Dartmouth Digital Library Program

Thumbnail

Title

Subject

Description

Collection

A computational dissection in the evolution of cell growth.
Genetic regulation. Cells -- Growth -- Regulation. Ribosomes. DNA -- Synthesis. Evolutionary genetics.
Gene regulation is a principle tool that all organisms utilize to control development, growth, and responses to environmental conditions. Understanding how organisms orchestrate the spatiotemporal regulation of gene expression remains a fundamental...
Dartmouth Dissertations

A mechanistic investigation of the ring expansion of vinylcyclopropenes to metallacyclohexadienes and cyclopentadienyl complexes through the use of isotopically labelled ligands.
Organometallic chemistry. Isomerization. Organoiridium compounds. Organoiron compounds. Organorhodium compounds.
Dartmouth Dissertations

A novel role for visual arrestin in endocytosis-mediated retinal degeneration.
Phospholipase C -- Mechanism of action. Retinal degeneration -- Pathophysiology. Retinal degeneration -- Genetic aspects. Endocytosis. Rhodopsin. Cellular signal transduction. Light -- Physiological effect. Arrestin. Clathrin. Adaptor Proteins
Mutations in the Drosophila retinal-specific Phospholipase C (NORPA) cause massive retinal degeneration within five days of constant light exposure. We have previously shown that in norpA mutants persistent complexes between the light receptor...
Dartmouth Dissertations

A spectroscopic investigation of chromium-thiolate complexes.
Chromium. Glutathione.
Dartmouth Dissertations

The role of the Drosophila SK channel in sensory processing and behavior / by Ahmad Nawwaf Abou Tayoun.
Partially ordered sets. ; Forcing (Model theory). ; Set theory.
Dartmouth Dissertations

Targeting of the erythroid transcription factor, GATA-1, to specific locations within the human genome.
Globin genes -- Expression. ; Transcription factors. ; Genetic transcription -- Regulation.
Dartmouth Dissertations

Activation of aliphatic carbon-fluorine bonds in iridium complexes.
Organoiridium compounds -- Synthesis. ; Organofluorine compounds -- Synthesis.
Dartmouth Dissertations

Activation of carbon-fluorine bonds and carbon-hydrogen bonds with transition metal compounds.
Organoiridium compounds -- Synthesis. Organofluorine compounds -- Synthesis. Transition metal compounds.
Fluorine forms the strongest single bond to carbon, however, it is well established that transition metals can lengthen and weaken C-F bonds in fluorinated ligands. Described here are studies on the activation of C-F bonds in iridium compounds...
Dartmouth Dissertations

Cytoskeletal reorganization in B lymphocyte activation.
Lymphocyte transformation.
Dartmouth Dissertations

Nucleophilic addition to electron deficient indoles and the synthesis of fused heterocyclic ring systems.
Indole -- Synthesis. ; Heterocyclic compounds -- Synthesis.
The chemistry of indole can be reversed and redirected by the addition of powerful electron-withdrawing groups. Incorporation of a nitro group at C-2 or C-3 renders the adjacent carbon susceptible to nucleophilic attack. Nitro, cyano, and...
Dartmouth Dissertations

The glucose transporter is a glycoprotein of Mr 55,000 and is probably not phosphorylated in response to biological activators of transport.
Glycoproteins. ; Monoclonal antibodies. ; Immune response.
Dartmouth Dissertations

Isolation and characterization of essential genes of Saccharomyces cerevisiae required for the efficient nucleocytoplasmic trafficking of mRNA.
Messenger RNA. ; Saccharomyces cerevisiae. ; Cytoplasm.
Dartmouth Dissertations

An electron paramagnetic resonance spectroscopic investigation of group 6 (Cr, Mo and W) transition metal complexes.
Transition metal complexes. Electron paramagnetic resonance spectroscopy.
Dartmouth Dissertations

An EPR spectroscopic investigation of paramagnetic organometallic complexes.
Organometallic compounds. ; Paramagnetism. ; Electron paramagnetic resonance spectroscopy.
Dartmouth Dissertations

