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- Metabolic Engineering of Thermoanaerobacterium saccharolyticum and Thermoanaerobacterium thermosaccharolyticum for n-butanol production / by Ashwini Bhandiwad.
- The increasing demand for transportation energy coupled with the need to reduce carbon emissions for a sustainable future are driving forces to develop alternative fuels. One promising alternative to petroleum is conversion of lignocellulosic...
- Dartmouth Dissertations
- Cellular and molecular effects of chromium on the activity and expression of fibrinolytic proteins in epithelial cells.
- Chromium -- Therapeutic use. ; Fibrinolysis. ; Epithelial cells. ; Pulmonary fibrosis.
- Transition metals play critical roles in biological systems as essential components of metalloproteins and metalloenzymes, as diagnostic probes and pharmaceuticals, and in some instances, as sources of toxicity. Cellular concentrations vary...
- Dartmouth Dissertations
- Reactor design considerations for the conversion of particulate biomass to ethanol.
- Bioreactors -- Design and construction. Alcohol as fuel. Biomass energy.
- Dartmouth Dissertations
- Hepatic toxicity and compensatory hyperplasia in a rat model of aflatoxin bi-induced liver cancer
- Liver -- Cancer -- Etiology. Hepatotoxicology. Aflatoxins -- Toxicology. Taurine. Liver -- Cancer -- Animal models.
- A hypothesis that chronic aflatoxin Bi- (AFBi) induced hepatotoxicity and the resulting compensatory cell proliferation are critical for the growth of preneoplastic lesions was investigated. A commonly utilized protocol which consists of 10 doses...
- Dartmouth Dissertations
- Glucocorticoids and interferons regulate the expression of a novel human mononuclear phagoctye-specific antigen.
- Antigens. ; Immune response -- Regulation. ; Glucocorticoids -- Physiological effect.
- Dartmouth Dissertations
- Regulation of human type I Fc[gamma] receptor by interferon-[gamma] and dexamethasone.
- Fc receptors. ; Cellular control mechanisms. ; Interferon. ; Dexamethasone.
- Dartmouth Dissertations
- The roles of glutathione and ascorbate in chromium (VI)-induced carcinogenesis in vivo.
- Chromium -- Toxicity testing. ; Glutathione. ; Vitamin C -- Physiological effect. ; Carcinogenesis. ; DNA damage.
- Chromium(VI) is a human carcinogen and causes DNA damage following reduction by intracellular reductants. In order to explore the effects of intracellular reductants on the carcinogenicity of Cr(VI), the roles of glutathione and ascorbate in...
- Dartmouth Dissertations
- The sexually dimorphic effects of prolactin on food intake by rats.
- Prolactin. ; Rats -- Feeding and feeds. ; Sexual dimorphism (Animals).
- Dartmouth Dissertations
- The role of brain serotonin in afferent and efferent inhibitory processes.
- Serotonin.
- Dartmouth Dissertations
- Investigation of the human monocyte receptors CD163 and CD64.
- Cell receptors. Fc receptors. Monocytes. Immune response -- Regulation. Proteins -- Immunology. Receptors
- Monocytes and macrophages play a key role in a number of immune functions including inflammation, antigen presentation and the clearance of microorganisms and free hemoglobin. Two surface receptors which are important for these functions are CD163...
- Dartmouth Dissertations
- Simultaneous saccharification and co-fermentation of paper sludge.
- Cellulose -- Biodegradation. Zymomonas mobilis -- Biotechnology. Saccharomyces cerevisiae -- Biotechnology. Fermentation. Hydrolysis. Biomass conversion -- Mathematical models.
- Production of fuel ethanol from cellulosic materials is a potentially attractive way to meet sustainability, energy security, and environmental goals. However, the high cost of processing using current technology has thus far prevented...
- Dartmouth Dissertations
- The role of gut commensals in regulating susceptibility to acute liver damage / by Stela Celaj.
