Dartmouth Digital Library Program

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Analyses of SOS-type DNA repair processes in mammalian cells
DNA repair. ; Mammals -- Cytology. ; Mutagenesis
Dartmouth Dissertations

Immunotherapy of B-cell malignancies: directing T-cell responses and blocking lineage-specific survival factor pathways.
B cells -- Tumors. ; Cancer -- Immunotherapy. ; T cells. ; CD antigens.
The indolent B-cell malignancies of lymphoma and myeloma account for a great number of adult cancers in the United States annually. Hi-dose combination chemotherapy, bone marrow transplants and monoclonal antibody therapeutics have improved the...
Dartmouth Dissertations

Targeting G1 cyclins in cancer chemoprevention.
Bronchi -- Cancer -- Chemoprevention. ; Cyclins. ; Retinoids -- Therapeutic use. ; Cellular control mechanisms. ; G1 Phase.
Retinoids, natural and synthetic derivatives of vitamin A, are active in cancer treatment and chemoprevention. There is a need for an in-depth understanding of the mechanisms that account for retinoid response or resistance in lung cancer...
Dartmouth Dissertations

The importance of p53-dependent transcriptional responses in the differentiation and curability of human embryonal carcinoma.
Testis -- Cancer -- Genetic aspects. p53 antioncogene -- Regulation. Embryonal tumors -- Pathophysiology. Germ cells -- Tumors -- Pathophysiology. Cisplatin -- Mechanism of action. Tretinoin. Testicular Neoplasms -- in children. Neoplasms
Dartmouth Dissertations

5-AMINOLEVULINIC-INDUCED PROTOPORPHYRIN.
Brain tumors account for ~2% of all cancers, with gliomas accounting for ~70% of all brain tumors. Evidence suggests that extent of resection provides both a quality of life and survival benefit to patients. Recent work has shown the utility of...
Dartmouth Dissertations

The function of tumor associated leukocytes in ovarian cancer growth.
Leucocytes -- Pathophysiology. Immunosuppression. Ovaries -- Cancer -- Pathophysiology. Peritoneum -- Cancer -- Pathophysiology. Medical Term Ovarian Neoplasms -- physiopathology. Peritoneal Neoplasms -- physiopathology.
Immunosuppressive leukocytes are emerging as a critical factor in facilitating tumor progression. These leukocytes are converted by the tumor microenvironment to become tolerogenic, facilitate metastasis, and to aid in neo-vascularization. The...
Dartmouth Dissertations

Causes and consequences of DeltaNp63 expression in mammary epithelial progenitors.
Epithelium -- Tumors -- Genetic aspects. p53 antioncogene -- Regulation. Stem cells. Breast -- Cancer -- Genetic aspects. Breast -- Cancer -- Etiology. Medical Terms: TP63 protein, human; Tumor Suppressor Proteins -- genetics; Breast Neoplasms --...
Efforts to elucidate the events that account for breast cancer initiation have focused sharply on a small subset of mammary epithelial cells, referred to in this document at mammary stem cells, whose features may enable them to accumulate and...
Dartmouth Dissertations

MicroRNA-10b promotes pancreatic cancer cell invasion by suppressing TIP30 and enhancing EGF and TGF-[beta] actions / by Haoxu Ouyang
MicroRNA-10b (miR-10b) is considered a marker of disease aggressiveness in pancreatic ductal adenocarcinoma (PDAC), in view of the fact that lower levels of miR-10b are associated with better response to neoadjuvant therapy, likelihood of surgical...
Dartmouth Dissertations

Noninvasive fluorescence monitoring for functional assessment of murine glioma treatment.
Gliomas -- Immunotherapy -- Evaluation. Fluorescence spectroscopy. Diagnosis.
Molecular optical imaging in vivo has potential for functional assessment of tumor tissue at the cellular and subcellular level. Advances in biological understanding of genomics and proteomics have increased the knowledge of possible cellular...
Dartmouth Dissertations

The SERM, Arzoxifene, and the rexinoid, LG100268, cooperate to prevent estrogen receptor-positive and -negative breast cancer as well as colon cancer.
Estrogen -- Receptors -- Regulation. Selective estrogen receptor modulators. Receptor-ligand complexes. Breast -- Cancer -- Chemoprevention. Colon (Anatomy) -- Cancer -- Chemoprevention.
We have previously shown that the selective estrogen receptor modulator, Arzoxifene (Arz), and the rexinoid, LG100268 (268) synergistically prevent breast cancer in an ER+ breast cancer model. This study was designed to determine the mechanism of...
Dartmouth Dissertations

