Dartmouth Digital Library Program

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A computational study of radio relics in galaxy cluster mergers / by Dane Patrick Owen.
Radio relics are extended regions of synchrotron radio emission that have been found in the outskirts of a few dozen galaxy clusters. Relics are often associated with clusters undergoing merger activity. They are not associated optically with a...
Dartmouth Dissertations

Laying a solid foundation for Manhattan : 'setting the functional basis for the post-GWAS era' / by Xiaoyang Zhang
Genome-wide association studies (GWAS) have identified more than 8,900 genetic variants, mainly single nucleotide polymorphisms (SNPs), associated with hundreds of human traits and diseases, which define risk-associated loci (Hindorff et al., 2012 ...
Dartmouth Dissertations

Identification of the glucose transport system in purified rat adipose cell plasma membranes
Glucose -- Metabolism. Insulin -- Physiological effect.
Dartmouth Dissertations

Role of the Menin-MLL1 interaction in normal hematopoiesis and leukemia / by Bin Li.
Leukemia represents a small percentage of human cancer, accounting for about 5% of all cases of cancer in adults, but, interestingly, for about 50% of all cases of cancer in children. The behavior of leukemia is often regulated by the chromosomal...
Dartmouth Dissertations

Identification and characterization of signaling pathways underlying the tumorigenic activity of [Delta]Np63[alpha] in breast cancer stem cells / by Amanda Lynn Balboni.
Studies presented in this dissertation focus on the transcriptional targets and cellular functions of [Delta]Np63[alpha], the predominant TP63 isoform expressed in epithelial stem cell compartments. TP63, a member of the p53 family of...
Dartmouth Dissertations

Small molecule modulation of morphology and metabolism in Candida albicans / by Allia Kaye Smith
Candida albicans is a fungal species that naturally exists as a commensal member of the human microbiota, but can assume a pathogenic lifestyle and subsequently induce life-threatening systemic infections. The ability of the fungus to grow in...
Dartmouth Dissertations

A role for membrane fusion in the activation of the respiratory burst in human neutrophils.
Membrane fusion. Oxidases. Neutrophils.
Dartmouth Dissertations

Excitation transfer in strain-induced quantum wires and dots.
Semiconductors -- Optical properties. Quantum wells. Quantum electronics.
Quantum wires and dots can be created by patterning inhomogeneous strain on semiconductor quantum wells. I have used laser spectroscopic methods to study the carrier transfer from the host quantum well to quantum wires and dots. For quantum dot...
Dartmouth Dissertations

Studies on hepatic uroporphyrinogen oxidation and its role in the uroporphyria caused by polyhalogenated aromatic hydrocarbins.
Porphyrins -- Oxidation. Aromatic compounds. Hydrocarbons.
Dartmouth Dissertations

Origin of epithermal Ag-Au-Cu-Pb-Zn mineralization on the Veta Madre, Guanajuato, Mexico.
Hydrothermal deposits -- Mexico -- Guanajuato (State). Ore deposits -- Mexico -- Guanajuato (State). Las Rayas Mine (Mexico).
Dartmouth Dissertations

Isolation and characterization of QCR9 the nuclear gene encoding the 7.3 kDa subunit 9 of the Saccharomyces cerevisiae bc1 complex.
Oxidoreductases. Cytochrome c. Saccharomyces cerevisiae.
Dartmouth Dissertations

Solute transport in snowpack and isotopic variations of a snowpack and its melt.
Snow -- Composition. Snow -- Mathematical models. Runoff. Hydrogen -- Isotopes. Oxygen -- Isotopes. Radioactive tracers.
Snowmelt from seasonal snow covers can be significant in many environments of northern and alpine areas. Water flow and chemical transport resulting from snowmelt have been studied for an understanding of contributions to watersheds or catchments....
Dartmouth Dissertations

Studies in the role of ubiquinone in the microbicidal events of neutrophils
Ubiquinones. Neutrophils.
The oxygen-dependent microbicidal events of neutrophils have been studied with reference to the triggering of the respiratory burst and with particular emphasis on the role of quinone. Ubiquinone as well as a previously described cytochrome b were...
Dartmouth Dissertations

Reconstitution and partial purification of acyl-coenzyme A:cholesterol acyltransferase and investigations of the enzyme's activity in cultured cells after reconstitution in lipid vesicles.
Acyltransferases. Esterification. Cholesterol -- Metabolism.
Dartmouth Dissertations

The occurrence of amino acid activating enzymes and transfer RNA in rat liver mitochondria.
Mitochondria. Enzymes. ; Rats.
Dartmouth Dissertations

Cerenkov radiation in dielectric-loaded waveguides.
Cherenkov radiation.
Dartmouth Dissertations

Structural, functional, and biochemical approaches to understanding the role of the C1 microtubule of the flagellar central apparatus.
Microtubules. Dynein. ; Eukaryotic cells -- Motility.
The eukaryotic flagellum is a complex organelle that uses the force generated by dynein motors to cause beating motion of the flagellum. The central apparatus of eukaryotic flagella has been implicated in the regulation of dynein-driven motility....
Dartmouth Dissertations

