Dartmouth Digital Library Program

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Characterization of the role of Bacillithiol in Staphylococcus aureus / by Ana Catalina Posada.
As methicillin-resistant Staphylococcus aureus (MRSA) hospitalizations keep increasing, the understanding of the characteristics that make one isolate more successful over another is paramount. Strain variations among Staphylococcus aureus observed...
Dartmouth Dissertations

Dexamethasone causes translocation of glucose transporters from the plasma membrane to an internal site.
Glucocorticoids. ; Glucose -- Physiological transport. ; Glucose -- Metabolism.
Dartmouth Dissertations

Cif, a novel Pseudomonas aeruginosa toxin.
Pseudomonas aeruginosa infections -- Pathogenesis. Hydrolases. Membrane proteins -- Physiological transport. Genetic regulation. Epoxide Hydrolases -- genetics.
Pseudomonas aeruginosa is the leading cause of morbidity and mortality amongst cystic fibrosis (CF) patients. Following initial colonization of the CF lung by P. aeruginosa , the bacterium establishes chronic, long-term infections. Chronic P....
Dartmouth Dissertations

Characterization of two S. Cerevisiae genes implicated in mRNA export: RAT7, encoding a novel nuclear pore complex protein and NPL3, encoding a putative hnRNP protein.
Messenger RNA -- Genetic aspects. Proteins -- Synthesis -- Genetic aspects. Saccharomyces cerevisiae -- Genetics.
Dartmouth Dissertations

Serotonin signaling in the nucleus tractus solitarius modulates the larybgeal chemoreflex : implications for sudden infant death syndrome / by William T. Donnelly
Sudden infant death syndrome (SIDS) occurs when a sleeping infant experiences a challenge to cardiorespiratory homeostasis which it fails to overcome. Analyses of brain tissue from SIDS cases from around the world consistently show abnormalities in...
Dartmouth Dissertations

Insulin regulation of the glucose transporters in 3T3-L1 adipocytes and BC3H-1 myocytes.
Glucose -- Physiological transport. ; Insulin -- Physiological effect. ; Fat cells. ; Muscle cells.
Dartmouth Dissertations

Cation selectivity of IRT1: restricting cadmium uptake by plants.
Plant genetic engineering. ; Plants -- Effect of cadmium on. ; Cadmium -- Physiological transport.
Iron plays a central role in key biological processes in both plants and animals. Lack of available iron commonly limits plant growth and nutritional value. Worldwide, dietary iron is primarily obtained from plant sources and, despite our best...
Dartmouth Dissertations

Studies on the role of the SH2 domain-containing phosphotyrosine phosphatase, PTP2C, in insulin signaling.
Insulin -- Receptors. ; Phosphatases. ; Phosphorylation. ; Cellular control mechanisms.
Dartmouth Dissertations

Characterization of spores and L-forms in C. Thermocellum and the identification of histidine kinases involved in spore formation through the use of established and novel genetic tools / by Elizabeth Barrett Mearls.
The expanding global population will need to look to alternative fuel sources in order to meet the increasing demand for transportation fuel, mitigate carbon emissions, and promote energy security. A promising alternative to traditional fossil...
Dartmouth Dissertations

Modflows : methods for studying and managing mesh editing workflows / by Jonathan D. Denning.
At the heart of computer games and computer generated films lies 3D content creation. A student wanting to learn how to create and edit 3D meshes can quickly find thousands of videos explaining the workflow process. These videos are a popular...
Dartmouth Dissertations

Characterization and rescue of a Drosophila model of prion disease; and The role of carcinine in signaling at the Drosophila photoreceptor synapse.
Drosophila melanogaster -- Genetic aspects. Prion diseases. Neurotransmitters. Photoreceptors.
Drosophila melanogaster is a model organism often used when studying the complex processes of neuronal signaling and neurodegeneration. The short life cycle, malleable genetics, amenability to in vivo electrophysiological assays and sensitivity to...
Dartmouth Dissertations

Modulation of CYPS: effect on acetaminophen hepatotoxicity.
Hepatotoxicology. ; Cytochrome P-450 -- Pathophysiology. ; Acetaminophen -- Toxicology. ; Alcohol -- Pathophysiology.
Cytochrome P450 (CYP) 2E1 is considered the sole CYP responsible for APAP bioactivation leading to hepatotoxicity. CYP2E1 is also considered the alcohol-inducible CYP and therefore, the sole CYP responsible for alcohol-mediated increases in APAP...
Dartmouth Dissertations

