The circadian clock of the filamentous fungus, Neurospora crassa, consists of a frequency-white-collar ( frq-wc ) based and transcription-translation-derived oscillator. Negative feedback regulation is essential for the oscillatory process, in...
The great strength of the C-F bond has enabled fluorocarbons to find many industrial and domestic applications, and makes C-F activation a chemical and technical challenge akin to that of C-H bond activation in hydrocarbons. In our mission to...
Visual pigments. ; Cellular signal transduction. ; Rhodopsin. ; G proteins. ; Phosphorylation. ; Photoreceptors. ; Retinal degeneration.
Arrestins are regulatory proteins that participate in the termination of G protein-mediated signal transduction. The major arrestin in the Drosophila visual system, Arrestin 2 (Arr2), has been demonstrated to be essential for the termination of the...
Phospholipase C -- Mechanism of action. Retinal degeneration -- Pathophysiology. Retinal degeneration -- Genetic aspects. Endocytosis. Rhodopsin. Cellular signal transduction. Light -- Physiological effect. Arrestin. Clathrin. Adaptor Proteins
Mutations in the Drosophila retinal-specific Phospholipase C (NORPA) cause massive retinal degeneration within five days of constant light exposure. We have previously shown that in norpA mutants persistent complexes between the light receptor...
Electron donor-acceptor complexes. ; Complex compounds. ; Photochemistry.
In this study we have utilized spectroscopic and photoconductivity techniques to investigate free ion formation in the fumaronitrile/trans-stilbene charge transfer-complex. We report free ion yields resulting from the direct excitation of this...
Part I. A photoprecursor for difluorocarbene . The goal of this research was to develop a more practical and efficient photoprecursor for difluorocarbene. The first approach was concerned with the synthesis of 4,4-difluoropyrazoline-3,5-dione ( 5...
Retinitis Pigmentosa is an inherited retinal degenerative disorder, initiated by point mutations on the rhodopsin gene. This thesis set forth to understand the mechanism of this pathogenesis, as well as to further improve our understanding of...
This thesis reports work on a new device to detect changes in spatially nonuniform intensity distributions, and shows how this device can be applied to the particular problem of optical vibration detection. The phase of optical radiation is very...
Part 1 . A computational study targeting the lowest energy structure, electronic state and physical properties of small carbon clusters containing one or two heteroatoms has been done. The structural properties sought included whether the most...
Retinal degeneration -- Genetic aspects. Photoreceptors -- Molecular aspects. Cell death.
Endocytosis.
Rhodopsin.
NF-kappa B (DNA-binding protein)
Cellular signal transduction.
In humans, progressive loss of vision accompanies many inherited retinal degenerative disorders. In many cases, the affected genes are known. However the molecular pathway of photoreceptor cell death is still elusive. In this thesis, I describe the...