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Acquisition and registration of 3D optical surface scanning, MRI, and microwave tomographic imaging for improved clinical breast imaging and surgical planning / by Matthew John Pallone.
Continual improvements to clinical breast imaging technologies have led to ever earlier detections and increasingly accurate localizations of female breast cancers. While these advancements have certainly improved the prognoses of many patients,...
Dartmouth Dissertations

Structural, stratigraphic, and thermo-chronological evolution of Trinidad.
Geochronometry -- Trinidad and Tobago -- Trinidad. ; Geology Structural -- Trinidad and Tobago -- Trinidad. ; Geology.
Dartmouth Dissertations

Discovering MII1 regulated pathways in hematopoietic stem cells.
Hematopoietic stem cells. ; Hematopoietic stem cell disorders -- Genetic aspects. ; Genetic transcription -- Regulation. ; Leukemia -- Genetic aspects. ; Cell proliferation. ; Myeloid-Lymphoid Leukemia Protein -- genetics.
Hematopoietic stem cells (HSCs) balance self-renewal with the continuous production of the suitable numbers of lineage-restricted progenitor cells. In this work we demonstrate that the Mixed lineage leukemia 1 (Mll1) gene is essential for this...
Dartmouth Dissertations

Jackson queueing networks with denumerably many stations.
Queuing theory.
Dartmouth Dissertations

Routing games.
In large and complex networks such as the Internet and road networks, traffic routing is typically decentralized. Users in the network choose their routes independently to minimize their own delay, leading to complicated and nonintuitive outcomes...
Dartmouth Dissertations

A new vortex model for free boundary layer flows.
Fluid dynamics. ; Vortex-motion. ; Boundary layer.
Dartmouth Dissertations

Dispositional emotional expressivity shapes the processing of facial expression / by Annemarie C. Brown
When we want to know what others are thinking or feeling, we look to their face for clues. Affective neuroscience has usefully documented behavioral, psychophysiological and neural responses to the facial displays of others. Though this work...
Dartmouth Dissertations

Biological and receptor binding properties of interleukin-2 analogs employing site-directed mutagenesis and filamentous phage display.
Interleukin-2 -- Derivatives. ; Ligand binding (Biochemistry). ; Mutagenesis.
Dartmouth Dissertations

Proteins of rat liver lysomal membranes: characterization, biosynthesis and comparison with plasma membranes.
Lysosomes. ; Cell membranes.
Dartmouth Dissertations

The effects of thyrotropin releasing hormone in the retrotrapezoid nucleus.
Thyrotropin releasing factor -- Physiological effect. ; Pons Varolii -- Physiology. ; Medulla oblongata -- Physiology. ; Respiration -- Regulation. ; Rats -- Respiration.
The respiratory control network (RC) is made up nuclei dispersed throughout the pons and medulla oblongata and receives information from various sources that alter respiratory output. My studies have been focussed on one of these nuclei that play a...
Dartmouth Dissertations

Intracellular cholesterol trafficking in CHO cells defective in NPC1.
Cholesterol -- Physiological transport. ; Cholesterol -- Genetic aspects.
Cholesterol is essential for the survival of all mammalian cells. Mammalian cells obtain cholesterol via two pathways: it can be endogenously synthesized in the endoplasmic reticulum, or it can be obtained from exogenous sources, mainly through the...
Dartmouth Dissertations

The structure and chemistry of polar glacier ice.
Ice -- Analysis -- Polar regions. ; Glaciers -- Polar regions.
This dissertation explores the spatial and temporal distributions of impurities in natural ice. Using polarized light, ion chromatography (IC), synchrotron x-ray topography (SXT), scanning electron microscopy (SEM), and energy-dispersive...
Dartmouth Dissertations

The role of p53 in retinoic acid-induced differentiation of human germ cell tumors.
p53 antioncogene -- Regulation. ; Retinoids -- Physiological effect. ; Retinoids -- Receptors. ; Cell differentiation -- Molecular aspects. ; Genetic transcription -- Regulation. ; Germ cells -- Tumors. ; Receptors.
The retinoids exert potent growth and differentiation effects on normal, embryonic and neoplastic cells. Although retinoids are known to regulate gene transcription through activation of retinoid receptors, the direct target genes of retinoid...
Dartmouth Dissertations

The identification and characterization of aldosterone responsive genes.
Aldosterone. ; Genetic regulation. ; Mineralocorticoids -- Receptors.
Dartmouth Dissertations

Biochemistry of isolated sea urchin mitotic apparatuses: protein phosphorylation and the control of mitosis.
Mitosis. ; Phosphorylation. ; Sea urchins -- Embryos.
Dartmouth Dissertations

Vibrational and electronic spectroscopic studies of metallothionein.
Metallothionein.
Dartmouth Dissertations

