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- A study of neutral amino acid and drug transport in slices from human and rabbit placentae.
- Placenta; Maternal-fetal exchange.
- Dartmouth Dissertations
- Molecularly imprinted polymer and applications in nicotine sensing / by Yuan Liu.
- Chemical sensing and separation is a constant challenge intriguing many scientists. Through numerous efforts, revolutionary techniques and innovative materials have been successfully developed to solve this old problem. However, a practical but...
- Dartmouth Dissertations
- Cytokinin and the transcriptional regulation of chloroplast development in Arabidopsis.
- Chloroplasts -- Formation. ; Genetic transcription -- Regulation. ; Transcription factors. ; Arabidopsis -- Genetics. ; Arabidopsis proteins. ; Cytokinins.
- Cytokinins regulate broad aspects of plant growth and development, such as cell division, root and shoot growth, chloroplast development, and leaf senescence. Cytokinins are perceived by a signal transduction pathway that involves receptors,...
- Dartmouth Dissertations
- Noninvasive fluorescence monitoring for functional assessment of murine glioma treatment.
- Gliomas -- Immunotherapy -- Evaluation. Fluorescence spectroscopy. Diagnosis.
- Molecular optical imaging in vivo has potential for functional assessment of tumor tissue at the cellular and subcellular level. Advances in biological understanding of genomics and proteomics have increased the knowledge of possible cellular...
- Dartmouth Dissertations
- SirT1 regulates vascular smooth muscle cell plasticity : implications for age-related cardiovascular disease / by Anne Marie Thompson.
- Loss of vascular smooth muscle cell function is a hallmark of vascular disease. Vascular smooth muscle cells become increasingly resistant to phenotypic modulation, apoptotic and senescent. Sirtuin 1 (SirT1) is a deactylase that regulates...
- Dartmouth Dissertations
- Memory consolidation in temporal lobe epilepsy / by Ali Seçkin Titiz.
- Epilepsy is associated with cognitive impairments which often manifest as a higher prevalence of memory impairments. Memory impairments in patients with epilepsy may persist even with sufficient control of seizures, suggesting other factors may...
- Dartmouth Dissertations
- UCN-01: a protein kinase antagonist abrogating cell cycle checkpoint control.
- Protein kinase C -- Antagonists. Cells -- Growth -- Regulation. Antineoplastic agents -- Mechanism of action.
- Dartmouth Dissertations
- Genetic inactivation of ACAT1 ameliorates the amyloid pathology and cognitive deficits in a mouse model of Alzheimer's disease.
- Acyltransferases -- Genetic aspects. Enzyme inhibitors. Alzheimer's disease. Amyloid.
- Acyl-CoA:Cholesterol Acyltransferases (ACATs) are key enzymes in cellular cholesterol metabolism. ACAT converts free cholesterol to cholesterol ester, which makes it more easily storable in lipid droplets. There are two ACAT genes encoding two...
- Dartmouth Dissertations
- The effects of context and familiarity on person perception: examining the neural substrates of facial attractiveness.
- Face perception -- Physiological aspects. Face perception -- Social aspects. Sex differences (Psychology). Neuropsychology.
- The general objective of the current thesis was to investigate the neural substrates underlying the perception of opposite-sex faces. Building on what is already known about the distributed network of brain areas supporting various dimensions of...
- Dartmouth Dissertations
- The interplay between BCL2 family members in response to pharmacologically induced apoptosis
- Apoptosis.; Cancer cells -- Growth -- Regulation. ; Cellular signal transduction. ; Apoptosis Regulatory Proteins -- pharmacology. ; Proto-Oncogene Proteins c-bcl-2 -- pharmacology. ; bcl2-Associated Death Protein -- pharmacology. ; Vinblastine --...
- Dartmouth Dissertations
- Modulation of CYPS: effect on acetaminophen hepatotoxicity.
- Hepatotoxicology. ; Cytochrome P-450 -- Pathophysiology. ; Acetaminophen -- Toxicology. ; Alcohol -- Pathophysiology.
- Cytochrome P450 (CYP) 2E1 is considered the sole CYP responsible for APAP bioactivation leading to hepatotoxicity. CYP2E1 is also considered the alcohol-inducible CYP and therefore, the sole CYP responsible for alcohol-mediated increases in APAP...
- Dartmouth Dissertations
- Nonstigmatized individuals' reactions to the acknowledgment and valuation of a stigma by overweight individuals and physically disabled individuals.