Bilingual and monolingual brains compared: a fMRI study of semantic processing.
Bilingualism -- Physiological aspects. ; Neurolinguistics. Cognition -- Physiological aspects. ; Brain -- Localization of functions.
Does early and sustained experience with two languages in childhood modify how language is processed in the adult bilingual brain? Does extensive exposure to two languages influence language processing in the bilingual brain as compared to...
Dartmouth Dissertations

Experiment planning for protein structure elucidation and site-directed protein recombination.
Proteins -- Structure -- Computer simulation -- Experiments. ; Amino acid sequence -- Data processing -- Experiments. Protein engineering -- Experiments. ; Recombinant proteins -- Mathematical models.
In order to most effectively investigate protein structure and improve protein function, it is necessary to carefully plan appropriate experiments. The combinatorial number of possible experiment plans demands effective criteria and efficient...
Dartmouth Dissertations

Modulation of CYPS: effect on acetaminophen hepatotoxicity.
Hepatotoxicology. ; Cytochrome P-450 -- Pathophysiology. ; Acetaminophen -- Toxicology. ; Alcohol -- Pathophysiology.
Cytochrome P450 (CYP) 2E1 is considered the sole CYP responsible for APAP bioactivation leading to hepatotoxicity. CYP2E1 is also considered the alcohol-inducible CYP and therefore, the sole CYP responsible for alcohol-mediated increases in APAP...
Dartmouth Dissertations

Mechanisms by which arsenite decreases CYP3A.
Cytochrome P-450 -- Pathophysiology. ; Cytochrome P-450 -- Genetics. ; Arsenic compounds -- Physiological effect. ; Liver cells.
Arsenic is implicated in numerous human pathologies, including cancer and several forms of liver disease. One contributing mechanism may involve alterations of CYP levels by arsenic. CYP3As are the most abundant CYP proteins in human liver and...
Dartmouth Dissertations

Exploring the role of CD4 T cell help in the generation of CD8+T cell responses against acute and persistent viral infections
T cells -- Receptors. ; Immunologic memory. ; CD8-Positive T-Lymphocytes -- immunology. ; CD4-Positive T-Lymphocytes -- immunology. ; Vaccinia virus -- immunology. ; Herpesviridae Infections -- immunology.
Dartmouth Dissertations

Allosteric modulation of GABAa receptors by anabolic-androgenic steroids.
GABA -- Receptors. Allosteric regulation. ; Anabolic steroids -- Physiological effect. ; Androgens -- Physiological effect. ; Receptors
Anabolic-androgenic steroids (AAS) are synthetic derivatives of the gonadal hormone, testosterone. Despite their many untoward side effects, AAS are wildly abused for their ergogenic properties. AAS have numerous effects on many organ systems,...
Dartmouth Dissertations

The planar orotron: a metal grating coupled, millimeter wavelength radiation source.
Millimeter wave devices.
Dartmouth Dissertations

Comparison of the Torpedo and mammalian postsynaptic 43K protein and its relationship to the nicotinic acetylcholine receptor.
Nicotinic receptors. ; Acetylcholine -- Receptors. ; Neuromuscular transmission. ; Myoneural junction. Proteins.
Dartmouth Dissertations

The role of mitochondria in chromium carcinogenesis.
Chromium. Carcinogens. ; Mitochondria.
Dartmouth Dissertations

An analysis of the locomotive stimulant and the ECoG effects of L-DOPA.
L-dihydroxphelylalanine. ; Amphetamines.
Dartmouth Dissertations

Regeneration studies of a single indentifiable motoneuron in the crayfish Procambarus Clarkii.
Motor neurons. ; Nervous system -- Regeneration. ; Crayfish.
Dartmouth Dissertations

Forebrain mechanisms of conditional hypoalgesia: involvement of the amygdala.
Analgesia. ; Amygdaloid body.
Dartmouth Dissertations

Emergent coherent structures in nonequilibrium field theory.
Coherent states. Quantum field theory. Nonlinear theories.
In this thesis we study the properties of time-dependent, nontopological configurations and their effect on the macroscopic properties of a system described by a nonlinear field theory. These structures seem to be ubiquitous in relativistic field...
Dartmouth Dissertations

Characterization of the human erythrocyte monosaccharide transport system.
Erythrocytes. ; Biological transport. ; Cell membranes. ; Monosaccharides.
Dartmouth Dissertations

Two new methods for 2,3-pyridyne formation.
Pyridine -- Synthesis. ; Alkaloids -- Synthesis.
Many alkaloids of biological importance have the 11H-pyrido (4,3,2-mn) acridine ring structure such as cystodytin and amphimedine. It would be desirable to find an effective way to synthesize a wide variety of these compounds using a single...
Dartmouth Dissertations

