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- A generalized least-squares minimization method for near infrared diffuse optical tomography.
- Optical tomography. ; Near infrared spectroscopy. ; Image analysis -- Mathematical models. ; Imaging systems -- Image quality -- Mathematical models. ; Image reconstruction -- Mathematical models. ; Least squares. Breast -- Tomography.
- Diffuse optical tomography (DOT) has the potential to become a non-invasive and non-ionizing diagnostic imaging technique for breast cancer imaging. DOT uses near-infrared (NIR) light to illuminate the breast, generally through the use of fiber...
- Dartmouth Dissertations
- A mechanistic and structural analysis of Ncd kinesin-like protein mutants and a class VII myosin.
- Muscle proteins. Myosin -- Structure-activity relationships. Kinesin -- Structure-activity relationships. Mechanism of action (Biochemistry). Molecular Motor Proteins.
- Protein motors, such as kinesin and myosin, use chemical energy in the form of ATP to physically move along filaments and perform complex mechanical tasks in the cell, such as intracellular transport, cell division and muscle contraction. Myosin...
- Dartmouth Dissertations
- $Stark-geometry photorefractive multiple quantum well spatial light modulators.$
- Stark-geometry photorefractive multiple quantum well spatial light modulators.
- Light modulators -- Mathematical models. ; Quantum wells. ; Photorefractive materials. ; Optoelectronic devices -- Mathematical models.
- Stark-geometry photorefractive multiple quantum well (PR-MQW) spatial light modulators (SLMs) show promise for several optoelectronic applications such as high-speed image correlation and real-time 3-D holographic imaging. Their performance is...
- Dartmouth Dissertations
- The role of the Drosophila SK channel in sensory processing and behavior / by Ahmad Nawwaf Abou Tayoun.
- Partially ordered sets. ; Forcing (Model theory). ; Set theory.
- Dartmouth Dissertations
- Targeting of the erythroid transcription factor, GATA-1, to specific locations within the human genome.
- Globin genes -- Expression. ; Transcription factors. ; Genetic transcription -- Regulation.
- Dartmouth Dissertations
- Measuring quality of life in economic evaluations of treatment for severe mental illness.
- Quality of life -- Evaluation. ; Health status indicators. ; Psychiatric rating scales. ; Mental illness -- Treatment -- Evaluation. ; Mental illness -- Treatment -- Economic aspects. ; Mental illness -- Treatment -- Social aspects.
- Background. It is not clear whether a generic quality-of-life instrument can appropriately represent severe mental illness in an economic evaluation. This problem is particularly salient for resource-allocation decisions where policymakers compare...
- Dartmouth Dissertations
- Fault modeling and design of dynamic logic.
- Logic programming. ; Electronic digital computers -- Circuits -- Testing -- Mathematical models. ; Fault-tolerant computing.
- Today''s fastest microprocessors, logic chips, and even memory chips employ dynamic logic as the key part to achieving advanced performance. Dynamic logic only retains the correct data state briefly and is far less robust than previous technologies...
- Dartmouth Dissertations
- The function of perceived gaze direction in emotion and person perception.
- Gaze -- Psychological aspects. ; Facial expression. ; Body language.
- The primary goal of the current research was to examine the effect of perceived gaze direction on the perception and processing of facially communicated emotion. There is good reason to believe that gaze direction and facial displays of emotion...
- Dartmouth Dissertations
- Cytoskeletal reorganization in B lymphocyte activation.
- Lymphocyte transformation.
- Dartmouth Dissertations
- Structure, petrology, and U-Th-Pb geochronology in the Milford (15') quadrangle, New Hampshire.
- Petrology -- New Hampshire -- Milford. ; Geological time.
- Dartmouth Dissertations
- Nucleophilic addition to electron deficient indoles and the synthesis of fused heterocyclic ring systems.
- Indole -- Synthesis. ; Heterocyclic compounds -- Synthesis.
