Dartmouth Digital Library Program

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The role of the Drosophila SK channel in sensory processing and behavior / by Ahmad Nawwaf Abou Tayoun.
Partially ordered sets. ; Forcing (Model theory). ; Set theory.
Dartmouth Dissertations

Targeting of the erythroid transcription factor, GATA-1, to specific locations within the human genome.
Globin genes -- Expression. ; Transcription factors. ; Genetic transcription -- Regulation.
Dartmouth Dissertations

Measuring quality of life in economic evaluations of treatment for severe mental illness.
Quality of life -- Evaluation. ; Health status indicators. ; Psychiatric rating scales. ; Mental illness -- Treatment -- Evaluation. ; Mental illness -- Treatment -- Economic aspects. ; Mental illness -- Treatment -- Social aspects.
Background. It is not clear whether a generic quality-of-life instrument can appropriately represent severe mental illness in an economic evaluation. This problem is particularly salient for resource-allocation decisions where policymakers compare...
Dartmouth Dissertations

Cytoskeletal reorganization in B lymphocyte activation.
Lymphocyte transformation.
Dartmouth Dissertations

Nucleophilic addition to electron deficient indoles and the synthesis of fused heterocyclic ring systems.
Indole -- Synthesis. ; Heterocyclic compounds -- Synthesis.
The chemistry of indole can be reversed and redirected by the addition of powerful electron-withdrawing groups. Incorporation of a nitro group at C-2 or C-3 renders the adjacent carbon susceptible to nucleophilic attack. Nitro, cyano, and...
Dartmouth Dissertations

Clay mineralogy and geochemistry of soils and sediments with perma frost in interior Alaska.
Clay minerals -- Alaska. ; Soils -- Alaska. ; Frozen ground -- Alaska.
Dartmouth Dissertations

The glucose transporter is a glycoprotein of Mr 55,000 and is probably not phosphorylated in response to biological activators of transport.
Glycoproteins. ; Monoclonal antibodies. ; Immune response.
Dartmouth Dissertations

Rhodopsin-arrestin complex formation as a novel mechanism for light-dependent retinal degeneration.
Visual pigments. ; Cellular signal transduction. ; Rhodopsin. ; G proteins. ; Phosphorylation. ; Photoreceptors. ; Retinal degeneration.
Arrestins are regulatory proteins that participate in the termination of G protein-mediated signal transduction. The major arrestin in the Drosophila visual system, Arrestin 2 (Arr2), has been demonstrated to be essential for the termination of the...
Dartmouth Dissertations

High resolution infrared spectroscopy and photolysis of solutes in cryogenic solids.
Infrared spectroscopy. ; Photodissociation. ; Argon. ; Nitrogen.
Dartmouth Dissertations

Neo-architectonics computer-aided histological examination of the human visual cortex.
Visual cortex -- Imaging. ; Visual cortex -- Histology. ; Image processing -- Digital techniques.
Functional neuroimaging has confirmed a high degree of localization of function in the cerebral cortex of man. In contrast, microstructural analysis has contributed very little to the topographical characterization of cortical areas. In this work I...
Dartmouth Dissertations

Imaging performance in advanced small pixel and low light image sensors / by Leo Anzagira
The proliferation of mobile devices and other consumer products has greatly expanded the market for CMOS image sensors. This in turn has promoted a trend of continued improvement in image sensor performance, as companies seek to gain an advantage...
Dartmouth Dissertations

The role of BRCA1 in estrogen receptor-α regulation in breast cancer.
Breast -- Cancer -- Genetic aspects. ; Estrogen -- Receptors -- Regulation. ; Genetic transcription -- Regulation. ; BRCA1 Protein. ; Breast Neoplasms -- genetics. ; Gene Expression Regulation Neoplastic. ; Repressor Proteins.
Dartmouth Dissertations

Isotopic phase separation in dilute solid mixtures of Helium-4 in Helium-3.
Helium -- Isotopes. ; Isotope separation.
Dartmouth Dissertations

Discovering MII1 regulated pathways in hematopoietic stem cells.
Hematopoietic stem cells. ; Hematopoietic stem cell disorders -- Genetic aspects. ; Genetic transcription -- Regulation. ; Leukemia -- Genetic aspects. ; Cell proliferation. ; Myeloid-Lymphoid Leukemia Protein -- genetics.
Hematopoietic stem cells (HSCs) balance self-renewal with the continuous production of the suitable numbers of lineage-restricted progenitor cells. In this work we demonstrate that the Mixed lineage leukemia 1 (Mll1) gene is essential for this...
Dartmouth Dissertations

Spectral studies of the enzyme rhodanese.
Enzymes.
Dartmouth Dissertations

Th-dependent B cell activation.
B cells. ; T cells. ; Cell interaction. ; Body fluids -- Immunology.
Dartmouth Dissertations

The dorsal tegmental nucleus of Gudden and angular velocity integration in the head direction system.
Space perception. ; Motion perception (Vision). ; Vestibular apparatus.
Head Direction (HD) cells are neurons located primarily in the limbic system that fire as a function of directional heading in the horizontal, or yaw, plane in the freely moving animal. Our hypothesis is that the HD signal is the result of two...
Dartmouth Dissertations

