Dartmouth Digital Library Program

Thumbnail

Title

Subject

Description

Collection

Neural and behavioral correlates of auditory-object processing.
Auditory perception. Temporal lobes -- Physiology. Prefrontal cortex -- Physiology. Neurophysiology.
The neurophysiological examination of auditory-object representations has focused on how early auditory cortical areas code for the spectral and temporal features of auditory objects. The goals of this dissertation was to investigate how auditory...
Dartmouth Dissertations

SGK1 is an important determinant of sodium channel activity in the mammalian collecting duct.
Aldosterone -- Mechanism of action. ; Aldosterone -- Physiological effect. ; Adrenocortical hormones -- Genetic aspects. ; Sodium channels -- Genetic aspects. ; Genetic regulation.
Hypertensive disorders, as well as congestive heart disease. Despite extensive research on the regulatory events that occur between aldosterone induced transcription and the early activation of epithelial sodium channels (ENaC ) in cortical...
Dartmouth Dissertations

Regulation of ENaC expression by corticosteroids and SGK1 in cortical collection duct cells and mammary epithelial cells.
Sodium channels. Adrenocortical hormones. Protein kinases. Epithelial cells. Mammary glands. Sgk protein.
Regulation of transepithelial sodium transport by corticosteroids occurs in two phases: early and delayed. The early phase involves the activation and translocation of pre-existing epithelial sodium channels (ENaC); whereas, the delayed phase...
Dartmouth Dissertations

Regulation of Wnt/Wingless signaling by the ADP-ribose polymerase Tankyrase / by Zhenghan Wang
The Wnt/β-catenin signaling pathway controls numerous biological processes from embryogenesis to adult homeostasis; aberrant Wnt signaling underlies a wide range of human diseases. In the absence of Wnt stimulation, a multiprotein “destruction...
Dartmouth Dissertations

Anticipated emotion in health decision making : an extension of the prototype-willingness model
Health behavior -- Decision making. ; Emotions.
Dartmouth Dissertations

Behavioral and neural investigations of behaviorally relevant features of auditory stimuli.
Auditory pathways -- Physiology. ; Auditory perception -- Physiological aspects. ; Directional hearing -- Physiological aspects. ; Speech perception -- Physiological aspects. ; Prefrontal cortex -- Physiology. ; Parietal lobes -- Physiology. ;...
Studies of the structure and function of the human and non-human primate auditory system have led to the hypothesis that it is composed of dorsal and ventral processing streams that are respectively dedicated to spatial and non-spatial processing....
Dartmouth Dissertations

Epithelial sodium channel regulation in the mouse kidney: two novel approaches to a classic question.
Sodium channels -- Physiology. Proteins -- Physiological transport. Biological transport -- Regulation. Aldosterone -- Physiological effect. Epithelial cells. Protein Transport. Vesicular Transport Proteins.
Nearly one billion individuals worldwide have elevated blood pressure (BP) and 90% of these cases are due to unknown causes. Aldosterone is the primary hormone regulating Na + reabsorption in the kidney and is therefore a major determinant of the...
Dartmouth Dissertations

Subcellular location and function studies of the serum and glucocorticoid induced kinase-1 (SGK1).
Protein kinases -- Mechanism of action. Sodium channels -- Genetic aspects. Glucocorticoids. Acetylation. Histones. Sgk protein. Receptors
The serum and glucocorticoid induced kinase 1 (SGK1) is involved in aldosterone-induced Na + reabsorption by increasing epithelial Na + channel (ENaC) activity in cortical collecting duct (CCD) cells. We found the SGK1-GFP fusion protein is...
Dartmouth Dissertations

ACAT1 blockage stimulates autophagy to emeliorate Alzheimer's disease / by Yohei Shibuya
Alzheimer’s disease (AD) is a progressive neurodegenerative disease and the most common cause of dementia in the aging population. Currently, there is no cure for AD. The hallmark of AD consists of extracellular amyloid plaques, mainly composed...
Dartmouth Dissertations

Cellular organization in syncytia : nuclear autonomy and cytosolic organization across kingdoms / by Samantha Elizabeth Roberts
All cells must organize their cytoplasm in order to carry out functions properly and survive in different environments, and the requirement for organization is increased in large, multinucleate cells. It has long been known that membrane-bound...
Dartmouth Dissertations