High resolution infrared spectroscopy and photolysis of solutes in cryogenic solids.
Infrared spectroscopy. ; Photodissociation. ; Argon. ; Nitrogen.
Dartmouth Dissertations

Mechanisms for the regulation of fibrinolysis and cytokine expression by nickel.
Pulmonary fibrosis -- Pathophysiology. ; Fibrinolysis --Genetic aspects. ; Cytokines. ; Immune response -- Regulation. ; Nickel -- Toxicology. ; Lungs -- Dust diseases.
Human epidemiological and animal studies have associated inhalation of nickel dusts with increased incidence of pulmonary fibrosis. The current studies examined the hypothesis that nickel promotes pulmonary fibrosis by inhibiting fibrinolysis and...
Dartmouth Dissertations

The role of BRCA1 in estrogen receptor-α regulation in breast cancer.
Breast -- Cancer -- Genetic aspects. ; Estrogen -- Receptors -- Regulation. ; Genetic transcription -- Regulation. ; BRCA1 Protein. ; Breast Neoplasms -- genetics. ; Gene Expression Regulation Neoplastic. ; Repressor Proteins.
Dartmouth Dissertations

Discovering MII1 regulated pathways in hematopoietic stem cells.
Hematopoietic stem cells. ; Hematopoietic stem cell disorders -- Genetic aspects. ; Genetic transcription -- Regulation. ; Leukemia -- Genetic aspects. ; Cell proliferation. ; Myeloid-Lymphoid Leukemia Protein -- genetics.
Hematopoietic stem cells (HSCs) balance self-renewal with the continuous production of the suitable numbers of lineage-restricted progenitor cells. In this work we demonstrate that the Mixed lineage leukemia 1 (Mll1) gene is essential for this...
Dartmouth Dissertations

Spectral studies of the enzyme rhodanese.
Enzymes.
Dartmouth Dissertations

Methods for rapid EEG-based mapping of human brain functions.
Electroencephalography. ; Brain mapping -- Methodology. ; Evoked potentials (Electrophysiology).
Brain mapping via EEG activation is a useful tool of basic neuroscience, and has wide clinical applications as well. The mapping is achieved by means of Event Related Potentials (ERPs), task-related changes in EEG time series. The methodology of...
Dartmouth Dissertations

Th-dependent B cell activation.
B cells. ; T cells. ; Cell interaction. ; Body fluids -- Immunology.
Dartmouth Dissertations

Quantitative analysis of EEG for the detection and localization of seizures in patients with medically refractory epilepsy.
Electroencephalography -- Data processing. ; Epilepsy -- Diagnosis. ; Signal processing -- Mathematics. ; Time-series analysis. ; Wavelets (Mathematics).
Visual interpretation of the EEG associated with an epileptic seizure (ictal EEG) can be cumbersome and sometimes misleading, due to rapid seizure spread, limited spatial resolution and the fact that signals of interest are often obscured by...
Dartmouth Dissertations

Isolation of interleukin-2-induced immediate-early genes.
Interleukin-2.
Dartmouth Dissertations

Characterization of COPII vesicle proteins involved in sorting between the endoplasmic reticulum and golgi apparatus in Sacch[a]romyces cerevisiae.
Membrane proteins -- Physiological transport. ; Carrier proteins. ; Biological transport -- Regulation. ; Saccharomyces cerevisiae -- Cytology. ; Golgi apparatus. ; Endoplasmic reticulum.
Intracellular transport between the ER and Golgi is mediated by vesicles that bud from donor membranes and then fuse with acceptor membranes. Bi-directional vesicle transport maintains distinct organelle composition through a process known as...
Dartmouth Dissertations

Probing a receptor-binding domain of interleukin-2 by combinatorial cassette mutagenesis.
Interleukin-2. ; Mutagenesis.
Dartmouth Dissertations

Synthetic approaches to indolo[2,3-a]carbazole alkaloids.
Indole alkaloids -- Synthesis. ; Carbazole.
Dartmouth Dissertations

