whether the most...
Problem Statement Patient safety in the modern hospital is supported by multiple human and technological systems, and this type of high-risk/high-complexity domain requires multiple layers of protection against harm. This fault-tolerant approach is...
For a local field K, we study the affine buildings Ξ n and Δ n naturally associated to SL n ( K ) and Sp n ( K ), respectively. Since Sp n ( K ) is a subgroup of SL 2 n ( K ), we investigate properties of a natural embedding of Δ n in Ξ 2 n ....
Electronic mail systems -- Security measures. Electronic mail systems -- Social aspects. Trust.
A secure system that cannot be used by real users to secure real-world processes is not really secure at all. While many believe that usability and security are diametrically opposed, a growing body of research from the field of Human-Computer...
Iron minerals are ubiquitous in near surface environments and often readily sorb or coprecipitate with many trace metals. Transformations of iron phases are, therefore, integral to the fate of trace metals in most near surface aqueous regimes....
An organism's long-term survival is critically dependent on its ability to protect itself from pathogenic microbial infections. The first line of defense against such infections is the branch of the immune response referred to as the innate immune...