Dartmouth Digital Library Program

Thumbnail

Title

Subject

Description

Collection

Advancement of magnetic resonance poroelastography for applications in brain imaging / by Adam J. Pattison.
Brain tissue mechanics are an important biomarker for neurological disorders, yet methods to obtain tissue information yield inconsistent conclusions. These techniques can be invasive or require excised tissue, where tissue function is altered from...
Dartmouth Dissertations

Endogenous leukocyte activation by chimeric antigen receptor T cell immunotherapy / by Paul Spear.
Many protocols for adoptive T cell therapy (ACT) include preparative conditioning strategies to deplete host lymphocytes prior to T cell infusion. Total body irradiation and high-dose chemotherapy regimens not only relieve immunosuppression, but...
Dartmouth Dissertations

A framework of computational opinions / by Fei Yu.
We have a limited understanding of how an opinion is originated, how an opinion and information supporting and explaining it gets conveyed, and how the communicated opinion is perceived and processed by others. One direction of current research...
Dartmouth Dissertations

Alterations in the production of bacteriochlorophyll a and okenone in purple sulfur bacteria : implications for the interpretaion of their biomarkers / by Derek A. Smith.
Purple sulfur bacteria (PSB) can dominate the nitrogen, carbon, and sulfur cycles in anoxic ecosystems via their anoxygenic photosynthetic metabolisms and are the only producers of the carotenoid, okenone, a biomarker targeted for photic zone...
Dartmouth Dissertations

Brain repair after trauma : birth and migration of immature neurons after focal traumatic brain injury in piglets and human children / by Sabrina Rose Taylor.
Traumatic brain injury (TBI) is the leading cause of acquired disability in children, yet innate repair mechanisms are incompletely understood. A possible innate mechanism to repair injury after insult is neurogenesis - the birth, migration,...
Dartmouth Dissertations

Tectonics of the Pacific margin of Northern Central America
Geology, Structural.; Geology -- Central America. ; Plate tectonics -- Pacific Coast (Central America)
Dartmouth Dissertations

The ecology and bioenergetics of the northern black-throated blue warbler.
Wood warblers.
Dartmouth Dissertations

The representation of size information in semantic memory.
Memory. Size perception. Semantics.
Dartmouth Dissertations

Lighting and optical tools for image forensics.
Image analysis. Image processing -- Digital techniques. Photography -- Retouching. Photographs -- Forgeries. Lighting. Optics. Forensic sciences.
We present new forensic tools that are capable of detecting traces of tampering in digital images without the use of watermarks or specialized hardware. These tools operate under the assumption that images contain natural properties from a variety...
Dartmouth Dissertations

Quantitative study of perceptual vector analysis.
Vector analysis. Motion perception (Vision)
Dartmouth Dissertations

Understanding PDZ affinity and selectivity: all residues considered / by Jeanine F. Amacher.
PDZ protein-protein interaction domains recognize short linear motif (SLiM) sequences typically at the extreme C-terminus of a target protein. These domains often act as scaffolds, connecting target proteins to additional interaction and catalytic...
Dartmouth Dissertations

The RNA binding landscape of the histone stem-loop binding protein / by Lionel (Lee) Brooks 3rd.
RNA binding proteins are fundamental components of crucial biological processes in all domains of life. The development of techniques to study RNA binding protein complexes is, therefore, broadly impactful. I employed multiple genome-wide...
Dartmouth Dissertations

The causes and consequences of regulation of [Delta]NP63[alpha] in mammary and breast cancer stem cells / by Andrew Joseph DeCastro.
Despite the array of targeted therapeutics that currently exist to combat breast cancer, disease progression leading to metastasis, and tumor recurrence still remains a significant clinical challenge. Efforts to identify novel pathways and...
Dartmouth Dissertations

Constitutively activated PI3K signaling accelerates tumor initiation and progression in breast and lung cancers / by Mee Rie Sheen.
Phosphatidylinositol 3-kinase (PI3K) is a major positive regulator of the PI3K signaling pathway that regulates many important cellular functions including growth, proliferation, survival, metabolism, and angiogenesis. The PIK3CA gene, encoding the...
Dartmouth Dissertations

Late glacial and holocene fluctuations of local glaciers and the Greenland Ice Sheet eastern and western Greenland / by Laura B. Levy.
The Greenland Ice Sheet (GrIS) is responding sensitively to climate change and its meltwater has the potential to influence global sea level. Recently, large changes in the GrIS have occurred including increased velocities of outlet glaciers and...
Dartmouth Dissertations

The role of gut commensals in regulating susceptibility to acute liver damage / by Stela Celaj.
Liver disease of different etiologies confers significant morbidity and mortality and hence it constitutes a major health concern worldwide. Stemming from a range of causes, such as viral, drug-induced, alcoholic, or autoimmune, the rate of...
Dartmouth Dissertations

Links and regulatory loops between phospholipase C activity and colonization by the O2-responsive regulator Anr in Pseudomonas aeruginosa / by Angelyca A. Jackson.
Pseudomonas aeruginosa is a virulent opportunistic pathogen that is frequently cultured from infectious sites, and is estimated to cause ~12% of nosocomial infections worldwide [1]. P. aeruginosa infections occur in a majority of adults with the...
Dartmouth Dissertations

