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14-3-3 sigma modulates pancreatic cancer cell survival and invasiveness.
Pancreas -- Cancer -- Pathophysiology. Pancreatic duct -- Pathophysiology. Proteins -- Pathophysiology. 14-3-3 Proteins -- physiology. Pancreatic Neoplasms -- pathology.
14-3-3 is down-regulated in certain human cancers, but its expression is increased in pancreatic ductal adenocarcinoma (PDAC). The purpose of the present study was to investigate the potential role of 14-3-3σ in PDAC. The levels of 14-3-3...
Dartmouth Dissertations

A framework of computational opinions / by Fei Yu.
We have a limited understanding of how an opinion is originated, how an opinion and information supporting and explaining it gets conveyed, and how the communicated opinion is perceived and processed by others. One direction of current research...
Dartmouth Dissertations

The role of the Drosophila SK channel in sensory processing and behavior / by Ahmad Nawwaf Abou Tayoun.
Partially ordered sets. ; Forcing (Model theory). ; Set theory.
Dartmouth Dissertations

Acetycholine receptor turnover in a muscle cell line.
Acetylcholine. ; Muscle cells. ; Cell lines.
The cellular mechanisms of degradation of a transmembrane protein, the acetylcholine receptor (AChR), have been examined in a mouse muscle cell line, BC3H-1. The half-time of degradation of cell surface receptors labeled with...
Dartmouth Dissertations

Targeting of the erythroid transcription factor, GATA-1, to specific locations within the human genome.
Globin genes -- Expression. ; Transcription factors. ; Genetic transcription -- Regulation.
Dartmouth Dissertations

Measuring quality of life in economic evaluations of treatment for severe mental illness.
Quality of life -- Evaluation. ; Health status indicators. ; Psychiatric rating scales. ; Mental illness -- Treatment -- Evaluation. ; Mental illness -- Treatment -- Economic aspects. ; Mental illness -- Treatment -- Social aspects.
Background. It is not clear whether a generic quality-of-life instrument can appropriately represent severe mental illness in an economic evaluation. This problem is particularly salient for resource-allocation decisions where policymakers compare...
Dartmouth Dissertations

The function of perceived gaze direction in emotion and person perception.
Gaze -- Psychological aspects. ; Facial expression. ; Body language.
The primary goal of the current research was to examine the effect of perceived gaze direction on the perception and processing of facially communicated emotion. There is good reason to believe that gaze direction and facial displays of emotion...
Dartmouth Dissertations

Affective and perceptual judgments of major and minor musical stimuli.
Musical intervals and scales -- Psychological aspects. ; Music -- Psychological aspects. ; Chords (Music) -- Psychological aspects. ; Stability.
In Western tonal music, the major mode is associated with positive emotions, and the minor mode is associated with negative emotions. Although this is a highly salient distinction, it is poorly understood. In 9 experiments, participants made...
Dartmouth Dissertations

Affective decision-making in rhesus monkeys : reward order risk and the roles of the anterior insula and premotor cortex / by Eric R. Xu.
From deciding what to eat first or what stock to invest in, the order in which we prefer to experience events and the amount of risk we are willing to undertake are factors that influence our choices. However, the mechanisms underlying order and...
Dartmouth Dissertations

Cytoskeletal reorganization in B lymphocyte activation.
Lymphocyte transformation.
Dartmouth Dissertations

Structure, petrology, and U-Th-Pb geochronology in the Milford (15') quadrangle, New Hampshire.
Petrology -- New Hampshire -- Milford. ; Geological time.
Dartmouth Dissertations

The glucose transporter is a glycoprotein of Mr 55,000 and is probably not phosphorylated in response to biological activators of transport.
Glycoproteins. ; Monoclonal antibodies. ; Immune response.
Dartmouth Dissertations

