Up to 43% of patients with schizophrenia suffer from a co-occurring cannabis use disorder (CUD), which results in symptom exacerbation, decreased response to antipsychotic medication, and an overall worsening of disease course. Available treatments...
Recent studies demonstrating that eye position modulates auditory responses in a brainstem auditory structure and in primary auditory cortex (Groh et al., 2001; Werner-Reiss et al., 2003a), suggest preparation of the auditory signal for eventual...
Emergency medical response requires timely and efficient assessment and treatment of casualties. Mass casualty situations, in particular, strain the resources of emergency responders, prompting the need for a well-organized, effective, automated...
Human cancer is developed as the consequence of the activation of oncogenes and inactivation of tumor suppression genes. Modern sciences has identified and characterized the functions of such genes to understand the mechanism of cancer development...
The TP63 gene produces a series of transcription factors as a result of multiple promoter usage and alternative splicing. These protein products are members of the p53 family of transcription factors due to strong structural similarity with...
Neuroglia -- Effect of drugs on. Astrocytes. Opioids -- Physiological effect. Central nervous system -- Pathophysiology. Nerves
Neuropathic pain is a debilitating condition that affects millions of individuals worldwide. Unfortunately, opioids are only partially effective in treating neuropathic pain while entraining tolerance and a myriad of side effects from the high...
Autonomous off-road navigation in unstructured, terrain can encounter mobility difficulties even when the surface that the vehicle is driving over is level and free from obstacles. Mobility challenges result from soil characteristics that prevent...
Many organisms recognize and respond to categories: predator, prey, rival, or juvenile. Organisms recognize these ecologically-important categories by assessing diverse sensory stimuli. A primary focus of my research has been understanding how...
Testicular germ cell tumors (TGCTs) are highly curable with cisplatin-based therapy. The p53 tumor suppressor is induced in response to a variety of cellular stresses. Our previous work has implicated an important role for p53 in TGCT...
Actin filaments are integral to a large number of cellular structures. Due to the widespread use of actin, cells must rigorously control when and where new filaments assemble. Formin proteins are expressed in all eukaryotes and provide the...
Psychopaths. Personality and emotions. Emotions and cognition.
Research investigating clinical and criminal psychopaths is quite extensive. Though it has evolved in terminology over the years, the basic premise and description of psychopathy has maintained deficits associated with emotional interpretation and...
Core binding factors are heterodimeric transcription factors involved in diverse developmental processes. They consist of a DNA binding Runx subunit and a non-DNA binding CBFβ sub-unit. Runx proteins are encoded by three genes: Runx1, Runx2 , and...
Natural killer (NK) cells are innate immune cells which have been shown to kill tumors and cells infected with viruses. This knowledge however is based on studies carried out with natural killer cells isolated from blood. The female reproductive...
The placenta is the extra-embryonic tissue that mediates the exchange of oxygen and nutrients between the fetus and mother. It was shown that the placenta is a source of hematopoietic stem cells (HSCs). However, it is not known whether the placenta...
Endothelial cell migration is an important element of a number of biological processes, including angiogenesis. The fibroblast growth factors (FGFs) are a family of angiogenic heparan-binding proteins that potently induce endothelial migration....
The Wnt/β-catenin signaling pathway controls numerous biological processes from embryogenesis to adult homeostasis; aberrant Wnt signaling underlies a wide range of human diseases. In the absence of Wnt stimulation, a multiprotein “destruction...
Fluorescence molecular imaging will have an important clinical impact in the area of guided oncology surgery, where emerging technologies are poised to provide the surgeon with real-time molecular information to guide resection, using targeted...
Kynurenic acid (KYNA) is produced and released by astrocytes, and acts as an α7-nicotinic acetylcholine receptor antagonist (at lower, physiological concentrations) and an antagonist of the glycine site of the NMDA receptor (at higher,...
This research extends previous findings that the behavior of individuals high as compared to low in Private Self-consciousness, an individual difference in self-awareness, is more influenced by subtle primes. Manipulations of self-awareness were...
Hypertensive disorders, as well as congestive heart disease. Despite extensive research on the regulatory events that occur between aldosterone induced transcription and the early activation of epithelial sodium channels (ENaC ) in cortical...
Core Binding Factors (CBFs) are members of a small family of transcription factors that play critical roles in a number of mammalian developmental processes. CBFs are heterodimers consisting of a CBFα subunit, which contacts and binds DNA at the...
A nocturnal activity pattern is central to almost all hypotheses on the adaptive origins of primates but this view has been challenged recently on the basis of variation in the cone opsin genes of nocturnal primates. The diversity among primates in...
Drosophila melanogaster is a model organism often used when studying the complex processes of neuronal signaling and neurodegeneration. The short life cycle, malleable genetics, amenability to in vivo electrophysiological assays and sensitivity to...
From deciding what to eat first or what stock to invest in, the order in which we prefer to experience events and the amount of risk we are willing to undertake are factors that influence our choices. However, the mechanisms underlying order and...