Dartmouth Digital Library Program

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Motion and position interact at both early and late stages of the human visual system / by Peter J. Kohler.
The ability to correctly determine the position of objects in space is fundamental to any visual system. For an animal to successfully engage with a dynamic and complex spatial environment it must be able to encode not only the identity of the...
Dartmouth Dissertations

Winter Carnival - Center Of Campus; Winter Carniva...
Drawer 18; Winter Carnival - Center Of Campus
Dartmouth College Photographic Records

Combined MRI and near-infrared spectroscopy for increased specificity of breast cancer imaging / by Michael A. Mastanduno.
A yearly breast contrast-MR scan is recommended to high-risk women because of MR's high sensitivity to breast tumors. However, breast contrast-MR yields a high number of false positives that lead to expensive and sometimes unnecessary biopsy...
Dartmouth Dissertations

Representation learning beyond labels / by Chen Fang
The performance of machine learning algorithms largely depends on data representation. As a critical step in machine learning, representation learning (feature learning) learns a transformation of training data to give a new representation that can...
Dartmouth Dissertations

Novel synthetic approaches to polycyclic aromatic hydrocarbons.
Polycyclic aromatic hydrocarbons -- Synthesis.
This research attempts to combine known methodology with new chemistry towards the preparation of extended polycyclic aromatic hydrocarbons (PAH). The generation and Diels-Alder trapping of 1,7- and 2,6-naphthalene bisarynes was attempted for the...
Dartmouth Dissertations

Cellulose hydrolysis and fermentation by Clostridium thermocellum for the production of ethanol.
Clostridium -- Biotechnology. ; Cellulose. ; Hydrolysis. ; Fermentation. ; Alcohol -- Synthesis.
Dartmouth Dissertations

Room-temperature mechanical properties of FeAl and NiAl.
Iron-aluminum alloys -- Mechanical properties. ; Nickel-aluminum alloys -- Mechanical properties.
Dartmouth Dissertations

Gene transfer in thermophilic Clostridium.
Clostridium -- Biotechnology. ; Genetic transformation. ; Restriction enzymes DNA.
Dartmouth Dissertations

Production of ethanol from lignocellulosic materials using thermophilic bacteria.
Alcohol -- Production methods. ; Lignocellulose. ; Thermophilic bacteria.
Dartmouth Dissertations

The regulation of gene expression by BRCA1 splice-variants in human mammary epithelial cells.
Antioncogenes. ; Genetic transcription -- Regulation. ; Mutation (Biology). ; Epithelial cells. ; Mammary glands -- Tumors. ; Proto-Oncogene Proteins. ; Breast Neoplasms -- genetics. ; BRCA1 Protein. ; Genes BRCA1 -- physiology.
Dartmouth Dissertations

Virulence and motility gene regulation in Vibrio cholerae.
Vibrio cholerae -- Molecular genetics. DNA-binding proteins. Genetic transcription -- Regulation. Promoters (Genetics)
The ctx and tcp genes that encode cholera toxin and the toxin co-regulated pilus, the major virulence determinants of Vibrio cholerae, are repressed by the nucleoid-associated protein H-NS and activated by the AraC-like transcriptional regulator...
Dartmouth Dissertations

Single cycle terahertz pulse propagation in water.
Electromagnetic devices -- Design. Electromagnetic waves -- Transmission -- Measurement. Picosecond pulses. Water.
Single cycle electromagnetic pulses have been difficult to experimentally generate and to theoretically analyze. With the recent development of terahertz systems based on near infrared femtosecond lasers it has become possible to perform single...
Dartmouth Dissertations

High-speed MRI-guided near-infrared tomography system to monitor breast hemodynamics in vivo ;
Near infrared spectroscopy -- Instruments -- Design and construction.;""Magnetic resonance imaging -- Instruments -- Design and construction."";""Breast -- Cancer -- Imaging."";""Breast -- Magnetic resonance imaging."";""Breast -- Cancer --...
Dartmouth Dissertations

Endogenous antitumor immunity elicited by adoptively transferred lymphocytes through CCL5 and CD40L signaling, and dendritic cell depletion.
Ovaries -- Cancer -- Immunotherapy. T cells -- Therapeutic use. CD4 antigen -- Therapeutic use. Dendritic cells -- Therapeutic use. Chemokines -- Physiological effect. Cellular signal transduction.
Adoptive cell transfer (ACT) is a promising therapy for various non-epithelial tumors but has not yet proven successful in ovarian cancer. Moreover, its effect upon endogenous antitumor immunity, and the contribution of CD4 + T cells, remain...
Dartmouth Dissertations