Rhodopsin-arrestin complex formation as a novel mechanism for light-dependent retinal degeneration.
Visual pigments. ; Cellular signal transduction. ; Rhodopsin. ; G proteins. ; Phosphorylation. ; Photoreceptors. ; Retinal degeneration.
Arrestins are regulatory proteins that participate in the termination of G protein-mediated signal transduction. The major arrestin in the Drosophila visual system, Arrestin 2 (Arr2), has been demonstrated to be essential for the termination of the...
Dartmouth Dissertations

Isolation and characterization of essential genes of Saccharomyces cerevisiae required for the efficient nucleocytoplasmic trafficking of mRNA.
Messenger RNA. ; Saccharomyces cerevisiae. ; Cytoplasm.
Dartmouth Dissertations

Analysis of inpatient surveillance data for automated classification of deterioration.
Problem Statement Patient safety in the modern hospital is supported by multiple human and technological systems, and this type of high-risk/high-complexity domain requires multiple layers of protection against harm. This fault-tolerant approach is...
Dartmouth Dissertations

High resolution infrared spectroscopy and photolysis of solutes in cryogenic solids.
Infrared spectroscopy. ; Photodissociation. ; Argon. ; Nitrogen.
Dartmouth Dissertations

Early earth and solar system evolution: insights from strontium, barium, neodymium, and samarium isotopes.
Chondrites (Meteorites). ; Mantle plumes. ; Samarium-neodymium dating. ; Strontium -- Isotopes. ; Barium -- Isotopes. ; Solar system. ; Earth -- Mantle.
Dartmouth Dissertations

Mechanisms for the regulation of fibrinolysis and cytokine expression by nickel.
Pulmonary fibrosis -- Pathophysiology. ; Fibrinolysis --Genetic aspects. ; Cytokines. ; Immune response -- Regulation. ; Nickel -- Toxicology. ; Lungs -- Dust diseases.
Human epidemiological and animal studies have associated inhalation of nickel dusts with increased incidence of pulmonary fibrosis. The current studies examined the hypothesis that nickel promotes pulmonary fibrosis by inhibiting fibrinolysis and...
Dartmouth Dissertations

Androgens and the display of sexual receptivity in female rats: mechanisms for the inhibition of estrogen-induced sexual receptivity.
Androgens -- Physiological effect. ; Androgens -- Receptors. ; Rats -- Physiology. ; Sexual behavior in animals.
The present dissertation examined the effects of naturally occurring and synthetic androgens on estrogen-induced sexual receptivity in rats and examined the role of the androgen receptor in mediating these effects. First, the effects of naturally...
Dartmouth Dissertations

Neo-architectonics computer-aided histological examination of the human visual cortex.
Visual cortex -- Imaging. ; Visual cortex -- Histology. ; Image processing -- Digital techniques.
Functional neuroimaging has confirmed a high degree of localization of function in the cerebral cortex of man. In contrast, microstructural analysis has contributed very little to the topographical characterization of cortical areas. In this work I...
Dartmouth Dissertations

The role of BRCA1 in estrogen receptor-α regulation in breast cancer.
Breast -- Cancer -- Genetic aspects. ; Estrogen -- Receptors -- Regulation. ; Genetic transcription -- Regulation. ; BRCA1 Protein. ; Breast Neoplasms -- genetics. ; Gene Expression Regulation Neoplastic. ; Repressor Proteins.
Dartmouth Dissertations

Isotopic phase separation in dilute solid mixtures of Helium-4 in Helium-3.
Helium -- Isotopes. ; Isotope separation.
Dartmouth Dissertations

Dependence of snow thermal and electrical conductiveness on microstructure.
Snow -- Thermal properties. ; Snow -- Electric properties. ; Microstructure.
Dartmouth Dissertations

