Mitomycin C -- Mechanism of action. ; DNA -- Effect of mitomycin C on. ; Genetic expression -- Effect of mitomycin C on. ; DNA-protein interactions -- Effect of mitomycin C on.
Mitomycin C (MMC) is a chemotherapeutic drug that reacts with the N$\sp2$ of guanine to form monoadducts, interstrand and intrastrand crosslinks. These lesions, especially the interstrand crosslink, are believed to be responsible for the potent...
Magnetic resonance imaging. ; Nuclear magnetic resonance.
Diffusion-weighted magnetic resonance imaging (MRI) provides unique contrast reflecting the translational motion of water in its microscopic environment. This imaging modality has been shown to highlight infarcted regions within minutes after an...
Liver disease of different etiologies confers significant morbidity and mortality and hence it constitutes a major health concern worldwide. Stemming from a range of causes, such as viral, drug-induced, alcoholic, or autoimmune, the rate of...
Antennas (Electronics); ; Thermotherapy. ; Cancer -- Treatment.
Engineers have devised many techniques by which to raise the temperature of a cancer tumor 8 degrees above body temperature. Such treatment is called hyperthermia; experiments in vitro suggest it may be an effective adjunct to standard radition...
While Cherenkov emission was discovered more than eighty years ago, the potential applications of imaging this during radiation therapy have just recently been explored. With approximately half of all cancer patients being treated by radiation at...
Serotonergic and non-serotonergic neurons located in the medullary raphe region of the mammalian brainstem are involved in numerous physiological processes. Concerning respiration, neurons in this region have been found to be chemosensitive, i.e.,...
Two strains of mice were identified that possess differing cardiopulmonary responses to hypoxia. CF 1 mice acclimated poorly to chronic hypoxia as indicated by right ventricular hypertrophy, decreased PO 2 , increased [Hb], and increased mortality....
Traumatic brain injury (TBI) is the leading cause of acquired disability in children, yet innate repair mechanisms are incompletely understood. A possible innate mechanism to repair injury after insult is neurogenesis - the birth, migration,...
Molecular optical imaging in vivo has potential for functional assessment of tumor tissue at the cellular and subcellular level. Advances in biological understanding of genomics and proteomics have increased the knowledge of possible cellular...
Despite the array of targeted therapeutics that currently exist to combat breast cancer, disease progression leading to metastasis, and tumor recurrence still remains a significant clinical challenge. Efforts to identify novel pathways and...
Pseudomonas aeruginosa is a virulent opportunistic pathogen that is frequently cultured from infectious sites, and is estimated to cause ~12% of nosocomial infections worldwide [1]. P. aeruginosa infections occur in a majority of adults with the...
Advances in medicine such as organ transplantations and cancer therapies involve the use of immunosuppressant drugs have led to rises in at risk patients and invasive fungal infections (IFIs). The filamentous fungus Aspergillus fumigatus is the...
Molecular imaging of cancer features is a critical part of advancing better tools for oncology management and drug discovery, yet it is still evolving as a useful tool. Diffuse Fluorescence Tomography (FT) is one approach to molecular imaging, used...
Candida albicans is a fungal species that naturally exists as a commensal member of the human microbiota, but can assume a pathogenic lifestyle and subsequently induce life-threatening systemic infections. The ability of the fungus to grow in...
ID proteins are naturally occurring dominant negative HLH-transcription factors that are highly expressed during development but generally not expressed in adult tissue except for selected cell types and some stem cells. Also, aberrant expression...
Angiogenesis is part of the natural defense mechanism in brain against hypoxia and ischemia. Animal models and methods for the non-invasive investigation of cerebral angiogenesis are needed. This thesis addresses the hypothesis that steady state,...
Despite immunogenicity, melanoma-specific vaccines have demonstrated minimal clinical efficacy in patients with established disease, but enhance survival when administered in the adjuvant setting. It has been shown that T cell infiltration of...
Elevated sympathetic discharge from the CNS is an underlying pathogenic mechanism in neurogenic hypertension and an exacerbating factor in chronic heart failure (CHF). Current treatment of these diseases focuses on attenuation of the downstream...
Morbidity and complexity involved in lymph node staging via surgical resection and biopsy could ideally be overcome using node assay techniques that are non-invasive. Visible blue dyes, fluorophores and radio-tracers are often used to locate the...
Sudden infant death syndrome (SIDS) occurs when a sleeping infant experiences a challenge to cardiorespiratory homeostasis which it fails to overcome. Analyses of brain tissue from SIDS cases from around the world consistently show abnormalities in...
Human epidemiological and animal studies have associated inhalation of nickel dusts with increased incidence of pulmonary fibrosis. The current studies examined the hypothesis that nickel promotes pulmonary fibrosis by inhibiting fibrinolysis and...
Hematopoietic stem cells (HSCs) balance self-renewal with the continuous production of the suitable numbers of lineage-restricted progenitor cells. In this work we demonstrate that the Mixed lineage leukemia 1 (Mll1) gene is essential for this...
The use of non-selective vasodilators for the purpose of pulmonary vasodilation has, to date, given mixed results; systemic hypotension has been the limiting factor. Lipid soluble gases (e.g. volatile anesthetics) are capable of inducing smooth...
Escherichia coli is the standard host for recombinant protein expression in bacteria, but suffers from some limitations (e.g. poor fermentation performance, inclusion body formation and proteolysis). A novel recombinant protein expression system,...
Post-transcriptional pathways provide a major means of regulating eukaryotic gene expression. Reiterations of the AU-rich element (AURE) located within the 3' UTR of many labile cytokine and proto-oncogene mRNA serve as signals for rapid...
Breast -- Magnetic resonance imaging. Breast -- Tomography. Near infrared spectroscopy. Optical tomography. Imaging systems -- Design and construction. Diagnostic imaging -- Mathematical models.
We have investigated the role of the p38 MAP kinase pathway in regulating gene expression at the level of mRNA stability. The inhibitory effect of thalidomide on Tumor Necrosis Factor (TNF)α production was characterized. Activation of the MAPK...