The Dartmouth Club of Springfield, Mass. recently presented Webster dictionaries to oustanding juniors in 14 area high schools and prep schools. The club also presented the firs Dr. Walter Baynes '68 Memorial Award to the outstanding Dartmough...
Elevated sympathetic discharge from the CNS is an underlying pathogenic mechanism in neurogenic hypertension and an exacerbating factor in chronic heart failure (CHF). Current treatment of these diseases focuses on attenuation of the downstream...
Evolutionary Computation (EC) is one of the most advanced computational techniques. It has been frequently and successfully used to find good solutions to many complicated optimization problems with limited computational resources. EC is the...
Sea ice appears to form an impenetrable boundary at the ocean-atmosphere interface in polar regions, yet in fact its porous structure provides critical pathways for the exchange of heat, gases, salts, and other chemical species impacting the global...
Mr. Walter Averill 105 Ferris Lane Poughkeepsie NY 12603; A.N. Bouchar Hanover Inn Hanover NH photo no. D-65 neg in photo records; I believe this is hauling material to build the Ravine Lodge
The furanosteroids are a special class of natural products that feature a furan ring fused to the steroid nucleus at C-4 and C-6. In 1945, viridin, the parent member of this group, was isolated by Grove and coworkers from the fungas Gliocladium...
This research extends previous findings that the behavior of individuals high as compared to low in Private Self-consciousness, an individual difference in self-awareness, is more influenced by subtle primes. Manipulations of self-awareness were...
Aberrant activation of cyclin D-Cdk4/6 is commonly found in pancreatic ductal adenocarcinoma (PDAC). Here, we show that PD-0332991, a highly specific inhibitor for Cdk4 and Cdk6, exerted growth inhibitory effects on human PDAC cell lines....
Many kinds of cancer, and almost universally metastatic cancer, are refractory to treatment by conventional methods: surgery, radiation, and non-specific cytotoxic chemotherapy. The dawn of the age of personalized medicine presaged 15 years ago...
It has been well established that physical exercise has broad impacts across the lifespan, including improved cognition, brain function, and mental health. Studies investigating the mechanism underlying the cognitive enhancing effect of exercise...
Chromatin -- Structure. DNA -- Methylation. Globin genes -- Expression. Adenosine triphosphatase. Proteins -- Chemical modification.
Epigenetic regulation of gene expression is a developing field of study with many potential therapeutic applications. Chromatin remodeling is necessary for proper mammalian development, and misregulation of this process is associated with many...
A fundamental question in decision neuroscience is how cognitive processes underlying decision-making give rise to efficient decisions, especially in complex situations with multiple choice options, and each option consisting of multiple attributes...
T cells -- Receptors. Killer cells. Cell-mediated cytotoxicity. Cancer -- Immunotherapy.
Despite advances in standard treatment options such as surgery, chemotherapy, and radiation, cancer remains the second leading cause of death in the United States. Moreover, many current therapies result in adverse effects. Therefore the...
The overarching goal of this thesis was two-fold. First, to determine if the effects of chronic anabolic androgenic steroid (AAS) treatment on anxiety-like behaviors are sex-specific and second to determine how different environmental modulators...
GABA -- Receptors. Anabolic steroids -- Physiological effect. Androgens -- Physiological effect. Prosencephalon. Neurotransmitters -- Effect of drugs on. Psychoneuroendocrinology.
Anabolic androgenic steroids (AAS) are derivatives of testosterone originally designed for therapeutic applications to enhance anabolic potency (protein synthesis and muscle growth) while exerting low androgenic (masculinizing) effects. The...
Human cancer is developed as the consequence of the activation of oncogenes and inactivation of tumor suppression genes. Modern sciences has identified and characterized the functions of such genes to understand the mechanism of cancer development...
The furanosteroids are an important class of natural products that have been found to effectively inhibit various biologically important enzymes. These enzymes include the phosphoinositide-3-kinase (PI3K) family and the polo-like kinase (PLK1)...
The furanosteroid class of compounds issues a siren call to both chemists and biologists alike -- the intriguing pentacyclic skeleton, densely packed and highly functionalized, continues to entice synthetic minds to develop new and elegant methods...
Glutamic acid -- Receptors. Ion channels -- Molecular aspects. Ligand binding (Biochemistry).
Medical Term: Glutamates.
AMPA receptors are glutamate-gated ion channels that mediate most of the excitatory synaptic signals in the central nervous system. They form tetrameric assemblies that are combinations of the subunits GluR1-4, each of which contains a...
Sigma Alpha Epsilon 1; New Hampshire Alpha Dartmouth 1934; gift of F. B. Tomlinson '35; 1. Beach Riley '34; 2. Johnny Roberts '34; 3. Ralph Brabbee '34; 4. Ed Marshall '34; 5. Bill Mock '34; 6. Jack Gordon '34; 7. Johnny Mullen '35; 8. Harry...
Arctic temperature and precipitation have been rising over recent decades, with implications for Greenland Ice Sheet (GrIS) mass balance, sea level rise, and thermohaline circulation via Arctic Ocean freshening. However, meteorological station data...