Increased fetal hemoglobin (HbF) expression is beneficial for [beta]-hemoglobinopathy patients; however, most inducing agents do not possess the ideal combination of efficacy, safety and availability. Better understanding the mechanisms involved in...
Lacrosse Teams Freshman, 1959; Class of 1962; Front row: Samuelson, D. S.; Cook, F. W.; Vaughan, M. C.; James, A., Jr.; Usher, D. P.; Kihlstedt, F. T. (Captain); Walters, J. C.; Rotter, S. A.; Slive, M. L.; McCollom, B. M.; Back row: Michael, K. B....
1961 Lacrosse Front row: Gillespie, JP '61, Walsh, PW '61, Sly, WG Jr '61 (Capt.), Rogers, TR '61, Walters, JC '62 2nd row: Cook, FW '62, Rotter, SA '62, Kihlstedt, FT '62, Thees, JD Jr '62, Weymuller, EA Jr '62 Back row: Duncan, DC '62, Whiting,...
1968-69 Dartmouth Varsity Basketball Team Front row , left to right: Randy Quayle; Cleve Penberthy; Jerry O'Brien, Captain; Greg Pickering, Van McQueen; Joe Cook; Tom Reddy; Middle row: John Ryzewic, Dave Howell; Gunnar Klintberg; Karl Steinmanis;...
1968-1969 Dartmouth Freshmen Basketball Team; Front row, left to right: Dave Friend; Gary Dicovitsky; Tim Copper; Captain Paul Erland; Pete Broberg; Bob Forman; Coach Gary Walters; Second row: Ed Wisneski; John J. Van Kurin; Robert M. King; James...
Antineoplastic agents -- Mechanism of action. Hemoglobin -- Synthesis -- Regulation. Protein kinases. Cellular signal transduction. Promoters (Genetics) -- Methylation. Azacitidine -- pharmacology. Fetal Hemoglobin -- biosynthesis. p38...
The β-hemoglobinopathies sickle cell disease and β-thalassemia represent some of the most common inherited diseases. It is recognized that increased fetal hemoglobin (HbF) ameliorates symptoms, mortality and morbidity in β-hemoglobinopathy...
Spatial heterogeneity inherent in ecological systems impacts both diversity and community structure. However, little is known about the influence of habitat heterogeneity on temporal variability in communities. I performed several studies to...
The overall scope of my thesis project is to determine effects of farnesol, a secreted factor produced by C. albicans , on P. aeruginosa virulence. These two organisms are frequently found with one another in mixed infections and our lab has...
This thesis approaches the problem of locating zero-day exploits used in network attacks. The hypothesis is that the advent of high-performance virtualization presents a unique opportunity to both discover these events and increase the attacker's...
1948 Rifle Squad Front row l to r: Moore, JW '50, Robie RA '50, Stahmer, HM Jr. '51, Abrahamson, JR '48 (capt.), Field, H Jr. '51, Hamlin, GB '51, Harvey, PV '51, Matthews, DI '51. Second Row: Rogal, BA '50, DeVaux, WJ '51, Carpenter, GC '50,...