- The chemistry of indole can be reversed and redirected by the addition of powerful electron-withdrawing groups. Incorporation of a nitro group at C-2 or C-3 renders the adjacent carbon susceptible to nucleophilic attack. Nitro, cyano, and...
- Dartmouth Dissertations
- Clay mineralogy and geochemistry of soils and sediments with perma frost in interior Alaska.
- Clay minerals -- Alaska. ; Soils -- Alaska. ; Frozen ground -- Alaska.
- Dartmouth Dissertations
- Migmatite systematics and geology : Carter Dome-Wild River Region White Mountains New Hampshire.
- Migmatite -- New Hampshire. ; Geology -- New Hampshire.
- Dartmouth Dissertations
- Rhodopsin-arrestin complex formation as a novel mechanism for light-dependent retinal degeneration.
- Visual pigments. ; Cellular signal transduction. ; Rhodopsin. ; G proteins. ; Phosphorylation. ; Photoreceptors. ; Retinal degeneration.
- Arrestins are regulatory proteins that participate in the termination of G protein-mediated signal transduction. The major arrestin in the Drosophila visual system, Arrestin 2 (Arr2), has been demonstrated to be essential for the termination of the...
- Dartmouth Dissertations
- Isolation and characterization of essential genes of Saccharomyces cerevisiae required for the efficient nucleocytoplasmic trafficking of mRNA.
- Messenger RNA. ; Saccharomyces cerevisiae. ; Cytoplasm.
- Dartmouth Dissertations
- High resolution infrared spectroscopy and photolysis of solutes in cryogenic solids.
- Infrared spectroscopy. ; Photodissociation. ; Argon. ; Nitrogen.
- Dartmouth Dissertations
- The role of BRCA1 in estrogen receptor-α regulation in breast cancer.
- Breast -- Cancer -- Genetic aspects. ; Estrogen -- Receptors -- Regulation. ; Genetic transcription -- Regulation. ; BRCA1 Protein. ; Breast Neoplasms -- genetics. ; Gene Expression Regulation Neoplastic. ; Repressor Proteins.
- Dartmouth Dissertations
- Dependence of snow thermal and electrical conductiveness on microstructure.
- Snow -- Thermal properties. ; Snow -- Electric properties. ; Microstructure.
- Dartmouth Dissertations
- Discovering MII1 regulated pathways in hematopoietic stem cells.
- Hematopoietic stem cells. ; Hematopoietic stem cell disorders -- Genetic aspects. ; Genetic transcription -- Regulation. ; Leukemia -- Genetic aspects. ; Cell proliferation. ; Myeloid-Lymphoid Leukemia Protein -- genetics.
- Hematopoietic stem cells (HSCs) balance self-renewal with the continuous production of the suitable numbers of lineage-restricted progenitor cells. In this work we demonstrate that the Mixed lineage leukemia 1 (Mll1) gene is essential for this...
- Dartmouth Dissertations
- Assortativity and the robustness of gene regulatory networks / by Dov A. Pechenick.
- Robustness to genetic perturbations is a fundamental property of all living things. The genetic code is degenerate, RNA secondary structure is robust to sequence changes, and protein structure is robust to amino acid substitutions. Complex systems...
- Dartmouth Dissertations
- Development and application of a dual-excitation, digital imaging, fluorescence microscope to investigate parathyroid hormone-stimulated calcium transport in kidney distal tubule cells.
- Fluorescence microscopy. ; Calcium -- Physiological transport -- Measurement. ; Renal tubular transport -- Measurement.
- Dartmouth Dissertations
- Spectral studies of the enzyme rhodanese.
- Enzymes.
- Dartmouth Dissertations
- Methods for rapid EEG-based mapping of human brain functions.
- Electroencephalography. ; Brain mapping -- Methodology. ; Evoked potentials (Electrophysiology).
