Fluorescence molecular imaging will have an important clinical impact in the area of guided oncology surgery, where emerging technologies are poised to provide the surgeon with real-time molecular information to guide resection, using targeted...
The identification of molecular alterations present in cancer is critical to better understand carcinogenesis as well as the clinical trajectories of patients with malignant tumors. Early detection and application of appropriate treatment...
Quality of life -- Evaluation. ; Health status indicators. ; Psychiatric rating scales. ; Mental illness -- Treatment -- Evaluation. ; Mental illness -- Treatment -- Economic aspects. ; Mental illness -- Treatment -- Social aspects.
Background. It is not clear whether a generic quality-of-life instrument can appropriately represent severe mental illness in an economic evaluation. This problem is particularly salient for resource-allocation decisions where policymakers compare...
Mitotic apparatuses from sea urchin embryos contain a protein (p62), previously shown to be required for mitotic progression. This protein localizes to the mitotic apparatus during cell division in urchin embryos and mammalian tissue culture cells....
A 62 kDa (p62) mitotic apparatus-associated protein has been shown to be important for the proper progression of mitosis in sea urchin embryos. The thesis project described here focuses on an immunological and a molecular characterization of p62....
Functional neuroimaging has confirmed a high degree of localization of function in the cerebral cortex of man. In contrast, microstructural analysis has contributed very little to the topographical characterization of cortical areas. In this work I...
This thesis describes the development of a cell free system for the study of the organization of microtubules into mitotic asters that lack conventional centrosomes and the use of this system, in combination with in vivo approaches, for the...
Microtubule motors are essential for cell division. Although the functions of some mitotic motor proteins have been elucidated, the precise mechanisms by which they govern spindle assembly and chromosome segregation remain largely unknown. This...
Problem Statement Patient safety in the modern hospital is supported by multiple human and technological systems, and this type of high-risk/high-complexity domain requires multiple layers of protection against harm. This fault-tolerant approach is...
Most solid tumors are aneuploid, and many tumor cells persistently mis-segregate whole chromosomes at an elevated rate in a process called chromosomal instability (CIN). CIN occurs due to loss of chromosome segregation fidelity during mitosis,...
Traditionally, mast cells have been studied for their role as proinflammatory effector cells in allergic disorders. Recent findings however have opened up the discussion in the community of immunologists regarding MCs should be considered as...
Mast cells -- Immunology. Mast cells -- Physiology. Dendritic cells. Immunological tolerance -- Molecular aspects. Medical Term Cell Degranulation.
Mast cells (MC) have until recently been regarded as pro-inflammatory, however this view changed with the observation that the absence of MC impairs the development of transplant tolerance to allografts. However, little is known about whether MC...
Something must bear the load of poleward forces exerted by kinetochore-associated motors so that chromosomes move toward the poles rather than the poles towards the chromosomes. I tested this hypothesis by monitoring chromosome movement in cultured...
Spindle (Cell division)
Microtubules.
Kinesin.
Medical Term Molecular Motor Proteins.
Microtubule-Associated Proteins.
A pre-requisite for proper health of the cell and the organism is accurate chromosome segregation during cell division. Defects in chromosome segregation lead to aneuploidy, a hallmark of an unstable genome and a frequent attribute of cancer and...
Solid tumors are frequently aneuploid and many display high rates of ongoing chromosome mis-segregation in a phenomenon called chromosomal instability (CIN). The most common cause of CIN is the persistence of aberrant kinetochore-microtubule (k-MT)...
Faithful chromosome segregation is vital for cell and organism viability, but is lost in many cancer cells with aneuploid karyotypes that display chromosomal instability (CIN). In normal cells, correct chromosome segragation is ensured through two...
Top row, left to right: Manager Moulton '89, Norton, Hoyt, John Abbott '91, John Fifield ("Aggie"), "Dutchy" Viau ("Aggie"), Woodcock '91, Gaulty, Ranney, ("Medic"), Jones, Baehr, Williams; From J. M. Reynolds '90; Hastings 147 Tremont Boston
Top: C. E. Moulton, Norton, Hoyt, John Abbott, John Fifield, Bathum; Bottom: Dutchy Viau, Fred Woodcock, Matthew Gault, Leon Scruton, Dan P. Jones, Baehr William; A. H. Baehr '90; Gift of A. H. Baehr; Hastings 147 Tremont St. Boston
back row left to right a sone Young Bugbee Beebee CF Robinson HArdy Reynolds a son a son Mcdonald a sone MH Robinson Beacham Humphreys AH Bacon Gault a sone Mills Morrison Rowe Perry Boynton White Locke MacDonald a son Fassett French Chas Perkins...
Rauner to come; 1890, Joint Winner of Attendance Cup, after fifty years; Back row Robin Robinson '24 Carroll Boynton'33 Charles L. Hardy '27 Betty McDonald Middle row Mrs Mathewson Mrs Robin Robinson Mrs Woods Mrs Locke Mrs H. Robinson Mrs C A...
The following are not in the picture viz: W. A. Bacon, Blanchard, C. S. Earle, Holmes, J. F. McDonald, Moses, Roberts, Shirley, Sparhawk, White, H. E. Abbott, Bartlett, C. W. Campbell, Dewey, C. A. Hall, Mann, Veazey
Class of '90 studying ? by Elm tree on corner of Reed Hall in June 1889 Front row left to right Woods, Bugbee second row left to right Mann, Canty, Hoyt & Jones third row left to right Tyler, ? , Humphreys, Leavens Gift of Mrs Perley Bugbee
This group from the class of 1890 photographed at the Norwich and Hanover station fifteen years after Graduation. Left to right: Henry H. Hilton, Mrs. McDuffee, Charles A. Hardy, Willis McDuffee
Dartmouth Class of 1907 June 1967; The 50 year class of 1907 won the class of 1894 cup for the highest percentage of members present on Commencement Weekend Issue of July 1957. Al. Mag.; List and key of names of class members on back
Dartmouth Class of 1921 Dinner- Green Room, Hotel Gardner Before Dartmouth Night at "Pops" - Boston Mass. May 19, 1948; seated left to right- Dick Barnes, Fran Cosgrove, Sue Barnes, Alice and Don Sawyer, Betty + Tom (Prexy) Cleveland, Chan + Jean...