Neuronal interferon signaling : implications for HSV-1 replication and pathogenesis / by Pamela Rosato
Herpes simplex virus-1 (HSV-1) establishes lifelong latent infections in the sensory neurons of the trigeminal ganglia (TG) wherein it retains the capacity to reactivate. The interferon (IFN)-driven antiviral response is critical for the control of...
Dartmouth Dissertations

Reciprocal benefits in a plant-pollinator mutualism.
Mutualism (Biology). Insect-plant relationships. Insect population density. Bumblebees -- Ecology. Delphinium -- Ecology.
Mutualisms may facilitate coupled population expansion or decline if changes in either partner species lead to similar changes in the other species. However, few studies have measured how both species in a mutualism respond to changes in each...
Dartmouth Dissertations

Novel approaches to targeting innate immunity for cancer immunotherapy / by Patrick H. Lizotte
Many kinds of cancer, and almost universally metastatic cancer, are refractory to treatment by conventional methods: surgery, radiation, and non-specific cytotoxic chemotherapy. The dawn of the age of personalized medicine presaged 15 years ago...
Dartmouth Dissertations

A study of neutral amino acid and drug transport in slices from human and rabbit placentae.
Placenta; Maternal-fetal exchange.
Dartmouth Dissertations

CD8+ T cell responses to acute and chronic viral infections governed by costimulatory signals and CD4 help.
T cells. T cells -- Receptors. CD antigens. CD4 antigen. Immunologic memory. Herpesvirus diseases -- Immunological aspects. Vaccinia. CD8-Positive T-Lymphocytes -- immunology. CD4-Positive T-Lymphocytes -- immunology. Herpesviridae Infections --...
The phenomenon of immunological memory has been known for thousands of years. This knowledge has been applied to vaccination, which has resulted in a dramatic reduction in the number of deaths due to infectious diseases. Immunological memory is...
Dartmouth Dissertations

A proteomics approach to NIMA-related kinase signaling in mitosis / by Sierra N. Cullati
NIMA-related kinases (Neks) control several aspects of cell division downstream of master mitotic regulators such as Cdk1 and Plk1. Though depletion of Nek6, Nek7, or Nek9 results in cytokinesis failure, to date no molecular mechanism has been...
Dartmouth Dissertations

Constraint-based robot knot tying / by Weifu Wang
In this thesis, we present different approaches to tying knots using robots by enforcing different types of constraints. We attack the problem from three different directions; mechanical design, motion planning with simple control strategies, and...
Dartmouth Dissertations

Regulation of Wnt/Wingless signaling by the ADP-ribose polymerase Tankyrase / by Zhenghan Wang
The Wnt/β-catenin signaling pathway controls numerous biological processes from embryogenesis to adult homeostasis; aberrant Wnt signaling underlies a wide range of human diseases. In the absence of Wnt stimulation, a multiprotein “destruction...
Dartmouth Dissertations

Algorithmic problems arising in posets and permutations / by Shahrzad Haddadan
Partially ordered sets and permutations are combinatorial structures having vast applications in theoretical computer science. In this thesis, we study various computational and algorithmic problems related to these structures. The first chapter of...
Dartmouth Dissertations

Implications of motion planning : optimality and K-survivability / by Yu-Han Lyu
We study motion planning problems, finding trajectories that connect two configurations of a system, from two different perspectives: optimality and survivability. For the problem of finding optimal trajectories, we provide a model in which the...
Dartmouth Dissertations

Identification and characterization of two mutants that affect Drosophila phototransduction.
Drosophila. Photoreceptors. TRP channels. Cellular signal transduction.
The phototransduction cascade in Drosophila is a prototypical G-protein signaling pathway and many of its components have been well-studied. Early genetic screens identified many of the major proteins involved in this pathway and study over the...
Dartmouth Dissertations

An investigation of the thiosulfate-mediated metabolism of cyanide in the perfused liver and musculature of the rat.
Cyanides -- Metabolic detoxification. ; Thiocyanates. ; Thiosulfates.
Dartmouth Dissertations

The purification and partial characterization of a reconstitutively active iron-sulfur protein.
Cytochrome c. ; Iron-sulfur proteins. ; Proteins -- Analysis.
Dartmouth Dissertations

Investigation of the molecular basis of directed particle movement in the squid giant axon.
Axonal transport. ; Molecular dynamics. ; Squids.
Dartmouth Dissertations

Chemistry of P-H bonds at metal centers.
Organophosphorus compounds -- Synthesis. ; Phosphine. ; Transition metal compounds.
Dartmouth Dissertations

Vibrio cholerae pathogenesis: molecular mechanisms of colonization.
Vibrio cholerae -- Molecular genetics. ; Bacteria -- Adhesion. ; Virulence (Microbiology). ; Cholera -- Pathogenesis. ; Pili (Microbiology).
Vibrio cholerae is a gram-negative bacterial pathogen that causes the severe diarrheal disease cholera. Several bacterial factors have been identified that are critical for V. cholerae intestinal colonization. The best characterized of these...
Dartmouth Dissertations

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