Effects of selenium deficiency on deiodinase expression and thyroid hormone economy in the rat during development.
Thyroid hormones -- Physiological effect. ; Selenium -- Physiological effect. ; Thyroid hormones -- Synthesis.
The iodothyronine deiodinases, D1, D2, and D3, play a crucial role in determining the circulating and intracellular levels of active and inactive thyroid hormone (TH), and thus have a major effect on TH action during development and adulthood. The...
Dartmouth Dissertations

Characterization of COPII vesicle proteins involved in sorting between the endoplasmic reticulum and golgi apparatus in Sacch[a]romyces cerevisiae.
Membrane proteins -- Physiological transport. ; Carrier proteins. ; Biological transport -- Regulation. ; Saccharomyces cerevisiae -- Cytology. ; Golgi apparatus. ; Endoplasmic reticulum.
Intracellular transport between the ER and Golgi is mediated by vesicles that bud from donor membranes and then fuse with acceptor membranes. Bi-directional vesicle transport maintains distinct organelle composition through a process known as...
Dartmouth Dissertations

Plasmodium falciparum SERA protein transgenics used in the study of parasite immunobiology and drug resistance.
Plasmodium falciparum -- Immunological aspects. ; Plasmodium falciparum -- Genetics. ; Toxoplasma gondii -- Genetics. ; Serine proteinases. ; Transgenic organisms. ; Drug resistance in microorganisms -- Genetic aspects.
Genetic and immunological tools have been used to study two protozoan parasites, Plasmodium falciparum and Toxoplasma gondii. Toxoplasma gondii provides an excellent model for the study of protozoan parasite biology. Plasmodium falciparum causes...
Dartmouth Dissertations

Interspecific competition and the niche of the American redstart.
Wood warblers -- Migration. ; Wood warblers -- Behavior. ; Bird populations.
Dartmouth Dissertations

Probing a receptor-binding domain of interleukin-2 by combinatorial cassette mutagenesis.
Interleukin-2. ; Mutagenesis.
Dartmouth Dissertations

Synthetic approaches to indolo[2,3-a]carbazole alkaloids.
Indole alkaloids -- Synthesis. ; Carbazole.
Dartmouth Dissertations

A benzonorbornyl model system for the study of carbocation-[pi] interactions.
Carbocations -- Reactivity. ; Aromatic compounds -- Reactivity.
An important mode of stabilization of cations in biochemical reactions is interaction with the π systems-of aromatic residues. As part of an investigation of the interaction of carbocations with aromatic π systems, a study of various model...
Dartmouth Dissertations

The mechanism of action for angiotensin-1-7 in the rostral ventrolateral medulla in the modulation of cardiovascular sympathetic nerve activity / by Mark S. Bilodeau
Elevated sympathetic discharge from the CNS is an underlying pathogenic mechanism in neurogenic hypertension and an exacerbating factor in chronic heart failure (CHF). Current treatment of these diseases focuses on attenuation of the downstream...
Dartmouth Dissertations

Novel synthetic approaches to polycyclic aromatic hydrocarbons.
Polycyclic aromatic hydrocarbons -- Synthesis.
This research attempts to combine known methodology with new chemistry towards the preparation of extended polycyclic aromatic hydrocarbons (PAH). The generation and Diels-Alder trapping of 1,7- and 2,6-naphthalene bisarynes was attempted for the...
Dartmouth Dissertations

The synthesis and characterization of transition metal vinylidene complexes.
Vinylidene complexes. ; Transition metal compounds. ; Organometallic compounds.
Dartmouth Dissertations

Interactions between the carcinogen chromium(VI) and DNA.
DNA. ; Chromium. ; Thiols.
Dartmouth Dissertations

The formation of chloroform and related products from the chlorination of polyhydroxybenzenes and diketones in dilute aqueous solution.
Chloroform. ; Chlorination.
Dartmouth Dissertations

Market-based control of mobile-agent systems.
Mobile agents (Computer software). ; Resource allocation -- Mathematical models. ; Computer networks -- Economic aspects.
Modern distributed systems scatter sensors, storage, and computation throughout the environment. Ideally these devices communicate and share resources, but there is seldom motivation for a device''s owner to yield control to another user. We...
Dartmouth Dissertations

Infinitary languages, generalized quantifiers, and generalized products.
Infinitary languages. ; Logic.
Dartmouth Dissertations

Mitochondrial biogenesis in Saccharomyces cerevisiae: transcriptional control by glucose.
Saccharomyces cerevisiae. ; Glucose. ; Mitochondria. ; Gene fusion. ; Cytochromes. ; Mutation (Biology).
Dartmouth Dissertations

High-throughput analysis of antigen-specific antibody effector function from polyclonal Ig / by Eric Brown
Antibodies are known to be a primary correlate of protection in almost all current vaccines, and thus evaluating the antibody response is of critical importance in attempting to predict the efficacy of novel vaccine candidates. Historically...
Dartmouth Dissertations

