Dartmouth Digital Library Program

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The synthesis and chemistry of novel cyclic perfluoromethyl-substituted molecules.
Fluorine compounds.
Dartmouth Dissertations

Amine catalysis of B-elimination reactions.
Catalysis. Chemical reactions. Amines.
Dartmouth Dissertations

Sulfobetaines as novel inhibitors of squalene synthase. A model system for Δ4-3-ketosteroid isomerase.
Cholesterol -- Synthesis. Enzymes -- Inhibition. Isomerases -- Synthesis.
This thesis describes the synthesis of sulfobetaines having the general structure $\rm RN\sp{+}(CH\sb3)\sb2(CH\sb2)\sb{x}SO\sb{3\sp{-}}$ as novel inhibitors of squalene synthase. Squalene synthase reductively couples two molecules of farnesyl...
Dartmouth Dissertations

Fluorinated ligands in organometallic chemistry.
Fluorocarbons. Ligands.
Dartmouth Dissertations

Synthetic studies of ellipticine alkaloids and structurally related compounds.
Alkaloids -- Synthesis.
Dartmouth Dissertations

Electron paramagnetic resonance spectroscopy of chromium compounds.
Chromium compounds. Electron paramagnetic resonance spectroscopy.
Dartmouth Dissertations

From nonmetal- and metal-chalcogen nanoclusters to chalcogenide nanotubes.
Chalcogenides. Nanotubes. ; Nanostructured materials.
A double-acceleration stage linear time of flight mass spectrometer (TOF MS) with Nd/YAG laser ablation cluster source was designed and constructed for cluster production, study and deposition. Cumulenic polycarbons SC n S ( n = 2-27) were...
Dartmouth Dissertations

Approaches to the synthesis of a helically-conjugated molecule.
Molecular orbitals.
Dartmouth Dissertations

Investigation of the reactivity of vinylimidazoles.
Imidazoles. ; Heterocyclic compounds -- Synthesis.
Dartmouth Dissertations

Synthetic, structural and dynamic investigations of organometallic complexes containing cyclopropenyl and olefin ligands.
Organometallic compounds. ; Ligands (Biochemistry). ; Alkenes.
Dartmouth Dissertations

Synthetic approaches to indolo[2,3-a]quinolizine alkaloids.
Indole alkaloids -- Synthesis.
Dartmouth Dissertations

Transition metal compounds containing cyclopentadienyl ligands substituted with adjacent tert-butyl groups.
Cyclopentadiene. Ligands. ; Transition metal compounds.
Dartmouth Dissertations

New technologies for constructing C-S and C-N bonds / by Markku Antti Savolainen
I. Markovnikov-Selective Hydrothiolation of Styrenes: Application to the Synthesis of Stereodefined Olefins There have been few reports in the literature describing Lewis Acid-catalyzed hydrothiolations that furnish Markovnikov-selective C–S bond...
Dartmouth Dissertations

I. Reactivity of electron deficient indoles toward nucleophiles, Diels-Alder reactions and dipolar cycloadditions; II. Synthesis of pyrrolo[3,4-b]indoles.
Indole -- Synthesis. Indole -- Reactivity. Pyrroles. Diels-Alder reaction.
Earlier in our laboratory, a facile synthesis of the 2- and 3-nitroindoles was realized. These compounds showed promise as powerful intermediates in the synthesis of novel structures and natural products. The reactivity of 2- and 3-nitroindoles...
Dartmouth Dissertations

The relationship between the apomorphine and the narcotic receptors of the emetic chemoreceptor trigger zone of the cat.
Emetics. ; Apomorphine. ; Morphine.
Dartmouth Dissertations

Design and synthesis of novel tricyclic-bis-enones: a series of highly active inhibitors of nitric oxide production in mouse macrophages.
Alicyclic compounds -- Synthesis. ; Nitric-oxide synthase -- Inhibitors. ; Cyclooxygenases -- Inhibitors. ; Macrophages. ; Oxidoreductases -- Inhibitors. ; Inflammation -- Mediators -- Pathophysiology.
Dartmouth Dissertations

Chemistry of P-H bonds at metal centers.
Organophosphorus compounds -- Synthesis. ; Phosphine. ; Transition metal compounds.
Dartmouth Dissertations

Preparation and reactivity of perfluorobenzyl complexes of the group 9 metals (Co, Rh, Ir).
Organometallic compounds. ; Organofluorine compounds. ; Organic compounds -- Synthesis. ; Transition metals. ; Cobalt compounds -- Synthesis. ; Rhodium compounds -- Synthesis. ; Organoiridium compounds -- Synthesis.
Dartmouth Dissertations