System and methodology for receptor-level fluorescence imaging during surgery / by Kristian Sexton.
Fluorescence molecular imaging will have an important clinical impact in the area of guided oncology surgery, where emerging technologies are poised to provide the surgeon with real-time molecular information to guide resection, using targeted...
Dartmouth Dissertations

The causes and consequences of regulation of [Delta]NP63[alpha] in mammary and breast cancer stem cells / by Andrew Joseph DeCastro.
Despite the array of targeted therapeutics that currently exist to combat breast cancer, disease progression leading to metastasis, and tumor recurrence still remains a significant clinical challenge. Efforts to identify novel pathways and...
Dartmouth Dissertations

Constitutively activated PI3K signaling accelerates tumor initiation and progression in breast and lung cancers / by Mee Rie Sheen.
Phosphatidylinositol 3-kinase (PI3K) is a major positive regulator of the PI3K signaling pathway that regulates many important cellular functions including growth, proliferation, survival, metabolism, and angiogenesis. The PIK3CA gene, encoding the...
Dartmouth Dissertations

Novel mechanisms of action of putative pro-apoptotic BH3 mimetics and their potential therapeutic use / by Ryan Scot Soderquist.
The BCL2 family of proteins control intrinsic apoptosis at the mitochondria through a delicate balance of pro and anti-apoptotic proteins. Anti-apoptotic proteins are frequently relied upon by cancer cells, making them ideal targets for...
Dartmouth Dissertations

Novel dimensions in a fluid genome : an integrative risk analysis for cancers of the bladder and breast / by Asaf Wyszynski.
The present thesis is focused on developing a better understanding of factors driving disease biology and overall risk using cancers of the bladder and breast as model systems. As no single approach was likely to unravel the complexities of these...
Dartmouth Dissertations

UCN-01: a protein kinase antagonist abrogating cell cycle checkpoint control.
Protein kinase C -- Antagonists. Cells -- Growth -- Regulation. Antineoplastic agents -- Mechanism of action.
Dartmouth Dissertations

Characterization of proteins that bind the conserved LVb and core sequences of mammalian type C retroviral enhancers.
Proteins. Protein binding. Mouse leukemia viruses. Retroviruses.
Dartmouth Dissertations

The identification of molecular targets of synthetic oleanane triterpenoids
Terpenes -- Mechanism of action. ; Protein kinases -- Inhibitors. ; Oleanolic Acid.
Synthetic oleanane triterpenoids (SO) are a novel class of therapeutic compounds based on the structure of oleanolic acid. These synthetic oleanane triterpenoids which include 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO), CDDO-methyl...
Dartmouth Dissertations

Modulation of CYPS: effect on acetaminophen hepatotoxicity.
Hepatotoxicology. ; Cytochrome P-450 -- Pathophysiology. ; Acetaminophen -- Toxicology. ; Alcohol -- Pathophysiology.
Cytochrome P450 (CYP) 2E1 is considered the sole CYP responsible for APAP bioactivation leading to hepatotoxicity. CYP2E1 is also considered the alcohol-inducible CYP and therefore, the sole CYP responsible for alcohol-mediated increases in APAP...
Dartmouth Dissertations

Microwave tomographic imaging using dielectric contrast in temperature and tissue content
Breast -- Cancer -- Tomography. ; Breast -- Cancer -- Imaging. ; Microwave imaging in medicine. ; Breast -- Electric properties. ; Breast Neoplasms -- diagnosis. ; Diagnostic Imaging -- methods.
Dartmouth Dissertations

The novel p53 target gene STK17A : implications for cancer therapy / by Pingping Mao
Testicular germ cell tumors (TGCTs) are highly curable with cisplatin-based therapy. The p53 tumor suppressor is induced in response to a variety of cellular stresses. Our previous work has implicated an important role for p53 in TGCT...
Dartmouth Dissertations

Targeting anaphase catastrophe through CDK inhibition in lung cancer / by Shanhu Hu
Aneuploidy is frequently detected in human cancers and is implicated in carcinogenesis. Pharmacological targeting of aneuploidy is an attractive therapeutic strategy, as this would preferentially eliminate malignant over normal cells. Our prior...
Dartmouth Dissertations

Wnt pathway activation by ADP-ribosylation / by Eungi Yang
Wnt/[beta]-catenin signaling directs metazoan development and is aberrantly activated in many cancers; however, effective inhibitors to treat Wnt-driven cancers have long been elusive. Following the recent discovery that the ADPribose polymerase...
Dartmouth Dissertations

Innate immune mechanisms contributing to LP-BM5 murine retroviral pathogenesis and immunodeficiency / by Megan Ashley O''Connor
LP-BM5 murine retroviral infection induces murine AIDS (MAIDS), and is characterized by profound and broad immunosuppression of T- and B-cell responses. Adaptive immune response to LP-BM5 infection, including the pathogenic role of CD4+ T-cells and...
Dartmouth Dissertations

