Dartmouth Digital Library Program

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Electrical impedance acquisition system for surgical margin assessment during robot-assisted laparoscopic prostatectomy / by Shadab Khan
Prostate cancer (PCa) recurrences are often predicted by assessing the status of surgical margins (SM) – positive surgical margins (PSM) increase the chances of biochemical recurrence by 2-4 times which may lead to PCa recurrence. At present,...
Dartmouth Dissertations

Facial expressions and identity as social cues for biologically relevant learning
Facial expression.; Threat (Psychology) ; Amygdaloid body -- Psychophysiology. ; Learning Psychology of. ; Memory. ; Attention.
The experiments comprising this thesis aimed to characterize the neural and behavioral correlates of learning about and responding to the predictive information conveyed by social cues. Facial expressions are cues that convey critical information...
Dartmouth Dissertations

CXCR3 and its cognate-chemokine expression : implications for cancer immunotherapy / by Eleanor Clancy-Thompson
Despite immunogenicity, melanoma-specific vaccines have demonstrated minimal clinical efficacy in patients with established disease, but enhance survival when administered in the adjuvant setting. It has been shown that T cell infiltration of...
Dartmouth Dissertations

The effect of suspended sediments on planktonic rotifers and cladocerans.
Freshwater zooplankton -- Effect of sediments on. Rotifera. Cladocera.
Dartmouth Dissertations

Assessing communication skills in medical education: development of the patient video interview.
Medicine -- Study and teaching -- Audio-visual aids. ; Communication -- Audio-visual aids. ; Medical history taking. ; Physician and patient. ; Psychometrics.
The Patient Video Interview (PVI) is an instrument designed to assess communication skills in medical education that overcomes some of the drawbacks of other assessment methods. Three studies were conducted to: (a) determine a measurement system...
Dartmouth Dissertations

The role of CD40 in cutaneous and regional immune responses.
CD antigens. ; Immune response -- Regulation. ; T cells -- Receptors. ; Antigens CD40. ; Lymphoma.
Dartmouth Dissertations

Opioid and nonopioid mechanisms of conditional analgesia.
Analgesia. ; Endorphins -- Physiological effect.
Dartmouth Dissertations

The function of tumor associated leukocytes in ovarian cancer growth.
Leucocytes -- Pathophysiology. Immunosuppression. Ovaries -- Cancer -- Pathophysiology. Peritoneum -- Cancer -- Pathophysiology. Medical Term Ovarian Neoplasms -- physiopathology. Peritoneal Neoplasms -- physiopathology.
Immunosuppressive leukocytes are emerging as a critical factor in facilitating tumor progression. These leukocytes are converted by the tumor microenvironment to become tolerogenic, facilitate metastasis, and to aid in neo-vascularization. The...
Dartmouth Dissertations

MLL1 plays an essential role in steady-state hematopoiesis and B Lymphopoiesis / by Tao Gan.
The Mixed Lineage Leukemia (MLL1) gene was first cloned as a hot spot of chromosomal translocations in acute leukemia. More than 70 fusion proteins of MLL1 have been described in both lymphoid and myeloid leukemia and many are highly associated...
Dartmouth Dissertations

Computational methods for the discovery and application of protein sequence-structure-function relationships / by Lu He.
Proteins are ubiquitous in cells and are essential to a wide range of biological processes. Since existing proteins occupy only a small portion of the space of possible amino acid composition, understanding their sequence-structure-function...
Dartmouth Dissertations

The role of cell stress signalling in the induction of [gamma]-globin gene expression / by Emily K. Schaeffer.
Increased fetal hemoglobin (HbF) expression is beneficial for [beta]-hemoglobinopathy patients; however, most inducing agents do not possess the ideal combination of efficacy, safety and availability. Better understanding the mechanisms involved in...
Dartmouth Dissertations

Novel dimensions in a fluid genome : an integrative risk analysis for cancers of the bladder and breast / by Asaf Wyszynski.
The present thesis is focused on developing a better understanding of factors driving disease biology and overall risk using cancers of the bladder and breast as model systems. As no single approach was likely to unravel the complexities of these...
Dartmouth Dissertations

An evaluation of adrenergic and sympathetic influences modulating behavior in an animal model of neuropathic pain.
Neuralgia -- Animal models. Allodynia -- Animal models. Adrenergic mechanisms. Sympathetic nervous system.
Dartmouth Dissertations