- Liver disease of different etiologies confers significant morbidity and mortality and hence it constitutes a major health concern worldwide. Stemming from a range of causes, such as viral, drug-induced, alcoholic, or autoimmune, the rate of...
- Dartmouth Dissertations
- Characterization of two S. Cerevisiae genes implicated in mRNA export: RAT7, encoding a novel nuclear pore complex protein and NPL3, encoding a putative hnRNP protein.
- Messenger RNA -- Genetic aspects. Proteins -- Synthesis -- Genetic aspects. Saccharomyces cerevisiae -- Genetics.
- Dartmouth Dissertations
- A study of neutral amino acid and drug transport in slices from human and rabbit placentae.
- Placenta; Maternal-fetal exchange.
- Dartmouth Dissertations
- An investigation of the thiosulfate-mediated metabolism of cyanide in the perfused liver and musculature of the rat.
- Cyanides -- Metabolic detoxification. ; Thiocyanates. ; Thiosulfates.
- Dartmouth Dissertations
- The relationship between the apomorphine and the narcotic receptors of the emetic chemoreceptor trigger zone of the cat.
- Emetics. ; Apomorphine. ; Morphine.
- Dartmouth Dissertations
- Bethanechol and central respiratory control.
- Bethanechol. ; Anesthetics.
- Dartmouth Dissertations
- Hydrothermal pretreatment of cellulosic biomass for bioconversion to ethanol.
- Alcohol as fuel. ; Cellulose -- Biotechnology. ; Hot water. ; Steam. ; Biomass energy.
- Dartmouth Dissertations
- Fragmentation of hemicellulose during pretreatment: the predicted effect of sulfuric acid on sugar release selectivity.
- Hemicellulose -- Biodegradation. Lignin -- Biodegradation. Biomass chemicals. Sulfuric acid. Hydrolysis.
- Dartmouth Dissertations
- A study of neutral amino acid and drug transport.
- Placenta. ; Maternal-fetal exchange.
- Dartmouth Dissertations
- The role of hepatic Mitochondrial thiosulfate: cyanide sulfurtransferase and serum albumin in cyanide detoxication.
- Cyanides -- Toxicology. ; Thiocyanates. ; Serum albumin.
- Dartmouth Dissertations
- Dose dependent effects of sodium arsenite on NF-κB and interleukin-8 in bronchial epithelial cells.
- Epithelial cells. ; NF-kappa B (DNA-binding protein). ; Interleukin-8. ; Arsenic compounds -- Physiological effect.
- Dartmouth Dissertations
- Impacts of arid land shrub expansion on soil carbon cycling from [superscript 14]C ages and carbon and oxygen isotope ratios of pedogenic calcite and organic matter.
- Desertification -- New Mexico. ; Humus -- New Mexico. ; Carbon cycle (Biogeochemistry). ; Calcite.
- Dartmouth Dissertations
- Conversion of paper sludge to ethanol and analysis of selection based strain improvement for recombinant Saccharomyces cerevisiae expressing saccharolytic enzymes through continuous culture.
- Cellulase -- Biotechnology. ; Hydrolysis. ; Paper industry -- Technological innovations. ; Biomass energy -- Economic aspects. ; Saccharomyces cerevisiae -- Genetics. ; Enzymes -- Industrial applications.
- Paper sludge is the largest solid waste stream produced by pulp and paper industry, and is also an attractive feedstock for emergent technologies based on processing of cellulosic biomass featuring enzymatic hydrolysis. This study focuses on...
- Dartmouth Dissertations
- Biochemical analysis of stimulus-secretion coupling in permeabilized mast cells.
- Cellular signal transduction. ; Secretion. ; Mast cells.
- Dartmouth Dissertations
- The effects of acute exposure to hypoxia on physiological tremor in humans.
- Anoxemia. ; Tremor.
- Dartmouth Dissertations
- Regulation of matrix metalloproteinase gene expression by a synthetic rexinoid.