Properties of Rathke's pouch.
Pituitary gland. ; Hypothalamus. ; Rats.
Dartmouth Dissertations

Rabbit genomic clones for synovial fibroblast collagenase: tools for understanding connective tissue disease.
Collagenases. ; Fibroblasts. ; Connective tissues -- Diseases -- Genetic aspects. ; Clone cells. ; Rabbits.
Dartmouth Dissertations

Bcl-2 family proteins and the regulation of apoptosis.
Apoptosis. ; Proteins. ; Cellular signal transduction. ; Proto-Oncogene Proteins c-bcl-2.
Apoptosis is induced by chemicals and death receptor activation. Although the stimuli are different, common proteins are activated downstream. The Bcl-2 family of proteins plays an important role in mediating apoptotic signaling at the mitochondria...
Dartmouth Dissertations

The role of core binding factor in the pathogenesis of the Moloney murine leukemia virus.
Retroviruses -- Pathogenesis. ; Virus diseases -- Pathogenesis. ; Genetic transcription -- Regulation. ; Viral genetics. ; Mouse leukemia viruses.
Dartmouth Dissertations

Regulation of the cystic fibrosis transmembrane conductance regulator by P-glycoprotein modulators.
Cystic fibrosis -- Chemotherapy. ; Cystic fibrosis -- Physiological aspects. ; P-glycoprotein. ; Membrane proteins -- Physiological transport. ; Cystic Fibrosis Transmembrane Conductance Regulator.
Dartmouth Dissertations

Investigation of trans-acting factors in AURE-mediated mRNA turnover.
Messenger RNA -- Metabolism. ; Trans-Activation (Genetics). ; RNA-protein interactions. ; Adenosine. ; Uridine. ; Lactate dehydrogenase. ; Genetic regulation. ; RNA-Binding Proteins. ; Protein processings Post-transcriptional. ; Hippel-Lindau...
Post-transcriptional pathways provide a major means of regulating eukaryotic gene expression. Reiterations of the AU-rich element (AURE) located within the 3' UTR of many labile cytokine and proto-oncogene mRNA serve as signals for rapid...
Dartmouth Dissertations

An examination of Raf-1 expression and kinase activity throughout the T lymphocyte cell cycle.
Proto-oncogenes. ; T cells. ; Phosphotransferases.
Dartmouth Dissertations

The role of BRCA1 in estrogen receptor-α regulation in breast cancer.
Breast -- Cancer -- Genetic aspects. ; Estrogen -- Receptors -- Regulation. ; Genetic transcription -- Regulation. ; BRCA1 Protein. ; Breast Neoplasms -- genetics. ; Gene Expression Regulation Neoplastic. ; Repressor Proteins.
Dartmouth Dissertations

Providing evidence and measurement tools to support health care reform in communities.
Community health services -- United States -- Evaluation. ; Health care reform -- United States. ; Medical care -- United States -- Evaluation. ; Evidence-based medicine.
Dartmouth Dissertations

A novel region in the collagenase promoter is involved in transcriptional activation and repression.
Collagenases. ; DNA-protein interactions.
Dartmouth Dissertations

Vasopressin gene expression by non-neuronal cells: production in the gastrointestinal system and neoplasms of the lung.
Vasopressin. ; Gene expression. ; Gastrointestinal system. ; Lungs -- Cancer. ; Immunocytochemistry.
Dartmouth Dissertations

Hedgehog signaling is a critical mediator for urinary bladder cancer.
Bladder -- Cancer -- Molecular aspects. ; Cellular signal transduction. ; Transcription factors -- Pathophysiology. ; Arsenic -- Carcinogenicity. ; Urinary Bladder Neoplasms -- genetics. ; Hedgehog Proteins.
The role of Hedgehog (HH) signaling in bladder cancer is controversial. The HH receptor and negative regulator Patched1 (PTCH1) resides on a region of chromosome 9q, one copy of which is frequently lost in bladder cancer. Inconsistent with PTCH1...
Dartmouth Dissertations

Solution structure determination of core binding factor ß(1-141) and map of CPFα binding site.
Transcription factors -- Structure. ; Genetic transcription. ; DNA-binding proteins.
Core binding factor (CBF) is a heterodimeric transcription factor that is essential for a number of developmental process including hemotopoiesis and bone development. CBFs contain a DNA-binding CBFα. subunit and a non-DNA binding CBFß. subunit...
Dartmouth Dissertations

Chromatin changes associated with the mammalian ß-globin switch.
Globin genes -- Expression. ; Chromatin. ; Epigenesis. ; DNA -- Methylation. ; Epigenesis.
Dartmouth Dissertations