- Overweight persons -- Attitudes. ; People with disabilities -- Attitudes. ; Obesity -- Public opinion. ; Stigma (Social psychology). ; Self-presentation.
- In the last few years, a new perspective on the management of obesity has emerged. Instead of focusing on dieting and weight loss efforts, the new approach focuses on size acceptance. The concept of positively accepting one's deviant features has...
- Dartmouth Dissertations
- Regulation of human type I Fc[gamma] receptor by interferon-[gamma] and dexamethasone.
- Fc receptors. ; Cellular control mechanisms. ; Interferon. ; Dexamethasone.
- Dartmouth Dissertations
- Applications of Cherenkov light emission for dosimetry in radiation therapy / by Adam Kenneth Glaser
- Since its discovery in the 1930's, the Cherenkov effect has been paramount in the development of high-energy physics research. It results in light emission from charged particles traveling faster than the local speed of light in a dielectric...
- Dartmouth Dissertations
- Targeting anaphase catastrophe through CDK inhibition in lung cancer / by Shanhu Hu
- Aneuploidy is frequently detected in human cancers and is implicated in carcinogenesis. Pharmacological targeting of aneuploidy is an attractive therapeutic strategy, as this would preferentially eliminate malignant over normal cells. Our prior...
- Dartmouth Dissertations
- Distances and motions of early-type galaxies in selected directions in the South Equatorial Strip.
- Galaxies -- Motion in line of sight
- The new APM South Equatorial Strip Catalog $({-}17\sp\circ.5<\delta<2\sp\circ.5)$ is used to select a sample of early-type galaxies in three directions: (1) 15h10-16h10; (2) 20h30-21h50; (3) 00h10-01h30. The distances and peculiar motions of...
- Dartmouth Dissertations
- CD8+ T cell responses to acute and chronic viral infections governed by costimulatory signals and CD4 help.
- T cells. T cells -- Receptors. CD antigens. CD4 antigen. Immunologic memory. Herpesvirus diseases -- Immunological aspects. Vaccinia. CD8-Positive T-Lymphocytes -- immunology. CD4-Positive T-Lymphocytes -- immunology. Herpesviridae Infections --...
- The phenomenon of immunological memory has been known for thousands of years. This knowledge has been applied to vaccination, which has resulted in a dramatic reduction in the number of deaths due to infectious diseases. Immunological memory is...
- Dartmouth Dissertations
- The consequences of land-use on subsidies of stream insects to terrestrial consumers / by Ramsa Chaves-Ulloa
- The image of a child standing at the side of a creek and skipping stones across it exemplifies how we tend to mentally separate aquatic habitats from dry land. But there is a constant exchange of materials from land to streams, and vice-versa....
- Dartmouth Dissertations
- Innate immune mechanisms contributing to LP-BM5 murine retroviral pathogenesis and immunodeficiency / by Megan Ashley O''Connor
- LP-BM5 murine retroviral infection induces murine AIDS (MAIDS), and is characterized by profound and broad immunosuppression of T- and B-cell responses. Adaptive immune response to LP-BM5 infection, including the pathogenic role of CD4+ T-cells and...
- Dartmouth Dissertations
- How we connect : neural mechanisms underpinning human social networks / by Carolyn M. Parkinson
- One of the most distinctive aspects of humans as a species is our propensity to form complex social networks made up of intense, non-reproductive bonds with non-kin. Navigating these networks presents a considerable cognitive challenge that is...
- Dartmouth Dissertations
- Isolation of interleukin-2-induced immediate-early genes.
- Interleukin-2.
- Dartmouth Dissertations
- Th-dependent B cell activation.
- B cells. ; T cells. ; Cell interaction. ; Body fluids -- Immunology.
- Dartmouth Dissertations
- In vitro reconstitution of exocytosis from sea urchin egg plasma membrane and isolated secretory vesicles.
- Sea urchins -- Cytology.
- Dartmouth Dissertations
- A comparison of the acute toxicity and teratogenic effects of succinonitrile and tetramethylsuccinonitrile: the role of cyanide.
- Nitriles -- Toxicology. ; Teratogenic agents. ; Cyanides -- Toxicology.
- Dartmouth Dissertations
- Methods for prevention of oral Toxoplasma gondii infection-induced hyperimmune response in mice.