Investigation into the syntheses and reactions of 2-nitroindoles and 3-nitroindoles and discovery of novel syntheses of the pyrrolo[3,4-b]indole and pyrrolo[2,3-b]indole ring systems.
Carbazole -- Synthesis. ; Indole. ; Pyrroles.
A new synthetic approach to both pyrrolo[2,3- b]indoles and pyrrolo[3,4- b]indoles by the reaction of 3-nitro-1-(substituted)indoles with functionalized isocyanides is presented. The reaction between 3-nitro-1-(phenylsulfonyl)indole (185) and ethyl...
Dartmouth Dissertations

Model systems for the study of carbocation-π interaction.
Carbocations -- Reactivity. ; Aromatic compounds -- Reactivity.
Interaction with aromatic π systems has become recognized as an important mode of stabilization of carbocation intermediates in biological reactions. To gain insight into such carbocation-π interactions, we have undertaken a study of...
Dartmouth Dissertations

Bimolecular and intramolecular fluorescence quenching of an amine by a nitrile: Solution properties and chain structure of poly(1-olefin sulfone)s.
Amines. ; Nitriles. ; Sulfones. ; Alkenes.
Dartmouth Dissertations

Part I, a photoprecursor for difluorocarbene: Part II, syntheses and studies of the highly fluorinated [2.2.2] propellanes.
Organofluorine compounds -- Synthesis. Carbenes (Methylene compounds) -- Synthesis. Propellanes -- Synthesis.
Part I. A photoprecursor for difluorocarbene . The goal of this research was to develop a more practical and efficient photoprecursor for difluorocarbene. The first approach was concerned with the synthesis of 4,4-difluoropyrazoline-3,5-dione ( 5...
Dartmouth Dissertations

Synthetic approaches to indolo[2,3-a]carbazole alkaloids.
Indole alkaloids -- Synthesis. ; Carbazole.
Dartmouth Dissertations

The synthesis and characterization of transition metal vinylidene complexes.
Vinylidene complexes. ; Transition metal compounds. ; Organometallic compounds.
Dartmouth Dissertations

Preparation of sterically hindered bis(secondary phosphines) : structure-selectivity relationships in Pt-catalyzed asymmetric phosphination and synthesis and structure of metal-phosphido complexes.
Phosphorus compounds -- Synthesis. ; Metal complexes -- Synthesis. ; Phosphine. ; Phosphides. ; Platinum catalysts. ; Asymmetric synthesis. ; Gold compounds -- Synthesis.
Dartmouth Dissertations

Studies related to cholesterol biosynthesis: synthesis of haptens, oxysterols, and late stage inhibitors.
Cholesterol -- Synthesis -- Inhibitors. ; Haptens -- Synthesis. ; Oxysterols -- Synthesis.
Dartmouth Dissertations

Reduction of the carcinogen chromate by cellular components and model compounds.
Chromate. ; Mitochondria. ; Carcinogens.
Dartmouth Dissertations

Investigations of cobalt complexes containing four-membered carbocyclic rings.
Carbonyl compounds. ; Cobalt carbonyl complexes.
Dartmouth Dissertations

Effects of mitomycin C and other DNA crosslinking agents on gene expression: modulation of cancer cell multidrug resistance in cell culture and in vivo.
Mitomycin C -- Genetic aspects. ; DNA damage. ; Drug resistance in cancer cells. ; Cancer -- Chemotherapy -- Genetic aspects.
Our laboratory is concerned whether the distribution of chemically-induced DNA damage is non-random at the level of individual genes. Using changes in gene expression as a marker for DNA damage, we have previously demonstrated that genotoxic...
Dartmouth Dissertations

Conformational studies of H-F and C-F spin-spin coupling.
Nuclear spin. ; Proton magnetic resonance. ; Carbon magnetic resonance.
Dartmouth Dissertations

Synthesis, structure and chemistry of η3-cyclopropenyl and η3-oxocyclobutenyl complexes of iron and cobalt.
Transition metal compounds. ; Complex compounds -- Synthesis. ; Carbonyl compounds. ; Organometallic compounds.
Dartmouth Dissertations

Highly fluorinated keto-enol systems.
Ketones. ; Enols. ; Alkenes. ; Organofluorine compounds.
Dartmouth Dissertations

Synthesis and chemistry of fluorinated cyclopropenes: The α excited state in polycyclic aromatic hydrocarbon photochemistry.
Cyclopropane. ; Fluorination. ; Excited state chemistry. ; Photochemistry. ; Aromatic compounds.
Dartmouth Dissertations

