Dartmouth Digital Library Program

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Regulation of CD8+ T cell immunity by retinoic acid / by Yanxia Guo.
Studies have implicated the essential role of Vitamin A (VA) and its active metobolite, retinoic acid (RA) in both host defense and tolerance through manipulation of various immune cells, including T cells, B cells, macrophages and others. CD8⁺ T...
Dartmouth Dissertations

Biochemical and electrophysiological analysis of the interaction between sodium channel α and ß subunits.
Sodium channels -- Genetic aspects. ; Sodium channels -- Chemistry. ; Sodium channels -- Physiology. ; Ion channels -- Genetic aspects. ; Neurotoxic agents -- Physiological effect.
Dartmouth Dissertations

The role of gut commensals in regulating susceptibility to acute liver damage / by Stela Celaj.
Liver disease of different etiologies confers significant morbidity and mortality and hence it constitutes a major health concern worldwide. Stemming from a range of causes, such as viral, drug-induced, alcoholic, or autoimmune, the rate of...
Dartmouth Dissertations

Examinations of structured dispersive features of auroral HF waves observed with sounding rockets.
Ionospheric radio wave propagation -- Observations. Auroras -- Alaska -- Observations. Electromagnetic waves -- Observations. Sounding rockets -- Observations.
Earth's high latitude ionosphere, highly disturbed by particle and energy inputs and associated aurora, is the stage for plasma wave activity across a wide range of frequencies. These waves often exhibit strikingly distinct time-frequency structure...
Dartmouth Dissertations

Intrinsic photoconductivity in molecular crystals,
Crystals -- Electric properties.; Photoconductivity.
Dartmouth Dissertations

Characterization of cancer risk and response to immunotherapy through pathway-based genomic analyses / by David C. Qian
For most cancers, the genetic mechanisms that predispose normal cells to neoplastic transformation and tumor cells to therapeutic eradication are poorly understood. High throughput genotyping technologies have allowed the rapid discovery of...
Dartmouth Dissertations

The use of computer models to capture, understand and control dynamic brain processes.
Brain -- Physiology -- Mathematical models. Brain stem -- Effect of chemicals on. Basal ganglia -- Physiology.
Understanding how the brain works remains one of the toughest problems in science, despite the progress in scientific technology available for its study. The difficulty lies in the fact that the brain is a dynamic system, while the body of facts...
Dartmouth Dissertations

Design of a magnetic field compatible, high-performance optical breast imaging system for MRI-guided optical spectroscopy / by Fadi El-Ghussein
Multimodality imaging is becoming the standard of care for research and clinical studies. Such an approach is able to provide complementary information which can detect and characterize tumors. Advancing instrumentation for diffuse near-infrared...
Dartmouth Dissertations

Head direction cells, grid cells, and the neural basis of spatial orientation
Space perception -- Physiological aspects.;""Thalamus -- Physiology."";""Hippocampus (Brain) -- Physiology."";""Neural networks (Neurobiology)"";""Neural Pathways -- physiology."";""Anterior Thalamic Nuclei -- physiology"";""Entorhinal Cortex --...
Dartmouth Dissertations

NK cells in the female reproductive tract; biology and protection against HIV-1.
Killer cells. Generative organs, Female -- Immunology. HIV infections -- Immunological aspects. Cellular immunity.
Natural killer (NK) cells are innate immune cells which have been shown to kill tumors and cells infected with viruses. This knowledge however is based on studies carried out with natural killer cells isolated from blood. The female reproductive...
Dartmouth Dissertations

Myc post-transcriptionally iduces HIF1 protein and target gene expression in normal and cancer cells
Myc oncogenes.;""Transcription factors."";""Genetic regulation."";""Genesmyc."";""Hypoxia-Inducible Factor 1 alpha Subunit.""
Dartmouth Dissertations

Anticipated emotion in health decision making : an extension of the prototype-willingness model
Health behavior -- Decision making. ; Emotions.
Dartmouth Dissertations

Impact of semen on mucosal transmission of HIV
Semen is the major vector for sexual transmission of HIV worldwide, yet little is known about its role in modulating mucosal transmission of HIV. Understanding the impact of semen on mucosal transmission of HIV could open up novel means of...
Dartmouth Dissertations

