Although genome-wide association studies (GWAS) and other high-throughput initiatives have led to an information explosion in human genetics and genetic epidemiology, the mapping from genotype to phenotype remains challenging as most of the...
In the past few years there has been a tremendous growth in the usage of digital images. Users can now access millions of photos, a fact that poses the need of having methods that can efficiently and effectively search the visual information of...
Smartphones we carry everyday represent the first truly context-aware mobile device. By embedding specialized sensors and pushing AI into phones, it is now possible to continuously sense and infer people's physical activities, social interactions,...
Motivated by quantum mechanics and geometric optics, it is a long-standing problem whether the length spectrum of a compact Riemannian manifold can be recovered from its Laplace spectrum. One route to proving that the length spectrum depends on the...
Identifying the determinants of reproductive success in small-scale societies is critical for understanding how natural selection has shaped human evolution and behavior. The available evidence suggests that status-accruing behaviors such as...
The performance of machine learning algorithms largely depends on data representation. As a critical step in machine learning, representation learning (feature learning) learns a transformation of training data to give a new representation that can...
A polynomial is a product of distinct cyclotomic polynomials if and only if it is a divisor over [Special characters omitted.] [x ] of xn - 1 for some positive integer n. In this thesis, we will examine two natural questions concerning the divisors...
The demand for novel molecularly targeted drugs will continue to rise as we make progress toward personalizing cancer treatments to the molecular signatures of individual tumors. While the collection and analysis of genomic data has become routine,...
Radio relics are extended regions of synchrotron radio emission that have been found in the outskirts of a few dozen galaxy clusters. Relics are often associated with clusters undergoing merger activity. They are not associated optically with a...
Thermodynamics, and the classic balance between entropy and enthalpy, provides a proverbial zoo of exotic phase behaviour that chemists can harness to create new materials out of simple liquids and polymers. The diversity of self-assembling...
We have a limited understanding of how an opinion is originated, how an opinion and information supporting and explaining it gets conveyed, and how the communicated opinion is perceived and processed by others. One direction of current research...
We begin with a result on the refocussing of null geodesics in space-times. We show that all oriented refocussing 2-dimensional Lorentz manifolds are also strongly refocussing. We also introduce a theory of virtual Legendrian knots. We show that...
After decades of searching we have yet to find the progenitor systems for type Ia supernovae. In fact most of what we know about this homogeneous class of supernovae is from spectral features associated with the incinerated remains of the C+O white...
Breast cancer is the most common cancer in women. The discovery of breast tumor subtypes and the subsequent development of treatments aimed at them has allowed a reduction in the mortality of breast cancer. However, tumors with similar...
Epilepsy is associated with cognitive impairments which often manifest as a higher prevalence of memory impairments. Memory impairments in patients with epilepsy may persist even with sufficient control of seizures, suggesting other factors may...
This thesis constitutes the first steps in the author's program to investigate the question of when a homotopy of 2-cocycles Ï‰ = {Ï‰[subscript t]}[subscript tâˆŠ[0,1]] on a locally compact Hausdorff groupoid Æ“ induces an isomorphism of the...
The focus of this thesis is the study of nuclearity and exactness for groupoid crossed product C*-algebras. In particular, we present generalizations of two well-known facts from group dynamical systems and crossed products to the groupoid setting....
Gene set testing has become a critical tool for interpreting the results of high-throughput genomic experiments. Despite the development of robust statistical methods and extensive gene set collections, however, the results from gene set testing...
In this thesis, we consider several problems relating to cyclic subgroups of the group [mathematical equation]. Each element of [mathematical equation] has a unique representative in one of the two intervals [mathematical equation] and...
In Chapter 2 we look at the distribution of permutation statistics in the context of pattern-avoiding permutations. The first part of this chapter deals with a recursively defined bijection of Robertson [37] between 123- and 132-avoiding...
