ToxT is a member of the AraC/XylS family of transcriptional regulators, and functions to activate expression of virulence genes in the intestinal pathogen Vibrio cholerae. The aim of this research was to investigate the mechanism of ToxT-dependent...
Dartmouth Track team 1945 Front row: M Burnham-N, RE De Forest II '49, SM Felton Jr.-N, JH Parks '48, RA Grady-N, KW Coyne-M, JF Conely-N, AA Snyder-N, LM Gold '48, SL Spaulding '45-N Second row: HL Hillman (Coach), WD Fetzer-N, LB Goodman-N, LD...
Genome-wide association studies (GWAS) have identified more than 8,900 genetic variants, mainly single nucleotide polymorphisms (SNPs), associated with hundreds of human traits and diseases, which define risk-associated loci (Hindorff et al., 2012 ...
Many organisms recognize and respond to categories: predator, prey, rival, or juvenile. Organisms recognize these ecologically-important categories by assessing diverse sensory stimuli. A primary focus of my research has been understanding how...
Access control is a core component of any information-security strategy. Researchers have spent tremendous energy over the past forty years defining abstract access-control models and proving various properties about them. However, surprisingly...
I investigate the kinematics and space densities of the local cataclysmic variable (CV) population. CVs are close binary star systems composed of a white dwarf that accretes matter from a less compact companion star in Roche lobe overflow....
The new APM South Equatorial Strip Catalog $({-}17\sp\circ.5<\delta<2\sp\circ.5)$ is used to select a sample of early-type galaxies in three directions: (1) 15h10-16h10; (2) 20h30-21h50; (3) 00h10-01h30. The distances and peculiar motions of...
Genome sequencing technology has enabled the identification of genetic variants that are linked with cancer phenotypes, whether these are somatically acquired mutations or common inherited single nucleotide polymorphisms (SNPs). Whereas coding...
Protein secretion is executed by the secretory pathway, which involves the delivery of membrane and soluble secretory proteins in vesicle intermediates that capture newly-synthesized proteins assembled in the endoplasmic reticulum (ER) and then...
Sepsis is a worldwide problem with an annual mortality rate reaching as high as 45%. Understanding its pathogenesis and the innate immune response to infection is key to the development of new treatments. CD163, a monocyte/macrophage-specific...
Arabidopsis thaliana -- Physiology. Zinc -- Physiological transport. Iron -- Physiological transport. Homeostasis. Trace elements in plant nutrition.
Iron and zinc are essential metal micronutrients that most humans acquire from plant-based diets. Unfortunately, plants are not a good source of these micronutrients, so billions of people worldwide suffer from deficiencies of these two elements....
Pervasive computing leads to an increased integration between the real world and the computational world, and many applications in pervasive computing adapt to the user's context, such as the location of the user and relevant devices, the presence...
Electronic mail systems -- Security measures. Electronic mail systems -- Social aspects. Trust.
A secure system that cannot be used by real users to secure real-world processes is not really secure at all. While many believe that usability and security are diametrically opposed, a growing body of research from the field of Human-Computer...
Southern pine beetle -- Ecology. Mutualism (Biology). Commensalism.
A challenge for ecologists is to identify and understand the mechanisms that produce population behaviors in nature. This is particularly difficult in complex communities that comprise of tightly linked multivoltine organisms that are...
Medicine -- Religious aspects. Health -- Religious aspects. Spirituality -- Health aspects. Spirituality -- Testing. Primary care (Medicine). Patients -- Religious life.
Background . Although the epidemiology of spirituality/religion is still an emerging field, initial research suggests spirituality may promote better health. Additionally, physician-inquiry about spirituality may enhance the quality and possibly...
The efficacy of many chemotherapeutic agents can be attenuated by expression of the anti-apoptotic proteins Bcl-2, Bcl-X and Mcl-1. When ML-1 leukemia cells are incubated with vinblastine, they rapidly upregulate Mcl-1. Suppression of Mcl-1 with...
Smartphones we carry everyday represent the first truly context-aware mobile device. By embedding specialized sensors and pushing AI into phones, it is now possible to continuously sense and infer people's physical activities, social interactions,...
The design and synthesis of biomimetic receptor systems capable of binding a target molecule with similar affinities and specificities to their natural counterparts, which are often difficult to obtain in large quantities, has long been a goal of...