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- Identification and characterization of signaling pathways underlying the tumorigenic activity of [Delta]Np63[alpha] in breast cancer stem cells / by Amanda Lynn Balboni.
- Studies presented in this dissertation focus on the transcriptional targets and cellular functions of [Delta]Np63[alpha], the predominant TP63 isoform expressed in epithelial stem cell compartments. TP63, a member of the p53 family of...
- Dartmouth Dissertations
- Press Translations, Japanese
- Tokyo, Japan
- Press Translations, Japan, 1945-1946
- Teaching diverse orthopaedic patient populations about deliberative decision making skills : testing a design strategy for online patients' decision aids
- Clinical medicine -- Decision making. ; Medical informatics. ; Patient participation. ; Osteoarthritis -- Treatment. ; Knee -- Diseases -- Treatment. ; Decision Making. ; Decision Support Techniques.
- Problem Statement. Effective patients' decision aids (PtDAs) help patients understand clinical information and reduce decisional conflict. PtDAs that also explicitly provide guidance through four """"Deliberative Steps"""" may achieve additional...
- Dartmouth Dissertations
- Rapamycin and adiponectin in vascular smooth muscle cells : implications in the development of drug-eluting stents
- Stents (Surgery);Coronary arteries -- Stenosis -- Relapse -- Prevention -- Vascular smooth muscle -- Differentiation."";""Rapamycin."";""Drug delivery devices."";""Drug-Eluting Stents."";""Coronary Restenosis -- prevention &...
- Statement of the problem. Drug-eluting stents (DES) dramatically reduce the incidence of coronary restenosis, a frequent complication of percutaneous coronary interventions in the treatment of obstructive arterial diseases. However, they have been...
- Dartmouth Dissertations
- Local hyperthermia and nanoparticle targeting for cancer immunotherapy / by Seiko Toraya Brown.
- Local hyperthermia treatment for cancer has been used clinically in combination with and to enhance the efficacy of traditional treatments such as chemotherapy and radiation. In association with recent understanding of the importance of stimulating...
- Dartmouth Dissertations
- Automated forensic techniques for locating zero-day exploits / by Stephen Kuhn.
- This thesis approaches the problem of locating zero-day exploits used in network attacks. The hypothesis is that the advent of high-performance virtualization presents a unique opportunity to both discover these events and increase the attacker's...
- Dartmouth Dissertations
- Webster Association; Webster Cottage; Advertising ...
- Dartmouth College Photographic Records
- Webster Association; Webster Cottage; Advertising ...
- Dartmouth College Photographic Records
- Webster Association; Webster Cottage; Advertising ...
- Dartmouth College Photographic Records
- Webster Association; Webster Cottage; Advertising ...
- Dartmouth College Photographic Records
- Press Translations, Japanese
- Tokyo, Japan
- Press Translations, Japan, 1945-1946
- Press Translations, Japanese
- Tokyo, Japan
- Press Translations, Japan, 1945-1946
- MicroRNA-10b promotes pancreatic cancer cell invasion by suppressing TIP30 and enhancing EGF and TGF-[beta] actions / by Haoxu Ouyang
- MicroRNA-10b (miR-10b) is considered a marker of disease aggressiveness in pancreatic ductal adenocarcinoma (PDAC), in view of the fact that lower levels of miR-10b are associated with better response to neoadjuvant therapy, likelihood of surgical...
- Dartmouth Dissertations
- Novel dimensions in a fluid genome : an integrative risk analysis for cancers of the bladder and breast / by Asaf Wyszynski.
- The present thesis is focused on developing a better understanding of factors driving disease biology and overall risk using cancers of the bladder and breast as model systems. As no single approach was likely to unravel the complexities of these...
- Dartmouth Dissertations
- An evaluation of adrenergic and sympathetic influences modulating behavior in an animal model of neuropathic pain.
- Neuralgia -- Animal models. Allodynia -- Animal models. Adrenergic mechanisms. Sympathetic nervous system.
- Dartmouth Dissertations
- Cholesterol metabolism and human diseases
- Cholesterol -- Metabolism. ; ATP-binding cassette transporters. ; Niemann-Pick diseases -- Genetic aspects. ; Acyltransferases. ; Pregnenolone. ; Sterols. ; Acetyl-CoA C-Acetyltransferase.