Medical imaging methods have become increasingly important in diagnosing diseases and assisting therapeutic treatment. In particular, early detection of breast cancer is considered as a critical factor in reducing the mortality rate of women....
Earlier work has suggested that various neurological or neuropsychiatric disorders may result in characteristic spatial patterns in brain activation, potentially allowing their detection from maps of brain activity under different conditions....
In the past decade, the use of ordinal patterns in the analysis of time series and dynamical systems has become an important tool. Ordinal patterns (otherwise known as a permutation patterns) are found in time series by taking n data points at...
This thesis centers around a generalization of the classical discrete Fourier transform. We first present a general diagrammatic approach to the construction of efficient algorithms for computing the Fourier transform of a function on a finite...
We provide a theoretical model for a design involving a dc voltage biased Josephson junction (JJ) that strongly drives a high quality factor microwave cavity via the ac Josephson effect. We explore the rich classical dynamics of the resultant...
'Orthogonal modular forms are algebraic modular forms arising from lattices in quadratic spaces. In this thesis, we define orthogonal modular forms, establish their basic properties, and then apply them to a case of ternary quadratic spaces to...
The ionosphere is the primary source for heavy ions which are ubiquitous in the terrestrial magnetosphere. Low-altitude energization in the auroral ionosphere results in bulk heating and transverse acceleration of ions, which begin to upwell and/or...
Shape modeling is an important area in computer vision and medical imaging. Shape models have proved valuable in the tasks of object representation, recognition, and classification. This thesis focuses on shape models of 3D surfaces extracted from...
Multisensor data fusion. Sensor networks. Plumes (Fluid dynamics). Automatic tracking. Signal processing -- Digital techniques -- Mathematics.
The work in this thesis deals with a novel approach for detecting and tracking chemical plumes in distributed sensor networks. The ultimate objective is solving the inverse location problem: given unknown sources released at unknown times, the...
This dissertation details the use of a new catalog of Galactic bulge field RR Lyrae variables to advance the understanding of the structure of the Milky Way Galaxy. The catalog contains 3667 RR0 Lyrae stars from the eight-year MACHO Project...
Nucleotide sequence -- Data processing. Linkage (Genetics) -- Data processing. Computer algorithms. Human population genetics. Medical Term Base Pairing -- genetics. Base Sequence -- genetics. Genome wide association studies.
This thesis investigates techniques for the discovery and use of phase information in genetic studies. ""Phase"" refers to the precise assignment of the members of a different base pairs at the same genomic locus to two possible candidate...
Manifolds (Mathematics) Geodesics (Mathematics) Space and time.
We investigate weak and strong refocusing of light rays in a space-time and related concepts. A strongly causal space-time ( X^ n +1 , g ) is emphstrongly refocusing at x âˆˆ X if there is a point y â‰ x such that all null-geodesics through y pass...
This thesis considers the two special sensor networks for future sensor network design: mobile sensor networks and hybrid network of sensors and robots. To investigate two types of networks, we abstract two most important aspects that are ingrained...
Throughout this work, a lattice model was used to capture the behavior of polymer systems. First, the phase behavior of solutions which contain polymer solute in an alkane solvent was investigated. The phase diagrams of these solutions are...
There is a renewed interest in the study of the radiation belts with the recent launch of the Van Allen Probes satellites. The mechanisms that drive the global response of the radiation belts to geomagnetic storms are not yet well understood....
Bayesian nonparametric methods have become increasingly popular in machine learning for their ability to allow the data to determine model complexity. In particular, Bayesian nonparametric versions of common latent variable models can learn as...
Multiresolution image transformations have become commonplace tools for analyzing images for a number of applications, including enhancement and restoration. Powerful models for these applications have been developed in the transform domain of...
We examine variations of cops and robbers games on graphs. Our goals are to introduce some randomness into their study, and to estimate (expected) capture time. We show that a cop chasing a random walker can capture him in expected time n + o(n)....