Factors controlling the seasonal abundance and distribution of Calanus finmarchicus in the Gulf of Maine/Georges Bank Region.
Calanus finmarchicus -- Georges Bank. ; Calanus finmarchicus -- Maine Gulf of. ; Calanus finmarchicus -- North Atlantic Ocean.
Calanus finmarchicus, a kind of marine zooplankton, plays an important ecological role throughout the North Atlantic. Striking seasonal variations exist in its abundance and distribution in the Gulf of Maine/Georges Bank region. On the Bank in...
Dartmouth Dissertations

Measuring the seeds of thermal ion outflow / by Philip A. Fernandes
The ionosphere is the primary source for heavy ions which are ubiquitous in the terrestrial magnetosphere. Low-altitude energization in the auroral ionosphere results in bulk heating and transverse acceleration of ions, which begin to upwell and/or...
Dartmouth Dissertations

Annual energy budget of a small forest stream ecosystem: Bear Brook, West Thornton, New Hampshire.
Bioenergetics. ; Freshwater ecology. ; Food chains (Ecology).
Dartmouth Dissertations

Echocardiographic tissue characterization of normal, ischemic and infarcted myocardium.
Echocardiography. ; Heart -- Diseases -- Diagnosis.
Dartmouth Dissertations

Dynamic model of the United States electric utility industry, 1950-2010.
Electric utilities -- United States -- Mathematical models.
Dartmouth Dissertations

Light and circadian regulation in Neurospora crassa.
Neurospora crassa -- Effect of light on. ; Neurospora crassa -- Genetics. ; Circadian rhythms. ; Genetic transcription -- Regulation. ; Cryptochrome. ; Phytochrome.
Dartmouth Dissertations

The role of CD40 in cutaneous and regional immune responses.
CD antigens. ; Immune response -- Regulation. ; T cells -- Receptors. ; Antigens CD40. ; Lymphoma.
Dartmouth Dissertations

Properties of Rathke's pouch.
Pituitary gland. ; Hypothalamus. ; Rats.
Dartmouth Dissertations

Functional analysis of cell cycle genes by genome-wide expression data and meta-analysis of RNAi screens.
Cell cycle -- Regulation. ; Genetic regulation. ; Small interfering RNA. ; Spindle (Cell division). ; Epithelial cells -- Genetic aspects. ; Mammary glands -- Cytology. ; Cell lines. ; Cell Cycle -- genetics. ; Genes cdc. ; RNA Interference. ;...
Successful traversal of the cell division cycle is paramount for maintaining a cell's genomic integrity and fitness. To ensure the faithful replication and segregation of the genome, cellular components, and cytoplasm, eukaryotes have evolved a...
Dartmouth Dissertations

Interrelationships between carbohydrate, uridine nucleotide and protein metabolism and effects of cortisol on these interrelationships.
Carbohydrates -- Metabolism. ; Proteins -- Metabolism. ; Hydrocortisone.
Dartmouth Dissertations

The effects of sodium on the growth velocity and growth morphology of silicon in aluminum - silicon alloys.
Sodium. ; Aluminum. ; Silicon. ; Silicon alloys.
Dartmouth Dissertations

The neural assembly of place cells and head direction cells.
Limbic system -- Psychophysiology. ; Neuropsychology. ; Cell interaction.
Previous research has identified neurons in a variety of limbic structures which discharge in relation to the animals ongoing head direction (HD) (Ranck 1984; Taube et al. 1990a) or location (O''Keefe & Dostrovsky 1971). Because these signals...
Dartmouth Dissertations

A simulation study of beam driven instabilities and solitary structures in the auroral acceleration region.
Auroras. ; Plasma (Ionized gases) -- Simulation methods. ; Electron beams. ; Ion bombardment.
Dartmouth Dissertations

Coupling of termination, 3' processing and mRNA export.
Messenger RNA -- Genetic aspects. ; Transcription factors. ; Genetic transcription -- Regulation. ; RNA-protein interactions. ; Saccharomyces cerevisiae -- Genetics.
Dartmouth Dissertations

Direct and indirect effects on planktonic ciliate assemblages.
Ciliata -- Effect of sediments on. ; Ciliata -- Effect of habitat modification on. ; Plankton -- Effect of sediments on. ; Plankton -- Effect of habitat modification on.
Dartmouth Dissertations

The polarization of Be stars.
B stars. ; Polarization (Light).
Dartmouth Dissertations

The study of an endonuclease and its potential role in apoptosis.
Deoxyribonucleases. ; Endonucleases. ; Apoptosis.
Previous work in this laboratory has implicated deoxyribonuclease II (DNase II) as an endonuclease responsible for DNA digestion during apoptosis. The goal of this thesis was to isolate the cDNA encoding DNase II and study its potential role in...
Dartmouth Dissertations