A role for TP63 in breast cancer initiation.
Despite the availability of targeted therapies, breast cancer metastasis and recurrence remain clinically challenging problems. Understanding the function of stem cells in this disease may lead to identification of genetic pathways underlying...
Dartmouth Dissertations

Effects of mitomycin C and other DNA crosslinking agents on gene expression: modulation of cancer cell multidrug resistance in cell culture and in vivo.
Mitomycin C -- Genetic aspects. ; DNA damage. ; Drug resistance in cancer cells. ; Cancer -- Chemotherapy -- Genetic aspects.
Our laboratory is concerned whether the distribution of chemically-induced DNA damage is non-random at the level of individual genes. Using changes in gene expression as a marker for DNA damage, we have previously demonstrated that genotoxic...
Dartmouth Dissertations

Structural and functional characterization of Runx1 point mutations identified in leukemia and cleidocranial dysplasia patients.
Transcription factors -- Pathophysiology. Hematopoiesis -- Genetic aspects. Genetic transcription -- Regulation. DNA-binding proteins. Leukemia -- Genetic aspects. Core Binding Factor Alpha 2 Subunit. Core Binding Factor beta Subunit. Cleidocranial...
Core binding factors are heterodimeric transcription factors involved in diverse developmental processes. They consist of a DNA binding Runx subunit and a non-DNA binding CBFβ sub-unit. Runx proteins are encoded by three genes: Runx1, Runx2 , and...
Dartmouth Dissertations

HIF1A-mediated STAT3 activation promotes self-renewal and malignancy of stem-like cells derived from spontaneous murine glioma.
Stem cells. ; Cerebral anoxia. ; Genetic transcription -- Regulation. ; Gliomas. ; STAT3 Transcription Factor. ; Hypoxia-Inducible Factor 1 alpha Subunit.
Dartmouth Dissertations

Biochemical characterization of T-cell growth factor (TCGF).
T cells. ; Cell proliferation.
Dartmouth Dissertations

The regulation of gene expression by BRCA1 splice-variants in human mammary epithelial cells.
Antioncogenes. ; Genetic transcription -- Regulation. ; Mutation (Biology). ; Epithelial cells. ; Mammary glands -- Tumors. ; Proto-Oncogene Proteins. ; Breast Neoplasms -- genetics. ; BRCA1 Protein. ; Genes BRCA1 -- physiology.
Dartmouth Dissertations

The Spot 14 gene resides on the telomeric end of the 11q13 amplicon and is expressed in lipogenic breast cancers: implications for control of tumor metabolism.
Nucleoproteins. ; Fatty acids -- Synthesis -- Genetic aspects. ; Breast -- Cancer -- Genetic aspects. ; Gene amplification. ; Oncogenes.
Spot 14 (S14) is a ~17 KD nuclear protein that functions at the transcriptional level to regulate de novo synthesis of fatty acids in liver, brown and white adipose, and. lactating mammary tissues. Localization of the S14 gene to chromosome 11q13.5...
Dartmouth Dissertations

Post-translational modification in retinoid action: a role for UBEIL in cancer therapy and chemoprevention.
Retinoids -- Mechanism of action. ; Post-translational modification. ; Tretinoin -- Therapeutic use. ; Lungs -- Cancer -- Chemoprevention.
The retinoids--natural and synthetic derivatives of vitamin A--are active in cancer therapy and chemoprevention. The signals that underlie retinoid clinical activity are triggered by induction of retinoid target genes. Therefore, a greater...
Dartmouth Dissertations

The 4S polycyclic aromatic hydrocarbon-binding protein: isolation, characterization, and evidence for the modulation of cytochrome P-4501A1 gene expression.
Polycyclic aromatic hydrocarbons -- Genetics. ; Enzyme induction. ; Oxidation -- Genetics.
Dartmouth Dissertations

Growth regulation of rat hepatocytes by the liver tumor promoter ethinyl estradiol.
Ethinyl estradiol. ; Liver cells. ; Liver -- Growth.
Dartmouth Dissertations

Characterization of CTL responses to the murine AIDS defective retrovirus.
Retroviruses. ; AIDS (Disease). ; Mouse leukemia viruses. ; Diseases -- Causes and theories of causation. ; Antineoplastic antibiotics. ; MHC antibodies.
Dartmouth Dissertations

Large bowel polyps: aspects of epidemiology and diagnosis.
Intestine, Large -- Cancer -- Epidemiology. ; Intestine.
Colorectal cancer is the fourth most common cancer diagnosis and the second leading cause of cancer-related death in the United States. Most colorectal cancers are believed to develop from precursor lesions known as colorectal adenomas....
Dartmouth Dissertations

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