Three factors influencing physical health in serious mental illness:smoking, health education, and employment
The confluence of patient, provider, and system level factors contributes to excess mortality due to preventable medical conditions among people with serious mental illness (SMI) compared to the general population. Study one explored how...
Dartmouth Dissertations

Phospho-regulation of the kinesin-13 Kif2b ensures error-free mitosis
Solid tumors are frequently aneuploid and many display high rates of ongoing chromosome mis-segregation in a phenomenon called chromosomal instability (CIN). The most common cause of CIN is the persistence of aberrant kinetochore-microtubule (k-MT)...
Dartmouth Dissertations

Synthetic studies of Munchnone reactivity and applications and the total synthesis of cyclopenta[B]indole natural products / by Justin M. Lopchuk.
Chapter 1: Munchnones and mesoionic heterocycles The reactivity, regioselectivity, and synthetic applications of munchnones (1,3-oxazolium-5-olates) is a common theme which runs through Chapters 2-5. The definition, structure, and reactivity of...
Dartmouth Dissertations

Acquisition and registration of 3D optical surface scanning, MRI, and microwave tomographic imaging for improved clinical breast imaging and surgical planning / by Matthew John Pallone.
Continual improvements to clinical breast imaging technologies have led to ever earlier detections and increasingly accurate localizations of female breast cancers. While these advancements have certainly improved the prognoses of many patients,...
Dartmouth Dissertations

MicroRNA-10b promotes pancreatic cancer cell invasion by suppressing TIP30 and enhancing EGF and TGF-[beta] actions / by Haoxu Ouyang
MicroRNA-10b (miR-10b) is considered a marker of disease aggressiveness in pancreatic ductal adenocarcinoma (PDAC), in view of the fact that lower levels of miR-10b are associated with better response to neoadjuvant therapy, likelihood of surgical...
Dartmouth Dissertations

Phosphoproteomic strategies to identify aberrant kinase signaling in lung cancer / by Devin Karl Schweppe
Lung cancer is the leading cause of cancer-related death in the USA and worldwide causing 160,000 and 1.5 million deaths per year, respectively. Due to the late stage of diagnosis, poor efficacy of chemotherapies (targeted and pleiotropic), and...
Dartmouth Dissertations

Examining functional variation in oncogene biology : the role of somatic mutations and germline variation on c-Myc and c-Myb / by Scott Andrew Turner.
The identification and characterization of functional genetic variation is essential for future advances in molecular diagnostics, pharmacogenomics, and personalized medicine. Recent attempts at identifying nucleotide level variation (somatic...
Dartmouth Dissertations

Microbial mediation of plant-pollinator interactions / by Robert N. Schaeffer II.
Floral nectar of many plant species is prone to colonization by microorganisms. Their presence and metabolism have the potential to modify a suite of traits important for pollinator attraction, including nectar quality and scent. However, studies...
Dartmouth Dissertations

Combined digital breast tomosynthesis and near-infrared spectral tomography for breast lesion characterization / by Kelly E. Michaelsen.
Annual screening mammograms are recommended for all women above 40 years of age for early detection of breast cancer, and are known to improve cancer mortality rates. However, mammography is hampered by low sensitivity and a high rate of false...
Dartmouth Dissertations

Multimodal electroencephalography and near-infrared spectroscopy neuroimaging measurement and analysis / by Paolo Giacometti
This project focuses on the development of research tools and methods that are used to study the relationship between neural activity and subsequent hemodynamic responses in the human brain. This relationship, referred to as neurovascular coupling,...
Dartmouth Dissertations

The causes and consequences of regulation of [Delta]NP63[alpha] in mammary and breast cancer stem cells / by Andrew Joseph DeCastro.
Despite the array of targeted therapeutics that currently exist to combat breast cancer, disease progression leading to metastasis, and tumor recurrence still remains a significant clinical challenge. Efforts to identify novel pathways and...
Dartmouth Dissertations

MLL1 plays an essential role in steady-state hematopoiesis and B Lymphopoiesis / by Tao Gan.
The Mixed Lineage Leukemia (MLL1) gene was first cloned as a hot spot of chromosomal translocations in acute leukemia. More than 70 fusion proteins of MLL1 have been described in both lymphoid and myeloid leukemia and many are highly associated...
Dartmouth Dissertations