Studies on the role of the SH2 domain-containing phosphotyrosine phosphatase, PTP2C, in insulin signaling.
Insulin -- Receptors. ; Phosphatases. ; Phosphorylation. ; Cellular control mechanisms.
Dartmouth Dissertations

Flow of bubbles through nozzles.
Two-phase flow -- Mathematical models. ; Bubbles.
Dartmouth Dissertations

Hydrothermal pretreatment of cellulosic biomass for bioconversion to ethanol.
Alcohol as fuel. ; Cellulose -- Biotechnology. ; Hot water. ; Steam. ; Biomass energy.
Dartmouth Dissertations

Localized spectroscopic imaging for the detection and discrimination of surgical breast tissue pathologies.
Two localized spectroscopic imaging methods were investigated to detect and discriminate microscopic pathologies at the surface of excised breast tissues in order to improve resection completeness during breast conserving surgery. A scanning in...
Dartmouth Dissertations

Preparations of oxysterols and derivatives for investigation of cholesterol regulation.
Oxysterols -- Synthesis. ; Oxysterols -- Derivatives -- Synthesis. ; Cholesterol -- Metabolism -- Regulation. ; Cholesterol -- Synthesis -- Regulation.
Dartmouth Dissertations

Opioid and nonopioid mechanisms of conditional analgesia.
Analgesia. ; Endorphins -- Physiological effect.
Dartmouth Dissertations

How sea ice microstructure influences the polar transport of salts from the ocean into the atmosphere / by Ross Lieb-Lappen
Sea ice appears to form an impenetrable boundary at the ocean-atmosphere interface in polar regions, yet in fact its porous structure provides critical pathways for the exchange of heat, gases, salts, and other chemical species impacting the global...
Dartmouth Dissertations

Increases in specific forms of hepatic cytochrome P450s by ethanol and isopentanol: mechanism of the response.
Hepatotoxicology. ; Alcohol -- Toxicology. ; Cytochromes.
Dartmouth Dissertations

Ku-band (13.9 GHz) radar backscatter over sea ice in the Southern Ocean.
Sea ice -- Antarctica -- Weddell Sea -- Remote sensing. ; Backscattering. ; Radar in earth sciences. ; Sea ice -- Computer simulation.
Dartmouth Dissertations

Solitary structure formation on auroral field lines.
Magnetohydrodynamic waves. ; Auroras -- Mathematical models.
Dartmouth Dissertations

Atmospheric influences on the biogeochemistry of high-elevation forests.
Acid deposition -- Environmental aspects -- New York (State) -- Adirondack Mountains. ; Acid deposition -- Environmental aspects -- Vermont -- Green Mountains. ; Forest ecology -- New York (State) -- Adirondack Mountains. ; Forest ecology --...
Dartmouth Dissertations

Forming, operating, and improving micro-systems of health care.
Clinical medicine -- Practice. ; Medicine -- Practice. ; Group medical practice.
Health care micro-systems are small, organized groups of clinicians and staff working together with a shared clinical purpose to provide care for a defined set of patients. The size of individual micro-systems vary--a micro-system must be large...
Dartmouth Dissertations

Mast fruiting and seed predation in a northern hardwoods forest.
Forest ecology -- New Hampshire. ; Trees -- New Hampshire. ; Hardwoods.
Dartmouth Dissertations

Mechanisms for chromium-induced signaling changes in pulmonary epithelial cells.
Chromium -- Pathophysiology. ; Lungs -- Pathophysiology. ; Epithelial cells. ; Cellular signal transduction. ; Transcription factors -- Pathophysiology. ; Protein kinases -- Pathophysiology. ; src-Family Kinases. ; Mitogen-Activated Protein Kinases.
Both human epidemiological and animal studies have associated inhalation of chromium(VI) (Cr(VI)) with increased incidence of pulmonary disease. This thesis examined the hypotheses that Cr(VI) activates cell signaling through kinase cascades and...
Dartmouth Dissertations

Mechanisms of a glial modulating agent, propentofylline :potential new treatment for glioblastoma multiforme
Glioblastoma multiforme is the most common and aggressive primary brain tumor with a very poor prognosis despite multi-modalities of treatment. As a result, there is a critical need to develop alternative therapies. Propentofylline (PPF) is a...
Dartmouth Dissertations

New technologies for constructing C-S and C-N bonds / by Markku Antti Savolainen
I. Markovnikov-Selective Hydrothiolation of Styrenes: Application to the Synthesis of Stereodefined Olefins There have been few reports in the literature describing Lewis Acid-catalyzed hydrothiolations that furnish Markovnikov-selective C–S bond...
Dartmouth Dissertations

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