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- The planar orotron: a metal grating coupled, millimeter wavelength radiation source.
- Millimeter wave devices.
- Dartmouth Dissertations
- Implementation, characterization, and applications of a scanning Kelvin probe force microscope.
- Scanning force microscopy. Scanning electron microscopes -- Design and construction. Semiconductors -- Analysis.
- Dartmouth Dissertations
- Methods for prevention of oral Toxoplasma gondii infection-induced hyperimmune response in mice.
- Toxoplasma gondii. ; Biological response modifiers. ; Immune response -- Regulation. ; Toxoplasmosis -- Immunotherapy. ; Interleukin-10 -- therapeutic use. ; Cholera Toxin -- therapeutic use. ; Anti-Inflammatory Agents -- therapeutic use.
- Dartmouth Dissertations
- Hepatic T cells and MDSCs in TGF-ß1-deficient mice.
- Chronic active hepatitis -- Pathogenesis. ; Suppressor cells. ; Transforming growth factors-beta. ; CD4-Positive T-Lymphocytes -- immunology. ; Transforming Growth Factor beta1 -- immunology.
- Autoimmune hepatitis (AIH) is an autoimmune liver disease characterized by immune-mediated necroinflammatory liver damage associated with CD4 + T cell infiltration in liver parenchyma. Despite advances in the understanding of AIH, its etiology...
- Dartmouth Dissertations
- Pre-clinical evaluation of the novel synthetic triterpenoid CDDO-imidazolide.
- Triterpenoid saponins -- Physiological effect. ; Triterpenoid saponins -- Mechanism of action. ; Triterpenoid saponins -- Therapeutic use. ; Imidazoles. ; Cancer cells -- Growth -- Regulation.
- 1[2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole (CDDO-lm) is a novel synthetic triterpenoid superior to its parent compound, 2-cyano-3, 12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO), both in vitro and in vivo. CDDO-Im is highly active in...
- Dartmouth Dissertations
- Peripheral and spinal mechanisms of neuropathic behaviors following peripheral nerve injury.
- Allodynia -- Animal models. ; Pain -- Physiological aspects. ; Nerves Peripheral -- Pathophysiology. ; Spinal cord -- Pathophysiology. ; Nerves.
- Dartmouth Dissertations
- Functions of prostacyclin in vascular and uterine smooth muscle.
- Prostacyclin -- Physiological effect. Vascular smooth muscle. Vascular endothelium -- Physiology. Myometrium -- Physiology. Cardiovascular system -- Diseases. Cellular signal transduction.
- Prostacyclin (PGI2) is a major product of COX-2 derived arachidonic acid metabolism in the endothelium and uterine myometrium. Evidence indicates that PGI 2 protects against development and progression of vascular disease. While it has been known...
- Dartmouth Dissertations
- Feasibility testing for magneto-optic ring cellular automata.
- Cellular automata. Magnetooptical devices -- Testing. Thin film devices -- Testing.
- The feasibility of a magnetic computation system was tested that consists of arranging thin film micromagnetic ring structures. Each ring is magnetized in a circular, vortex state in either the clockwise (CW) or counterclockwise (CCW) directions,...
- Dartmouth Dissertations
- Tectonics of the Pacific margin of Northern Central America
- Geology, Structural.; Geology -- Central America. ; Plate tectonics -- Pacific Coast (Central America)
- Dartmouth Dissertations
- The synthesis and chemistry of novel cyclic perfluoromethyl-substituted molecules.
- Fluorine compounds.
- Dartmouth Dissertations
- Sulfobetaines as novel inhibitors of squalene synthase. A model system for Δ4-3-ketosteroid isomerase.
- Cholesterol -- Synthesis. Enzymes -- Inhibition. Isomerases -- Synthesis.
- This thesis describes the synthesis of sulfobetaines having the general structure $\rm RN\sp{+}(CH\sb3)\sb2(CH\sb2)\sb{x}SO\sb{3\sp{-}}$ as novel inhibitors of squalene synthase. Squalene synthase reductively couples two molecules of farnesyl...