A benzonorbornyl model system for the study of carbocation-[pi] interactions.
Carbocations -- Reactivity. ; Aromatic compounds -- Reactivity.
An important mode of stabilization of cations in biochemical reactions is interaction with the π systems-of aromatic residues. As part of an investigation of the interaction of carbocations with aromatic π systems, a study of various model...
Dartmouth Dissertations

Novel synthetic approaches to polycyclic aromatic hydrocarbons.
Polycyclic aromatic hydrocarbons -- Synthesis.
This research attempts to combine known methodology with new chemistry towards the preparation of extended polycyclic aromatic hydrocarbons (PAH). The generation and Diels-Alder trapping of 1,7- and 2,6-naphthalene bisarynes was attempted for the...
Dartmouth Dissertations

Interactions between the carcinogen chromium(VI) and DNA.
DNA. ; Chromium. ; Thiols.
Dartmouth Dissertations

Stratigraphy and structure of the Kennebago Lake quadrangle of central western Maine.
Geology, Stratigraphic. ; Geology -- Maine -- Kennebago Lake.
Dartmouth Dissertations

Carbon-fluorine bond activation of iridium (III) compounds induced by acids and reducing agents.
Organoiridium compounds -- Synthesis. ; Organofluorine compounds -- Synthesis. ; Ligands.
Dartmouth Dissertations

Mitochondrial biogenesis in Saccharomyces cerevisiae: transcriptional control by glucose.
Saccharomyces cerevisiae. ; Glucose. ; Mitochondria. ; Gene fusion. ; Cytochromes. ; Mutation (Biology).
Dartmouth Dissertations

Biological and receptor binding properties of interleukin-2 analogs employing site-directed mutagenesis and filamentous phage display.
Interleukin-2 -- Derivatives. ; Ligand binding (Biochemistry). ; Mutagenesis.
Dartmouth Dissertations

Building a better trap: the use of iron dithiocarbamate complexes in the in vivo and ex vivo detection and quantification of nitric oxide.
Nitric oxide -- Analysis. ; Dithiocarbamates. ; Iron compounds. ; Organonitrogen compounds. ; Electron paramagnetic resonance spectroscopy.
Nitric oxide is synthesized by living organisms and plays important roles in circulatory, neurological, and immune function. Nitric oxide can also play pathophysiological roles, depending on the amount of the molecule, the presence of other species...
Dartmouth Dissertations

Proteins of rat liver lysomal membranes: characterization, biosynthesis and comparison with plasma membranes.
Lysosomes. ; Cell membranes.
Dartmouth Dissertations

Torsional movements in the large free living amoebae.
Amoeba. ; Torsion.
Dartmouth Dissertations

C₂-Symmetric Bis(phosphines) and Their Metal Complexes : Synthesis, Materials Application, and Screening Racemic Catalysts / Sanderson, Matthew David
Chapter 1: The dimethylation of the C2-symmetric Pt-phosphido complex Pt((R,R)-Me-DuPhos)(IsPCH2PIs) (Is = 2,4,6-(iPr)3C6H2) to yield rac- and meso- [Pt((R,R)-Me-DuPhos)(IsMePCH2PMeIs)][OTf]2 represents an interesting case of the Horeau principle...
Dartmouth Dissertations

Isolation and characterization of two distinct mutations affecting cholesteryl ester synthesis in mammalian cells.
Cholesterol. ; Esters. ; Mammals -- Cytology. ; Cell metabolism.
Dartmouth Dissertations

Insulin regulation of the glucose transporters in 3T3-L1 adipocytes and BC3H-1 myocytes.
Glucose -- Physiological transport. ; Insulin -- Physiological effect. ; Fat cells. ; Muscle cells.
Dartmouth Dissertations

Investigation of vesicle fusion in ER to Golgi transport.
Membrane proteins -- Physiological transport. ; Biological transport -- Regulation. ; Cell membranes. ; Golgi apparatus. ; Endoplasmic reticulum. ; Saccharomyces cerevisiae -- Cytology.
Many intracellular transport events are mediated by vesicles that bud from donor membranes and then fuse with acceptor membranes. The transport of secretory proteins between the ER and Golgi compartments of the yeast Saccharomyces cerevisiae has...
Dartmouth Dissertations

