Staphylococcus aureus contains 4 native, membrane-bound penicillin-binding proteins (PBP1-4) which are responsible for critical peptidoglycan transglycosylation and transpeptidation reactions in the cell wall. Additionally, PBP2 and PBP4 also...
Prion diseases are infectious neurodegenerative disorders characterized by a conformational change of the host-encoded prion protein. The normal nonpathogenic isoform of the prion protein (PrPc) is primarily composed of α-helices and very low...
Stark-geometry photorefractive multiple quantum well (PR-MQW) spatial light modulators (SLMs) show promise for several optoelectronic applications such as high-speed image correlation and real-time 3-D holographic imaging. Their performance is...
Over the past decade, a pair of instructions called load-linked (LL) and store-conditional (SC) have emerged as the most suitable synchronization instructions for the design of lock-free algorithms. However, current architectures do not support...
The study of twin primes gives rise to several famously difficult problems in number theory--in fact, we still cannot definitively say whether there are infinitely many twin primes. In this work, we consider a related problem, namely: What is the...
Arctic soils in the permafrost region store substantially more carbon than is contained in the atmosphere, and are undergoing rapid change associated with anthropogenic climate change. Soil decomposition is an important component of ecosystem...
The transmissible spongiform encephalopathies (TSEs), also known as the prion diseases, are a unique group of fatal neurodegenerative diseases affecting humans and other mammals that have infectious, inherited and sporadic etiologies. A central...
Yeast vacuole fusion requires 4 SNAREs, the Rab GTPase Ypt7p, vacuolar lipids, the SNARE complex disassembly machinery Sec17p and Sec18p, and the heterohexameric HOPS complex. Vacuole fusion occurs in stages: cis-SNARE complexes (bound to one...
Introduction. Nosocomial sepsis in extremely low birth weight (ELBW) infants 501-1000 grams is associated with increased mortality risk, prolonged hospitalization, and increased costs of care. Purpose. The purpose of this thesis was to evaluate the...
Oligomers -- Structure -- Mathematical models. Nuclear magnetic resonance spectroscopy.
Medical Term: Nuclear Magnetic Resonance, Biomolecular.
Protein complexes play vital roles in the fundamental processes of life. In particular, homo-oligomers are involved in cell signaling, regulation, and transport. To make detailed studies of these symmetric proteins, they need to be discovered, and...
Riemannian manifolds. Singularities (Mathematics). Laplacian operator. Spectral theory (Mathematics). Riemann surfaces. Curves on surfaces. Geometry
Historically, inverse spectral theory has been concerned with the relationship between the geometry and the spectrum of compact Riemannian manifolds, where spectrum means the eigenvalue spectrum of the Laplace operator as it acts on smooth...
This thesis reports work on a new device to detect changes in spatially nonuniform intensity distributions, and shows how this device can be applied to the particular problem of optical vibration detection. The phase of optical radiation is very...
This thesis explores practical and theoretical aspects of several privacy-providing technologies, including tools for anonymous web-browsing, verifiable electronic voting schemes, and private information retrieval from databases. State-of-art...
In this thesis we develop a theory of Fourier analysis and fast Fourier transforms (FFTs) for finite inverse semigroups. Our results generalize results in the theory of Fourier analysis for finite groups. There is a general method for generating...
Proteins -- Structure -- Mathematical models. Recombinant proteins -- Mathematical models. Mathematical optimization -- Data processing. Dynamic programming. Protein engineering.
Site-directed protein recombination produces improved and novel protein variants by recombining sequence fragments from parent proteins. The resulting hybrids accumulate multiple mutations that have been evolutionarily accepted together. Subsequent...
Electric generators -- Windings. Electric inductors -- Design and construction -- Mathematical models. Electric current converters -- Design and construction -- Mathematical models. Energy dissipation -- Mathematical models.
Magnetic components for high-frequency power conversion applications can have significant losses that compromise the performance of the converter. In particular, winding losses can be large due to high-frequency effects that are difficult to model...
Information retrieval -- Mathematical models. ; Electronic information resource searching. ; Computer algorithms. ; Decision making -- Data processing. ; Mathematical optimization.
This thesis presents a unified method for simultaneous solution of three problems in Information Retrieval--metasearch (the fusion of ranked lists returned by retrieval systems to elicit improved performance), efficient system evaluation (the...
The BCL2 family of proteins control intrinsic apoptosis at the mitochondria through a delicate balance of pro and anti-apoptotic proteins. Anti-apoptotic proteins are frequently relied upon by cancer cells, making them ideal targets for...
In the late 1960s, Ihara began work that led to the Ihara zeta function, a zeta function which is defined on a finite graph. This function is an interesting graph invariant which gives information on expansion properties of the graph. It also...
This dissertation examines the behavioral and physiological adaptations employed by modern humans to subsist in tropical rainforests. I employ various theoretical and methodological approaches to test hypotheses using empirical data from African...
Information resources management -- Mathematical models. ; Database management -- Methodology. ; Change. ; World Wide Web.
Many modern information management tasks consist of an observer that must maintain current knowledge of a collection of changing information. The goal of this observer is to maintain acceptably accurate state estimates given limited observation...
The processes affecting gas transport through the firn column are important to understand in order to accurately interpret climate records from ice cores. Historically, density measurements have been used to estimate open and closed porosity in the...
As methicillin-resistant Staphylococcus aureus (MRSA) hospitalizations keep increasing, the understanding of the characteristics that make one isolate more successful over another is paramount. Strain variations among Staphylococcus aureus observed...
Tetrapyrroles -- Synthesis. Tetrapyrroles -- Mechanism of action. Transition metal catalysts.
Previous studies have shown that the mucosal immune system is present in the female reproductive tract and under hormonal control. With the recognition that underlying stromal cells regulate epithelial cell function and hormonal responsiveness,...
In order to most effectively investigate protein structure and improve protein function, it is necessary to carefully plan appropriate experiments. The combinatorial number of possible experiment plans demands effective criteria and efficient...
Wireless communication systems. Computer networks. Routers (Computer networks).
A mesh network is a network of wireless routers that employ multi-hop routing and can be used to provide network access for mobile clients. Mobile mesh networks can be deployed rapidly to provide an alternate communication infrastructure for...
NAD (Coenzyme) -- Metabolism. Nicotinamide -- Mechanism of action. Genetic regulation. Nicotinamide-beta-riboside.
NAD+ is an essential co-enzyme for hydride transfer enzymes and a consumed substrate of multiple signaling enzymes including the sirtuins, a family of protein lysine deacetylases shown to regulate longevity in a wide array of organisms. We have...
For a local field K, we study the affine buildings Ξ n and Δ n naturally associated to SL n ( K ) and Sp n ( K ), respectively. Since Sp n ( K ) is a subgroup of SL 2 n ( K ), we investigate properties of a natural embedding of Δ n in Ξ 2 n ....
Solar (Computer architecture). ; Ubiquitous computing. Sensor networks. ; Detectors. ; User interfaces (Computer systems).
The complexity of developing context-aware pervasive-computing applications calls for distributed software infrastructures that assist applications to collect, aggregate, and disseminate contextual data. In this dissertation, we present a Context...