Dartmouth Digital Library Program

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Operating system support for resilience / by Kathleen McGill.
Robots. ; Reinforcement learning. ; Social interaction. ; Cooperation. ; Biomimetics.
Dartmouth Dissertations

Characterization of Saccharomyces cerevisiae genes RAT8, RAT9/NUP85 and RAT10/NUP145.
Messenger RNA -- Physiological transport. ; Saccharomyces cerevisiae -- Genetics.
Dartmouth Dissertations

The molecular evolution of the Drosophila neurogenic ectodermal enhancers.
Drosophila -- Genetics. Transcription factors. DNA-protein interactions. Genetic transcription -- Regulation. Evolutionary genetics.
The control of gene expression is central to developmental biology, pattern formation, and phenotypic evolution. Enhancers are a class of regulatory DNAs that control when and where genes are turned ON or OFF. This highly regulated process is...
Dartmouth Dissertations

Coordination of cell proliferation and cell fate determination by C. elegans CES-1 Snail / by Bo Yan.
Cyclin-dependent kinases (CDKs) and their associated cyclins are key regulators of cell cycle progression. Caenorhabditis elegans has two predicted A- type cyclins, encoded by the genes cya-1 and cya-2. Cyclin A has been shown to be required for...
Dartmouth Dissertations

Inf2-formin that polymerizes and depolymerizes actin on endoplasmic reticulum.
Actin. Microfilament proteins. Polymerization. Endoplasmic reticulum.
Dartmouth Dissertations

Type-safe operating system abstractions.
Operating systems (Computers) -- Security measures. ; Device drivers (Computer programs).
Operating systems and low-level applications are usually written in languages like C and assembly, which provide access to low-level abstractions. These languages have unsafe type systems that allow many bugs to slip by programmers. For example, in...
Dartmouth Dissertations

Identification of signaling pathways coordinating cell growth and division in fission yeast / by Lin Deng
Cell growth and division are coordinated to keep homeostasis of cell size. The components of the core machinery are conserved in a wide range of cell types. Fission yeast (S. pombe) has been an important model organism to study cell size control...
Dartmouth Dissertations

Design and end-to-end test of a cloud-based Mobile Product Authentication architecture for low resource environments
Product counterfeiting -- Prevention.;""Drugs -- Marketing -- Corrupt practices -- Nigeria -- Prevention."";""Computer architecture."";""Cloud computing -- Security measures."";""Mobile computing -- Security measures.""
Dartmouth Dissertations

Understanding the vulnerabilities of tumors : a network-based approach to drug target discovery / by Nadia M. Penrod.
The demand for novel molecularly targeted drugs will continue to rise as we make progress toward personalizing cancer treatments to the molecular signatures of individual tumors. While the collection and analysis of genomic data has become routine,...
Dartmouth Dissertations

Laying a solid foundation for Manhattan : 'setting the functional basis for the post-GWAS era' / by Xiaoyang Zhang
Genome-wide association studies (GWAS) have identified more than 8,900 genetic variants, mainly single nucleotide polymorphisms (SNPs), associated with hundreds of human traits and diseases, which define risk-associated loci (Hindorff et al., 2012 ...
Dartmouth Dissertations

The ecology and bioenergetics of the northern black-throated blue warbler.
Wood warblers.
Dartmouth Dissertations

Integration of machine learning network science and pathway analysis in genetic epidemiology / by Qinxin Pan.
Although genome-wide association studies (GWAS) and other high-throughput initiatives have led to an information explosion in human genetics and genetic epidemiology, the mapping from genotype to phenotype remains challenging as most of the...
Dartmouth Dissertations

Quantitative risk analysis of computer networks.
Computer networks -- Security measures. Computer security. Risk assessment. Operating systems (Computers) -- Evaluation.
Quantitative Risk Analysis of Computer Networks (QSRA) addresses the problem of risk opacity of software in networks. It allows risk managers to get a detailed and comprehensive snapshot of the constitutive software on the network, assess its risk...
Dartmouth Dissertations

Bottom-up effects of nutrient enrichment on plants, pollinators, and their interactions.
Meadow ecology -- Colorado. Angiosperms -- Nutrition. Angiosperms -- Pollination. Plants -- Effect of nitrogen on. Insect pollinators -- Ecology -- Colorado. Mountain plants -- Ecology -- Colorado. Bees -- Ecology -- Colorado. Bees -- Nutrition --...
Nutrients play fundamental roles in biological systems, affecting plant growth and quality, community structure, and species interactions. Although the effects of nutrients on primary and secondary production have been well documented, their...
Dartmouth Dissertations