Targeting CFTR endocytic interactions as a therapeutic strategy in cystic fibrosis / by Lemira Sahar Al Ayyoubi.
Despite the recent FDA approval of the potentiator drug Kalydeco for treatment of cystic fibrosis (CF), only a small (3-5%) portion of patients benefit from this drug. Other functional classes of drugs including correctors are under clinical...
Dartmouth Dissertations

Sexual selection and sexual conflict in Anolis lizards : from molecules to populations / by M. Catherine Duryea.
Sexual selection is a driver of biodiversity and creates spectacular forms of variation. However, only recently have we begun to understand how this variation operates on the postcopulatory level and how cryptic mechanisms affect male-male...
Dartmouth Dissertations

Modulation of swarming motility in Pseudomonas aeruginosa / by Dae Gon Ha.
Swarming motility is a flagella-dependent surface motility, and is also a form of bacterial group behavior. Similar to its counterpart biofilm formation, our understanding of swarming motility has been hampered by its complex set of requirements...
Dartmouth Dissertations

Shared decision making for people with severe mental illness.
Mentally ill -- Care -- Decision making. Mental illness -- Treatment -- Decision making. Mental health services -- Decision making. Mental health -- Information services. Medical informatics. Mental Disorders -- drug therapy.
Objective. We explored preferences and perceptions about treatment decision-making roles among persons with severe mental illness and evaluated two computer-based medication values clarification tools. Methods. In this study we conducted a pilot...
Dartmouth Dissertations

The bedrock geology of the Gilmanton 15-minute Quadrangle, New Hampshire.
Geology -- New Hampshire -- Gilmanton Quadrangle.
Dartmouth Dissertations

Importance of nest predation to avian population regulation and community structure in a northern hardwoods fores
Bird populations -- New Hampshire; Predation (Biology); Birds -- Nests; Black-throated blue warbler; Chipmunks; Tamiasciurus hudsonicus
Dartmouth Dissertations

Nd, Sr and O isotopic study of midcrustal granitoid petrogenesis within the Acadian central Maine terrane.
Petrology -- Maine. Granite -- Maine. Isotope geology -- Maine.
Dartmouth Dissertations

Habitat selection by breeding black-throated blue warblers: different patterns at two spatial scales and the use of habitat for foraging and nesting.
Black-throated blue warbler -- Habitat. Black-throated blue warbler -- Behavior. Black-throated blue warbler -- Food. Black-throated blue warbler -- Nests.
Dartmouth Dissertations

The effect of suspended sediments on planktonic rotifers and cladocerans.
Freshwater zooplankton -- Effect of sediments on. Rotifera. Cladocera.
Dartmouth Dissertations

Serpentine/chlorite and illite/smectite in the Tuscaloosa formation: origins, chemistry, mineralogic structures, and oxygen isotope compositions.
Silicate minerals -- Louisiana. Silicate minerals -- Mississippi. Formations (Geology) -- Louisiana. Formations (Geology) -- Mississippi.
Dartmouth Dissertations

The bedrock geology of the Holderness quadrangle, New Hampshire.
Geology -- New Hampshire -- Holderness Quadrangle.
Dartmouth Dissertations

Dendritic cell Fcγ receptor expression and function
Fc receptors. Dendritic cells. Immune recognition.
Three types of Fc receptors for IgG, FcyRI (CD64), FcyRII (CD32), and FcyRIII (CD 16) are expressed differentially on blood leukocytes. In particular, CD64 and CD32 are constitutively expressed on mononuclear phagocytes of the human myeloid system....
Dartmouth Dissertations

Activation of vascular endothelial cells in response to mineral fibers.
Asbestosis -- Pathophysiology. Asbestosis -- Molecular aspects. Pulmonary endothelium -- Genetic aspects. Endothelium -- Effect of asbestos on. Fibers -- Toxicology.
Dartmouth Dissertations

Brittle failure of columnar S2 ice under triaxial compression.
Ice mechanics. Compressibility. Fracture mechanics. Strains and stresses. Brittleness.
This work describes the effect of triaxial compressive confinement on the strength of columnar S2 ice loaded under conditions leading to brittle failure. Cubes of columnar S2 ice were tested at -10 °C under triaxial (proportional) loading where...
Dartmouth Dissertations

Origin of epithermal Ag-Au-Cu-Pb-Zn mineralization on the Veta Madre, Guanajuato, Mexico.
Hydrothermal deposits -- Mexico -- Guanajuato (State). Ore deposits -- Mexico -- Guanajuato (State). Las Rayas Mine (Mexico).
Dartmouth Dissertations

Solute transport in snowpack and isotopic variations of a snowpack and its melt.
Snow -- Composition. Snow -- Mathematical models. Runoff. Hydrogen -- Isotopes. Oxygen -- Isotopes. Radioactive tracers.
Snowmelt from seasonal snow covers can be significant in many environments of northern and alpine areas. Water flow and chemical transport resulting from snowmelt have been studied for an understanding of contributions to watersheds or catchments....
Dartmouth Dissertations