Links and regulatory loops between phospholipase C activity and colonization by the O2-responsive regulator Anr in Pseudomonas aeruginosa / by Angelyca A. Jackson.
Pseudomonas aeruginosa is a virulent opportunistic pathogen that is frequently cultured from infectious sites, and is estimated to cause ~12% of nosocomial infections worldwide [1]. P. aeruginosa infections occur in a majority of adults with the...
Dartmouth Dissertations

K-Theory for twisted groupoid C*-algebras / by Elizabeth Gillaspy.
This thesis constitutes the first steps in the author's program to investigate the question of when a homotopy of 2-cocycles ω = {ω[subscript t]}[subscript t∊[0,1]] on a locally compact Hausdorff groupoid Ɠ induces an isomorphism of the...
Dartmouth Dissertations

Methods for efficient object categorization detection scene recognition and image search / by Alessandro Bergamo.
In the past few years there has been a tremendous growth in the usage of digital images. Users can now access millions of photos, a fact that poses the need of having methods that can efficiently and effectively search the visual information of...
Dartmouth Dissertations

Modulation of swarming motility in Pseudomonas aeruginosa / by Dae Gon Ha.
Swarming motility is a flagella-dependent surface motility, and is also a form of bacterial group behavior. Similar to its counterpart biofilm formation, our understanding of swarming motility has been hampered by its complex set of requirements...
Dartmouth Dissertations

The role of cell stress signalling in the induction of [gamma]-globin gene expression / by Emily K. Schaeffer.
Increased fetal hemoglobin (HbF) expression is beneficial for [beta]-hemoglobinopathy patients; however, most inducing agents do not possess the ideal combination of efficacy, safety and availability. Better understanding the mechanisms involved in...
Dartmouth Dissertations

Image reconstruction optimization and quantification for image-guided luminescent tomography / by Robert William Holt.
Molecular imaging of cancer features is a critical part of advancing better tools for oncology management and drug discovery, yet it is still evolving as a useful tool. Diffuse Fluorescence Tomography (FT) is one approach to molecular imaging, used...
Dartmouth Dissertations

Small molecule modulation of morphology and metabolism in Candida albicans / by Allia Kaye Smith
Candida albicans is a fungal species that naturally exists as a commensal member of the human microbiota, but can assume a pathogenic lifestyle and subsequently induce life-threatening systemic infections. The ability of the fungus to grow in...
Dartmouth Dissertations

Conceptual processing of concrete objects in the brain / by Melissa M. Rundle.
How is concrete conceptual information represented in the brain? Little is known about the neural organization for details of concrete objects when presented as words. The goal of the first two studies was to investigate this. In the third study,...
Dartmouth Dissertations

On the nature mechanisms and neural correlates of visual feature conjunction learning / by Eric Andrew Reavis.
Visual searches for a conjunction of features (e.g., a particular combination of color and shape) are ordinarily slow and difficult. However, search efficiency for a particular conjunction can improve dramatically within a few hundred practice...
Dartmouth Dissertations

Transcriptional regulation of the neuronal nACh receptor ?4 subunit gene.
Nicotinic receptors -- Genetic aspects. Gene expression. Molecular genetics.
Dartmouth Dissertations

Through-space hydrogen-fluorine and carbon-fluorine nuclear spin-spin coupling: an experimental study.
Nuclear magnetic resonance. Fluorine -- Spectra. Hydrogen -- Spectra.
Dartmouth Dissertations

From nonmetal- and metal-chalcogen nanoclusters to chalcogenide nanotubes.
Chalcogenides. Nanotubes. ; Nanostructured materials.
A double-acceleration stage linear time of flight mass spectrometer (TOF MS) with Nd/YAG laser ablation cluster source was designed and constructed for cluster production, study and deposition. Cumulenic polycarbons SC n S ( n = 2-27) were...
Dartmouth Dissertations

The interplay between BCL2 family members in response to pharmacologically induced apoptosis
Apoptosis.; Cancer cells -- Growth -- Regulation. ; Cellular signal transduction. ; Apoptosis Regulatory Proteins -- pharmacology. ; Proto-Oncogene Proteins c-bcl-2 -- pharmacology. ; bcl2-Associated Death Protein -- pharmacology. ; Vinblastine --...
Dartmouth Dissertations