ACAT1 blockage stimulates autophagy to emeliorate Alzheimer's disease / by Yohei Shibuya
Alzheimer’s disease (AD) is a progressive neurodegenerative disease and the most common cause of dementia in the aging population. Currently, there is no cure for AD. The hallmark of AD consists of extracellular amyloid plaques, mainly composed...
Dartmouth Dissertations

Innate immune mechanisms contributing to LP-BM5 murine retroviral pathogenesis and immunodeficiency / by Megan Ashley O''Connor
LP-BM5 murine retroviral infection induces murine AIDS (MAIDS), and is characterized by profound and broad immunosuppression of T- and B-cell responses. Adaptive immune response to LP-BM5 infection, including the pathogenic role of CD4+ T-cells and...
Dartmouth Dissertations

The dual role of the Pseudomonas aeruginosa type I-F CRISPR-Cas system in group behavior modification and viral immunity / by Gary E. Heussler
CRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISPR associated) systems have been characterized as adaptive immune systems in bacteria and archaea, providing defense against mobile genetic elements, including bacteriophage,...
Dartmouth Dissertations

Iron acquisition in Bradyrhizobium japonicum.
Rhizobium -- Physiology. ; Plants -- Effect of iron on.
Dartmouth Dissertations

Vibrio cholerae H-NS: investigation of regulated genes and structure-function analysis.
Vibrio cholerae -- Genetics. ; DNA-binding proteins. ; Genetic transcription -- Regulation. ; Bacterial proteins.
H-NS, an abundant nucleoid associated protein, has a role in silencing the expression of a variety of environmentally regulated genes during growth under nonpermissive conditions. A genetic approach was used to study H-NS regulation of genes in...
Dartmouth Dissertations

The molecular mechanisms of circadian phase in Arabidopsis thaliana.
Arabidopsis thaliana -- Genetics. ; Circadian rhythms. ; Genetic regulation.
Dartmouth Dissertations

Regulation of epithelial chloride channels: implications for cell volume regulation and cystic fibrosis.
Chloride channels. ; Epithelial cells. ; Cellular control mechanisms. ; Cystic fibrosis.
Dartmouth Dissertations

Structure-function relations of cell membrane Ca efflux proteins.
Calcium-binding proteins. ; Renal tubular transport. ; Calcium -- Metabolism -- Regulation.
Dartmouth Dissertations

Isolation and characterization of two distinct mutations affecting cholesteryl ester synthesis in mammalian cells.
Cholesterol. ; Esters. ; Mammals -- Cytology. ; Cell metabolism.
Dartmouth Dissertations

Structural studies of Vibrio cholerae virulence gene regulators.
Vibrio cholerae -- Molecular genetics. ; Virulence (Microbiology) -- Molecular aspects. ; Genetic regulation. ; Viral proteins.
Cholera is a diarrheal disease caused by the Gram-negative bacterium Vibrio cholerae. The disease is acquired by oral ingestion of contaminated water or food. In order for Vibrio cholerae to cause the disease cholera, it must produce two important...
Dartmouth Dissertations

Investigating ACAT allosterism.
Acyltransferases. Allosteric proteins. Esterification. Cholesterol -- Metabolism.
Acyl coenzyme A:cholesterol acyltransferase (ACAT) is a membrane bound enzyme whose primary biochemical activity is to convert cholesterol, along with long chain fatty acyl Coenzyme A, into cholesterol esters. ACAT plays an important role in the...
Dartmouth Dissertations

Metal distribution in Arabidopsis.
Arabidopsis -- Effect of metals on. ; Zinc -- Physiological transport. ; Iron -- Physiological transport. ; Plants -- Effect of iron on. ; Plants -- Effect of zinc on.
Iron and zinc deficiency commonly limit plant growth and crop yields. Furthermore, deficiencies in both of these micronutrients are common throughout the world, particularly in developing countries where people may only consume simple diets...
Dartmouth Dissertations

Coupling of termination, 3' processing and mRNA export.
Messenger RNA -- Genetic aspects. ; Transcription factors. ; Genetic transcription -- Regulation. ; RNA-protein interactions. ; Saccharomyces cerevisiae -- Genetics.
Dartmouth Dissertations

Preparations of oxysterols and derivatives for investigation of cholesterol regulation.
Oxysterols -- Synthesis. ; Oxysterols -- Derivatives -- Synthesis. ; Cholesterol -- Metabolism -- Regulation. ; Cholesterol -- Synthesis -- Regulation.
Dartmouth Dissertations