- Toxoplasma gondii. ; Biological response modifiers. ; Immune response -- Regulation. ; Toxoplasmosis -- Immunotherapy. ; Interleukin-10 -- therapeutic use. ; Cholera Toxin -- therapeutic use. ; Anti-Inflammatory Agents -- therapeutic use.
- Dartmouth Dissertations
- Hemodynamic effects of an intravenous infusion of a volatile vasodilator.
- Vasodilators -- Physiological effect -- Mathematical models. ; Lungs -- Blood-vessels -- Effect of drugs on. ; Hemodynamics. ; Halothane -- Physiological effect. ; Rats -- Respiration. ; Swine -- Respiration.
- The use of non-selective vasodilators for the purpose of pulmonary vasodilation has, to date, given mixed results; systemic hypotension has been the limiting factor. Lipid soluble gases (e.g. volatile anesthetics) are capable of inducing smooth...
- Dartmouth Dissertations
- A study of neutral amino acid and drug transport.
- Placenta. ; Maternal-fetal exchange.
- Dartmouth Dissertations
- Von Hippel Lindau (VHL) tumor suppressor regulation of MT1-MMP in renal cell carcinoma.
- Antioncogenes. Metalloproteinases. Genetic regulation. Kidneys -- Cancer.
- Dartmouth Dissertations
- In vitro and in vivo assessment of endothelium-derived relaxing factor during pregnancy in the ra.
- Nitric oxide.
- Dartmouth Dissertations
- The function of perceived gaze direction in emotion and person perception.
- Gaze -- Psychological aspects. ; Facial expression. ; Body language.
- The primary goal of the current research was to examine the effect of perceived gaze direction on the perception and processing of facially communicated emotion. There is good reason to believe that gaze direction and facial displays of emotion...
- Dartmouth Dissertations
- Splicing thermotolerance in Drosophila melanogaster.
- Heat -- Physiological effect. ; Cells -- Effect of temperature on. ; RNA splicing. ; Drosophila melanogaster.
- Dartmouth Dissertations
- Differential MCL1 phosphorylation occurs through distinct pathways.
- Myeloid leukemia -- Genetic aspects. ; Phosphorylation. ; Antioncogenes. ; Cancer cells -- Growth -- Regulation. ; Immune response -- Regulation.
- Protein kinase C activators and microtubule damaging drugs stimulate BCL2 phosphorylation, which has been associated with either enhancement or inhibition of cell viability. In a Burkitt lymphoma cell line, both types of agents likewise stimulated...
- Dartmouth Dissertations
- Immunomodulation and the prevention of pathogen-driven ileitis.
- Crohn's disease -- Prevention. Crohn's disease -- Treatment. Immune response -- Regulation. Toxoplasma gondii -- Pathophysiology.
- Oral infection with Toxoplasma gondii in susceptible C57BL/6 mice results in the morphologic, histologic and immunologic changes in the small intestine consistent with the human Inflammatory Bowel Disease (IBD) of unknown etiology, Crohn's disease....
- Dartmouth Dissertations
- Cytotoxic trigger molecules on human myeloid cells.
- Cell-mediated cytotoxicity.
- Dartmouth Dissertations
- A versatile approach to ellipticine and its analogues: Preparation and free radical reactions of 2-bromo-3-substituted indoles.
- Alkaloids -- Synthesis. ; Heterocyclic compounds -- Synthesis. ; Indole.
- Dartmouth Dissertations
- An integrated approach to structure-function analysis: a study of interleukin-2 and ligand-based agonist and antagonist design.
- Interleukin-2.
- Dartmouth Dissertations
- Cloning and expression of HVACM, a cullin protein, from small cell lung cancer.
- Vasopressin -- Receptors. ; Small cell lung cancer. ; Genetic regulation. ; Molecular cloning. ; Immunohistochemistry.
- Dartmouth Dissertations
- The role of brain serotonin in afferent and efferent inhibitory processes.
- Serotonin.
- Dartmouth Dissertations
- Cortical contractility in amphibian eggs and embryos: response to the calcium ionophore A23187.
- Amphibians -- Physiology. ; Embryology Experimental.
- Dartmouth Dissertations
- The spectrophotometric determination of lead with 5, 10, 15, 20-Tetra(4-N-sulfoethylpyridinium)porphine using merging zones flow injection analysis.
- Lead. ; Drinking water -- Lead content. ; Flow injection analysis.
- Dartmouth Dissertations
- Characterization of catalase and its role in life-span determination in Caenorhabditis elegans.
