Inbred C57BL/6 mice develop an acute necrotizing ileitis following oral infection with Toxoplasma gondii that is associated with massive inflammatory infiltrates and morphologic tissue changes consistent with human Crohn's disease. In the course of...
1. A. E. Rowley; 2. J. P. Williams; 3. G. G. Cleveland; 4. A. H. Hastorf; 5. H. W. Hill; 6. L.D. Stilwell; 7. A. E. Jensen; 8. H. E. Angelo; 9. J. F. Ross; 10. F. W. Stolz; 11. W. J. Tietjen; 12. J. P. Billhardt; 13. H. S. Kingman, Jr.; 14. R. H....
The furanosteroids are an important class of natural products that have been found to effectively inhibit various biologically important enzymes. These enzymes include the phosphoinositide-3-kinase (PI3K) family and the polo-like kinase (PLK1)...
The furanosteroids are a special class of natural products that feature a furan ring fused to the steroid nucleus at C-4 and C-6. In 1945, viridin, the parent member of this group, was isolated by Grove and coworkers from the fungas Gliocladium...
Football Teams Freshmen, 1966; Class of 1970; Front row: Decker, J. H.; Koenig, W. E.; Holmberg, R. E.; Young, L. A., III; Schad, T. O. (Captain); Lease, R. K.; Mlaker or Mlakar, R. B.; Landholm, R. A.; Donovan, P. M.; Chartrand, J. J.; Second row:...
Library Staff (Formal Group Photos); Identifications: 1. Monique C. Cleland; 2. Michael J. Lach; 3. Donald L. Saporito; 4. Molly M. O'Connor; 5. Theresa Blake; 6. Stanley Brown; 7. William B. Meredith; 8. Edward Connery Lathem; 9. June I. Hicks;...
Interaction with aromatic π systems has become recognized as an important mode of stabilization of carbocation intermediates in biological reactions. To gain insight into such carbocation-π interactions, we have undertaken a study of...
I. Intermolecular C-S Bond Forming Reactions
The relatively small number of efficient C-S bond forming reactions in the literature prompted an investigation into the synthesis of allylic thioethers. The technology that we developed allowed us, in...
Football Teams Freshmen, 1964; Class of 1968; Front row, left to right: Hugg, F. B.; Ryzewicz, E. F., Jr.; Eldridge, J. F.; Small, L. M., III (Captain); Machan, M. J.; Johnson, J. C.; Bradford, E. L., Jr.; Second row: Thomas, R. S.; McNeely, D. C.;...
1. H. J. Patterson; 2. J.F. Ross; 3. R. E. Riegel; 4. H. W. Hill; 5. A. E. Jensen; 6. C. D. Campbell; 7. S. Heller; 8. W. Chan; 9. R. G. Smith; 10. C. H. Miller; 11. R. D. Hill; 12. H. T. Wood; 13. P. A. Toole; 14. A. W. Conti; 15. B. H. Ineson;...
The great strength of the C-F bond has enabled fluorocarbons to find many industrial and domestic applications, and makes C-F activation a chemical and technical challenge akin to that of C-H bond activation in hydrocarbons. In our mission to...
Indole alkaloids -- Synthesis. Ring formation (Chemistry). Radicals (Chemistry).
A novel radical cyclization of 2-bromoindoles was examined, generating a series of hexahydropyrrolo[3,4- b ]indoles in fair yield. This process involved the generation of a variety of indole-3-carboxamides followed by the introduction of bromine at...
Ocean circulation -- Georges Bank -- Mathematical models. ; Submarine topography -- Georges Bank.
A two-dimensional continuously-stratified model is derived for the study of instability properties of oceanic density fronts in the presence of sloping bottom topography. While the model retains several traditional assumptions, such as uniformity...
I. (3 + 2) Cycloaddition Reactions of Oxyallyl Cationic Intermediates with Indoles Cyclopenta- and cyclohexa[b]indolines are ubiquitous molecular skeletons in natural products and pharmaceutical agents. We have developed (3 + 2) cycloaddition...
In this thesis I present analyses of optical and X-ray data of early-type galaxies in nearby rich clusters as part of the NOAO Fundamental Plane Survey. Spectroscopic parameters, including linestrengths and velocity dispersions are measured for...
Football Teams Freshmen; 1963 Freshman Football; Class of 1967; Front row: Steiner, R. W. , Jr.; Patterson, B. L.; Smith, D. A.; Klungness, P. H.; Calhoun, W. A. (Captain); Danver, J. A., III; Beard, M. V., Jr.; Walton, P. L.; 2nd row: Sutherland,...
Part 1 . A computational study targeting the lowest energy structure, electronic state and physical properties of small carbon clusters containing one or two heteroatoms has been done. The structural properties sought included whether the most...
Since its discovery in the 1930's, the Cherenkov effect has been paramount in the development of high-energy physics research. It results in light emission from charged particles traveling faster than the local speed of light in a dielectric...
This study presents δ18O analyses of garnets microsampled by laser fluorination from two localities in the deep seated, Barrovian metamorphic terrane of eastern Vermont. The broad goals of the research were to constrain further the amount,...
A new synthetic approach to both pyrrolo[2,3- b]indoles and pyrrolo[3,4- b]indoles by the reaction of 3-nitro-1-(substituted)indoles with functionalized isocyanides is presented. The reaction between 3-nitro-1-(phenylsulfonyl)indole (185) and ethyl...