- Dartmouth Dissertations
- Characterization and rescue of a Drosophila model of prion disease; and The role of carcinine in signaling at the Drosophila photoreceptor synapse.
- Drosophila melanogaster -- Genetic aspects. Prion diseases. Neurotransmitters. Photoreceptors.
- Drosophila melanogaster is a model organism often used when studying the complex processes of neuronal signaling and neurodegeneration. The short life cycle, malleable genetics, amenability to in vivo electrophysiological assays and sensitivity to...
- Dartmouth Dissertations
- A novel role for visual arrestin in endocytosis-mediated retinal degeneration.
- Phospholipase C -- Mechanism of action. Retinal degeneration -- Pathophysiology. Retinal degeneration -- Genetic aspects. Endocytosis. Rhodopsin. Cellular signal transduction. Light -- Physiological effect. Arrestin. Clathrin. Adaptor Proteins
- Mutations in the Drosophila retinal-specific Phospholipase C (NORPA) cause massive retinal degeneration within five days of constant light exposure. We have previously shown that in norpA mutants persistent complexes between the light receptor...
- Dartmouth Dissertations
- The role of CD40 in cutaneous and regional immune responses.
- CD antigens. ; Immune response -- Regulation. ; T cells -- Receptors. ; Antigens CD40. ; Lymphoma.
- Dartmouth Dissertations
- In vitro and in vivo assessment of endothelium-derived relaxing factor during pregnancy in the ra.
- Nitric oxide.
- Dartmouth Dissertations
- Mode-locking in a grating coupled oscillator.
- Mode-locked lasers. ; Free electron lasers. ; Laser pulses Ultrashort.
- Dartmouth Dissertations
- Non-resonant photon absorption by reactive chemical systems.
- Lasers in chemistry. ; Zinc. ; Oxidation-reduction reaction.
- Dartmouth Dissertations
- Synthesis and reactivity of terminal platinum(II) phosphido complexes: application to the platinum-catalyzed asymmetric hydrophosphination of acrylonitrile.
- Organoplatinum compounds -- Synthesis. ; Organoplatinum compounds -- Reactivity. ; Organophosphorus compounds -- Synthesis. ; Organophosphorus compounds -- Reactivity. ; Acrylonitrile.
- Dartmouth Dissertations
- Pharmacologic induction of human fetal hemoglobin through activation of the NRF2 antioxidant response signaling pathway
- Pharmacologic induction of fetal hemoglobin (HbF) has proven therapeutic potential for ß-hemoglobinopathy patients. Increased HbF reduces disease severity by decreasing sickling in sickle cell disease and reducing α-chain imbalance in...
- Dartmouth Dissertations
- Magnetic nanoparticle hyperthermia as an adjuvant cancer therapy with chemotherapy / by Alicia Ailie Petryk.
- Magnetic nanoparticle-based hyperthermia for cancer treatment is a promising technology, particularly when applied as part of an adjuvant strategy with established cancer therapies (chemotherapy, radiation and surgery). In Europe, early clinical...
- Dartmouth Dissertations
- Silicon/silicon-germanium quantum dots with single-electron transistor charge sensors / by Mingyun Yuan.
- Si/SiGe quantum dots (QDs) are promising candidates for spin-based quantum bits (qubits) as a result of the reduced spin-orbit coupling as well as the Si isotopes with zero nuclear spin. Meanwhile qubit readout is a challenge related to...
- Dartmouth Dissertations
- Studies of equilibrium and dynamic properties of polymers.
- Polymers. Chemical equilibrium.
- Dartmouth Dissertations
- Magnetic susceptibility imaging of magnetic nanoparticles / by Bradley W. Ficko.
- Magnetic susceptibility imaging of magnetic nanoparticles (mNPs) has many potential applications in biomedicine such as contrast enhanced imaging and image guidance for magnetic hyperthermia therapy. This thesis describes three imaging methods...
- Dartmouth Dissertations
- Modulation of swarming motility in Pseudomonas aeruginosa / by Dae Gon Ha.
- Swarming motility is a flagella-dependent surface motility, and is also a form of bacterial group behavior. Similar to its counterpart biofilm formation, our understanding of swarming motility has been hampered by its complex set of requirements...