Investigating the role of ARP2/3 complex and formins in assembly of cell surface protusions.
Cells -- Motility. Cell membranes -- Formation. Cytoskeletal proteins. Actin. Cell Movement -- physiology. Actin-Related Protein 2-3 Complex -- physiology. Microvilli.
Despite years of study, the mechanisms by which cells protrude their leading edge during cell motility are still highly controversial. Two candidates for mediating this actin-based process are the Arp2/3 complex and formin family proteins. In order...
Dartmouth Dissertations

New synthetic approaches to chlorins and bacteriochlorins.
Pyrroles -- Synthesis. Porphyrins -- Synthesis.
Naturally occurring macrocyclic tetrapyrroles of the chlorin and bacteriochlorin classes play important roles in essential biological processes, including photosynthesis and nitrogen cycling. The chromophores also show promise in various...
Dartmouth Dissertations

Relating behavioral control and brain development : insights from adolescence / by Heidi Catherine Meyer
Across mammalian species, adolescence is characterized by a unique combination of cognitive, behavioral and neurobiological changes. Behavioral tendencies observed during this period promote a variety of flexible interactions with the surrounding...
Dartmouth Dissertations

MRI-coupled broadband near-infrared tomography for small animal brain studies.
Brain -- Tomography. Magnetic resonance imaging -- Brain. Near infrared spectroscopy. Image processing -- Digital techniques.
Diffuse optical tomography (DOT) using near infrared (NIR) light has become a promising modality because it has the capability to non-invasively quantify oxygen saturation and hemoglobin content with potentially high temporal resolution and...
Dartmouth Dissertations

Track Teams Freshman
Track Teams Freshman
1969 Dartmouth Freshman Outdoor Track (l-r) Front Row: Elliot Bradbury Noyes (Coach), Robert Ellis III, Mark Ginsburg, Bruce Andrews, Theodore Moody, Kenneth Hohenstein, Kenneth Weinbel (Assistant Coach). Second Row: Steven Shirey, Jeffrey Pulis,...
Dartmouth College Photographic Files

A study of neutral amino acid and drug transport in slices from human and rabbit placentae.
Placenta; Maternal-fetal exchange.
Dartmouth Dissertations

A study of neutral amino acid and drug transport.
Placenta. ; Maternal-fetal exchange.
Dartmouth Dissertations

Combined MRI and near-infrared spectroscopy for increased specificity of breast cancer imaging / by Michael A. Mastanduno.
A yearly breast contrast-MR scan is recommended to high-risk women because of MR's high sensitivity to breast tumors. However, breast contrast-MR yields a high number of false positives that lead to expensive and sometimes unnecessary biopsy...
Dartmouth Dissertations

Optical spectroscopy guided by structural and functional MRI for breast cancer imaging.
Optical spectroscopy. Magnetic resonance imaging. Breast -- Cancer -- Imaging.
Magnetic Resonance (MR)-guided Diffuse Optical Imaging is an emerging technique to improve breast cancer imaging. This modality combines the high sensitivity of breast MR with images of tissue physiology, including blood content, oxygen saturation,...
Dartmouth Dissertations

Wnt pathway activation by ADP-ribosylation / by Eungi Yang
Wnt/[beta]-catenin signaling directs metazoan development and is aberrantly activated in many cancers; however, effective inhibitors to treat Wnt-driven cancers have long been elusive. Following the recent discovery that the ADPribose polymerase...
Dartmouth Dissertations

Computational aspect of tomographic microwave imaging for biomedical applications
Microwave imaging (MI) is based on recovering dielectric properties (permittivity and conductivity) of materials. Over the last two decades, MI has attracted increasing interests in biomedical applications, in particular, for breast cancer...
Dartmouth Dissertations

Genetic inactivation of ACAT1 ameliorates the amyloid pathology and cognitive deficits in a mouse model of Alzheimer's disease.
Acyltransferases -- Genetic aspects. Enzyme inhibitors. Alzheimer's disease. Amyloid.
Acyl-CoA:Cholesterol Acyltransferases (ACATs) are key enzymes in cellular cholesterol metabolism. ACAT converts free cholesterol to cholesterol ester, which makes it more easily storable in lipid droplets. There are two ACAT genes encoding two...
Dartmouth Dissertations