- Brain mapping via EEG activation is a useful tool of basic neuroscience, and has wide clinical applications as well. The mapping is achieved by means of Event Related Potentials (ERPs), task-related changes in EEG time series. The methodology of...
- Dartmouth Dissertations
- Metamorphism in east central Vermont.
- Metamorphism (Geology) -- Vermont. ; Nappes (Geology) -- Vermont.
- Dartmouth Dissertations
- Th-dependent B cell activation.
- B cells. ; T cells. ; Cell interaction. ; Body fluids -- Immunology.
- Dartmouth Dissertations
- The dorsal tegmental nucleus of Gudden and angular velocity integration in the head direction system.
- Space perception. ; Motion perception (Vision). ; Vestibular apparatus.
- Head Direction (HD) cells are neurons located primarily in the limbic system that fire as a function of directional heading in the horizontal, or yaw, plane in the freely moving animal. Our hypothesis is that the HD signal is the result of two...
- Dartmouth Dissertations
- Effects of selenium deficiency on deiodinase expression and thyroid hormone economy in the rat during development.
- Thyroid hormones -- Physiological effect. ; Selenium -- Physiological effect. ; Thyroid hormones -- Synthesis.
- The iodothyronine deiodinases, D1, D2, and D3, play a crucial role in determining the circulating and intracellular levels of active and inactive thyroid hormone (TH), and thus have a major effect on TH action during development and adulthood. The...
- Dartmouth Dissertations
- Isolation of interleukin-2-induced immediate-early genes.
- Interleukin-2.
- Dartmouth Dissertations
- Bedrock geologic map of New Hampshire, by John B. Lyons ... [et al.] ; U.S. Department of the Interior, U.S. Geological Survey ; prepared in cooperation with the U.S. Department of Energy and the State of New Hampshire
- The Granite State in Maps, 1756-2003
- Characterization of COPII vesicle proteins involved in sorting between the endoplasmic reticulum and golgi apparatus in Sacch[a]romyces cerevisiae.
- Membrane proteins -- Physiological transport. ; Carrier proteins. ; Biological transport -- Regulation. ; Saccharomyces cerevisiae -- Cytology. ; Golgi apparatus. ; Endoplasmic reticulum.
- Intracellular transport between the ER and Golgi is mediated by vesicles that bud from donor membranes and then fuse with acceptor membranes. Bi-directional vesicle transport maintains distinct organelle composition through a process known as...
- Dartmouth Dissertations
- Plasmodium falciparum SERA protein transgenics used in the study of parasite immunobiology and drug resistance.
- Plasmodium falciparum -- Immunological aspects. ; Plasmodium falciparum -- Genetics. ; Toxoplasma gondii -- Genetics. ; Serine proteinases. ; Transgenic organisms. ; Drug resistance in microorganisms -- Genetic aspects.
- Genetic and immunological tools have been used to study two protozoan parasites, Plasmodium falciparum and Toxoplasma gondii. Toxoplasma gondii provides an excellent model for the study of protozoan parasite biology. Plasmodium falciparum causes...
- Dartmouth Dissertations
- Probing a receptor-binding domain of interleukin-2 by combinatorial cassette mutagenesis.
- Interleukin-2. ; Mutagenesis.
- Dartmouth Dissertations
- Synthetic approaches to indolo[2,3-a]carbazole alkaloids.
- Indole alkaloids -- Synthesis. ; Carbazole.
- Dartmouth Dissertations
- A benzonorbornyl model system for the study of carbocation-[pi] interactions.
- Carbocations -- Reactivity. ; Aromatic compounds -- Reactivity.
- An important mode of stabilization of cations in biochemical reactions is interaction with the π systems-of aromatic residues. As part of an investigation of the interaction of carbocations with aromatic π systems, a study of various model...
- Dartmouth Dissertations
- Biochemical and structural studies of prion protein misfolding / by Geoffrey P. Noble
- The transmissible spongiform encephalopathies (TSEs), also known as the prion diseases, are a unique group of fatal neurodegenerative diseases affecting humans and other mammals that have infectious, inherited and sporadic etiologies. A central...
