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All fields: NITRIC

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- Hepatic T cells and MDSCs in TGF-ß1-deficient mice.
- Chronic active hepatitis -- Pathogenesis. ; Suppressor cells. ; Transforming growth factors-beta. ; CD4-Positive T-Lymphocytes -- immunology. ; Transforming Growth Factor beta1 -- immunology.
- Autoimmune hepatitis (AIH) is an autoimmune liver disease characterized by immune-mediated necroinflammatory liver damage associated with CD4 + T cell infiltration in liver parenchyma. Despite advances in the understanding of AIH, its etiology...
- Dartmouth Dissertations
- A study of neutral amino acid and drug transport in slices from human and rabbit placentae.
- Placenta; Maternal-fetal exchange.
- Dartmouth Dissertations
- Methods for prevention of oral Toxoplasma gondii infection-induced hyperimmune response in mice.
- Toxoplasma gondii. ; Biological response modifiers. ; Immune response -- Regulation. ; Toxoplasmosis -- Immunotherapy. ; Interleukin-10 -- therapeutic use. ; Cholera Toxin -- therapeutic use. ; Anti-Inflammatory Agents -- therapeutic use.
- Dartmouth Dissertations
- A study of neutral amino acid and drug transport.
- Placenta. ; Maternal-fetal exchange.
- Dartmouth Dissertations
- Pre-clinical evaluation of the novel synthetic triterpenoid CDDO-imidazolide.
- Triterpenoid saponins -- Physiological effect. ; Triterpenoid saponins -- Mechanism of action. ; Triterpenoid saponins -- Therapeutic use. ; Imidazoles. ; Cancer cells -- Growth -- Regulation.
- 1[2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole (CDDO-lm) is a novel synthetic triterpenoid superior to its parent compound, 2-cyano-3, 12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO), both in vitro and in vivo. CDDO-Im is highly active in...
- Dartmouth Dissertations
- Functions of prostacyclin in vascular and uterine smooth muscle.
- Prostacyclin -- Physiological effect. Vascular smooth muscle. Vascular endothelium -- Physiology. Myometrium -- Physiology. Cardiovascular system -- Diseases. Cellular signal transduction.
- Prostacyclin (PGI2) is a major product of COX-2 derived arachidonic acid metabolism in the endothelium and uterine myometrium. Evidence indicates that PGI 2 protects against development and progression of vascular disease. While it has been known...
- Dartmouth Dissertations
- Laser-based oxygen isotopic studies of Acadian metamorphism in eastern Vermont.
- Metamorphism (Geology) -- Vermont. Garnet -- Vermont. Laser spectroscopy.
- This study presents δ18O analyses of garnets microsampled by laser fluorination from two localities in the deep seated, Barrovian metamorphic terrane of eastern Vermont. The broad goals of the research were to constrain further the amount,...
- Dartmouth Dissertations
- The structure and chemistry of polar glacier ice.
- Ice -- Analysis -- Polar regions. ; Glaciers -- Polar regions.
- This dissertation explores the spatial and temporal distributions of impurities in natural ice. Using polarized light, ion chromatography (IC), synchrotron x-ray topography (SXT), scanning electron microscopy (SEM), and energy-dispersive...
- Dartmouth Dissertations
- The role of CD40 in cutaneous and regional immune responses.
- CD antigens. ; Immune response -- Regulation. ; T cells -- Receptors. ; Antigens CD40. ; Lymphoma.
- Dartmouth Dissertations
- The role of phytoplankton in the accumulation of organic and inorganic mercury in freshwater zooplankton.
- Freshwater zooplankton -- Effect of heavy metals on. ; Freshwater zooplankton -- Food. ; Freshwater phytoplankton -- Ecology. ; Mercury -- Environmental aspects. ; Mercury -- Isotopes -- Environmental aspects. ; Daphnia pulex -- Effect of heavy...
- Dartmouth Dissertations
- Structure and function of misfolded rhodopsin protein in Retinitis pigmentosa.
- Retinitis pigmentosa -- Pathogenesis. Retinitis pigmentosa -- Genetic aspects. Rhodopsin. G proteins -- Receptors. Prostacyclin -- Receptors.
- Retinitis Pigmentosa is an inherited retinal degenerative disorder, initiated by point mutations on the rhodopsin gene. This thesis set forth to understand the mechanism of this pathogenesis, as well as to further improve our understanding of...
- Dartmouth Dissertations
- In vitro and in vivo assessment of endothelium-derived relaxing factor during pregnancy in the ra.