The Polycomb Group Complex PRC1 collaborates with cohesin to stabilize the synaptonemal complex and promote crossovers during meiosis / by Pei Zhou.
Lightning -- New Mexico -- Observations.;""Photon emission."";""X-rays -- Spectra -- Measurement -- Instruments."";""X-rays -- Spectra -- Mathematical models.""
Dartmouth Dissertations

Exercise and the brain : impacts on cognition neural function and mental health / by Andrea M. Robinson.
It has been well established that physical exercise has broad impacts across the lifespan, including improved cognition, brain function, and mental health. Studies investigating the mechanism underlying the cognitive enhancing effect of exercise...
Dartmouth Dissertations

CO2 chemoreceptor function in the pulmonate snail.
Helix (Mollusks) -- Respiration. ; Chemoreceptors. ; Carbonic anhydrase.
Dartmouth Dissertations

Bethanechol and central respiratory control.
Bethanechol. ; Anesthetics.
Dartmouth Dissertations

The effects of context and familiarity on person perception: examining the neural substrates of facial attractiveness.
Face perception -- Physiological aspects. Face perception -- Social aspects. Sex differences (Psychology). Neuropsychology.
The general objective of the current thesis was to investigate the neural substrates underlying the perception of opposite-sex faces. Building on what is already known about the distributed network of brain areas supporting various dimensions of...
Dartmouth Dissertations

Endogenous antitumor immunity elicited by adoptively transferred lymphocytes through CCL5 and CD40L signaling, and dendritic cell depletion.
Ovaries -- Cancer -- Immunotherapy. T cells -- Therapeutic use. CD4 antigen -- Therapeutic use. Dendritic cells -- Therapeutic use. Chemokines -- Physiological effect. Cellular signal transduction.
Adoptive cell transfer (ACT) is a promising therapy for various non-epithelial tumors but has not yet proven successful in ovarian cancer. Moreover, its effect upon endogenous antitumor immunity, and the contribution of CD4 + T cells, remain...
Dartmouth Dissertations

Innate immune mechanisms contributing to LP-BM5 murine retroviral pathogenesis and immunodeficiency / by Megan Ashley O''Connor
LP-BM5 murine retroviral infection induces murine AIDS (MAIDS), and is characterized by profound and broad immunosuppression of T- and B-cell responses. Adaptive immune response to LP-BM5 infection, including the pathogenic role of CD4+ T-cells and...
Dartmouth Dissertations

Mutations that compromise cohesion predispose chiasmate and achiasmate chromosomes to age-dependent nondisjunction in Drosophila oocytes.
Chromosome abnormalities. Ovum. Maternal age. Aneuploidy. Aging -- Genetic aspects. Drosophila -- Molecular genetics. Nondisjunction.
Aneuploidy is the leading cause of pregnancy loss and birth defects in humans. At least 5% of all recognized pregnancies are aneuploid. Maternal meiosis is especially error-prone and the rate of chromosome missegregation increases exponentially...
Dartmouth Dissertations

The dual role of the Pseudomonas aeruginosa type I-F CRISPR-Cas system in group behavior modification and viral immunity / by Gary E. Heussler
CRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISPR associated) systems have been characterized as adaptive immune systems in bacteria and archaea, providing defense against mobile genetic elements, including bacteriophage,...
Dartmouth Dissertations

CXCR3 and its cognate-chemokine expression : implications for cancer immunotherapy / by Eleanor Clancy-Thompson
Despite immunogenicity, melanoma-specific vaccines have demonstrated minimal clinical efficacy in patients with established disease, but enhance survival when administered in the adjuvant setting. It has been shown that T cell infiltration of...
Dartmouth Dissertations

Identification and characterization of two mutants that affect Drosophila phototransduction.
Drosophila. Photoreceptors. TRP channels. Cellular signal transduction.
The phototransduction cascade in Drosophila is a prototypical G-protein signaling pathway and many of its components have been well-studied. Early genetic screens identified many of the major proteins involved in this pathway and study over the...
Dartmouth Dissertations

Serotonin signaling in the nucleus tractus solitarius modulates the larybgeal chemoreflex : implications for sudden infant death syndrome / by William T. Donnelly
Sudden infant death syndrome (SIDS) occurs when a sleeping infant experiences a challenge to cardiorespiratory homeostasis which it fails to overcome. Analyses of brain tissue from SIDS cases from around the world consistently show abnormalities in...
Dartmouth Dissertations

