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- Dartmouth Track 1957; Hugo Hartenstein Jr., Class ...
- Dartmouth College Photographic Records
- Dartmouth Track 1957; Hugo Hartenstein Jr., Class ...
- Dartmouth College Photographic Records
- Track Teams 1950s And Undated
- Track Teams 1950s And Undated
- 1957 Varsity Track First Row: (left to right) Shanaman, FC Jr '57, Sterling, RL '57, Gilson, GJ '57, Brew, DC '57 (Captain), Hartenstein, H Jr. '57, Springer, WJ Jr '57, Pullen, PM '57 Second Row: Dietz, PO '57 (Manager), Prouty, KA Jr '58...
- Dartmouth College Photographic Files
- Track Teams 1950s And Undated
- Track Teams 1950s And Undated
- Varsity Track Team-1955-6; 1956 Varsity Track First Row: (l.to r.) Landgraf, LJ '57, Brew, DC '58, Einarsson, V '56, Hartenstein, H Jr '57, Philipps, E '57, Sterling, RL '57, Metzger, EL III '56 (Captain), Heath, DD '56; Drescher, PC '58, Kerr, CD...
- Dartmouth College Photographic Files
- Track Teams Freshman
- Track Teams Freshman
- Robert Bull Photographer Hanover New Hampshire 96E4; Dartmouth College Freshman Track 1954, 1957 1st ROW: Kirwin, PH, Brew, DC, Eichler, EY, Sterling, RL (Capt.), Bixby, GH III, Greene, JJ II, Landgraf, LJ. 2nd ROW: Springer, WJ Jr., Bancroft, AC...
- Dartmouth College Photographic Files
- Track Teams 1950s And Undated
- Track Teams 1950s And Undated
- Robert Bull Studio Hanover New Hampshire 114E5; Varsity Track 1954 -1955 Front Row: (left to right) Hogarty, RA '55, Merriken, P '55, Stultz, NM '55, Harlor, JT '55 (Captain), Jebsen, PM '55, Meneely, JK '52, Berry, PS '56 Second Row: Metzger, EL...
- Dartmouth College Photographic Files
- The importance of dosage of core binding factors α and ß in hematopoietic development.
- Hematopoiesis -- Regulation. ; Transcription factors.
- Core Binding Factors (CBFs) are members of a small family of transcription factors that play critical roles in a number of mammalian developmental processes. CBFs are heterodimers consisting of a CBFα subunit, which contacts and binds DNA at the...
- Dartmouth Dissertations
- The effects of endocrine disruptors on the development of Xenopus embryos.
- Xenopus laevis -- Embryology. Xenopus laevis -- Endocrinology. ; Estrogen -- Physiological effect. ; Estrogen -- Toxicology. ; Nonylphenol -- Physiological effect. Endocrine toxicology.
- Many environmental toxicants found in pesticides, herbicides, and industrial solvents are believed to have deleterious effects on development by disrupting hormone-sensitive processes. Xenopus embryos were exposed to commonly encountered endocrine...
- Dartmouth Dissertations
- Identification and characterization of two mutants that affect Drosophila phototransduction.
- Drosophila. Photoreceptors. TRP channels. Cellular signal transduction.
- The phototransduction cascade in Drosophila is a prototypical G-protein signaling pathway and many of its components have been well-studied. Early genetic screens identified many of the major proteins involved in this pathway and study over the...
- Dartmouth Dissertations
- A novel role for visual arrestin in endocytosis-mediated retinal degeneration.
- Phospholipase C -- Mechanism of action. Retinal degeneration -- Pathophysiology. Retinal degeneration -- Genetic aspects. Endocytosis. Rhodopsin. Cellular signal transduction. Light -- Physiological effect. Arrestin. Clathrin. Adaptor Proteins
- Mutations in the Drosophila retinal-specific Phospholipase C (NORPA) cause massive retinal degeneration within five days of constant light exposure. We have previously shown that in norpA mutants persistent complexes between the light receptor...
- Dartmouth Dissertations
- Synthesis of porphobilinogen and studies on the synthesis of cobyric acid.