Isolation and characterization of Chinese hamster ovary cell lines possessing abnormal LDL-derived cholesterol trafficking.
Cholesterol. ; Mutation (Biology). ; Low density lipoproteins. ; Cell lines.
Dartmouth Dissertations

Iron uptake in Arabidopsis thaliana.
Arabidopsis thaliana. ; Iron -- Metabolism. ; Growth (Plants). ; Plants -- Effect of iron on.
Dartmouth Dissertations

Analysis of intracellular ion homeostasis during apoptotic cell death.
Apoptosis. ; Endonucleases. ; Calcium ions. ; Magnesium ions. ; Hydrogen-ion concentration.
A hallmark of apoptosis is internucleosomal DNA fragmentation catalyzed by an endogenous endonuclease. Many laboratories have implicated the activation of Ca2+/Mg2+-dependent endonucleases or the acid-dependent deoxyribonucleases, (DNase II),...
Dartmouth Dissertations

Constructing a dynamic model of hedgehog signaling.
Cellular signal transduction. Transcription factors. cos protein, Drosophila. Medical Terms: Hedgehog Proteins; Signal Transduction -- physiology; ci protein, Drosophila.
The evolutionarily conserved Hedgehog (Hh) signaling pathway is required for proper embryonic patterning and development. Deregulated Hh signaling has been implicated in various human carcinomas and developmental defects, thus elucidation of the...
Dartmouth Dissertations

A thermodynamic study of essential and toxic metals binding to proteins, peptides and small molecules involved in detoxification, storage, and gene regulation.
Metals -- Physiological effect. Binding sites (Biochemistry) -- Thermodynamics. Thiols. Thermometric titration. Zinc. Metallothionein. Genetic transcription -- Regulation.
Bioinorganic chemistry, a discipline that bridges chemistry and biology, has become increasingly popular as new techniques and analytical methods have emerged to study metals in biological systems. One such technique that has become increasingly...
Dartmouth Dissertations

New pathways of NAD+ metabolism and longevity.
NAD (Coenzyme) -- Metabolism. Nicotinamide -- Mechanism of action. Genetic regulation. Nicotinamide-beta-riboside.
NAD+ is an essential co-enzyme for hydride transfer enzymes and a consumed substrate of multiple signaling enzymes including the sirtuins, a family of protein lysine deacetylases shown to regulate longevity in a wide array of organisms. We have...
Dartmouth Dissertations

Cross-kingdom communication: The role of quorum sensing signals in Candida albicans and Pseudomonas aeruginosa interactions.
Pseudomonas aeruginosa -- Molecular genetics. Candida albicans. Pseudomonas aeruginosa infections. Plant-pathogen relationships. Cystic fibrosis -- Immunological aspects. Virulence (Microbiology) -- Molecular aspects. Medical Terms: Farnesol;...
The overall scope of my thesis project is to determine effects of farnesol, a secreted factor produced by C. albicans , on P. aeruginosa virulence. These two organisms are frequently found with one another in mixed infections and our lab has...
Dartmouth Dissertations

Distinct functions for diguanylate cyclases in regulating Pseudomonas aeruginosa PA14 surface-associated behaviors.
Pseudomonas aeruginosa -- Genetics. Biofilms -- Growth. Bacteria -- Motility. Guanylate cyclase. Cellular signal transduction.
Biofilm formation is a complex process culminating in a multicellular microbial structure encased in an extracellular matrix. In order for planktonic cells to initiate and proceed through biofilm formation, they must appropriately regulate a number...
Dartmouth Dissertations

Mechanisms of a glial modulating agent, propentofylline :potential new treatment for glioblastoma multiforme
Glioblastoma multiforme is the most common and aggressive primary brain tumor with a very poor prognosis despite multi-modalities of treatment. As a result, there is a critical need to develop alternative therapies. Propentofylline (PPF) is a...
Dartmouth Dissertations

Understanding the mechanisms of transcriptional control by the oncoprotein MYC / by Mandeep Kaur.
Even though 25 years have passed since the discovery of MYC, a complete understanding of the mechanism(s) of transcriptional control by this oncogenic transcription factor has not been achieved. Mcy is one of the most frequently deregulated...
Dartmouth Dissertations

