One of the most distinctive aspects of humans as a species is our propensity to form complex social networks made up of intense, non-reproductive bonds with non-kin. Navigating these networks presents a considerable cognitive challenge that is...
Brain tissue mechanics are an important biomarker for neurological disorders, yet methods to obtain tissue information yield inconsistent conclusions. These techniques can be invasive or require excised tissue, where tissue function is altered from...
We have a limited understanding of how an opinion is originated, how an opinion and information supporting and explaining it gets conveyed, and how the communicated opinion is perceived and processed by others. One direction of current research...
Recent years have witnessed a new class of monitoring applications that need to continuously collect information from remote data sources. Those data sources, such as web click-streams, stock quotes, and sensor data, are often characterized as...
Visual searches for a conjunction of features (e.g., a particular combination of color and shape) are ordinarily slow and difficult. However, search efficiency for a particular conjunction can improve dramatically within a few hundred practice...
Two experiments were designed to investigate the effects of brain damage on source monitoring. Source monitoring is the process of making decisions about the origins of memories. Previous research has demonstrated that source monitoring judgments...
Developmental prosopagnosia (DP) is a neurodevelopmental disorder defined by impaired face recognition in the absence of brain damage, low-level visual deficits, or broad cognitive problems. Behavioral and neural findings suggest different types of...
Hedgehog (HH) proteins play an important and evolutionary conserved patterning role in metazoan development. Aside from this physiological role, pathologically HH proteins are implicated in human developmental disorders and post-developmental...
Gaze -- Psychological aspects. ; Facial expression. ; Body language.
The primary goal of the current research was to examine the effect of perceived gaze direction on the perception and processing of facially communicated emotion. There is good reason to believe that gaze direction and facial displays of emotion...
Behavior during interracial contact is sometimes positive but often negative. Previous work has examined individual differences, such as racial attitudes and motivations to respond without prejudice, as predictors of behavior during interracial...
Magnetoencephalography -- Technique.; Magnetic susceptibility.
The measurement of human brain function is the goal of many noninvasive medical imaging modalities. Two sources of physiological contrast are commonly targeted to achieve this goal. The most direct approach to measuring neuronal activity is with...
Traumatic brain injury (TBI) is the leading cause of acquired disability in children, yet innate repair mechanisms are incompletely understood. A possible innate mechanism to repair injury after insult is neurogenesis - the birth, migration,...
A fundamental question in decision neuroscience is how cognitive processes underlying decision-making give rise to efficient decisions, especially in complex situations with multiple choice options, and each option consisting of multiple attributes...
From deciding what to eat first or what stock to invest in, the order in which we prefer to experience events and the amount of risk we are willing to undertake are factors that influence our choices. However, the mechanisms underlying order and...
The present thesis is focused on developing a better understanding of factors driving disease biology and overall risk using cancers of the bladder and breast as model systems. As no single approach was likely to unravel the complexities of these...
Face perception -- Physiological aspects. Face perception -- Social aspects. Sex differences (Psychology). Neuropsychology.
The general objective of the current thesis was to investigate the neural substrates underlying the perception of opposite-sex faces. Building on what is already known about the distributed network of brain areas supporting various dimensions of...
Information retrieval -- Mathematical models. ; Electronic information resource searching. ; Computer algorithms. ; Decision making -- Data processing. ; Mathematical optimization.
This thesis presents a unified method for simultaneous solution of three problems in Information Retrieval--metasearch (the fusion of ranked lists returned by retrieval systems to elicit improved performance), efficient system evaluation (the...
Sex determination in C. elegans leads to the development of sex-specific structures and contributes to the regulation of sexually dimorphic programmed cell death. A search for factors that regulate the sexually dimorphic cell death of the...
As humans we create goals and strive toward ideals, engaging in a constant endeavor to better ourselves or maintain our success. Whether goals are distant hopes for the future, or small steps of change, success requires some control over...
Every moment of our waking lives, our brains filter large quantities of sensory data for goal relevant information. This ability to modulate our sensitivity to incoming inputs is critical in the face of an otherwise overwhelming world, and...
Herpes simplex virus-1 (HSV-1) establishes lifelong latent infections in the sensory neurons of the trigeminal ganglia (TG) wherein it retains the capacity to reactivate. The interferon (IFN)-driven antiviral response is critical for the control of...
When we want to know what others are thinking or feeling, we look to their face for clues. Affective neuroscience has usefully documented behavioral, psychophysiological and neural responses to the facial displays of others. Though this work...
Hematopoietic stem cells (HSCs) balance self-renewal with the continuous production of the suitable numbers of lineage-restricted progenitor cells. In this work we demonstrate that the Mixed lineage leukemia 1 (Mll1) gene is essential for this...
Functional neuroimaging has confirmed a high degree of localization of function in the cerebral cortex of man. In contrast, microstructural analysis has contributed very little to the topographical characterization of cortical areas. In this work I...
The motivational and rewarding properties of our immediate environment affect how humans interact with our world in a number of ways. One important aspect in which reward representation shapes behavior is in the development, maintenance and...
There is a long history of attempts to explain why music is perceived as expressive of emotion. Many of the acoustic parameters that are used to communicate emotion in music are also used in human vocal expressions of emotion, suggesting that the...
Human behavior -- Mathematical models. ; Web usage mining. ; Internet users.
Whom we e-mail, where we browse, what we purchase, and the things we search for on the World Wide Web all leave identifiable traces of who we are as individuals. In today's technology focused landscape, cyberspace represents the new environment in...
Radiculitis -- Endocrine aspects. Radiculitis -- Sex factors. Radiculitis -- Pathophysiology. Pain -- Sex factors. Progesterone -- Physiological effect. Cellular signal transduction. Neuregulin-1 -- physiology.
Chronic low back pain is a debilitating and devastating disease affecting millions of people worldwide. Considerable evidence indicates that there are sex-related differences in clinical and experimental pain sensitivity in men and women. Women...
Predictive control. Adaptive control systems -- Design. Airplanes -- Control systems.
A direct method to design data-based model predictive controllers is presented. The design method uses system identification techniques to identify model predictive controller gains directly from a set of excitation input and disturbance corrupted...
Microglia -- Effect of drugs on.
Morphine -- Physiological effect.
Purines -- Receptors.
Drug tolerance.
Cell culture -- Technique.
Medical Term Receptors, Purinergic P2 -- physiology.
Chronic pain is a debilitating condition which exacts severe emotional, physical and economic tolls on the millions of people who suffer from it worldwide. Opioids are a mainstay of acute, postoperative and cancer pain therapy, however, their use...
The studies described within the present dissertation build upon and extend the neuroimaging literature in the domains of imagery and semantic retrieval of perceptual memories. These investigations focus on the range of retrieval experiences--from...