- Caenorhabditis elegans -- Genetics. ; Caenorhabditis elegans -- Larvae. ; Caenorhabditis elegans -- Growth. ; Catalase -- Genetic aspects.
- In nematodes an alternative third larval stage, often called the dauer stage, allows the animals to weather periods of low food availability (if free living) or to disperse (if parasitic). Recently, studies of mutations in the nematode...
- Dartmouth Dissertations
- The interleukin 2 receptor: functional consequences of its biomolecular structure.
- T cells -- Receptors. ; Interleukin-2.
- Dartmouth Dissertations
- Inter-specialty differences in outcomes associated with adult primary care physician supply.
- Primary care (Medicine) -- United States -- Evaluation. ; Medicine -- Specialties and specialists. ; Physicians -- Supply and demand -- United States.
- Background. Strengthening the role of primary care is considered a key element in improving the outcomes and efficiency of health care delivery. Previous studies of the benefits of primary care have primarily examined the association of primary...
- Dartmouth Dissertations
- Chimeric NKG2D receptor expressing T cells as immunotherapy for cancer.
- T cells -- Receptors. Killer cells. Cell-mediated cytotoxicity. Cancer -- Immunotherapy.
- Despite advances in standard treatment options such as surgery, chemotherapy, and radiation, cancer remains the second leading cause of death in the United States. Moreover, many current therapies result in adverse effects. Therefore the...
- Dartmouth Dissertations
- Functions of prostacyclin in vascular and uterine smooth muscle.
- Prostacyclin -- Physiological effect. Vascular smooth muscle. Vascular endothelium -- Physiology. Myometrium -- Physiology. Cardiovascular system -- Diseases. Cellular signal transduction.
- Prostacyclin (PGI2) is a major product of COX-2 derived arachidonic acid metabolism in the endothelium and uterine myometrium. Evidence indicates that PGI 2 protects against development and progression of vascular disease. While it has been known...
- Dartmouth Dissertations
- Bridging the adaptive and innate immune system: A study on mast cells and the regulation of tumor immunity.
- Mast cells -- Immunology. Tumors -- Immunological aspects. Immune response -- Regulation.
- Traditionally, mast cells have been studied for their role as proinflammatory effector cells in allergic disorders. Recent findings however have opened up the discussion in the community of immunologists regarding MCs should be considered as...
- Dartmouth Dissertations
- The function of tumor associated leukocytes in ovarian cancer growth.
- Leucocytes -- Pathophysiology. Immunosuppression. Ovaries -- Cancer -- Pathophysiology. Peritoneum -- Cancer -- Pathophysiology. Medical Term Ovarian Neoplasms -- physiopathology. Peritoneal Neoplasms -- physiopathology.
- Immunosuppressive leukocytes are emerging as a critical factor in facilitating tumor progression. These leukocytes are converted by the tumor microenvironment to become tolerogenic, facilitate metastasis, and to aid in neo-vascularization. The...
- Dartmouth Dissertations
- Discovery of new NAD+ metabolic pathways and nutritional regulation.
- NAD (Coenzyme) -- Metabolism. Nicotinamide -- Mechanism of action. Phosphatases. Phosphates -- Metabolism -- Regulation. Medical Term Nucleotidases -- metabolism. Nicotinamide-beta-riboside.
- Nicotinamide adenine dinucleotide (NAD+) is classically known as an essential co-enzyme for hydride transfer reactions in metabolism. More recently, it has been recognized as a consumed substrate of ADPribose transfer enzymes...
- Dartmouth Dissertations
- New pathways of NAD+ metabolism and longevity.
- NAD (Coenzyme) -- Metabolism. Nicotinamide -- Mechanism of action. Genetic regulation. Nicotinamide-beta-riboside.
- NAD+ is an essential co-enzyme for hydride transfer enzymes and a consumed substrate of multiple signaling enzymes including the sirtuins, a family of protein lysine deacetylases shown to regulate longevity in a wide array of organisms. We have...
- Dartmouth Dissertations
- Inter-specialty differences in outcomes associated with adult primary care physician supply.
- Primary care (Medicine) -- United States -- Evaluation. Medicine -- Specialties and specialists. Physicians -- Supply and demand -- United States.
- Background: Strengthening the role of primary care is considered a key element in improving the outcomes and efficiency of health care delivery. Previous studies of the benefits of primary care have primarily examined the association of primary...
- Dartmouth Dissertations

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