- Dartmouth Dissertations
- The effects of endocrine disruptors on the development of Xenopus embryos.
- Xenopus laevis -- Embryology. Xenopus laevis -- Endocrinology. ; Estrogen -- Physiological effect. ; Estrogen -- Toxicology. ; Nonylphenol -- Physiological effect. Endocrine toxicology.
- Many environmental toxicants found in pesticides, herbicides, and industrial solvents are believed to have deleterious effects on development by disrupting hormone-sensitive processes. Xenopus embryos were exposed to commonly encountered endocrine...
- Dartmouth Dissertations
- Design of a magnetic field compatible, high-performance optical breast imaging system for MRI-guided optical spectroscopy / by Fadi El-Ghussein
- Multimodality imaging is becoming the standard of care for research and clinical studies. Such an approach is able to provide complementary information which can detect and characterize tumors. Advancing instrumentation for diffuse near-infrared...
- Dartmouth Dissertations
- The experimental analysis of mutlitple computationally-driven methods for the deletion of broadly distributed T cell epitopes in a functional biotherapeutic candidate / by Regina Salvat
- Novel biotherapeutics have reshaped drug discovery and promise a continued revolution in disease therapy, yet therapeutic proteins present unique design challenges. One distinguishing risk factor is the prospect of eliciting an adaptive immune...
- Dartmouth Dissertations
- Securing operating systems through utility virtual machines / by Robert Denz
- The advent of hypervisors revolutionized the computing industry in terms of malware prevention and detection, secure virtual machine managers, and cloud resilience. However, this has resulted in a disjointed response to handling known threats...
- Dartmouth Dissertations
- Historical and functional ecology of rainforest foragers / by Vivek V. Venkataraman
- This dissertation examines the behavioral and physiological adaptations employed by modern humans to subsist in tropical rainforests. I employ various theoretical and methodological approaches to test hypotheses using empirical data from African...
- Dartmouth Dissertations
- Determinants of the il-1β response to Pseudomonas aeruginosa / by Yash R. Patankar
- IL-1β is a potent proinflammatory cytokine produced in response to Pseudomonas aeruginosa infection. While it is appreciated that IL-1β is a critical modulator of the host response to P. aeruginosa infection, the host and bacterial determinants...
- Dartmouth Dissertations
- Design and synthesis of novel tricyclic-bis-enones: a series of highly active inhibitors of nitric oxide production in mouse macrophages.
- Alicyclic compounds -- Synthesis. ; Nitric-oxide synthase -- Inhibitors. ; Cyclooxygenases -- Inhibitors. ; Macrophages. ; Oxidoreductases -- Inhibitors. ; Inflammation -- Mediators -- Pathophysiology.
- Dartmouth Dissertations
- Patient outcomes and decision making in the treatment of hypoplastic left heart syndrome.
- Congenital heart disease in children -- Surgery -- Evaluation. ; Heart -- Abnormalities -- Surgery -- Evaluation. ; Outcome assessment (Medical care).
- Hypoplastic left heart syndrome (HLHS) is a heart malformation that requires surgical intervention for survival. Without surgery, 95% of neonates with HLHS die in the first month of life. Two surgical approaches are available, a series of...
- Dartmouth Dissertations
- Monitoring late radiation damage in normal muscle tissue with electrical impedance spectroscopy.
- Muscle cells -- Effect of radiation on. ; Radiation -- Physiological effect. ; Electrical impedance tomography. ; Spectroscopic imaging.
- Dartmouth Dissertations
- Immunomodulation and the prevention of pathogen-driven ileitis.
- Crohn's disease -- Prevention. Crohn's disease -- Treatment. Immune response -- Regulation. Toxoplasma gondii -- Pathophysiology.
- Oral infection with Toxoplasma gondii in susceptible C57BL/6 mice results in the morphologic, histologic and immunologic changes in the small intestine consistent with the human Inflammatory Bowel Disease (IBD) of unknown etiology, Crohn's disease....
- Dartmouth Dissertations
- Molecular characterization of the TCP biogenesis apparatus in Vibrio cholerae.
- Vibrio cholerae -- Molecular genetics. Pili (Microbiology). Cholera -- Pathogenesis. Proteins -- Secretion.