A mechanistic and structural analysis of Ncd kinesin-like protein mutants and a class VII myosin.
Muscle proteins. Myosin -- Structure-activity relationships. Kinesin -- Structure-activity relationships. Mechanism of action (Biochemistry). Molecular Motor Proteins.
Protein motors, such as kinesin and myosin, use chemical energy in the form of ATP to physically move along filaments and perform complex mechanical tasks in the cell, such as intracellular transport, cell division and muscle contraction. Myosin...
Dartmouth Dissertations

Utilization and health outcomes in a spatial model of the US health care system / by Laura C. Yasaitis.
Objectives: This dissertation comprises three essays on geographic variations in healthcare, and the association between utilization and health outcomes. I first explore associations between outpatient visits and Medicare beneficiaries'...
Dartmouth Dissertations

The role of lysosomal cysteine proteases in endocytosis-mediated retinal degeneration
Many retinal degenerative diseases result in blindness. The causes and clinical progression of these diseases are heterogeneous in nature. In many instances the genes involved are known, yet the molecular mechanisms leading to blindness still...
Dartmouth Dissertations

Thermodynamic and spectroscopic studies of metalloprotein stability ligation and reactivity / by George P. Lisi III.
Metal ions confer structural stability and reactivity to a large number of proteins that use the amino acids histidine (His) and cysteine (Cys) to form stable metal-ligand complexes. The stability of metal-His and metal-Cys interactions and their...
Dartmouth Dissertations

Modulating innate and adaptive immunity in the Toxoplasma gondii-induced model of inflammatory bowel disease.
Toxoplasma gondii -- Immunology. Inflammatory bowel diseases -- Immunological aspects. C-reactive protein. T cells. Immune response -- Regulation. Protein precursors -- Immunology.
Inbred C57BL/6 mice develop an acute necrotizing ileitis following oral infection with Toxoplasma gondii that is associated with massive inflammatory infiltrates and morphologic tissue changes consistent with human Crohn's disease. In the course of...
Dartmouth Dissertations

Budding yeast discovery tools for neurofibromatosis type 1.
Neurofibromatosis type 1 (NF1) is a genetic disorder that predisposes affected individuals to a variety of benign and malignant nervous system tumors. NF1 is caused by a mutation in the NF1 tumor suppressor gene, which encodes neurofibromin, a...
Dartmouth Dissertations

Motion optimized conformal microwave imaging for biomedical applications / by Neil R. Epstein.
Investigations into alternative breast cancer (BC) imaging techniques have become increasingly popular based on the limitations of traditional imaging modalities: X-ray mammography uses ionizing radiation, has limited intrinsic contrast and is...
Dartmouth Dissertations

Novel dimensions in a fluid genome : an integrative risk analysis for cancers of the bladder and breast / by Asaf Wyszynski.
The present thesis is focused on developing a better understanding of factors driving disease biology and overall risk using cancers of the bladder and breast as model systems. As no single approach was likely to unravel the complexities of these...
Dartmouth Dissertations

Leptin DNA methylation and maternal and infant pregnancy outcomes in the Rhode Island child health study / by Corina Lesseur Perez.
In utero exposure to maternal malnutrition is associated with increase offspring susceptibility to cardiometabolic and neuropsychiatric disease. Epigenetic mechanisms mediate, at least in part, fetal adaptations to adverse in utero environments...
Dartmouth Dissertations

Integrative multi-tissue genomic analyses identify mechanisms of pathogenesis in systemic sclerosis / by Jaclyn N. Taroni
Systemic sclerosis (SSc) is a rare and often-fatal systemic autoimmune disease characterized by vasculature dysfunction, immune activation, and extracellular matrix deposition in skin and internal organs. The etiology of SSc is unknown, but it is...
Dartmouth Dissertations

Microfabrication of magnetic components for high frequency DC-DC power conversion at high currents and low voltages.
DC-to-DC converters -- Design and construction. Electric inductors -- Design and construction. Thin film devices -- Design and construction. Microprocessors -- Power supply. Microfabrication. Transients (Dynamics).
Dartmouth Dissertations