Vibrio cholerae lipopolysaccharide peptide mimicry.
Endotoxins -- Immunology. Vibrio cholerae -- Immunology. Mimicry (Chemistry). Antigenic determinants. Peptides -- Immunology. Molecular mimicry -- immunology. Epitopes -- immunology.
The potential of peptide mimics of V. cholerae lipopolysaccharide (LPS) to elicit cross-reactive immune responses against LPS was investigated, as an alternative approach towards the development of a cholera vaccine. Peptide mimics of two...
Dartmouth Dissertations

Understanding the vulnerabilities of tumors : a network-based approach to drug target discovery / by Nadia M. Penrod.
The demand for novel molecularly targeted drugs will continue to rise as we make progress toward personalizing cancer treatments to the molecular signatures of individual tumors. While the collection and analysis of genomic data has become routine,...
Dartmouth Dissertations

Laying a solid foundation for Manhattan : 'setting the functional basis for the post-GWAS era' / by Xiaoyang Zhang
Genome-wide association studies (GWAS) have identified more than 8,900 genetic variants, mainly single nucleotide polymorphisms (SNPs), associated with hundreds of human traits and diseases, which define risk-associated loci (Hindorff et al., 2012 ...
Dartmouth Dissertations

Understanding PDZ affinity and selectivity: all residues considered / by Jeanine F. Amacher.
PDZ protein-protein interaction domains recognize short linear motif (SLiM) sequences typically at the extreme C-terminus of a target protein. These domains often act as scaffolds, connecting target proteins to additional interaction and catalytic...
Dartmouth Dissertations

Fusion proteins and select lipids cooperate as membrane receptors for the soluble snare Vam7p / by Vidya Karunakaran.
Yeast vacuole fusion involves three transmembrane SNAREs and a unique soluble SNARE, Vam7p. This SNARE cycles between vacuolar membrane-bound and cytosolic state. In its membrane-bound state, it is able to participate in vacuolar fusion by...
Dartmouth Dissertations

Nerve growth factor and the septohippocampal system / by Lan Guo.
Nerve growth factor (NGF), the prototypic neurotrophin, is well characterized for its pro-survival and growth effects in sympathetic and sensory neurons. Acting as a target-derived factor, NGF regulates the maturation of innervating neurons, and...
Dartmouth Dissertations

Links and regulatory loops between phospholipase C activity and colonization by the O2-responsive regulator Anr in Pseudomonas aeruginosa / by Angelyca A. Jackson.
Pseudomonas aeruginosa is a virulent opportunistic pathogen that is frequently cultured from infectious sites, and is estimated to cause ~12% of nosocomial infections worldwide [1]. P. aeruginosa infections occur in a majority of adults with the...
Dartmouth Dissertations

Novel mechanisms of action of putative pro-apoptotic BH3 mimetics and their potential therapeutic use / by Ryan Scot Soderquist.
The BCL2 family of proteins control intrinsic apoptosis at the mitochondria through a delicate balance of pro and anti-apoptotic proteins. Anti-apoptotic proteins are frequently relied upon by cancer cells, making them ideal targets for...
Dartmouth Dissertations

Exercise and the brain : impacts on cognition neural function and mental health / by Andrea M. Robinson.
It has been well established that physical exercise has broad impacts across the lifespan, including improved cognition, brain function, and mental health. Studies investigating the mechanism underlying the cognitive enhancing effect of exercise...
Dartmouth Dissertations

Sexual selection and sexual conflict in Anolis lizards : from molecules to populations / by M. Catherine Duryea.
Sexual selection is a driver of biodiversity and creates spectacular forms of variation. However, only recently have we begun to understand how this variation operates on the postcopulatory level and how cryptic mechanisms affect male-male...
Dartmouth Dissertations

The role of cell stress signalling in the induction of [gamma]-globin gene expression / by Emily K. Schaeffer.
Increased fetal hemoglobin (HbF) expression is beneficial for [beta]-hemoglobinopathy patients; however, most inducing agents do not possess the ideal combination of efficacy, safety and availability. Better understanding the mechanisms involved in...
Dartmouth Dissertations

Small molecule modulation of morphology and metabolism in Candida albicans / by Allia Kaye Smith
Candida albicans is a fungal species that naturally exists as a commensal member of the human microbiota, but can assume a pathogenic lifestyle and subsequently induce life-threatening systemic infections. The ability of the fungus to grow in...
Dartmouth Dissertations

On the nature mechanisms and neural correlates of visual feature conjunction learning / by Eric Andrew Reavis.
Visual searches for a conjunction of features (e.g., a particular combination of color and shape) are ordinarily slow and difficult. However, search efficiency for a particular conjunction can improve dramatically within a few hundred practice...
Dartmouth Dissertations

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