- Dartmouth Dissertations
- Molecularly imprinted polymer and applications in nicotine sensing / by Yuan Liu.
- Chemical sensing and separation is a constant challenge intriguing many scientists. Through numerous efforts, revolutionary techniques and innovative materials have been successfully developed to solve this old problem. However, a practical but...
- Dartmouth Dissertations
- Nd, Sr and O isotopic study of midcrustal granitoid petrogenesis within the Acadian central Maine terrane.
- Petrology -- Maine. Granite -- Maine. Isotope geology -- Maine.
- Dartmouth Dissertations
- The chemistry of clay minerals associated with evaporites in New York and Utah.
- Clay minerals -- Composition. Chlorites. Evaporites -- New York (State). Evaporites -- Utah.
- Dartmouth Dissertations
- Synthetic studies of ellipticine alkaloids and structurally related compounds.
- Alkaloids -- Synthesis.
- Dartmouth Dissertations
- From nonmetal- and metal-chalcogen nanoclusters to chalcogenide nanotubes.
- Chalcogenides. Nanotubes. ; Nanostructured materials.
- A double-acceleration stage linear time of flight mass spectrometer (TOF MS) with Nd/YAG laser ablation cluster source was designed and constructed for cluster production, study and deposition. Cumulenic polycarbons SC n S ( n = 2-27) were...
- Dartmouth Dissertations
- Novel syntheses of polycyclic aromatic hydrocarbons.
- Aromatic compounds. ; Polycyclic compounds. ; Diels-Alder reaction.
- Dartmouth Dissertations
- Synthetic approaches to indolo[2,3-a]quinolizine alkaloids.
- Indole alkaloids -- Synthesis.
- Dartmouth Dissertations
- Approaches to the synthesis of sarpagine alkaloids.
- Alkaloids. ; Sarpagine.
- Dartmouth Dissertations
- Novel approaches to targeting innate immunity for cancer immunotherapy / by Patrick H. Lizotte
- Many kinds of cancer, and almost universally metastatic cancer, are refractory to treatment by conventional methods: surgery, radiation, and non-specific cytotoxic chemotherapy. The dawn of the age of personalized medicine presaged 15 years ago...
- Dartmouth Dissertations
- Density functional theory study of transition metal doped chalcogenides / by Stefano Poggio
- The main driving force behind the development of computers was the attempt to solve problems that would otherwise require a large amount of time to be solved. Despite the technological development that has made computers ubiquitous in daily lives,...
- Dartmouth Dissertations
- A benzonorbornyl model system for the study of carbocation-[pi] interactions.
- Carbocations -- Reactivity. ; Aromatic compounds -- Reactivity.
- An important mode of stabilization of cations in biochemical reactions is interaction with the π systems-of aromatic residues. As part of an investigation of the interaction of carbocations with aromatic π systems, a study of various model...
- Dartmouth Dissertations
- Identification and characterization of two mutants that affect Drosophila phototransduction.
- Drosophila. Photoreceptors. TRP channels. Cellular signal transduction.
- The phototransduction cascade in Drosophila is a prototypical G-protein signaling pathway and many of its components have been well-studied. Early genetic screens identified many of the major proteins involved in this pathway and study over the...
- Dartmouth Dissertations
- Building a better trap: the use of iron dithiocarbamate complexes in the in vivo and ex vivo detection and quantification of nitric oxide.
- Nitric oxide -- Analysis. ; Dithiocarbamates. ; Iron compounds. ; Organonitrogen compounds. ; Electron paramagnetic resonance spectroscopy.
- Nitric oxide is synthesized by living organisms and plays important roles in circulatory, neurological, and immune function. Nitric oxide can also play pathophysiological roles, depending on the amount of the molecule, the presence of other species...
- Dartmouth Dissertations
- Residential indoor and outdoor air pollution.
- Air -- Pollution. ; Indoor air pollution. ; Air -- Pollution -- Measurement.
- The polycyclic aromatic hydrocarbon (PAH) content of ambient air at several locations is described. The indoor sites examined included those having woodstoves, fireplaces, and kerosene heaters as supplements to oil heat, as well as one test home...