An investigation into the mechanism of action of aldosterone on ENaC: A search for endogenous substrates of SGK1.
Subject Protein kinases. Aldosterone -- Physiological effect. Sodium -- Physiological transport. Sodium channels. Epithelial cells. Glucocorticoids. Medical Term Sgk protein.
It is well established that SGK1 plays a role in aldosterone mediated sodium transport. The intracellular localization of SGK1 has recently been demonstrated as mitochondrial. The studies described here evaluate the hypothesis that SGK1...
Dartmouth Dissertations

Improvement and evaluation of nonlinear inversion MR elastography / by Matthew D. J. McGarry.
Magnetic resonance elastography (MRE) is a technique to produce images of the mechanical properties of tissue, which are indicative of a variety of diseases. Tissue motions measured using MRI are used to solve an inverse problem to recover...
Dartmouth Dissertations

Advancement of magnetic resonance poroelastography for applications in brain imaging / by Adam J. Pattison.
Brain tissue mechanics are an important biomarker for neurological disorders, yet methods to obtain tissue information yield inconsistent conclusions. These techniques can be invasive or require excised tissue, where tissue function is altered from...
Dartmouth Dissertations

Investigations on optimizing the energy transmission of ultrafast optical pulses in pure water.
Laser pulses, Ultrashort. Electromagnetic waves -- Transmission.
Many of today's communication and imaging technologies share the common challenge of signal deterioration due to water's large absorption coefficient. As an example, it is water molecules that contaminate the fused silica of optical fibers and...
Dartmouth Dissertations

Neural basis underlying auditory categorization in the human brain.
Auditory perception -- Physiological aspects. Categorization (Psychology) Musical perception -- Physiological aspects. Speech perception -- Physiological aspects.
Our daily lives are pervaded by sounds, predominantly speech, music, and environmental sounds. We readily recognize and categorize such sounds. Our understanding of how the brain so effortlessly recognizes and categorizes sounds is still...
Dartmouth Dissertations

Solution structure determination of core binding factor ß(1-141) and map of CPFα binding site.
Transcription factors -- Structure. ; Genetic transcription. ; DNA-binding proteins.
Core binding factor (CBF) is a heterodimeric transcription factor that is essential for a number of developmental process including hemotopoiesis and bone development. CBFs contain a DNA-binding CBFα. subunit and a non-DNA binding CBFß. subunit...
Dartmouth Dissertations

Track Teams 1950s And Undated
Track Teams 1950s And Undated
Class of 1973; 1969 Dartmouth Freshman Outdoor Track (l-r) Front Row: Ellie Noyes (Coach), Robert Ellis III, Mark Ginsburg, Bruce Andrews, Theodore Moody, Kenneth Hohenstein, Ken Weinbel, Second row: Steven Shirey, Jeffrey Pulis, Edward Agoos, Carl...
Dartmouth College Photographic Files

Motion artifacts in computed tomography.
Tomography. ; Human mechanics.
Dartmouth Dissertations

Memory and the resting brain.
Memory -- Physiological aspects. Hippocampus (Brain) -- Physiology. Perceptual-motor processes. Brain -- Variation.
Dartmouth Dissertations

Whole brain hyperalignment : inter-subject hyperalignment of local representational spaces / by Jyothi Swaroop Guntupalli.
Functional magnetic resonance imaging (fMRI) is an important tool for understanding neural mechanisms underlying human brain function. Most fMRI studies use limited sets of well-controlled stimuli to understand neural systems in isolation. The...
Dartmouth Dissertations

Strain confined GaAs/A1xGa1-xAs quantum wires and quantum dots: experiment and theory.
Nanostructures. Semiconductors -- Optical properties. Quantum wells.
Dartmouth Dissertations

Excitation transfer in strain-induced quantum wires and dots.
Semiconductors -- Optical properties. Quantum wells. Quantum electronics.
Quantum wires and dots can be created by patterning inhomogeneous strain on semiconductor quantum wells. I have used laser spectroscopic methods to study the carrier transfer from the host quantum well to quantum wires and dots. For quantum dot...
Dartmouth Dissertations