Genetic inactivation of ACAT1 ameliorates the amyloid pathology and cognitive deficits in a mouse model of Alzheimer's disease.
Acyltransferases -- Genetic aspects. Enzyme inhibitors. Alzheimer's disease. Amyloid.
Acyl-CoA:Cholesterol Acyltransferases (ACATs) are key enzymes in cellular cholesterol metabolism. ACAT converts free cholesterol to cholesterol ester, which makes it more easily storable in lipid droplets. There are two ACAT genes encoding two...
Dartmouth Dissertations

Fish foraging and learning in complex environments.
Sunfishes -- Food. Sunfishes -- Effect of habitat modification on
Dartmouth Dissertations

From target discovery to high-throughput screens--selective CAL PDZ inhibitors as candidate CF therapeutics
Peptides -- Therapeutic use. ; Chloride channels -- Pathophysiology. ; Ligands (Biochemistry) ; Protein-protein interactions. ; Cystic fibrosis -- Molecular aspects. ; High throughput screening (Drug development) ; PDZ Domains. ; Cystic Fibrosis...
PDZ domains are protein:protein interaction domains that serve as molecular scaffolds, especially in the case of specialized cellular environments like polarized airway epithelial cells of the human lung. Historically the domains have been thought...
Dartmouth Dissertations

Structural, functional, and biochemical approaches to understanding the role of the C1 microtubule of the flagellar central apparatus.
Microtubules. Dynein. ; Eukaryotic cells -- Motility.
The eukaryotic flagellum is a complex organelle that uses the force generated by dynein motors to cause beating motion of the flagellum. The central apparatus of eukaryotic flagella has been implicated in the regulation of dynein-driven motility....
Dartmouth Dissertations

Experiment planning for protein structure elucidation and site-directed protein recombination.
Proteins -- Structure -- Computer simulation -- Experiments. ; Amino acid sequence -- Data processing -- Experiments. Protein engineering -- Experiments. ; Recombinant proteins -- Mathematical models.
In order to most effectively investigate protein structure and improve protein function, it is necessary to carefully plan appropriate experiments. The combinatorial number of possible experiment plans demands effective criteria and efficient...
Dartmouth Dissertations

Exploring the role of CD4 T cell help in the generation of CD8+T cell responses against acute and persistent viral infections
T cells -- Receptors. ; Immunologic memory. ; CD8-Positive T-Lymphocytes -- immunology. ; CD4-Positive T-Lymphocytes -- immunology. ; Vaccinia virus -- immunology. ; Herpesviridae Infections -- immunology.
Dartmouth Dissertations

Children's interpretations of observed noncontingent reward: effects of sharing behavior.
Child psychology. ; Sharing.
Dartmouth Dissertations

Neuronal interferon signaling : implications for HSV-1 replication and pathogenesis / by Pamela Rosato
Herpes simplex virus-1 (HSV-1) establishes lifelong latent infections in the sensory neurons of the trigeminal ganglia (TG) wherein it retains the capacity to reactivate. The interferon (IFN)-driven antiviral response is critical for the control of...
Dartmouth Dissertations

Novel approaches to targeting innate immunity for cancer immunotherapy / by Patrick H. Lizotte
Many kinds of cancer, and almost universally metastatic cancer, are refractory to treatment by conventional methods: surgery, radiation, and non-specific cytotoxic chemotherapy. The dawn of the age of personalized medicine presaged 15 years ago...
Dartmouth Dissertations

Biological significance of VIVID photocycle length and the control of gene expression by the Neurospora clock / by Arko Dasgupta
Sensing light from the environment using photoreceptors is of great adaptive significance to eukaryotes. A prominent feature of the photochemistry of these receptors is the photocycle length, the time taken to decay from the initial signaling light...
Dartmouth Dissertations

Relating behavioral control and brain development : insights from adolescence / by Heidi Catherine Meyer
Across mammalian species, adolescence is characterized by a unique combination of cognitive, behavioral and neurobiological changes. Behavioral tendencies observed during this period promote a variety of flexible interactions with the surrounding...
Dartmouth Dissertations

Cellular organization in syncytia : nuclear autonomy and cytosolic organization across kingdoms / by Samantha Elizabeth Roberts
All cells must organize their cytoplasm in order to carry out functions properly and survive in different environments, and the requirement for organization is increased in large, multinucleate cells. It has long been known that membrane-bound...
Dartmouth Dissertations

Cytoskeletal reorganization in B lymphocyte activation.
Lymphocyte transformation.
Dartmouth Dissertations