- Nitric oxide.
- Dartmouth Dissertations
- Synthesis of highly fluorinated bicyclo [2.2.0] hex-2-ene derivatives.
- Ketones. ; Fluorocarbons.
- Dartmouth Dissertations
- Peripheral and spinal mechanisms of neuropathic behaviors following peripheral nerve injury.
- Allodynia -- Animal models. ; Pain -- Physiological aspects. ; Nerves Peripheral -- Pathophysiology. ; Spinal cord -- Pathophysiology. ; Nerves.
- Dartmouth Dissertations
- Pharmacologic induction of human fetal hemoglobin through activation of the NRF2 antioxidant response signaling pathway
- Pharmacologic induction of fetal hemoglobin (HbF) has proven therapeutic potential for ß-hemoglobinopathy patients. Increased HbF reduces disease severity by decreasing sickling in sickle cell disease and reducing α-chain imbalance in...
- Dartmouth Dissertations
- Modulation of swarming motility in Pseudomonas aeruginosa / by Dae Gon Ha.
- Swarming motility is a flagella-dependent surface motility, and is also a form of bacterial group behavior. Similar to its counterpart biofilm formation, our understanding of swarming motility has been hampered by its complex set of requirements...
- Dartmouth Dissertations
- The role of cell stress signalling in the induction of [gamma]-globin gene expression / by Emily K. Schaeffer.
- Increased fetal hemoglobin (HbF) expression is beneficial for [beta]-hemoglobinopathy patients; however, most inducing agents do not possess the ideal combination of efficacy, safety and availability. Better understanding the mechanisms involved in...
- Dartmouth Dissertations
- Detection of hydrocarbons and hydrocarbon microseepage in the Bighorn Basin, Wyoming using isotopic, biogeochemical, and spectral reflectance techniques.
- Hydrocarbons -- Secretion. Petroleum -- Geology -- Bighorn Basin (Mont. and Wyo.). Natural gas -- Geology -- Bighorn Basin (Mont. and Wyo.). Isotope geology -- Bighorn Basin (Mont. and Wyo.). Sagebrush -- Bighorn Basin (Mont. and Wyo.) -- Analysis....
- Dartmouth Dissertations
- The identification of molecular targets of synthetic oleanane triterpenoids
- Terpenes -- Mechanism of action. ; Protein kinases -- Inhibitors. ; Oleanolic Acid.
- Synthetic oleanane triterpenoids (SO) are a novel class of therapeutic compounds based on the structure of oleanolic acid. These synthetic oleanane triterpenoids which include 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO), CDDO-methyl...
- Dartmouth Dissertations
- Novel approaches to targeting innate immunity for cancer immunotherapy / by Patrick H. Lizotte
- Many kinds of cancer, and almost universally metastatic cancer, are refractory to treatment by conventional methods: surgery, radiation, and non-specific cytotoxic chemotherapy. The dawn of the age of personalized medicine presaged 15 years ago...
- Dartmouth Dissertations
- Structure, petrology, and U-Th-Pb geochronology in the Milford (15') quadrangle, New Hampshire.
- Petrology -- New Hampshire -- Milford. ; Geological time.
- Dartmouth Dissertations
- Building a better trap: the use of iron dithiocarbamate complexes in the in vivo and ex vivo detection and quantification of nitric oxide.
- Nitric oxide -- Analysis. ; Dithiocarbamates. ; Iron compounds. ; Organonitrogen compounds. ; Electron paramagnetic resonance spectroscopy.
- Nitric oxide is synthesized by living organisms and plays important roles in circulatory, neurological, and immune function. Nitric oxide can also play pathophysiological roles, depending on the amount of the molecule, the presence of other species...
- Dartmouth Dissertations
- Study of the molecular mechanism of the Neurospora circadian clock.
- Neurospora -- Genetics. ; Neurospora -- Effect of light on. ; Circadian rhythms. ; Proteins -- Synthesis -- Effect of light on. ; Genetic regulation.
- The frequency gene and the two proteins it encodes are central components of the Neurospora circadian clock. The frq message and proteins are involved in a negative feedback loop in which FRO represses its own transcript level. Based on this...
- Dartmouth Dissertations
- The role of CD154/CD40 interactions in the development and persistence of CD4+ T cell-mediated immunity.
- CD antigens. ; T cells -- Receptors. ; Tumors -- Immunological aspects. ; Mice -- Immunology. ; CD4-Positive T-Lymphocytes. ; Antigens CD40.