Biological and receptor binding properties of interleukin-2 analogs employing site-directed mutagenesis and filamentous phage display.
Interleukin-2 -- Derivatives. ; Ligand binding (Biochemistry). ; Mutagenesis.
Dartmouth Dissertations

Proteins of rat liver lysomal membranes: characterization, biosynthesis and comparison with plasma membranes.
Lysosomes. ; Cell membranes.
Dartmouth Dissertations

The functional importance of the head direction signal for homing behavior / by William Nelson Butler
The rat limbic system contains head direction (HD) cells that fire according to heading in the horizontal plane. These HD cells are thought to provide animals with an internal compass to guide navigation. Previous work has found that HD cell tuning...
Dartmouth Dissertations

Torsional movements in the large free living amoebae.
Amoeba. ; Torsion.
Dartmouth Dissertations

C₂-Symmetric Bis(phosphines) and Their Metal Complexes : Synthesis, Materials Application, and Screening Racemic Catalysts / Sanderson, Matthew David
Chapter 1: The dimethylation of the C2-symmetric Pt-phosphido complex Pt((R,R)-Me-DuPhos)(IsPCH2PIs) (Is = 2,4,6-(iPr)3C6H2) to yield rac- and meso- [Pt((R,R)-Me-DuPhos)(IsMePCH2PMeIs)][OTf]2 represents an interesting case of the Horeau principle...
Dartmouth Dissertations

Investigation of vesicle fusion in ER to Golgi transport.
Membrane proteins -- Physiological transport. ; Biological transport -- Regulation. ; Cell membranes. ; Golgi apparatus. ; Endoplasmic reticulum. ; Saccharomyces cerevisiae -- Cytology.
Many intracellular transport events are mediated by vesicles that bud from donor membranes and then fuse with acceptor membranes. The transport of secretory proteins between the ER and Golgi compartments of the yeast Saccharomyces cerevisiae has...
Dartmouth Dissertations

Organometallic chemistry with perfluorinated ligands. Investigation of group 8-10 metal complexes derived from octafluorocyclooctatetraene (OFCOT).
Organometallic chemistry. ; Ligands.
Dartmouth Dissertations

Differential effects of mitomycin C on constitutive and inducible gene expression in the chick embryo liver in vivo: correlation with developmental age and chromatin structure.
Mitomycin C -- Mechanism of action. ; Gene expression. ; Chromatin.
Dartmouth Dissertations

Mechanisms of the nephrotoxicity of acetaminophen studied in the mouse kidney cortex slice system.
Renal pharmacology. ; Acetaminophen. ; Mice -- Physiology.
Dartmouth Dissertations

Novel diphosphate surrogates: synthesis of potential inhibitors of cholesterol biosynthesis.
Cholesterol -- Synthesis -- Inhibitors. ; Anticholesteremic agents -- Synthesis. ; Pyrophosphates.
Dartmouth Dissertations

Reward and self-regulation in online digital environments.
Reward (Psychology). ; Self-control. ; Internet addiction -- Physiological aspects. ; Behavior Addictive -- pathophysiology.
The motivational and rewarding properties of our immediate environment affect how humans interact with our world in a number of ways. One important aspect in which reward representation shapes behavior is in the development, maintenance and...
Dartmouth Dissertations

A novel region in the collagenase promoter is involved in transcriptional activation and repression.
Collagenases. ; DNA-protein interactions.
Dartmouth Dissertations

Study of 3' end RNA processing of herpes simplex virus type 1 thymindine kinase mRNA in vivo and in vitro.
RNA -- Metabolism. ; Herpes simplex virus.
Dartmouth Dissertations

Interleukin-2 analogs with enhanced biological response: a novel ligand based mechanism.
Interleukin-2 -- Derivatives. ; Interleukin-2 -- Receptors. ; Ligand binding (Biochemistry).
Interleukin-2 (IL-2) is an immunoregulatory cytokine whose biological effects are mediated through interaction with specific receptors (IL-2R) on the surface of target cells. Due to its presumed role in generating a normal immune response, IL-2 is...
Dartmouth Dissertations

Preparation of sterically hindered bis(secondary phosphines) : structure-selectivity relationships in Pt-catalyzed asymmetric phosphination and synthesis and structure of metal-phosphido complexes.
Phosphorus compounds -- Synthesis. ; Metal complexes -- Synthesis. ; Phosphine. ; Phosphides. ; Platinum catalysts. ; Asymmetric synthesis. ; Gold compounds -- Synthesis.
Dartmouth Dissertations

Characterization of two Saccharamyces cerevisiae genes involved in mRNA export.
Messenger RNA -- Physiological transport. ; Saccharomyces cerevisiae -- Genetics. ; Proteins -- Synthesis -- Genetic aspects.
I report the further characterization of an essential S. cerevisiae nucleoporin, RAT7/NUP159, shown previously to be involved in mRNA export. The Rat7p/Nup159p can be divided into three domains: an N-terminal domain, a central repeat domain, and a...
Dartmouth Dissertations

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