Neuroimmune and behavioral responses to peripheral nerve injury in the rat.
Nerves. ; Peripheral -- Pathophysiology. ; Nervous system -- Diseases -- Immunological aspects. ; Spinal cord -- Pathophysiology. ; Pain -- Physiological aspects. ; Rats -- Nervous system -- Diseases -- Immunological aspects. ; Rats -- Behavior.
The pain that follows nerve injury is chronic and consistently refractory to available analgesics. Neuropathic pain syndromes include deafferentation pain, diabetic, cancer and ischemic neuropathies, phantom limb pain, trigeminal neuralgia,...
Dartmouth Dissertations

The regulation of apoptosis by protein phosphatases: impact on intracellular acidification and processing of the retinoblastoma protein.
Apoptosis. ; Phosphoprotein phosphatases. ; Retinoblastoma. ; Immunosuppression.
Dartmouth Dissertations

Impacts of arid land shrub expansion on soil carbon cycling from [superscript 14]C ages and carbon and oxygen isotope ratios of pedogenic calcite and organic matter.
Desertification -- New Mexico. ; Humus -- New Mexico. ; Carbon cycle (Biogeochemistry). ; Calcite.
Dartmouth Dissertations

Immunotherapy of B-cell malignancies: directing T-cell responses and blocking lineage-specific survival factor pathways.
B cells -- Tumors. ; Cancer -- Immunotherapy. ; T cells. ; CD antigens.
The indolent B-cell malignancies of lymphoma and myeloma account for a great number of adult cancers in the United States annually. Hi-dose combination chemotherapy, bone marrow transplants and monoclonal antibody therapeutics have improved the...
Dartmouth Dissertations

Effects of mitomycin C and other DNA crosslinking agents on gene expression: modulation of cancer cell multidrug resistance in cell culture and in vivo.
Mitomycin C -- Genetic aspects. ; DNA damage. ; Drug resistance in cancer cells. ; Cancer -- Chemotherapy -- Genetic aspects.
Our laboratory is concerned whether the distribution of chemically-induced DNA damage is non-random at the level of individual genes. Using changes in gene expression as a marker for DNA damage, we have previously demonstrated that genotoxic...
Dartmouth Dissertations

Biophysical analysis of the role of γc in the assembly of the interleukin-2 receptor.
Interleukin-2. ; T cells -- Receptors. ; Structure-activity relationships (Biochemistry). ; Biophysics.
Dartmouth Dissertations

Stimulus control in children under blocking paradigm.
Learning, Psychology of. ; Stimulus compounding. ; Response consistency.
Dartmouth Dissertations

IL-1 regulation of collagenase-3 (MMP-13) gene expression in chondrocytic cells.
Interleukin-1. ; Extracellular matrix proteins -- Metabolism. ; Cartilage cells -- Metabolism. ; Metalloproteinases -- Genetic aspects. ; Collagenases -- Genetic aspects. ; Genetic transcription -- Regulation. ; Chondrocytes
The matrix metalloproteinases (MMPs) are family of enzymes with a common domain structure that degrade extracellular matrix proteins; these enzymes are overexpressed in numerous diseases including cancer and arthritis. Collagenase-1, 2, 3 (MMP-1,...
Dartmouth Dissertations

The identification of Gp39:CD40-A ligand receptor pair essential to humoral immunity: studies in the regulation of GP39 expression.
T cells -- Genetic aspects. ; B cells -- Genetic aspects. ; Ligand binding (Biochemistry). ; Lymphocyte transformation. ; Immune response -- Regulation. ; Immunogenetics.
Dartmouth Dissertations

Effects of elevated endogenous kynurenic acid on spatial working memory, contextual conditioning, and conditional learning.
Kynurenine -- Derivatives. Cognition. Memory. Brain chemistry. Brain -- Pathophysiology -- Animal models.
Kynurenic acid (KYNA) is produced and released by astrocytes, and acts as an α7-nicotinic acetylcholine receptor antagonist (at lower, physiological concentrations) and an antagonist of the glycine site of the NMDA receptor (at higher,...
Dartmouth Dissertations

The influence of trait psychopathy on the decoding, interference and utilization of emotional information.
Psychopaths. Personality and emotions. Emotions and cognition.
Research investigating clinical and criminal psychopaths is quite extensive. Though it has evolved in terminology over the years, the basic premise and description of psychopathy has maintained deficits associated with emotional interpretation and...
Dartmouth Dissertations

DNA damage and cell cycle checkpoint regulation: The search for novel anticancer agents and combinations.
Ataxia telangiectasia -- Molecular aspects. DNA damage. Cell cycle -- Regulation. Antineoplastic agents. Cancer cells -- Growth -- Regulation. Medical Term Cell cycle proteins.
DNA can be damaged by many endogenous and exogenous factors. In response to DNA damage, cells activate cell cycle checkpoints to stop the cell cycle and allow time for repair of the damage. Defects in these pathways allow replication to continue...
Dartmouth Dissertations