- The data presented herein demonstrate the requirement for CD154/CD40 in the development of experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis. Blockade of CD154/CD40 interactions causes a decrease in T cell and...
- Dartmouth Dissertations
- Differentiating and anti-inflammatory activities of the triterpenoid, CDDO: interactions with transcription factors PPARγ and NF-κ B.
- Triterpenoid saponins -- Physiology. ; Cell receptors. ; Receptor-ligand complexes. ; NF-kappa B (DNA-binding protein). ; Peroxisomes. ; Nucleophilic reactions. ; Dithiole.
- Dartmouth Dissertations
- Accurate K/Ar dating of and preservation of oxygen in zeolites.
- Zeolites. ; Potassium-argon dating. ; Isotope geology.
- Dartmouth Dissertations
- Studies on the syntheses of bis-pyridocarbazoles and derivatives of ellipticine.
- Pyridocarbazoles. ; Ellipticine. ; Cancer -- Research.
- Dartmouth Dissertations
- The role of CD40 and its ligand in transplant tolerance.
- CD antigens. T cells -- Receptors. Receptor-ligand complexes. Transplantation immunology. Immunological tolerance -- Molecular aspects. Antigens
- Voltage-dependent sodium channels (Na v ) are critical determinants of the ability of a neuron to generate and propagate action potentials. While a large family of Na v isoforms has been identified, the impact of specific isoforms on the electrical...
- Dartmouth Dissertations
- Si-Au Schottky barrier nuclear battery.
- Nuclear batteries.
- Dartmouth Dissertations
- Microstructural determinants in glacial ice.
- Ice -- Microstructure. Ice crystals -- Growth. Glaciers -- Composition. Paleoclimatology.
- Dartmouth Dissertations
- Chimeric NKG2D receptor expressing T cells as immunotherapy for cancer.
- T cells -- Receptors. Killer cells. Cell-mediated cytotoxicity. Cancer -- Immunotherapy.
- Despite advances in standard treatment options such as surgery, chemotherapy, and radiation, cancer remains the second leading cause of death in the United States. Moreover, many current therapies result in adverse effects. Therefore the...
- Dartmouth Dissertations
- Iron and sulfur mineralogy and redox transformations in soils and sediments: implications for trace metal dynamics.
- Soils -- Arsenic content. Arsenic wastes -- Biodegradation. Ferric hydroxides -- Biodegradation. Sulfides -- Metallurgy. Groundwater -- Arsenic content -- Cambodia.
- Iron minerals are ubiquitous in near surface environments and often readily sorb or coprecipitate with many trace metals. Transformations of iron phases are, therefore, integral to the fate of trace metals in most near surface aqueous regimes....
- Dartmouth Dissertations
- Re-programming tumor-infiltrating dendritic cells in situ via RNAi elicits therapeutic immunity against ovarian cancer.
- Ovaries -- Cancer -- Immunotherapy. Dendritic cells. Small interfering RNA. Nanoparticles -- Therapeutic use. Medical Term Ovarian Neoplasms -- therapy. RNA Interference.
- Current therapies for ovarian carcinoma are based on surgical debulking followed by chemotherapy. After more than three decades implementing treatments that selectively target the tumor cell, the 5-year survival rate for metastatic ovarian cancer...
- Dartmouth Dissertations
- Unraveling mechanisms underlying myeloid-derived suppressor cell orchestration of ovarian cancer progression
- Suppressor cells -- Cellular immunity. -- Interleukin-10 -- Pathophysiology -- Ovaries -- Cancer -- Immunological aspects. -- Myeloid cells -- immunology -- Ovarian Neoplasms -- immunology.
- Dartmouth Dissertations
- Modulating innate and adaptive immunity in the Toxoplasma gondii-induced model of inflammatory bowel disease.
- Toxoplasma gondii -- Immunology. Inflammatory bowel diseases -- Immunological aspects. C-reactive protein. T cells. Immune response -- Regulation. Protein precursors -- Immunology.
- Inbred C57BL/6 mice develop an acute necrotizing ileitis following oral infection with Toxoplasma gondii that is associated with massive inflammatory infiltrates and morphologic tissue changes consistent with human Crohn's disease. In the course of...
- Dartmouth Dissertations
- Magnetic nanoparticle hyperthermia as an adjuvant cancer therapy with chemotherapy / by Alicia Ailie Petryk.
- Magnetic nanoparticle-based hyperthermia for cancer treatment is a promising technology, particularly when applied as part of an adjuvant strategy with established cancer therapies (chemotherapy, radiation and surgery). In Europe, early clinical...