Differential effects of mitomycin C on constitutive and inducible gene expression in the chick embryo liver in vivo: correlation with developmental age and chromatin structure.
Mitomycin C -- Mechanism of action. ; Gene expression. ; Chromatin.
Dartmouth Dissertations

Mechanisms of the nephrotoxicity of acetaminophen studied in the mouse kidney cortex slice system.
Renal pharmacology. ; Acetaminophen. ; Mice -- Physiology.
Dartmouth Dissertations

Novel diphosphate surrogates: synthesis of potential inhibitors of cholesterol biosynthesis.
Cholesterol -- Synthesis -- Inhibitors. ; Anticholesteremic agents -- Synthesis. ; Pyrophosphates.
Dartmouth Dissertations

Catalytic asymmetric P-C bond formation with Pt-phosphido complexes.
Organoplatinum compounds -- Synthesis. Organoplatinum compounds -- Reactivity. Organophosphorus compounds -- Synthesis. Organophosphorus compounds -- Reactivity. Asymmetric synthesis. Phosphate carbon. Platinum catalysts.
Chapter One. Synthesis and Structure of Chiral Pt(Duphos) Terminal Phosphido Complexes. Treatment of Pt halide precursors with a secondary phosphine in the presence of the base NaOSiMe 3 gave the terminal phosphido complexes Pt(Duphos)(Ph)(PMeIs)....
Dartmouth Dissertations

A novel region in the collagenase promoter is involved in transcriptional activation and repression.
Collagenases. ; DNA-protein interactions.
Dartmouth Dissertations

Study of 3' end RNA processing of herpes simplex virus type 1 thymindine kinase mRNA in vivo and in vitro.
RNA -- Metabolism. ; Herpes simplex virus.
Dartmouth Dissertations

Interleukin-2 analogs with enhanced biological response: a novel ligand based mechanism.
Interleukin-2 -- Derivatives. ; Interleukin-2 -- Receptors. ; Ligand binding (Biochemistry).
Interleukin-2 (IL-2) is an immunoregulatory cytokine whose biological effects are mediated through interaction with specific receptors (IL-2R) on the surface of target cells. Due to its presumed role in generating a normal immune response, IL-2 is...
Dartmouth Dissertations

Characterization of the interaction of the chemotherapeutic drug mitomycin C with DNA in vitro and in vivo and effects on specific DNA-protein interactions.
Mitomycin C -- Mechanism of action. ; DNA -- Effect of mitomycin C on. ; Genetic expression -- Effect of mitomycin C on. ; DNA-protein interactions -- Effect of mitomycin C on.
Mitomycin C (MMC) is a chemotherapeutic drug that reacts with the N$\sp2$ of guanine to form monoadducts, interstrand and intrastrand crosslinks. These lesions, especially the interstrand crosslink, are believed to be responsible for the potent...
Dartmouth Dissertations

Characterization of two Saccharamyces cerevisiae genes involved in mRNA export.
Messenger RNA -- Physiological transport. ; Saccharomyces cerevisiae -- Genetics. ; Proteins -- Synthesis -- Genetic aspects.
I report the further characterization of an essential S. cerevisiae nucleoporin, RAT7/NUP159, shown previously to be involved in mRNA export. The Rat7p/Nup159p can be divided into three domains: an N-terminal domain, a central repeat domain, and a...
Dartmouth Dissertations

Find results with:

Searching collections:

Add or remove other collections to your search:

Narrow your search by:

Title

Date

Subject

You've searched:

Thumbnail

Title

Subject

Description

Collection

QuickView

Layout options:

		Thumbnail with title
		Grid with smaller thumbnails and more detail

Find results with:

Searching collections:

Add or remove other collections to your search:

Narrow your search by:

Title

Date

Subject

You've searched:

Thumbnail Title Subject Description Collection

QuickView

Layout options:

Thumbnail

Title

Subject

Description

Collection