Three factors influencing physical health in serious mental illness:smoking, health education, and employment
The confluence of patient, provider, and system level factors contributes to excess mortality due to preventable medical conditions among people with serious mental illness (SMI) compared to the general population. Study one explored how...
Dartmouth Dissertations

Combined MRI and near-infrared spectroscopy for increased specificity of breast cancer imaging / by Michael A. Mastanduno.
A yearly breast contrast-MR scan is recommended to high-risk women because of MR's high sensitivity to breast tumors. However, breast contrast-MR yields a high number of false positives that lead to expensive and sometimes unnecessary biopsy...
Dartmouth Dissertations

Understanding the vulnerabilities of tumors : a network-based approach to drug target discovery / by Nadia M. Penrod.
The demand for novel molecularly targeted drugs will continue to rise as we make progress toward personalizing cancer treatments to the molecular signatures of individual tumors. While the collection and analysis of genomic data has become routine,...
Dartmouth Dissertations

MicroRNA-10b promotes pancreatic cancer cell invasion by suppressing TIP30 and enhancing EGF and TGF-[beta] actions / by Haoxu Ouyang
MicroRNA-10b (miR-10b) is considered a marker of disease aggressiveness in pancreatic ductal adenocarcinoma (PDAC), in view of the fact that lower levels of miR-10b are associated with better response to neoadjuvant therapy, likelihood of surgical...
Dartmouth Dissertations

Magnetic nanoparticle hyperthermia as an adjuvant cancer therapy with chemotherapy / by Alicia Ailie Petryk.
Magnetic nanoparticle-based hyperthermia for cancer treatment is a promising technology, particularly when applied as part of an adjuvant strategy with established cancer therapies (chemotherapy, radiation and surgery). In Europe, early clinical...
Dartmouth Dissertations

Estradiol regulation of innate immune protection in the human female reproductive tract / by Mickey Vinay Patel.
Estradiol is a key regulator of immune protection in the female reproductive tract (FRT). Its concentration varies during the menstrual cycle, leading to changes in innate immune protection. In this thesis, I demonstrate the multiple levels at...
Dartmouth Dissertations

Rejuvenation of cohesion during meiotic prophase is required for maintenance of chiasmata and accurate chromosome segregation / by Katherine Adalia Weng.
Accurate chromosome segregation in human oocytes requires that meiotic sister chromatid cohesion remain intact for decades and work in model organisms indicates that deterioration of meiotic cohesion over time may be a major determinant of...
Dartmouth Dissertations

Endogenous leukocyte activation by chimeric antigen receptor T cell immunotherapy / by Paul Spear.
Many protocols for adoptive T cell therapy (ACT) include preparative conditioning strategies to deplete host lymphocytes prior to T cell infusion. Total body irradiation and high-dose chemotherapy regimens not only relieve immunosuppression, but...
Dartmouth Dissertations

Using theory to predict phase behaviour in liquids, copolymer melts, and ultrathin polymer films / by Nicholas B. Tito.
Thermodynamics, and the classic balance between entropy and enthalpy, provides a proverbial zoo of exotic phase behaviour that chemists can harness to create new materials out of simple liquids and polymers. The diversity of self-assembling...
Dartmouth Dissertations

Laying a solid foundation for Manhattan : 'setting the functional basis for the post-GWAS era' / by Xiaoyang Zhang
Genome-wide association studies (GWAS) have identified more than 8,900 genetic variants, mainly single nucleotide polymorphisms (SNPs), associated with hundreds of human traits and diseases, which define risk-associated loci (Hindorff et al., 2012 ...
Dartmouth Dissertations

Alterations in the production of bacteriochlorophyll a and okenone in purple sulfur bacteria : implications for the interpretaion of their biomarkers / by Derek A. Smith.
Purple sulfur bacteria (PSB) can dominate the nitrogen, carbon, and sulfur cycles in anoxic ecosystems via their anoxygenic photosynthetic metabolisms and are the only producers of the carotenoid, okenone, a biomarker targeted for photic zone...
Dartmouth Dissertations

Utilization and health outcomes in a spatial model of the US health care system / by Laura C. Yasaitis.
Objectives: This dissertation comprises three essays on geographic variations in healthcare, and the association between utilization and health outcomes. I first explore associations between outpatient visits and Medicare beneficiaries'...
Dartmouth Dissertations

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