General base catalysis of reversible beta elimination reactions.
Elimination reactions. ; Chemical kinetics.
The reversible elimination reactions of beta acyloxyketone 1 and beta alkoxyketone 2 were studied by monitering formation of the product enones in the UV spectra, and, in the case of 2, by using ('13)C NMR to follow deuterium incorporation into the...
Dartmouth Dissertations

Synthetic studies directed toward investigation of cholesterol regulation.
Cholesterol -- Synthesis -- Regulation. ; Anticholesteremic agents -- Synthesis. ; Squalene.
Chapter II of this thesis describes the synthesis of a number of sulfobetaines and bissulfobetaines to be evaluated as inhibitors of squalene synthase (SS) on the basis of the idea proposed by Shechter that their zwitterionic structure would be...
Dartmouth Dissertations

Approaches to the synthesis of tetracyanocyclobutadiene dianon: Synthesis and NMR investigation of perfluorocyclooctatetraene derivatives.
Cycloalkanes. ; Cyclobutadiene. ; Nuclear magnetic resonance.
Dartmouth Dissertations

Part I, Approaches to the synthesis of perfluorosemibullvalene; part II, Synthesis and studies of perfluorobenzene oxide/perfluorooxepin.
Fluorocarbons -- Synthesis. ; Oxides -- Synthesis.
Dartmouth Dissertations

Electrochemical intramolecular cyclizations involving silyl enol ethers and appended heterocycles.
Ring formation (Chemistry). ; Heterocyclic compounds -- Synthesis. ; Ethers. ; Enols.
Synthetic electrochemistry is a rapidly growing area of interest within the synthetic community, although it is far from being a routine technique. Despite the fact that many oxidative and reductive conversions are known, electrochemical methods...
Dartmouth Dissertations

Theoretical study of carbon-heteroatom clusters: Theoretical study and comparison of the intradiol and extradiol oxidation of catechol.
Catechol -- Biodegradation. Glycols. Oxidation. Carbon compounds -- Mathematical models.
Part 1 . A computational study targeting the lowest energy structure, electronic state and physical properties of small carbon clusters containing one or two heteroatoms has been done. The structural properties sought included whether the most...
Dartmouth Dissertations

Synthetic, mechanistic, photochemical studies of highly fluorinated organic compounds. Part I; Perfluorobicyclo[2.2.0]hex-1(4)-ene. Part II.
Organofluorine compounds -- Synthesis. ; Organofluorine compounds -- Thermal properties. ; Fluorination. ; Photochemistry.
Dartmouth Dissertations

Metal-catalyzed asymmetric synthesis of P-stereogenic phosphines.
Phosphine. Phosphorus compounds -- Synthesis. Platinum catalysts. Palladium catalysts. Asymmetric synthesis. Enantiomers.
Abstract (Summary) Chapter One. Platinum-Catalyzed Asymmetric Alkylation of Bis(secondary) Phosphines. Efficient Screening and the Synthesis of an Enantiomerically Pure C 2 -Symmetric Diphosphine . Platinum-catalyzed asymmetric alkylation of...
Dartmouth Dissertations

Structural studies of dihydrofolate reductase-thymidylate synthase from Toxoplasma gondii and dynamin 1 from Rattus norvegicus.
Microbial enzymes -- Structure. Antiprotozoal agents -- Design. Toxoplasma gondii. Guanosine triphosphatase -- Structure. G proteins -- Structure. Thymidylate synthase-dihydrofolate reductase -- chemistry. Dynamins -- chemistry.
The first chapter of this thesis encompasses progress towards the X-ray structure determination and drug design for the dihydrofolate reductase-thymidylate synthase (DHFR-TS) enzyme from the protozoa Toxoplasma gondii, along with another mutant...
Dartmouth Dissertations

Radical methodologies with indole and synthetic strategies towards the indole alkaloids, echitamine and prenostodione.
Indole alkaloids -- Synthesis. Ring formation (Chemistry). Radicals (Chemistry).
A novel radical cyclization of 2-bromoindoles was examined, generating a series of hexahydropyrrolo[3,4- b ]indoles in fair yield. This process involved the generation of a variety of indole-3-carboxamides followed by the introduction of bromine at...
Dartmouth Dissertations

Synthesis of aryl-based cyclopentadienyl lithium compounds for self-assembly and proton relays in hydrazone-based rotary switches / by Justin T. Foy.
Chapter One: Synthesis of aryl-based cyclopentadienyl lithium compounds for self-assembly. Cyclopentadienyl (Cp) lithium derivatives are known to form [eta]⁵-coordinated, electrostatically bonded, polymeric supersandwich structures in the solid...
Dartmouth Dissertations

Group 6B metal complexes of three and four membered organic rings.
Organometallic compounds. Transition metal compounds.
Dartmouth Dissertations

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