Discovering MII1 regulated pathways in hematopoietic stem cells.
Hematopoietic stem cells. ; Hematopoietic stem cell disorders -- Genetic aspects. ; Genetic transcription -- Regulation. ; Leukemia -- Genetic aspects. ; Cell proliferation. ; Myeloid-Lymphoid Leukemia Protein -- genetics.
Hematopoietic stem cells (HSCs) balance self-renewal with the continuous production of the suitable numbers of lineage-restricted progenitor cells. In this work we demonstrate that the Mixed lineage leukemia 1 (Mll1) gene is essential for this...
Dartmouth Dissertations

Development and application of a dual-excitation, digital imaging, fluorescence microscope to investigate parathyroid hormone-stimulated calcium transport in kidney distal tubule cells.
Fluorescence microscopy. ; Calcium -- Physiological transport -- Measurement. ; Renal tubular transport -- Measurement.
Dartmouth Dissertations

Spectral studies of the enzyme rhodanese.
Enzymes.
Dartmouth Dissertations

Methods for rapid EEG-based mapping of human brain functions.
Electroencephalography. ; Brain mapping -- Methodology. ; Evoked potentials (Electrophysiology).
Brain mapping via EEG activation is a useful tool of basic neuroscience, and has wide clinical applications as well. The mapping is achieved by means of Event Related Potentials (ERPs), task-related changes in EEG time series. The methodology of...
Dartmouth Dissertations

Metamorphism in east central Vermont.
Metamorphism (Geology) -- Vermont. ; Nappes (Geology) -- Vermont.
Dartmouth Dissertations

Th-dependent B cell activation.
B cells. ; T cells. ; Cell interaction. ; Body fluids -- Immunology.
Dartmouth Dissertations

The dorsal tegmental nucleus of Gudden and angular velocity integration in the head direction system.
Space perception. ; Motion perception (Vision). ; Vestibular apparatus.
Head Direction (HD) cells are neurons located primarily in the limbic system that fire as a function of directional heading in the horizontal, or yaw, plane in the freely moving animal. Our hypothesis is that the HD signal is the result of two...
Dartmouth Dissertations

Quantitative analysis of EEG for the detection and localization of seizures in patients with medically refractory epilepsy.
Electroencephalography -- Data processing. ; Epilepsy -- Diagnosis. ; Signal processing -- Mathematics. ; Time-series analysis. ; Wavelets (Mathematics).
Visual interpretation of the EEG associated with an epileptic seizure (ictal EEG) can be cumbersome and sometimes misleading, due to rapid seizure spread, limited spatial resolution and the fact that signals of interest are often obscured by...
Dartmouth Dissertations

Providing evidence and measurement tools to support health care reform in communities.
Community health services -- United States -- Evaluation. ; Health care reform -- United States. ; Medical care -- United States -- Evaluation. ; Evidence-based medicine.
Dartmouth Dissertations

Behavioral, psychophysiological, and neural responses to ambiguously valenced facial expressions.
Facial expression. Emotions -- Social aspects. Emotions -- Physiological aspects. Ambiguity. Neuropsychology.
Successfully navigating our social world requires the ability to understand the facial expressions of others. Indeed, facial expressions provide information about the emotions and intentions of others. While some expressions provide clear...
Dartmouth Dissertations

Characterization of COPII vesicle proteins involved in sorting between the endoplasmic reticulum and golgi apparatus in Sacch[a]romyces cerevisiae.
Membrane proteins -- Physiological transport. ; Carrier proteins. ; Biological transport -- Regulation. ; Saccharomyces cerevisiae -- Cytology. ; Golgi apparatus. ; Endoplasmic reticulum.
Intracellular transport between the ER and Golgi is mediated by vesicles that bud from donor membranes and then fuse with acceptor membranes. Bi-directional vesicle transport maintains distinct organelle composition through a process known as...
Dartmouth Dissertations