- Vibrio cholerae is a water-borne, Gram negative enteropathogen that causes the gastrointestinal disorder, cholera, in humans. A critical step in cholera pathogenesis is the attachment and colonization of intestinal cells, and the formation of...
- Dartmouth Dissertations
- Identifying airway obstructions from photoplethysmography (PPG).
- Plethysmography. ; Airway (Medicine) -- Obstructions. ; Respiration -- Mathematical models. ; Respiration -- Data processing. ; Airway Obstruction -- diagnosis.
- Emergency medical response requires timely and efficient assessment and treatment of casualties. Mass casualty situations, in particular, strain the resources of emergency responders, prompting the need for a well-organized, effective, automated...
- Dartmouth Dissertations
- Targeted manipulation of ß-globin promoter chromatin structure: implications for gene therapy of ß-hemoglobinopathies.
- Chromatin. ; Promoters (Genetics). ; Gene targeting. ; Globin genes -- Expression. ; Genetic vectors -- Therapeutic use. ; Hemoglobinopathy -- Treatment. ; Hemoglobinopathy -- Genetic aspects.
- Dartmouth Dissertations
- Secure context-sensitive authorization.
- Computers -- Access control. ; Authentication. ; Ubiquitous computing.
- Pervasive computing leads to an increased integration between the real world and the computational world, and many applications in pervasive computing adapt to the user's context, such as the location of the user and relevant devices, the presence...
- Dartmouth Dissertations
- Pre-clinical evaluation of the novel synthetic triterpenoid CDDO-imidazolide.
- Triterpenoid saponins -- Physiological effect. ; Triterpenoid saponins -- Mechanism of action. ; Triterpenoid saponins -- Therapeutic use. ; Imidazoles. ; Cancer cells -- Growth -- Regulation.
- 1[2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole (CDDO-lm) is a novel synthetic triterpenoid superior to its parent compound, 2-cyano-3, 12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO), both in vitro and in vivo. CDDO-Im is highly active in...
- Dartmouth Dissertations
- Peripheral and spinal mechanisms of neuropathic behaviors following peripheral nerve injury.
- Allodynia -- Animal models. ; Pain -- Physiological aspects. ; Nerves Peripheral -- Pathophysiology. ; Spinal cord -- Pathophysiology. ; Nerves.
- Dartmouth Dissertations
- A methodology for evaluating the development of new clinical emergency response technologies: Testing its validity using the case of electron paramagnetic resonance dosimetry.
- Electron paramagnetic resonance spectroscopy -- Technological innovations. Radiation dosimetry -- Technological innovations. Emergency management -- Technological innovations.
- Background. The development and implementation of emergency response technologies have relied on two independent and rarely integrated processes. Initially, research labs develop technologies without systematic consideration of the special needs...
- Dartmouth Dissertations
- Characterization of molecular subsets of scleroderma using pathway analysis and animal models.
- Scleroderma (Disease) -- Genetic aspects. Scleroderma (Disease) -- Molecular aspects. Cytokines -- Pathophysiology. Gene expression. Cellular signal transduction.
- Scleroderma (systemic sclerosis; SSc) is a devastating autoimmune disease of unknown etiology for which there is no cure, and no truly effective therapies available. Immune dysfunction, fibrosis and vasculopathy are the three major features of the...
- Dartmouth Dissertations
- The Matrix Metalloproteinase-1/protease activated receptor-1 signaling axis in melanoma progression.
- Collagenases -- Pathophysiology. Metalloproteinases -- Pathophysiology. Melanoma -- Molecular aspects. Matrix Metalloproteinase 1.
- The inappropriate expression of Matrix Metalloproteinases (MMPs) contributes to the pathology of many cancers. Among these, melanoma is a particularly insidious disease in that it is almost completely resistant to every known the therapy, and the...
- Dartmouth Dissertations
- The use of computer models to capture, understand and control dynamic brain processes.
- Brain -- Physiology -- Mathematical models. Brain stem -- Effect of chemicals on. Basal ganglia -- Physiology.
- Understanding how the brain works remains one of the toughest problems in science, despite the progress in scientific technology available for its study. The difficulty lies in the fact that the brain is a dynamic system, while the body of facts...
- Dartmouth Dissertations
- Antibody mediated targeting of nanoparticles to tumor cells
- Tumors -- Treatment -- Methodology.;""Nanoparticles -- Therapeutic use."";""Cell receptors."";""Antigenic determinants."";""Neoplasms -- therapy."";""Nanotechnology -- methods."";""Epitopes.""