- Metalloproteinases -- Inhibitors -- Mechanism of action. Collagenases -- Inhibitors -- Mechanism of action. Receptor-ligand complexes. Extracellular matrix proteins. Matrix Metalloproteinases.
- The irreversible destruction of the tissues that comprise synovial joints is the hallmark of both rheumatoid arthritis and osteoarthritis. In both diseases, inflammatory cytokines, such as interleukin-1β, stimulate the production of matrix...
- Dartmouth Dissertations
- Consolidated bioprocessing and liquid hot water pretreatment for the production of ethanol from cellulosic substrates.
- Cellulose -- Biotechnology. ; Alcohol as fuel. ; Compressed water.
- Dartmouth Dissertations
- Fundamentals of microbial cellulose utilization by the thermophilic bacterium Clostridium thermocellum.
- Clostridium -- Biotechnology. ; Cellulose -- Biodegradation. ; Thermophilic bacteria. ; Hydrolysis.
- The thermophilic anaerobic bacterium Clostridium thermocellum has attracted researchers attention because of its potential industrial application and high cellulose hydrolysis rates. This study focuses on the physiological fundamentals of C....
- Dartmouth Dissertations
- Differential response in p53 wild-type cells to p53 activation by DNA damage and Nutlin-3
- DNA damage induces cell cycle arrest through both Chk1 and the p53 tumor suppressor protein, the latter arresting cells through induction of p21waf1 protein. Arrest permits cells to repair the damage and recover. The frequent loss of p53 in tumor...
- Dartmouth Dissertations
- Understanding the vulnerabilities of tumors : a network-based approach to drug target discovery / by Nadia M. Penrod.
- The demand for novel molecularly targeted drugs will continue to rise as we make progress toward personalizing cancer treatments to the molecular signatures of individual tumors. While the collection and analysis of genomic data has become routine,...
- Dartmouth Dissertations
- Magnetic nanoparticle hyperthermia as an adjuvant cancer therapy with chemotherapy / by Alicia Ailie Petryk.
- Magnetic nanoparticle-based hyperthermia for cancer treatment is a promising technology, particularly when applied as part of an adjuvant strategy with established cancer therapies (chemotherapy, radiation and surgery). In Europe, early clinical...
- Dartmouth Dissertations
- Estradiol regulation of innate immune protection in the human female reproductive tract / by Mickey Vinay Patel.
- Estradiol is a key regulator of immune protection in the female reproductive tract (FRT). Its concentration varies during the menstrual cycle, leading to changes in innate immune protection. In this thesis, I demonstrate the multiple levels at...
- Dartmouth Dissertations
- Endogenous leukocyte activation by chimeric antigen receptor T cell immunotherapy / by Paul Spear.
- Many protocols for adoptive T cell therapy (ACT) include preparative conditioning strategies to deplete host lymphocytes prior to T cell infusion. Total body irradiation and high-dose chemotherapy regimens not only relieve immunosuppression, but...
- Dartmouth Dissertations
- Brain repair after trauma : birth and migration of immature neurons after focal traumatic brain injury in piglets and human children / by Sabrina Rose Taylor.
- Traumatic brain injury (TBI) is the leading cause of acquired disability in children, yet innate repair mechanisms are incompletely understood. A possible innate mechanism to repair injury after insult is neurogenesis - the birth, migration,...
- Dartmouth Dissertations
- Evaluation and engineering of Saccharomyces cerevisiae for cellulase expression and growth on insoluble cellulose.
- Saccharomyces cerevisiae -- Genetics. Cellulase -- Biotechnology. Cellulose -- Biotechnology. Biomass conversion -- Technological innovations.
- Dartmouth Dissertations
- Performance decrement following insolvable problems: learned helplessness or failure anxiety?
- Failure (Psychology);Helplessness (Psychology)
- Dartmouth Dissertations
- Identification of the glucose transport system in purified rat adipose cell plasma membranes
- Glucose -- Metabolism. Insulin -- Physiological effect.
