During our fieldwork with real-world organizations---including those in Public Key Infrastructure (PKI), network configuration management, and the electrical power grid---we repeatedly noticed that security policies and related security artifacts...
Recent years have witnessed a new class of monitoring applications that need to continuously collect information from remote data sources. Those data sources, such as web click-streams, stock quotes, and sensor data, are often characterized as...
RNA binding proteins are fundamental components of crucial biological processes in all domains of life. The development of techniques to study RNA binding protein complexes is, therefore, broadly impactful. I employed multiple genome-wide...
The Greenland Ice Sheet (GrIS) is responding sensitively to climate change and its meltwater has the potential to influence global sea level. Recently, large changes in the GrIS have occurred including increased velocities of outlet glaciers and...
The multisubunit eukaryotic Mediator complex integrates diverse positive and negative gene regulatory signals and transmits them to the core transcription machinery. It is also involved in chromatin structure related epigenetic silencing through...
GABA -- Receptors. Anabolic steroids -- Physiological effect. Androgens -- Physiological effect. Prosencephalon. Neurotransmitters -- Effect of drugs on. Psychoneuroendocrinology.
Anabolic androgenic steroids (AAS) are derivatives of testosterone originally designed for therapeutic applications to enhance anabolic potency (protein synthesis and muscle growth) while exerting low androgenic (masculinizing) effects. The...
Anabolic-androgenic steroids (AAS) are synthetic derivatives of the gonadal hormone, testosterone. Despite their many untoward side effects, AAS are wildly abused for their ergogenic properties. AAS have numerous effects on many organ systems,...
Cell growth and division are coordinated to keep homeostasis of cell size. The components of the core machinery are conserved in a wide range of cell types. Fission yeast (S. pombe) has been an important model organism to study cell size control...
The cortical cytoskeleton mediates a range of cellular activities such as endocytosis, cell motility, and the maintenance of cell rigidity. In yeast cells, prominent cortical structures called eisosomes generate specialized domains termed MCCs to...
Arctic temperature and precipitation have been rising over recent decades, with implications for Greenland Ice Sheet (GrIS) mass balance, sea level rise, and thermohaline circulation via Arctic Ocean freshening. However, meteorological station data...
Niemann-Pick type C (NPC) is a neurovisceral disease that causes intracellular accumulation of cholesterol and other lipids. The exact mechanism how the defects in cholesterol trafficking pathways result in the progressive neurological damage is...
The ectomycorrhizal symbiosis between temperate forest trees and some soil fungi is an adaptation to resource limitations of both symbionts. Nitrogen enrichment of historically N-limited forest ecosystems may change this symbiosis through direct...
We have investigated the role of the p38 MAP kinase pathway in regulating gene expression at the level of mRNA stability. The inhibitory effect of thalidomide on Tumor Necrosis Factor (TNF)α production was characterized. Activation of the MAPK...
Upon activation by binding of insulin, the insulin receptor tyrosine kinase phosphorylates a group of proteins known as the insulin receptor substrates (IRS's). The tyrosine phosphorylated IRS's then act as docking/effector molecules for SH2...
Hypertensive disorders, as well as congestive heart disease. Despite extensive research on the regulatory events that occur between aldosterone induced transcription and the early activation of epithelial sodium channels (ENaC ) in cortical...
Emergency medical response requires timely and efficient assessment and treatment of casualties. Mass casualty situations, in particular, strain the resources of emergency responders, prompting the need for a well-organized, effective, automated...
Soils -- Lead content -- New Hampshire. ; Soils -- Lead content -- Vermont. ; Lead -- Environmental aspects -- New Hampshire. ; Lead -- Environmental aspects -- Vermont. ; Atmospheric deposition -- Environmental aspects -- New Hampshire. ; ...
A basic understanding of how atmospherically-derived elements behave in soils is of concern in contaminant transport, nutrient cycling, and carbon sequestration studies. Here, I use stable and radioactive tracers to evaluate the fate of...
This thesis characterized the solubilities of sugar monomers and xylooligomers in water and explored the potential role of solubility for pretreatment of cellulosic Biomass by hemicellulose hydrolysis in only water. A novel apparatus was developed...
Climatic geomorphology -- Sierra Nevada (California and Nevada). ; Slopes (Physical geography) -- Sierra Nevada (California and Nevada). ; Weathering -- Sierra Nevada (California and Nevada). ; Chemical denudation -- Sierra Nevada (California and...
Landscapes evolve in response to external forcings such as climate and tectonics that influence the pace and patterns of erosion and weathering processes. Furthermore, internal feedbacks between erosion and weathering regulate the expression of...
Problem Statement Patient safety in the modern hospital is supported by multiple human and technological systems, and this type of high-risk/high-complexity domain requires multiple layers of protection against harm. This fault-tolerant approach is...
Natural arsenic contamination of drinking water occurs in communities worldwide, presenting a significant threat to public health. The processes that dictate arsenic partitioning between minerals and the aqueous phase are highly variable and...
Sodium channels -- Physiology. Proteins -- Physiological transport. Biological transport -- Regulation. Aldosterone -- Physiological effect. Epithelial cells. Protein Transport. Vesicular Transport Proteins.
Nearly one billion individuals worldwide have elevated blood pressure (BP) and 90% of these cases are due to unknown causes. Aldosterone is the primary hormone regulating Na + reabsorption in the kidney and is therefore a major determinant of the...
For the most part, research on self-regulation has focused on behavior-control, which is how people self-regulate in the face of immediate urges and temptations (e.g., resisting cookies that are close at hand, or resisting beer that is being freely...