- Dartmouth Dissertations
- Site-specific modification of glycoproteins expressed in an engineered strain of Escherichia coli.
- Glycoproteins -- Synthesis. Escherichia coli -- Biotechnology. Bioconjugates -- Synthesis. Protein engineering.
- We have created an E. coli based platform for protein modification by coupling an engineered glycosylation pathway with a subsequent chemoenzymatic labeling strategy in which the glycans are oxidized to provide a bioorthogonal aldehyde group that...
- Dartmouth Dissertations
- Immunomodulatory effects of chronic low dose arsenic exposure.
- Arsenic -- Toxicology. Lungs -- Diseases -- Immunological aspects. Lungs -- Diseases -- Genetic aspects. Medical Term Arsenic -- toxicity.
- Toxic metals are a major health concern in the environment and particularly in Superfund and other toxic waste sites. Arsenic (As) is considered the number one environmental chemical of human health concern both in the U.S. and worldwide. It is...
- Dartmouth Dissertations
- Development of a three-dimensional model for micrometastatic ovarian cancer: A translational research platform to rapidly evaluate mechanism-based combination treatments.
- Ovaries -- Cancer -- Photochemotherapy. Ovaries -- Cancer -- Treatment -- Evaluation. Ovaries -- Cancer -- Treatment -- Mathematical models.
- The translational potential of new therapeutic strategies for cancer is limited, in part, by a lack of biological models that capture important aspects of tumor growth and treatment response. It is also becoming increasingly evident that no single...
- Dartmouth Dissertations
- Impact of semen on mucosal transmission of HIV
- Semen is the major vector for sexual transmission of HIV worldwide, yet little is known about its role in modulating mucosal transmission of HIV. Understanding the impact of semen on mucosal transmission of HIV could open up novel means of...
- Dartmouth Dissertations
- Pharmacologic induction of human fetal hemoglobin through activation of the NRF2 antioxidant response signaling pathway
- Pharmacologic induction of fetal hemoglobin (HbF) has proven therapeutic potential for ß-hemoglobinopathy patients. Increased HbF reduces disease severity by decreasing sickling in sickle cell disease and reducing α-chain imbalance in...
- Dartmouth Dissertations
- Mechanisms of a glial modulating agent, propentofylline :potential new treatment for glioblastoma multiforme
- Glioblastoma multiforme is the most common and aggressive primary brain tumor with a very poor prognosis despite multi-modalities of treatment. As a result, there is a critical need to develop alternative therapies. Propentofylline (PPF) is a...
- Dartmouth Dissertations
- Investigation of the ISG15 deisgylase UBP43 in carcinogenesis : tumor suppressor or oncogene? / by Fadzai Chinyengetere.
- ISGylation is a type 1 interferon-regulated process that involves conjugation of ISG15, an ubiquitin-like protein, to target proteins. This posttranslational modification is reversed by a deubiquitinase known as UBP43 or USP18. UBP43 is deregulated...
- Dartmouth Dissertations
- Role of proteolytic processing of tumor necrosis factor-[alpha] in immunopathology during influenza infection / by Matthew Peter DeBerge.
- Influenza virus is a respiratory pathogen that is capable of causing considerable pulmonary pathology and respiratory dysfunction in humans. Seasonal influenza epidemics and the occasional influenza pandemic are responsible for significant...
- Dartmouth Dissertations
- Natural and engineered metabolism of Thermoanaerobacterium saccharolyticum during growth on plant derived mono- and polysaccharides / by Devin Hedley Currie.
- Many microbes thrive in conditions that would be detrimental to human life. These microorganisms have been dubbed extremophiles. Of these, members of a subcategory, termed thermophiles, grow optimally above 45°C. Thermoanaerobacterium...
- Dartmouth Dissertations
- Press Translations, Japanese
- Tokyo, Japan
- Press Translations, Japan, 1945-1946
- Press Translations, Japanese
- Tokyo, Japan
- Press Translations, Japan, 1945-1946
- Press Translations, Japanese
- Tokyo, Japan
- Press Translations, Japan, 1945-1946
- Press Translations, Japanese
- Tokyo, Japan
- Press Translations, Japan, 1945-1946

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