- Dartmouth Dissertations
- Examining functional variation in oncogene biology : the role of somatic mutations and germline variation on c-Myc and c-Myb / by Scott Andrew Turner.
- The identification and characterization of functional genetic variation is essential for future advances in molecular diagnostics, pharmacogenomics, and personalized medicine. Recent attempts at identifying nucleotide level variation (somatic...
- Dartmouth Dissertations
- The SERM, Arzoxifene, and the rexinoid, LG100268, cooperate to prevent estrogen receptor-positive and -negative breast cancer as well as colon cancer.
- Estrogen -- Receptors -- Regulation. Selective estrogen receptor modulators. Receptor-ligand complexes. Breast -- Cancer -- Chemoprevention. Colon (Anatomy) -- Cancer -- Chemoprevention.
- We have previously shown that the selective estrogen receptor modulator, Arzoxifene (Arz), and the rexinoid, LG100268 (268) synergistically prevent breast cancer in an ER+ breast cancer model. This study was designed to determine the mechanism of...
- Dartmouth Dissertations
- Novel mechanisms of action of putative pro-apoptotic BH3 mimetics and their potential therapeutic use / by Ryan Scot Soderquist.
- The BCL2 family of proteins control intrinsic apoptosis at the mitochondria through a delicate balance of pro and anti-apoptotic proteins. Anti-apoptotic proteins are frequently relied upon by cancer cells, making them ideal targets for...
- Dartmouth Dissertations
- Exercise and the brain : impacts on cognition neural function and mental health / by Andrea M. Robinson.
- It has been well established that physical exercise has broad impacts across the lifespan, including improved cognition, brain function, and mental health. Studies investigating the mechanism underlying the cognitive enhancing effect of exercise...
- Dartmouth Dissertations
- Metabolic engineering of catabolic product metabolism in thermophilic bacteria.
- Thermophilic bacteria -- Metabolism. Thermophilic bacteria -- Genetics. Thermophilic bacteria -- Biotechnology. Cells
- Metabolic engineering of the catabolic end-product metabolism of Thermoanaerobacterium saccharolyticum was initiated. T. saccharolyticum is an anaerobic, thermophilic bacterium that utilizes xylans and xylose, the second most prominent sugar after...
- Dartmouth Dissertations
- A role for membrane fusion in the activation of the respiratory burst in human neutrophils.
- Membrane fusion. Oxidases. Neutrophils.
- Dartmouth Dissertations
- Studies on hepatic uroporphyrinogen oxidation and its role in the uroporphyria caused by polyhalogenated aromatic hydrocarbins.
- Porphyrins -- Oxidation. Aromatic compounds. Hydrocarbons.
- Dartmouth Dissertations
- An evaluation of adrenergic and sympathetic influences modulating behavior in an animal model of neuropathic pain.
- Neuralgia -- Animal models. Allodynia -- Animal models. Adrenergic mechanisms. Sympathetic nervous system.
- Dartmouth Dissertations
- Nocturnality and defense in the rat: selective association of light and aversive stimulation.
- Rats -- Behavior. Nocturnal animals. Defensiveness (Psychology). Aversive stimuli.
- Dartmouth Dissertations
- UCN-01: a protein kinase antagonist abrogating cell cycle checkpoint control.
- Protein kinase C -- Antagonists. Cells -- Growth -- Regulation. Antineoplastic agents -- Mechanism of action.
- Dartmouth Dissertations
- Role of genetic and endocrinological factors in the regulation of rat serum dopamine-beta-hydroxylase activity.
- Dopamine.
- Dartmouth Dissertations
- Characterization of the monosaccharide transport system of the thioglycollate-elicited mouse peritoneal macrophage and in vitro actions of glucocorticoids on macrophage growth, glucose metabolism, and monosaccharide transport
- Glucose -- Metabolism. Macrophages. Glucocorticoids. Mice
- Dartmouth Dissertations

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