The role of the genes tra-4 and glp-5 in C. elegans development.
Caenorhabditis elegans -- Genetics. ; Caenorhabditis elegans -- Generative organs. ; Caenorhabditis elegans -- Development. ; Genetic transcription -- Regulation.
Sex determination in C. elegans leads to the development of sex-specific structures and contributes to the regulation of sexually dimorphic programmed cell death. A search for factors that regulate the sexually dimorphic cell death of the...
Dartmouth Dissertations

Biochemical studies of prion composition and conversion.
Prions. Proteins -- Conformation. Prions -- physiology. Prions -- genetics.
Prion diseases are fatal neurodegenerative disorders which affect a variety of different animal species including humans. The central pathogenic event underlying prion diseases is the conformational conversion of the cellular prion protein (PrP C )...
Dartmouth Dissertations

SHEMP: secure hardware enhanced MyProxy.
Public key infrastructure (Computer security). ; Computer networks -- Security measures. ; Operating systems (Computers). ; Microcomputers.
In 1976, Whitfield Diffie and Martin Hellman demonstrated how public key cryptography could enable secure information exchange between parties that do not share secrets. In order for public key cryptography to work in modern distributed...
Dartmouth Dissertations

A complex of the BCL2-like protein CED-9 and the BH3-only protein EGL-1 recruits DRP-1 to mitochondria and promotes mitochondrial fission
Mitochondria -- Physiology.; Fission (Biology) ; Guanosine triphosphatase. ; Caenorhabditis elegans. ; Caenorhabditis elegans Proteins -- physiology. ; GTP Phosphohydrolases -- physiology. ; bcl2-Associated Death Protein -- physiology.
Dartmouth Dissertations

Mesh-Mon: a monitoring and management system for wireless mesh networks.
Wireless communication systems. Computer networks. Routers (Computer networks).
A mesh network is a network of wireless routers that employ multi-hop routing and can be used to provide network access for mobile clients. Mobile mesh networks can be deployed rapidly to provide an alternate communication infrastructure for...
Dartmouth Dissertations

Anthropogenic changes to mercury and lead biogeochemistry in forest soils across the Northeastern United States / by Justin Byron Richardson
Understanding mercury (Hg) and lead (Pb) accumulation and retention in forest soils is needed to reduce their negative impacts on human and wildlife health. In addition, mercury and lead can be used to characterize the role of soil in terrestrial...
Dartmouth Dissertations

Characterizing the impact of single nucleotide variation in breast cancer / by Kinjal Desai
Genome sequencing technology has enabled the identification of genetic variants that are linked with cancer phenotypes, whether these are somatically acquired mutations or common inherited single nucleotide polymorphisms (SNPs). Whereas coding...
Dartmouth Dissertations

Mechanisms regulating interphase condensin II control of genome organization / by Huy Nguyen
How the genome is shaped directly influences how it is expressed. In fact, the genome is organized at many different levels, each imparting specific regulation over transcription. Fundamental principles regulating genome organization are poorly...
Dartmouth Dissertations

Identification and characterization of two mutants that affect Drosophila phototransduction.
Drosophila. Photoreceptors. TRP channels. Cellular signal transduction.
The phototransduction cascade in Drosophila is a prototypical G-protein signaling pathway and many of its components have been well-studied. Early genetic screens identified many of the major proteins involved in this pathway and study over the...
Dartmouth Dissertations

Evolution in fickle environments: dispersal, specialization, and the problem of heterogeneity.
Caenorhabditis elegans -- Ecology. ; Ecological heterogeneity. ; Evolution (Biology). ; Adaptation (Biology). ; Nematodes -- Dispersal.
All ecological theories regarding the distribution and relative abundance of species refer to organisms'' abilities to utilize an environment and (sometimes implicitly) their ability to colonize and re-colonize habitats that change in character or...
Dartmouth Dissertations