- Dartmouth Dissertations
- Biochemical characterization of prion conversion.
- Prion diseases. Prions. Proteolytic enzymes -- Pathophysiology. Proteins -- Conformation.
- Prion diseases are infectious neurodegenerative disorders characterized by a conformational change of the host-encoded prion protein. The normal nonpathogenic isoform of the prion protein (PrPc) is primarily composed of α-helices and very low...
- Dartmouth Dissertations
- Patient outcomes and clinical decision making in aortic valve replacement.
- Outcome assessment (Medical care). ; Aortic valve -- Surgery -- Complications. ; Aortic valve -- Surgery -- New England. ; Cardiovascular instruments Implanted.
- Aortic valve disease is a frequent and serious disorder. Although aortic valve replacement (AVR) is arguably the only effective treatment, important issues remain unresolved in the care of patients with this disease. Recent studies have focused...
- Dartmouth Dissertations
- A test apparatus for frozen soil in complex stress.
- Frozen ground. ; Soil mechanics.
- Dartmouth Dissertations
- The wear resistance mechanism of particulate fillers in polytetrafluoroethylene-based polymer composites.
- Polytef. ; Mechanical wear. ; Fillers (Materials).
- Dartmouth Dissertations
- Interactions between the carcinogen chromium(VI) and DNA.
- DNA. ; Chromium. ; Thiols.
- Dartmouth Dissertations
- Stratigraphy and structure of the Kennebago Lake quadrangle of central western Maine.
- Geology, Stratigraphic. ; Geology -- Maine -- Kennebago Lake.
- Dartmouth Dissertations
- Carbon-fluorine bond activation of iridium (III) compounds induced by acids and reducing agents.
- Organoiridium compounds -- Synthesis. ; Organofluorine compounds -- Synthesis. ; Ligands.
- Dartmouth Dissertations
- The formation of chloroform and related products from the chlorination of polyhydroxybenzenes and diketones in dilute aqueous solution.
- Chloroform. ; Chlorination.
- Dartmouth Dissertations
- Dielectric relaxation and local chain motion in concentrated polymer solutions.
- Polymers.
- Dartmouth Dissertations
- Observation of changing information sources.
- Information resources management -- Mathematical models. ; Database management -- Methodology. ; Change. ; World Wide Web.
- Many modern information management tasks consist of an observer that must maintain current knowledge of a collection of changing information. The goal of this observer is to maintain acceptably accurate state estimates given limited observation...
- Dartmouth Dissertations
- Large-scale structure of the universe: a clustering analysis.
- Cosmology -- Mathematical models. ; Galaxies -- Clusters -- Mathematical models. ; Dark matter (Astronomy).
- Dartmouth Dissertations
- Mitochondrial biogenesis in Saccharomyces cerevisiae: transcriptional control by glucose.
- Saccharomyces cerevisiae. ; Glucose. ; Mitochondria. ; Gene fusion. ; Cytochromes. ; Mutation (Biology).
- Dartmouth Dissertations
- Random quantum dynamics : from random quantum circuits to quantum chaos.
- Quantum computers. ; Quantum chaos. ; Many-body problem. ; Hamiltonian systems.
- Dartmouth Dissertations
- Dispositional emotional expressivity shapes the processing of facial expression / by Annemarie C. Brown
- When we want to know what others are thinking or feeling, we look to their face for clues. Affective neuroscience has usefully documented behavioral, psychophysiological and neural responses to the facial displays of others. Though this work...
- Dartmouth Dissertations
- High-throughput analysis of antigen-specific antibody effector function from polyclonal Ig / by Eric Brown
- Antibodies are known to be a primary correlate of protection in almost all current vaccines, and thus evaluating the antibody response is of critical importance in attempting to predict the efficacy of novel vaccine candidates. Historically...
- Dartmouth Dissertations

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