- Tetrapyrroles -- Synthesis. ; Porphyrins -- Synthesis. ; Vitamin B12 -- Synthesis.
- This thesis describes the synthetic study of two biologically related natural products: porphobilinogen (PBG) and cobyric acid. PBG is the key intermediate in the biosynthesis of all naturally occurring tetrapyrrolic 'pigments of life', including...
- Dartmouth Dissertations
- Runx1 expression and function in the development of murine definitive hematopoietic stem cells and blood lineages.
- Transcription factors. ; Hematopoietic stem cells -- Genetic aspects. ; DNA-binding proteins. ; Mutation (Biology).
- Dartmouth Dissertations
- The role of the core-binding factor ß (CBFß) subunit in the CBF heterodimeric complex.
- DNA-binding proteins. ; Transcription factors -- Structure. ; Genetic transcription -- Regulation.
- Dartmouth Dissertations
- Synthetic approaches to indolo[2,3-a]carbazole alkaloids.
- Indole alkaloids -- Synthesis. ; Carbazole.
- Dartmouth Dissertations
- Functional analysis of the Runx1 C-terminal sequences.
- Transcription factors. ; Hematopoiesis -- Regulation. ; Genetic transcription -- Regulation. ; DNA-binding proteins.
- RUNX1 is a transcription factor regulating hematopoietic development. Study of the RUNX1 structure revealed two functional domains. The runt domain binds DNA and mediates interaction with CBFß. Sequences C terminal to the runt domain form the...
- Dartmouth Dissertations
- Structural and functional characterization of Runx1 point mutations identified in leukemia and cleidocranial dysplasia patients.
- Transcription factors -- Pathophysiology. Hematopoiesis -- Genetic aspects. Genetic transcription -- Regulation. DNA-binding proteins. Leukemia -- Genetic aspects. Core Binding Factor Alpha 2 Subunit. Core Binding Factor beta Subunit. Cleidocranial...
- Core binding factors are heterodimeric transcription factors involved in diverse developmental processes. They consist of a DNA binding Runx subunit and a non-DNA binding CBFβ sub-unit. Runx proteins are encoded by three genes: Runx1, Runx2 , and...
- Dartmouth Dissertations
- Part I, Approaches to the synthesis of perfluorosemibullvalene; part II, Synthesis and studies of perfluorobenzene oxide/perfluorooxepin.
- Fluorocarbons -- Synthesis. ; Oxides -- Synthesis.
- Dartmouth Dissertations
- Regulation of apoptosis in the Caenorhabditis elegans nervous system.
- Caenorhabditis elegans -- Genetics. Neurons. Apoptosis. Genetic transcription -- Regulation.
- Most of the cells that die during the development of a C. elegans hermaphrodite do so within 30 min after being generated. In these cells, the pro-caspase proCED-3 is inherited from progenitors and the transcriptional upregulation of the BH3-only...
- Dartmouth Dissertations
- Role of rhodopsin endocytosis and NF-kappa B signaling in mediating light-dependent retinal degeneration.
- Retinal degeneration -- Genetic aspects. Photoreceptors -- Molecular aspects. Cell death. Endocytosis. Rhodopsin. NF-kappa B (DNA-binding protein) Cellular signal transduction.
- In humans, progressive loss of vision accompanies many inherited retinal degenerative disorders. In many cases, the affected genes are known. However the molecular pathway of photoreceptor cell death is still elusive. In this thesis, I describe the...
- Dartmouth Dissertations
- Chromosome movement in prometaphase requires microtubule anchorage at spindle poles.
- Chromosomes. Cells -- Motility. Microtubules. Spindle (Cell division). Tubulins. Kinetochores -- physiology. Mitotic Spindle Apparatus -- physiology. Microtubule-Associated Proteins.
- Something must bear the load of poleward forces exerted by kinetochore-associated motors so that chromosomes move toward the poles rather than the poles towards the chromosomes. I tested this hypothesis by monitoring chromosome movement in cultured...
- Dartmouth Dissertations

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