Studies presented in this dissertation focus on the transcriptional targets and cellular functions of [Delta]Np63[alpha], the predominant TP63 isoform expressed in epithelial stem cell compartments. TP63, a member of the p53 family of...
IL-1β is a potent proinflammatory cytokine produced in response to Pseudomonas aeruginosa infection. While it is appreciated that IL-1β is a critical modulator of the host response to P. aeruginosa infection, the host and bacterial determinants...
Functional neuroimaging has confirmed a high degree of localization of function in the cerebral cortex of man. In contrast, microstructural analysis has contributed very little to the topographical characterization of cortical areas. In this work I...
The control of gene expression is central to developmental biology, pattern formation, and phenotypic evolution. Enhancers are a class of regulatory DNAs that control when and where genes are turned ON or OFF. This highly regulated process is...
Sodium channels -- Physiology. Proteins -- Physiological transport. Biological transport -- Regulation. Aldosterone -- Physiological effect. Epithelial cells. Protein Transport. Vesicular Transport Proteins.
Nearly one billion individuals worldwide have elevated blood pressure (BP) and 90% of these cases are due to unknown causes. Aldosterone is the primary hormone regulating Na + reabsorption in the kidney and is therefore a major determinant of the...
Inbred C57BL/6 mice develop an acute necrotizing ileitis following oral infection with Toxoplasma gondii that is associated with massive inflammatory infiltrates and morphologic tissue changes consistent with human Crohn's disease. In the course of...
Influenza virus is a respiratory pathogen that is capable of causing considerable pulmonary pathology and respiratory dysfunction in humans. Seasonal influenza epidemics and the occasional influenza pandemic are responsible for significant...