Plasmodium falciparum SERA protein transgenics used in the study of parasite immunobiology and drug resistance.
Plasmodium falciparum -- Immunological aspects. ; Plasmodium falciparum -- Genetics. ; Toxoplasma gondii -- Genetics. ; Serine proteinases. ; Transgenic organisms. ; Drug resistance in microorganisms -- Genetic aspects.
Genetic and immunological tools have been used to study two protozoan parasites, Plasmodium falciparum and Toxoplasma gondii. Toxoplasma gondii provides an excellent model for the study of protozoan parasite biology. Plasmodium falciparum causes...
Dartmouth Dissertations

Bilingual and monolingual brains compared: a fMRI study of semantic processing.
Bilingualism -- Physiological aspects. ; Neurolinguistics. Cognition -- Physiological aspects. ; Brain -- Localization of functions.
Does early and sustained experience with two languages in childhood modify how language is processed in the adult bilingual brain? Does extensive exposure to two languages influence language processing in the bilingual brain as compared to...
Dartmouth Dissertations

The role of dichoptic brightness in binocular vision.
Binocular vision.
Dartmouth Dissertations

The mechanism of action for angiotensin-1-7 in the rostral ventrolateral medulla in the modulation of cardiovascular sympathetic nerve activity / by Mark S. Bilodeau
Elevated sympathetic discharge from the CNS is an underlying pathogenic mechanism in neurogenic hypertension and an exacerbating factor in chronic heart failure (CHF). Current treatment of these diseases focuses on attenuation of the downstream...
Dartmouth Dissertations

Biochemical studies of prion composition and conversion.
Prions. Proteins -- Conformation. Prions -- physiology. Prions -- genetics.
Prion diseases are fatal neurodegenerative disorders which affect a variety of different animal species including humans. The central pathogenic event underlying prion diseases is the conformational conversion of the cellular prion protein (PrP C )...
Dartmouth Dissertations

Effect of increased hemoglobin oxygen affinity on oxygen transport and its regulation in the rat.
Hemoglobin. ; Oxygen -- Physiological transport. ; Rats.
Dartmouth Dissertations

Patient outcomes and clinical decision making in aortic valve replacement.
Outcome assessment (Medical care). ; Aortic valve -- Surgery -- Complications. ; Aortic valve -- Surgery -- New England. ; Cardiovascular instruments Implanted.
Aortic valve disease is a frequent and serious disorder. Although aortic valve replacement (AVR) is arguably the only effective treatment, important issues remain unresolved in the care of patients with this disease. Recent studies have focused...
Dartmouth Dissertations

Tectonic evolution of the NW-Himalayan thrust front: the Trans-Indus Ranges, northern Pakistan.
Geology, Structural -- Pakistan -- Trans-Indus Ranges. ; Geology Stratigraphic. ; Paleomagnetism -- Pakistan -- Trans-Indus Ranges. ; Geology -- Pakistan -- Trans-Indus Ranges.
Dartmouth Dissertations

Density-dependent dynamics in a tropical rain forest canopy tree.
Dipterocarpaceae -- Ecology -- Indonesia -- Kalimantan Barat. ; Rain forest ecology -- Indonesia -- Kalimantan Barat. ; Herbivores -- Ecology.
A decline in population growth as the abundance of a species increases can stabilize population size. In Western Borneo, I found evidence for such density dependence in juveniles of the genus Shorea (Dipterocarpaceae) that dominates southeast...
Dartmouth Dissertations

Interactions between the carcinogen chromium(VI) and DNA.
DNA. ; Chromium. ; Thiols.
Dartmouth Dissertations

Influence of long-term sensitization on long-term habituation of the acoustic startle response: brain and behavioral manipulations.
Conditioned response. ; Habituation (Neuropsychology). ; Acoustic reflex. ; Startle reaction.
Dartmouth Dissertations

Sensing eye position.
Saccadic eye movements. ; Eye -- Movements. ; Visual perception -- Physiological aspects. ; Senses and sensation.
The oculomotor system needs up-to-date information about eye position in order to make accurate saccades to stimuli in the environment. This thesis investigated how well the oculomotor system uses information about eye position to make a variety of...
Dartmouth Dissertations