Computational methods for microwave medical imaging.
Microwave imaging -- Mathematics. ; Three-dimensional imaging -- Mathematics. ; Image reconstruction -- Mathematics. ; Microwave imaging in medicine. ; Computer algorithms.
Medical imaging methods have become increasingly important in diagnosing diseases and assisting therapeutic treatment. In particular, early detection of breast cancer is considered as a critical factor in reducing the mortality rate of women....
Dartmouth Dissertations

Characterization of factors critical for initial stages of Vibrio cholerae intestinal colonization.
Vibrio cholerae -- Molecular genetics. ; Bacteria -- Adhesion. ; Virulence (Microbiology) -- Molecular aspects. ; Pili (Microbiology). ; DNA-binding proteins. ; Cholera -- Pathogenesis.
Vibrio cholerae is the etiologic agent of cholera in humans. Intestinal colonization occurs via ingestion of contaminated food and water and results in symptoms that include the production of the characteristic rice water stool, vomiting, and...
Dartmouth Dissertations

Experiment planning for protein structure elucidation and site-directed protein recombination.
Proteins -- Structure -- Computer simulation -- Experiments. ; Amino acid sequence -- Data processing -- Experiments. Protein engineering -- Experiments. ; Recombinant proteins -- Mathematical models.
In order to most effectively investigate protein structure and improve protein function, it is necessary to carefully plan appropriate experiments. The combinatorial number of possible experiment plans demands effective criteria and efficient...
Dartmouth Dissertations

Patient classification from fMRI brain activation patterns.
Brain -- Magnetic resonance imaging. ; Brain mapping. Brain -- Localization of functions. ; Diagnostic imaging. ; Pattern perception. ; Patients -- Classification. ; Alzheimer's disease -- Diagnosis. ; Schizophrenia -- Diagnosis. ; Brain damage --...
Earlier work has suggested that various neurological or neuropsychiatric disorders may result in characteristic spatial patterns in brain activation, potentially allowing their detection from maps of brain activity under different conditions....
Dartmouth Dissertations

Roles for protein phosphatases in cell survival and cell death pathways.
Apoptosis. ; Phosphoprotein phosphatases -- Inhibitors. ; Cellular signal transduction. ; Genetic transcription -- Regulation.
Apoptosis is important for tissue homeostasis and is the mechanism of cell death induced by many anticancer agents. The apoptotic machinery is present in all cells, such that tight regulation must exist to prevent untimely cell and tissue death. To...
Dartmouth Dissertations

Modulation of CYPS: effect on acetaminophen hepatotoxicity.
Hepatotoxicology. ; Cytochrome P-450 -- Pathophysiology. ; Acetaminophen -- Toxicology. ; Alcohol -- Pathophysiology.
Cytochrome P450 (CYP) 2E1 is considered the sole CYP responsible for APAP bioactivation leading to hepatotoxicity. CYP2E1 is also considered the alcohol-inducible CYP and therefore, the sole CYP responsible for alcohol-mediated increases in APAP...
Dartmouth Dissertations

Mechanisms by which arsenite decreases CYP3A.
Cytochrome P-450 -- Pathophysiology. ; Cytochrome P-450 -- Genetics. ; Arsenic compounds -- Physiological effect. ; Liver cells.
Arsenic is implicated in numerous human pathologies, including cancer and several forms of liver disease. One contributing mechanism may involve alterations of CYP levels by arsenic. CYP3As are the most abundant CYP proteins in human liver and...
Dartmouth Dissertations

Microwave tomographic imaging using dielectric contrast in temperature and tissue content
Breast -- Cancer -- Tomography. ; Breast -- Cancer -- Imaging. ; Microwave imaging in medicine. ; Breast -- Electric properties. ; Breast Neoplasms -- diagnosis. ; Diagnostic Imaging -- methods.
Dartmouth Dissertations

A complex of the BCL2-like protein CED-9 and the BH3-only protein EGL-1 recruits DRP-1 to mitochondria and promotes mitochondrial fission
Mitochondria -- Physiology.; Fission (Biology) ; Guanosine triphosphatase. ; Caenorhabditis elegans. ; Caenorhabditis elegans Proteins -- physiology. ; GTP Phosphohydrolases -- physiology. ; bcl2-Associated Death Protein -- physiology.
Dartmouth Dissertations

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