Performance evaluation of distributed security protocols using discrete event simulation.
Computer networks -- Security measures. BGP (Computer network protocol). Public key infrastructure (Computer security). Discrete-time systems -- Mathematical models. Computer simulation.
The Border Gateway Protocol (BGP) that manages inter-domain routing on the Internet lacks security. Protective measures using public key cryptography introduce complexities and costs. To support authentication and other security functionality in...
Dartmouth Dissertations

Analysis of reactor configurations for combined anaerobic-aerobic biotreatment of perchloroethylene.
Anaerobic bacteria -- Analysis. ; Biodegradation -- Testing. ; Bacteria Aerobic -- Analysis. ; In situ bioremediation -- Methodology. ; Bioremediation -- Methodology. ; Tetrachloroethylene -- Analysis.
Chlorinated ethenes are ubiquitous environmental pollutants of public concern due to their potential toxicity and carcinogenicity. Under appropriate conditions anaerobic bacteria mediate the dechlorination of perchloroethylene (a common dry...
Dartmouth Dissertations

Northeastern Venezuela''s Jurassic through Eocene passive margin, Hispaniola''s Neogene Cibao Basin, and their histories and causes of evolution.
Geology -- Venezuela. ; Geology -- Dominican Republic -- Cibao Basin. ; Geology Structural -- Venezuela. ; Geology.
Dartmouth Dissertations

Synthesis of porphobilinogen and studies on the synthesis of cobyric acid.
Tetrapyrroles -- Synthesis. ; Porphyrins -- Synthesis. ; Vitamin B12 -- Synthesis.
This thesis describes the synthetic study of two biologically related natural products: porphobilinogen (PBG) and cobyric acid. PBG is the key intermediate in the biosynthesis of all naturally occurring tetrapyrrolic 'pigments of life', including...
Dartmouth Dissertations

Control of developmental timing in Caenorhabditis elegans by lin-14.
Caenorhabditis elegans -- Genetics. ; Caenorhabditis elegans -- Growth. ; Cellular control mechanisms. ; Heterochrony (Biology). ; Developmental genetics.
The heterochronic gene lin-14 affects certain somatic cell-fate choices during post-embryonic development in C. elegans. In lin-14 mutants, cells express stage-specific developmental programs, such as cell divisions or dauer entry, at inappropriate...
Dartmouth Dissertations

Molecular characterization of human deoxyribonuclease II[alpha]: structural determinants of activity and therapeutic implications.
Deoxyribonucleases. ; Deoxyribonucleases -- Therapeutic use. ; Endonucleases -- Genetic aspects. ; Structure-activity relationships (Biochemistry). ; Pichia pastoris -- Cytogenetics. ; Cystic fibrosis -- Chemotherapy.
Dartmouth Dissertations

The regulation of apoptosis by protein phosphatases: impact on intracellular acidification and processing of the retinoblastoma protein.
Apoptosis. ; Phosphoprotein phosphatases. ; Retinoblastoma. ; Immunosuppression.
Dartmouth Dissertations

Runx1 expression and function in the development of murine definitive hematopoietic stem cells and blood lineages.
Transcription factors. ; Hematopoietic stem cells -- Genetic aspects. ; DNA-binding proteins. ; Mutation (Biology).
Dartmouth Dissertations

The molecular mechanisms of circadian phase in Arabidopsis thaliana.
Arabidopsis thaliana -- Genetics. ; Circadian rhythms. ; Genetic regulation.
Dartmouth Dissertations

Structural, stratigraphic, and thermo-chronological evolution of Trinidad.
Geochronometry -- Trinidad and Tobago -- Trinidad. ; Geology Structural -- Trinidad and Tobago -- Trinidad. ; Geology.
Dartmouth Dissertations

Functional analysis of the Runx1 C-terminal sequences.
Transcription factors. ; Hematopoiesis -- Regulation. ; Genetic transcription -- Regulation. ; DNA-binding proteins.
RUNX1 is a transcription factor regulating hematopoietic development. Study of the RUNX1 structure revealed two functional domains. The runt domain binds DNA and mediates interaction with CBFß. Sequences C terminal to the runt domain form the...
Dartmouth Dissertations

Biochemistry of isolated sea urchin mitotic apparatuses: protein phosphorylation and the control of mitosis.
Mitosis. ; Phosphorylation. ; Sea urchins -- Embryos.
Dartmouth Dissertations

Insights into the assembly and organization of higher-order septin structures.
Septins. ; Proteins -- Structure. ; Fluorescence spectroscopy. ; Molecular biology -- Instruments. ; GTP-Binding Proteins.
Dartmouth Dissertations