Causes of tree mortality in wave-regenerated balsam fir forests
Balsam fir. Trees -- Physiology.
Fir waves are spatially and temporally repeating patterns of stand development and destruction in subalpine, balsam fir-dominated forests of the northeastern United States, perpetuated by downwind migration of strips of dying trees, "dieback...
Dartmouth Dissertations

Laser-based oxygen isotopic studies of Acadian metamorphism in eastern Vermont.
Metamorphism (Geology) -- Vermont. Garnet -- Vermont. Laser spectroscopy.
This study presents δ18O analyses of garnets microsampled by laser fluorination from two localities in the deep seated, Barrovian metamorphic terrane of eastern Vermont. The broad goals of the research were to constrain further the amount,...
Dartmouth Dissertations

A frequency analysis of the tidal volume controller in CO2 regulation in decerebrate cats with peripheral denervations.
Respiration. Carbon dioxide in the body.
Dartmouth Dissertations

Identification and regulation of a circadian clock protein, FRQ, and a clock-controlled protein, CCG-1, in Neurospora crassa.
Circadian rhythms. Proteins -- Synthesis -- Effect of light on. Genetic regulation. Neurospora crassa -- Reproduction -- Effect of light on. Neurospora crassa -- Genetics.
To understand how the circadian clock can temporally organize a cell, the biochemical characterization of a clock protein, FRQ, was initiated in Neurospora crassa using immunochemical techniques. FRQ accumulated in constant light to maximum levels...
Dartmouth Dissertations

The chemistry of clay minerals associated with evaporites in New York and Utah.
Clay minerals -- Composition. Chlorites. Evaporites -- New York (State). Evaporites -- Utah.
Dartmouth Dissertations

Solution chemistry of a New Hampshire subalpine ecosystem.
Forest ecology -- New Hampshire. Solution (Chemistry).
Dartmouth Dissertations

The chronology and stratigraphic evolution of the Kashmir and Peshawar intermontane basins, northwestern Himalaya.
Geology, Stratigraphic. Geology -- India -- Kashmir Vale of. Geology -- Pakistan -- Peshawar.
Dartmouth Dissertations

Detection of hydrocarbons and hydrocarbon microseepage in the Bighorn Basin, Wyoming using isotopic, biogeochemical, and spectral reflectance techniques.
Hydrocarbons -- Secretion. Petroleum -- Geology -- Bighorn Basin (Mont. and Wyo.). Natural gas -- Geology -- Bighorn Basin (Mont. and Wyo.). Isotope geology -- Bighorn Basin (Mont. and Wyo.). Sagebrush -- Bighorn Basin (Mont. and Wyo.) -- Analysis....
Dartmouth Dissertations

Dielectric properties of moist soils at RF and microwave frequencies.
Soils -- Electric properties. Soil moisture -- Measurement. Dielectrics.
Dartmouth Dissertations

Stratigraphy, structure, and petrology of the Peterborough 15-minute quadrangle, New Hampshire; and Part II. Graphite textural and isotopic variations in plutonic rocks, south-central New Hampshire.
Geology -- New Hampshire -- Peterborough Quadrangle. Geology Stratigraphic. Geology.
Dartmouth Dissertations

The identification of molecular targets of synthetic oleanane triterpenoids
Terpenes -- Mechanism of action. ; Protein kinases -- Inhibitors. ; Oleanolic Acid.
Synthetic oleanane triterpenoids (SO) are a novel class of therapeutic compounds based on the structure of oleanolic acid. These synthetic oleanane triterpenoids which include 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO), CDDO-methyl...
Dartmouth Dissertations

Host-epibiont population dynamics.
Daphnia pulex -- Ecology. ; Epibiosis. Host-parasite relationships. ; Euglenoids -- Ecology.
Regulatory linkage between epibiotic organisms and their host zooplankton populations is one of the least understood topics in zooplankton biology, despite the likely importance of epibionts to pelagic communities. These laboratory studies with...
Dartmouth Dissertations

Experiment planning for protein structure elucidation and site-directed protein recombination.
Proteins -- Structure -- Computer simulation -- Experiments. ; Amino acid sequence -- Data processing -- Experiments. Protein engineering -- Experiments. ; Recombinant proteins -- Mathematical models.
In order to most effectively investigate protein structure and improve protein function, it is necessary to carefully plan appropriate experiments. The combinatorial number of possible experiment plans demands effective criteria and efficient...
Dartmouth Dissertations

Allosteric modulation of GABAa receptors by anabolic-androgenic steroids.
GABA -- Receptors. Allosteric regulation. ; Anabolic steroids -- Physiological effect. ; Androgens -- Physiological effect. ; Receptors
Anabolic-androgenic steroids (AAS) are synthetic derivatives of the gonadal hormone, testosterone. Despite their many untoward side effects, AAS are wildly abused for their ergogenic properties. AAS have numerous effects on many organ systems,...
Dartmouth Dissertations