- Dartmouth Dissertations
- Endogenous leukocyte activation by chimeric antigen receptor T cell immunotherapy / by Paul Spear.
- Many protocols for adoptive T cell therapy (ACT) include preparative conditioning strategies to deplete host lymphocytes prior to T cell infusion. Total body irradiation and high-dose chemotherapy regimens not only relieve immunosuppression, but...
- Dartmouth Dissertations
- Chemico-physical and pharmacologic factors that influence delivery of IONPs to tumors in rodent breast cancer models / by Jennifer Tate.
- Nanoparticles have made significant advances in recent years in the realm of cancer therapy. These nanoparticles typically range in size from 10-250nm in diameter, allowing for differential systemic-based biodistribution. The enhanced permeability...
- Dartmouth Dissertations
- Characterization of the role of Bacillithiol in Staphylococcus aureus / by Ana Catalina Posada.
- As methicillin-resistant Staphylococcus aureus (MRSA) hospitalizations keep increasing, the understanding of the characteristics that make one isolate more successful over another is paramount. Strain variations among Staphylococcus aureus observed...
- Dartmouth Dissertations
- The synthesis and chemistry of novel cyclic perfluoromethyl-substituted molecules.
- Fluorine compounds.
- Dartmouth Dissertations
- SirT1 regulates vascular smooth muscle cell plasticity : implications for age-related cardiovascular disease / by Anne Marie Thompson.
- Loss of vascular smooth muscle cell function is a hallmark of vascular disease. Vascular smooth muscle cells become increasingly resistant to phenotypic modulation, apoptotic and senescent. Sirtuin 1 (SirT1) is a deactylase that regulates...
- Dartmouth Dissertations
- Understanding PDZ affinity and selectivity: all residues considered / by Jeanine F. Amacher.
- PDZ protein-protein interaction domains recognize short linear motif (SLiM) sequences typically at the extreme C-terminus of a target protein. These domains often act as scaffolds, connecting target proteins to additional interaction and catalytic...
- Dartmouth Dissertations
- Sex-specific interactions of anabolic androgenic steroids with voluntary exercise and chronic alcohol consumption on anxiety-like behaviors in mice (Mus musculus) / by Marie Morenike Onakomaiya.
- The overarching goal of this thesis was two-fold. First, to determine if the effects of chronic anabolic androgenic steroid (AAS) treatment on anxiety-like behaviors are sex-specific and second to determine how different environmental modulators...
- Dartmouth Dissertations
- Links and regulatory loops between phospholipase C activity and colonization by the O2-responsive regulator Anr in Pseudomonas aeruginosa / by Angelyca A. Jackson.
- Pseudomonas aeruginosa is a virulent opportunistic pathogen that is frequently cultured from infectious sites, and is estimated to cause ~12% of nosocomial infections worldwide [1]. P. aeruginosa infections occur in a majority of adults with the...
- Dartmouth Dissertations
- Thermodynamic and spectroscopic studies of metalloprotein stability ligation and reactivity / by George P. Lisi III.
- Metal ions confer structural stability and reactivity to a large number of proteins that use the amino acids histidine (His) and cysteine (Cys) to form stable metal-ligand complexes. The stability of metal-His and metal-Cys interactions and their...
- Dartmouth Dissertations
- Exercise and the brain : impacts on cognition neural function and mental health / by Andrea M. Robinson.
- It has been well established that physical exercise has broad impacts across the lifespan, including improved cognition, brain function, and mental health. Studies investigating the mechanism underlying the cognitive enhancing effect of exercise...
- Dartmouth Dissertations
- Novel techniques for the investigation of GPCR structure and function / by Joshua A. Weiner.
- G protein coupled receptors (GPCRs) make up somewhere between 30-50% of all current drug targets, yet the structural characterization of these receptors has been moderate at best. Until recently, structural data were almost nonexistent and...
- Dartmouth Dissertations
- Part I: synthetic approaches to the perfluorotropylium ion; Part II: a new, mild and selective dehydrohalogenating reagent.
- Fluorine.
- Dartmouth Dissertations
- Optical constants of ZnS and ZnS:Mn thin films from 1.5 eV to 3.2 eV as determined by transverse photothermal deflection spectroscopy.
- Thin films -- Optical properties. Zinc sulfide -- Spectra.
- Dartmouth Dissertations
- An electron paramagnetic resonance spectroscopic investigation of group 6 (Cr, Mo and W) transition metal complexes.
- Transition metal complexes. Electron paramagnetic resonance spectroscopy.
- Dartmouth Dissertations

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