Metal distribution in Arabidopsis.
Arabidopsis -- Effect of metals on. ; Zinc -- Physiological transport. ; Iron -- Physiological transport. ; Plants -- Effect of iron on. ; Plants -- Effect of zinc on.
Iron and zinc deficiency commonly limit plant growth and crop yields. Furthermore, deficiencies in both of these micronutrients are common throughout the world, particularly in developing countries where people may only consume simple diets...
Dartmouth Dissertations

Coupling of termination, 3' processing and mRNA export.
Messenger RNA -- Genetic aspects. ; Transcription factors. ; Genetic transcription -- Regulation. ; RNA-protein interactions. ; Saccharomyces cerevisiae -- Genetics.
Dartmouth Dissertations

Molecular analysis of heterochronic gene lin-14 and developmental cell cycle control in Caenorhabditis elegans.
Caenorhabditis elegans -- Genetics. ; Cellular control mechanisms. ; Cell cycle.
During postembryonic development of C. elegans the heterochronic gene lin-14 controls the timing of developmental events in diverse cell types. Three alternative lin-14 transcripts are predicted to encode isoforms of a novel nuclear protein that...
Dartmouth Dissertations

Self-reconfiguring robots: designs, algorithms, and applications.
Robots -- Control systems. ; Robots -- Motion. ; Computer algorithms. ; Electronic data processing -- Distributed processing.
Self-reconfiguring robots are robots composed of many physically connected modules which can change their structural configuration to support multiple functionalities. We claim that self-reconfiguring robots are more versatile, extensible, and...
Dartmouth Dissertations

The study of an endonuclease and its potential role in apoptosis.
Deoxyribonucleases. ; Endonucleases. ; Apoptosis.
Previous work in this laboratory has implicated deoxyribonuclease II (DNase II) as an endonuclease responsible for DNA digestion during apoptosis. The goal of this thesis was to isolate the cDNA encoding DNase II and study its potential role in...
Dartmouth Dissertations

Cloning and expression of HVACM, a cullin protein, from small cell lung cancer.
Vasopressin -- Receptors. ; Small cell lung cancer. ; Genetic regulation. ; Molecular cloning. ; Immunohistochemistry.
Dartmouth Dissertations

Tools for studying Drosophila snRNAs: gene cloning and liposome fusion.
Drosophila. ; RNA.
Dartmouth Dissertations

Characterization of catalase and its role in life-span determination in Caenorhabditis elegans.
Caenorhabditis elegans -- Genetics. ; Caenorhabditis elegans -- Larvae. ; Caenorhabditis elegans -- Growth. ; Catalase -- Genetic aspects.
In nematodes an alternative third larval stage, often called the dauer stage, allows the animals to weather periods of low food availability (if free living) or to disperse (if parasitic). Recently, studies of mutations in the nematode...
Dartmouth Dissertations

A computational dissection in the evolution of cell growth.
Genetic regulation. Cells -- Growth -- Regulation. Ribosomes. DNA -- Synthesis. Evolutionary genetics.
Gene regulation is a principle tool that all organisms utilize to control development, growth, and responses to environmental conditions. Understanding how organisms orchestrate the spatiotemporal regulation of gene expression remains a fundamental...
Dartmouth Dissertations

Temporal regulation of microRNA expression during animal development.
RNA. Cells -- Growth -- Regulation. Caenorhabditis elegans -- Genetics. Caenorhabditis elegans -- Development. Drosophila melanogaster -- Genetic aspects. Drosophila melanogaster -- Development. Neurons -- Growth. Animal genetics.
MicroRNAs (miRNAs) are recently discovered family of genes with short non-coding RNA transcripts of 18 to 25 nucleotides in length. lin-4 and let-7 , the founding members of the miRNA gene family, control the timing of developmental programs in the...
Dartmouth Dissertations

Regulation of apoptosis in the Caenorhabditis elegans nervous system.
Caenorhabditis elegans -- Genetics. Neurons. Apoptosis. Genetic transcription -- Regulation.
Most of the cells that die during the development of a C. elegans hermaphrodite do so within 30 min after being generated. In these cells, the pro-caspase proCED-3 is inherited from progenitors and the transcriptional upregulation of the BH3-only...
Dartmouth Dissertations

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