- Dartmouth Dissertations
- Characterization and modeling of the charge distribution in silicon/silicon-germanium/silicon P-channel MOSFETs.
- Metal oxide semiconductor field-effect transistors -- Computer simulation. ; Metal oxide semiconductor field-effect transistors -- Testing. ; Electric charge and distribution. ; Silicon. ; Germanium. ; Heterostructures.
- Dartmouth Dissertations
- Study of the molecular mechanism of the Neurospora circadian clock.
- Neurospora -- Genetics. ; Neurospora -- Effect of light on. ; Circadian rhythms. ; Proteins -- Synthesis -- Effect of light on. ; Genetic regulation.
- The frequency gene and the two proteins it encodes are central components of the Neurospora circadian clock. The frq message and proteins are involved in a negative feedback loop in which FRO represses its own transcript level. Based on this...
- Dartmouth Dissertations
- The role of CD154/CD40 interactions in the development and persistence of CD4+ T cell-mediated immunity.
- CD antigens. ; T cells -- Receptors. ; Tumors -- Immunological aspects. ; Mice -- Immunology. ; CD4-Positive T-Lymphocytes. ; Antigens CD40.
- The data presented herein demonstrate the requirement for CD154/CD40 in the development of experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis. Blockade of CD154/CD40 interactions causes a decrease in T cell and...
- Dartmouth Dissertations
- Dose dependent effects of sodium arsenite on NF-κB and interleukin-8 in bronchial epithelial cells.
- Epithelial cells. ; NF-kappa B (DNA-binding protein). ; Interleukin-8. ; Arsenic compounds -- Physiological effect.
- Dartmouth Dissertations
- Bimolecular and intramolecular fluorescence quenching of an amine by a nitrile: Solution properties and chain structure of poly(1-olefin sulfone)s.
- Amines. ; Nitriles. ; Sulfones. ; Alkenes.
- Dartmouth Dissertations
- The macromolecular assembly of NuMA.
- Nucleoproteins. ; Macromolecules. ; Cell organelles -- Formation. ; Mitosis. ; Phosphorylation.
- Dartmouth Dissertations
- Differentiating and anti-inflammatory activities of the triterpenoid, CDDO: interactions with transcription factors PPARγ and NF-κ B.
- Triterpenoid saponins -- Physiology. ; Cell receptors. ; Receptor-ligand complexes. ; NF-kappa B (DNA-binding protein). ; Peroxisomes. ; Nucleophilic reactions. ; Dithiole.
- Dartmouth Dissertations
- Ultrastructure and histochemistry of the cellular stomach and gastric gland of female Asplanchna sieboldi and of the rudimentary gut of male Asplanchna sieboldi.
- Rotifera.
- Dartmouth Dissertations
- Isotopic phase separation in dilute solid mixtures of Helium-4 in Helium-3.
- Helium -- Isotopes. ; Isotope separation.
- Dartmouth Dissertations
- $Stark-geometry photorefractive multiple quantum well spatial light modulators.$
- Stark-geometry photorefractive multiple quantum well spatial light modulators.
- Light modulators -- Mathematical models. ; Quantum wells. ; Photorefractive materials. ; Optoelectronic devices -- Mathematical models.
- Stark-geometry photorefractive multiple quantum well (PR-MQW) spatial light modulators (SLMs) show promise for several optoelectronic applications such as high-speed image correlation and real-time 3-D holographic imaging. Their performance is...
- Dartmouth Dissertations
- Organometallic chemistry with perfluorinated ligands. Investigation of group 8-10 metal complexes derived from octafluorocyclooctatetraene (OFCOT).
- Organometallic chemistry. ; Ligands.
- Dartmouth Dissertations
- Preparation of sterically hindered bis(secondary phosphines) : structure-selectivity relationships in Pt-catalyzed asymmetric phosphination and synthesis and structure of metal-phosphido complexes.
- Phosphorus compounds -- Synthesis. ; Metal complexes -- Synthesis. ; Phosphine. ; Phosphides. ; Platinum catalysts. ; Asymmetric synthesis. ; Gold compounds -- Synthesis.
- Dartmouth Dissertations

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