Self-relevance, attention and the brain.
Selectivity (Psychology). Self-perception. Self-interest. Brain -- Imaging. Psychophysiology.
The central topic of the self has proven a vexing conundrum for philosophers and psychologists alike for centuries. Prior research suggests that the self is a powerful cognitive structure which biases attentional mechanisms in favor of apprehension...
Dartmouth Dissertations

Characterization of post-surgical immunity and memory responses to the poorly-immunogenic B16 melanoma.
T cells. Melanoma -- Immunotherapy. Immunologic memory. Immune response -- Regulation. Medical Term T-Lymphocytes, Regulatory -- immunology. CD8-Positive T-Lymphocytes -- immunology. Melanoma, Experimental -- immunology.
The potential for the immune system to control growing tumors was recognized over a century ago. Studies during the past 20 years have presented undisputable evidence that host T cells have the ability to recognize, and kill tumor cells. However,...
Dartmouth Dissertations

Computer based electron beam treatment planning.
Radiotherapy. ; Electron beams. ; Computers.
Dartmouth Dissertations

Mapping the junction of action perception and production.
Perceptual-motor learning -- Physiological aspects. ; Language acquisition -- Physiological aspects. ; Motor ability -- Physiological aspects. ; Knots and splices.
The studies presented in this dissertation explore several points of intersection between action perception and production within the human brain. One's ability to use perceptual information about another individual's actions to guide and inform...
Dartmouth Dissertations

The role of DEG/ENaC ion channel subunits in pheromone detection and mating behaviors in Drosophila melanogaster / by Vinoy Vijayan.
Gustatory pheromones regulate mating behaviors in Drosophila melanogaster and represent an important model for understanding how sensory stimuli can drive behavior. However, the genes and cells involved in pheromone detection have remained poorly...
Dartmouth Dissertations

Brittle-ductile transition in intermetallic compounds, Ni[subscript 3]Ga and Ni[subscript 3]A1.
Nickel alloys -- Brittleness. ; Nickel alloys -- Ductility. ; Nickel alloys -- Fracture.
Dartmouth Dissertations

Electrical impedance imaging for temperature field estimation during hyperthermia treatment of cancer.
Electrical impedance tomography. Newton-Raphson method. Cancer -- Thermotherapy -- Technique.
Dartmouth Dissertations

Post-translational modification in retinoid action: a role for UBEIL in cancer therapy and chemoprevention.
Retinoids -- Mechanism of action. ; Post-translational modification. ; Tretinoin -- Therapeutic use. ; Lungs -- Cancer -- Chemoprevention.
The retinoids--natural and synthetic derivatives of vitamin A--are active in cancer therapy and chemoprevention. The signals that underlie retinoid clinical activity are triggered by induction of retinoid target genes. Therefore, a greater...
Dartmouth Dissertations

Isolation and functional characterization of yeast vacuole snare complexes.
Membrane proteins -- Physiological transport. ; Plant proteins -- Physiological transport. ; Biological transport -- Regulation. ; Plant vacuoles. Saccharomyces cerevisiae -- Physiology.
Eukaryotic cells are compartmentalized into membrane-enclosed organelles. Genetic screens and reconstituted biochemical assays have revealed that intracellular protein trafficking is mediated by a conserved mechanism of vesicle budding, transport,...
Dartmouth Dissertations

Habitat selection by breeding black-throated blue warblers: different patterns at two spatial scales and the use of habitat for foraging and nesting.
Black-throated blue warbler -- Habitat. Black-throated blue warbler -- Behavior. Black-throated blue warbler -- Food. Black-throated blue warbler -- Nests.
Dartmouth Dissertations

Synchrotron X-ray topographic studies of polycrystalline ice.
Ice crystals -- Radiography. ; Synchrotron radiation. ; Dislocations in crystals.
Dartmouth Dissertations

Regulation of cohesion, recombination and chromosome core dynamics during Drosophila meiosis.
Drosophila -- Cytogenetics. Meiosis. Sister chromatid exchange. Chromosome Segregation.
Accurate chromosome segregation during mitosis and meiosis requires that sister-chromatid cohesion hold sisters together until the appropriate time. In addition, meiotic cohesion is necessary for normal synaptonemal complex (SC) and homologous...
Dartmouth Dissertations

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