Hospitals -- After care -- United States. Medicare beneficiaries -- Hospital care -- Costs. Geriatric orthopedics -- Economic aspects. Health services accessibility -- United States. After care -- supply & distribution -- United States.
Estradiol is a key regulator of immune protection in the female reproductive tract (FRT). Its concentration varies during the menstrual cycle, leading to changes in innate immune protection. In this thesis, I demonstrate the multiple levels at...
Many organisms recognize and respond to categories: predator, prey, rival, or juvenile. Organisms recognize these ecologically-important categories by assessing diverse sensory stimuli. A primary focus of my research has been understanding how...
The processes affecting gas transport through the firn column are important to understand in order to accurately interpret climate records from ice cores. Historically, density measurements have been used to estimate open and closed porosity in the...
Leukemia represents a small percentage of human cancer, accounting for about 5% of all cases of cancer in adults, but, interestingly, for about 50% of all cases of cancer in children. The behavior of leukemia is often regulated by the chromosomal...
In Chapter 2 we look at the distribution of permutation statistics in the context of pattern-avoiding permutations. The first part of this chapter deals with a recursively defined bijection of Robertson [37] between 123- and 132-avoiding...
The multisubunit eukaryotic Mediator complex integrates diverse positive and negative gene regulatory signals and transmits them to the core transcription machinery. It is also involved in chromatin structure related epigenetic silencing through...
Snowmelt from seasonal snow covers can be significant in many environments of northern and alpine areas. Water flow and chemical transport resulting from snowmelt have been studied for an understanding of contributions to watersheds or catchments....
Apoptosis is important for tissue homeostasis and is the mechanism of cell death induced by many anticancer agents. The apoptotic machinery is present in all cells, such that tight regulation must exist to prevent untimely cell and tissue death. To...
This thesis centers around a generalization of the classical discrete Fourier transform. We first present a general diagrammatic approach to the construction of efficient algorithms for computing the Fourier transform of a function on a finite...
Testicular germ cell tumors (TGCTs) are highly curable with cisplatin-based therapy. The p53 tumor suppressor is induced in response to a variety of cellular stresses. Our previous work has implicated an important role for p53 in TGCT...
In this thesis we study 1=k-geodesics, those closed geodesics that minimize on any subinterval of length L=k, where L is the length of the geodesic. These curves arise as critical points of the uniform energy, a function introduced in Morse theory...
In this thesis, we present different approaches to tying knots using robots by enforcing different types of constraints. We attack the problem from three different directions; mechanical design, motion planning with simple control strategies, and...
Immune response -- Regulation. Tretinoin. T cells. B cells. Plasma cells. Immunity.
Adaptive immunity licenses higher organisms to generate potent immune responses against foreign antigens. Two hallmarks of adaptive immunity are A) the ability of T and B cells to distinguish self from non-self and B) the ability to mount a...
CRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISPR associated) systems have been characterized as adaptive immune systems in bacteria and archaea, providing defense against mobile genetic elements, including bacteriophage,...
The essential QSR1 gene in Saccharomyces cerevisiae is a member of a highly conserved family of genes found in eukaryotic and archaebacterial cells. QSR1 was discovered by its synthetic lethal relationship with QCR6, the nuclear encoded gene for...
The Border Gateway Protocol (BGP) that manages inter-domain routing on the Internet lacks security. Protective measures using public key cryptography introduce complexities and costs. To support authentication and other security functionality in...
Electron donor-acceptor complexes. ; Complex compounds. ; Photochemistry.
In this study we have utilized spectroscopic and photoconductivity techniques to investigate free ion formation in the fumaronitrile/trans-stilbene charge transfer-complex. We report free ion yields resulting from the direct excitation of this...
This thesis describes a new synthesis of substituted (3H)-1,2-dithiole-3-thiones (dithiolethiones) from readily available starting materials. Dithiolethiones have a wide variety of industrial and pharmaceutical applications. These include use as...
Clinical medicine -- Practice. ; Medicine -- Practice. ; Group medical practice.
Health care micro-systems are small, organized groups of clinicians and staff working together with a shared clinical purpose to provide care for a defined set of patients. The size of individual micro-systems vary--a micro-system must be large...
Steep terrain produces a topographic effect in digital satellite data that can make it difficult to distinguish changes in vegetation species or health from changes in illumination geometry. A multiple linear regression analysis of direct solar...
Chronic neuropathic pain is a debilitating condition that exacts an emotional and physical toll on its sufferers and their family as well as an enormous monetary toll on society. Neuropathic pain can arise following nerve injury induced by trauma,...
Retinitis Pigmentosa is an inherited retinal degenerative disorder, initiated by point mutations on the rhodopsin gene. This thesis set forth to understand the mechanism of this pathogenesis, as well as to further improve our understanding of...